The Scientific Revolution involved a new way of thinking that challenged traditional views. Copernicus developed a heliocentric model of the solar system that placed the Sun, not Earth, at the center. Kepler later proved that planets orbit in ellipses, not circles. Galileo used a telescope to observe craters on the Moon and moons orbiting Jupiter, supporting Copernicus' theory. Newton later published Principia, explaining gravity and its effects on planetary motion. Discoveries were also made in biology through anatomy studies and microscopy, and in chemistry through experimentation and precise measurements. While the Catholic Church initially opposed challenges to its authority, it benefited from advances that enabled Renaissance art and architecture.
The Scientific Revolution, which is a modern term to describe the precursor to contemporary science, refers to a period of changing doctrinal beliefs and using a more scientific approach to find out logical truth. Factors such as the Renaissance, Reformation, weakening of the Roman Catholic Church, are some major factors which lead to the Scientific Revolution. Furthermore, this powerpoint will cover a series of "scientists" or philosophers who had the courage to change the mentality of Europe during the 1400s up until 1727.
The Scientific Revolution, which is a modern term to describe the precursor to contemporary science, refers to a period of changing doctrinal beliefs and using a more scientific approach to find out logical truth. Factors such as the Renaissance, Reformation, weakening of the Roman Catholic Church, are some major factors which lead to the Scientific Revolution. Furthermore, this powerpoint will cover a series of "scientists" or philosophers who had the courage to change the mentality of Europe during the 1400s up until 1727.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...
Scientific Revolution.ppt
1. Section 1
Enlightenment and Revolution
“If I have seen farther than others, it is
because I was standing on the shoulders
of giants.”
- Isaac Newton
Americans on average eat 18 acres of
pizza every day.
4. Section 1
Enlightenment and Revolution
Main Idea
New ways of thinking led to remarkable
discoveries during the Scientific
Revolution.
The Scientific Revolution
5. Section 1
Enlightenment and Revolution
Some Middle Ages scholars sought answers about the natural world from
the church. In the mid-1500s, others began to think in new ways.
• Scholars relied on traditional
authorities for beliefs about
structure of universe
• Geocentric theory, Aristotle
– Earth center of universe
– Sun, moon, planets revolved
around sun
• Ideas upheld by church, accepted
authority for European intellectuals
The Old View
• Scholars began to challenge
traditional authorities, 1500s
• Scientific Revolution, new way
of thinking
• Posed theories, developed
procedures to test ideas
• Why open to new ideas?
– Exploration
– New lands, new people, new
animals
New Viewpoints
Dawn of Modern Science
7. Section 1
Enlightenment and Revolution
Dawn of Modern Science
Ancient scholars could provide no information about
new lands, people, animals
• Age of Exploration led scientists to study natural world
more closely
• Other things to be discovered, things unknown to
ancients
• Navigators needed more accurate instruments,
geographic knowledge
• Scientists examined natural world, found it did not
match ancient beliefs
8. Section 1
Enlightenment and Revolution
• Francis Bacon,
experimentation to gain
scientific knowledge
• Rene Descartes, reason key
• Believed everything should be
doubted until proved by reason
• Relied on math, logic
• Ideas of both continue to
influence modern scientific
methods
Scientific Method Scholars
• Scientific Method
• Identify problem
• Form hypothesis
• Perform experiments to test
hypothesis
• Record results
• Analyze results, form
conclusion
New Approach to Investigation
The Scientific Method
11. Section 1
Enlightenment and Revolution
Question:
What was the Scientific Revolution?
Answer(s): a new way of thinking about the
natural world that challenged traditional views and
instead relied upon experimentation
12. Section 1
Enlightenment and Revolution
Early scientists
• Made significant contributions in astronomy, physics and math
• Began to explain complexities of solar system, limits of physical world
• Nicolaus Copernicus, Polish astronomer, among first
Copernicus’ theory
• Idea of earth orbiting sun was not completely new
• Copernicus developed detailed mathematical explanation of process
• Was first scientist to create complete model of solar system
Copernicus
• Found geocentric theory of movement of sun, moon, planets not accurate
• Concluded sun, not earth, near center of solar system
• Heliocentric theory, earth revolves around sun
Discoveries in Astronomy, Physics, and Math
16. Section 1
Enlightenment and Revolution
Weaknesses of theory
• Mathematical formulas did not predict positions of planets well
• Copernicus did not want to be ridiculed for weaknesses
• Died 1543 after work published, other scientists expanded on ideas
On the Revolutions of the Heavenly Spheres
• Copernicus’ famous book not published until last year of his life
• Knew church would oppose work
• Work contradicted teachings of church
18. Section 1
Enlightenment and Revolution
Brahe, Danish Astronomer
• Wrote book proving bright object over Denmark sky was newly visible
star
• Called it supernova, distant exploding star suddenly visible on earth
• Book impressed Denmark’s King Frederick II
• Gave Brahe money to build two observatories
• Brahe used observatories -
developed system to explain
planetary movement
