The document discusses various types of corneal diseases including congenital, traumatic, inflammatory, degenerative/dystrophic, and neoplastic conditions. It provides details on infectious keratitis caused by bacteria like Staphylococcus, Pseudomonas, and Neisseria as well as fungi and protozoa. Viral keratitis from herpes simplex virus, herpes zoster virus, and adenovirus are also examined. Signs, risk factors, investigations, and treatment approaches are described for each condition. Inflammatory keratitis can be infective or immune-related disorders like marginal keratitis and Mooren's ulcer are also reviewed.
This presentation describes all clinical aspects of infectious corneal ulcers
You can watch the illustrated presentation in this link :
https://www.youtube.com/watch?v=okWDPG3C34g&list=PLZ_mM13I_TrhwqZuGjB6M9Z3n7MntrURd
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3. Corneal ex.
• Assessment of any sign (diameter, thickness,
steepness)
• Any sign defect, scar, odema, opacity, infiltrate,
precipitate, deposit, filament, guttatta, folds,
desmatocele, sensation, PEDAL
Site
Size
Level
Surrounding
Laterality
4. Sailing through cornea
Hx, symptoms, signs
+ assessment + any sign
Sailing through eye
Lid problem, OSD, scleritis, IOP, infection
Sailing through body
Age (ulcer), autoimmune, systemic , drug
5. Corneal diseases
1. Congenital
2. Traumatic
3. Inflammatory (infective, autoimmune)
4. Degeneration/Dystrophies
5. Neoplastic
Sailing through cornea
Sailing through eye
Sailing through body
7. 1. Traumatic keratitis
(Sailing) through cornea
CL, baby nail, iatrogenic? as PRK, DMEK, DSEK,
burn, topical drops(Hx) …..
(Sailing) through eye
trichiasis, mass , papillae. Trachoma
(Sailing) through body
radiotherapy for tumours
44. HSV Viral keratitis
C/P: necrotizing keratitis
• Immune mediate challenging with disciform Dx
• Hypersensitivity reaction
• Stromal and epith. Odema, descment folds
• Anterior uveitis, infiltrates, KPs
• IOP
• Decrease sensation
• Stromal scarring and vascularization, lipid keratopathy
TTT: topical steroid with antiviral cover, IOP control,
cycloplegic
• topical cyclosporin 0.05% (restasis)
• Oral steroid
• Fine needle diathermy in established NV
45.
46. HSV Viral keratitis
C/P: neurotrophic keratopathy
• Loss of sensation
• Excerbated by drug toxicity
• Non healing epithelium
• Stroma is opaque and thin
• 2ry infection
TTT:
• Lubricant , decrease steroid
60. Corneal diseases
1. Congenital
2. Traumatic
3. Inflammatory (infective, immune related)
4. Degeneration/Dystrophies
5. Neoplastic
Sailing through cornea
Sailing through eye
Sailing through body
61. 2. Inflamatory keratitis
(immune related)
• Marginal keratitis, Phlyctenulosis , Rosacea
(staph hypersensitivity)
• Peripheral ulcerative keratitis (PUK).
• Mooren ulcer
• Ulcer or not (edges).
• Site.
• Clear zone from limbus.
• Sclera involved or not.
• Interstitial keratitis.
62. Marinal keratitis
Hypersensitivity to staph exotoxin….. Ag-Ab complex
Risk factors:
• Blepharitis, epithelial erosion, recent LASIK
C/P:
• Site… inferior (marginal blepharitis), NO ULCER, subepithelial
infiltrate.
• Clear zone from limbus.
• C&S: –ve from cornea.
TTT:
• Cause (tetracycline not in children and pregnant)
Tetracycline ( antibacterial, decrease free lipid, anticollagenase)
• Short course of topical steroid
63.
64.
65. Phlyctenulosis
Delayed hypersensitivity to staph
Risk factors:
• Age( child)
• Rosacea
• TB, Helminthic infestation
C/P:
• Small white elevated superficial nodule with hyperemia… scar.
• NO ULCER
• Site … Conjunctiva, limbus, cornea.
• Lacrimation, photophobia, blepharospasm.
• Stool analysis, tuberculin test (endemic areas and RF)
TTT:
• Topical steroid , treat cause.
• Recurrent … tetracycline.
81. Mooren ulcer
Old age…. Unilateral
Younger…. Bilateral
C/P
• Pain
• Site ---- peripheral ULCER (undermined edges),
perforation, bl.vs at bed and margins.
• No clear zone from limbus (but there is limbitis)
• Sclera not involved (no scleritis)
• NB: Dx by exclusion.
85. Interstisial keratitis
Stromal inflamation without epithelium or
endothelium affection.
Causes:
• Infectious as syphilis, herpes, TB, lyme.
• Non infectious as sarcoidosis, Cogan syndrome
C/P
• Mid-stromal feathery scarring with gost vessels.
• Early phase is incidental
86. Interstisial keratitis
Syphilis
Congenital (more common) or acquired
C/P
• Systemic (saddle nose, sabre tibia, Hutchinson
teeth, deafness)
• Ocular (IK, ant uveitis, salt and pepper fundus, argyll
robertson pupil)
• IK: limbitis, feathery stromal infiltrate, deep stromal
vascularization, ghost vs, thinning, band
keratopathy.