This study evaluated the anti-inflammatory properties of the aqueous extract of Solena amplexicaulis leaves in rats. Rats were injected with egg white to induce paw edema and treated with the extract, diclofenac sodium (standard drug), or saline (control). Paw volume was measured over 60 minutes. The extract significantly reduced paw edema compared to control, demonstrating anti-inflammatory effects comparable to diclofenac sodium. The extract likely inhibits the release of inflammatory mediators like histamine and prostaglandins. Therefore, the aqueous extract of S. amplexicaulis leaves has potent anti-inflammatory activity.