• Believed sun revolved around earth
• Other five known planets revolved
around sun
Observations
• Hired as Brahe’s assistant to form
mathematical theory from
measurements of planets
• Published result of measurements of
orbit of Mars after Brahe’s death
Kepler, German
Mathematician
Brahe and Kepler
20. Section 1
Enlightenment and Revolution
Kepler’s Solution
Kepler solved main problem of Copernican
theory
• Copernicus assumed planets orbited in circle
• Kepler found assumption untrue - proved planets
orbited in oval pattern, ellipse
• Wanted to prove Copernicus wrong, instead
proved heliocentric theory correct
• Kepler’s mathematical solar system model also
correct
24. Section 1
Enlightenment and Revolution
More support
• Italian scientist Galileo Galilei
• Built first telescope used for
astronomy
• Scanned heavens beginning in
1609
Change in science world
• Isaac Newton, English scientist
• Brought together astronomy,
physics, math
• Wondered about gravity
Starry Messenger
• Galileo described discoveries
• Craters on moon, sunspots
• Saturn, moons of Jupiter
• Milky Way made up of stars
Principia
• Book explained law of universal
gravitation
• Gravity affects objects on earth,
also in universe
• Keeps planets in orbit
Discoveries in Astronomy, Physics, and Math
34. Section 1
Enlightenment and Revolution
Newton’s Findings
Newton developed calculus, new kind of math
• Used calculus to predict effects of gravity
• German philosopher Gottfried von Leibniz also
developed calculus at same time
• Each accused the other of plagiarism
• Historians believe it was simple case of
independent discovery
35. Section 1
Enlightenment and Revolution
Question:
How did Copernicus and Brahe differ in their
views of the universe?
Answer(s): Copernicus—all planets orbit the sun;
Brahe—sun orbits Earth, other planets orbit sun
36. Section 1
Enlightenment and Revolution
Just as astronomers moved away from the works of ancient Greeks, other
scientists used the scientific method to acquire new knowledge and make
great discoveries in the fields of Biology and Chemistry.
• European Middle Ages
doctors relied on
Greek, Galen
• Galen’s works
inaccurate
• Flemish doctor
Andreas Vesalius
became known for
work in anatomy
Biology
• Used bodies of
executed criminals for
dissection
• Hired artists to
produce accurate
drawings
• On the Workings of
the Human Body,
1543
Vesalius
• English physician,
early 1600s
• Observed, explained
workings of human
heart
• Described blood,
circulatory system
functions
William Harvey
Discoveries in Biology and Chemistry
39. Section 1
Enlightenment and Revolution
Robert Hooke
• English physician, inventor
• Used early microscope to describe appearance of plants at microscopic
level
• Credited with creating the term cell
Antony van Leeuwenhoek
• Dutch scientist, 1600s
• Used interest in developing magnifying lens to invent microscope
• First to describe appearance of bacteria, red blood cells, yeast, other
microorganisms
42. Section 1
Enlightenment and Revolution
• French chemist, 1700s
• Developed methods for precise
measurements
• Discovered law of Conservation of
Mass, proved matter could not be
created, destroyed
• Recognized, named oxygen,
introduced metric system,
invented first periodic table
Antoine-Laurent Lavoisier
• Father of modern chemistry
• First to define element
• The Sceptical Chemist, 1661,
described matter as cluster of tiny
particles (now called atoms)
• Changes in matter occurred when
clusters rearranged
• Boyle’s law - temperature,
volume, pressure affect gases
Robert Boyle
Chemistry
46. Section 1
Enlightenment and Revolution
Question:
What were the major contributions made in
biology and chemistry?
Answer(s): importance of anatomy and
dissection; function of blood and circulatory
system; invention of microscope; discovery of
certain laws of matter
47. Section 1
Enlightenment and Revolution
The church feared reason as an enemy of faith, but eventually began to
embrace some of the achievements of the Scientific Revolution.
As science assumed greater significance, the question of the role of the
Roman Catholic Church in a changing culture became important. While the
church opposed the views of many scientists, it benefited from new
discoveries that made Renaissance art and architecture possible.
• Church most powerful institution in
Europe, Middle Ages
• Primary resource for knowledge,
learning
• Cathedral schools, universities
trained people to run the church
Science and the Church
Science and Society
• Most scientists did not want to
challenge role of Christianity
• Church explained world through
inspiration, revealed truth
• Science explained world through
logical reasoning
Conflicts
49. Section 1
Enlightenment and Revolution
Renaissance
• Study of art, architecture not
separate from study of science
• Artists learned anatomy in order
to paint the body
Architecture
• Mathematics, physics crucial to
great architecture
• Also used in engineering
achievements of the time
Artists
• Experimented with chemistry of
paints, nature of light
• Used math to create compositions
of perfect balance
Science and religion
• Combined to produce great
artistic achievements of
Renaissance
• Most art, architecture dedicated to
glory of God
Science and Art
50. Section 1
Enlightenment and Revolution
Science and Community
Scientific Revolution established new way of
thinking about physical world
• Great advances made in astronomy, physics,
biology, chemistry
• Advances influenced developments in arts,
architecture
• Impact of Scientific Revolution soon would cause
philosophers, scholars to wonder if reason could
solve poverty, war, ignorance