SlideShare a Scribd company logo
ROLE OF PREBIOTICS IN HUMAN
HEALTH
Presented BY
MR. Sachin M. Uttarwar
M. Pharm. Sem-II
Department of Phrmaceutics
1/27
 Introduction
 Probiotics
 Functions of probiotics
 Applications of probiotics
 Prebiotic
 Functions of prebiotics
 Prebiotic vs probiotics
 Types of prebiotics
 Applications of prebiotics
 Marketed formulations
 Conclusion
 Reference
2/27
o The concept of of prebiotic was introduced by Gibbson &
Roberfroid in 1995 .
o Probiotics and prebiotics in the diet can modify the
composition and metabolic activites of microflora.
o Prebiotics can be defined as non-digestible food ingredients
or fiber that beneficially affect the body by selectively
stimulating the growth and/or activity of a limited number of
bacteria in the colon.
o Microflora of the intestine complete digestion through
fermantation, protect against pathogenic bacteria and
stimulate the immune system
3/27
o Probiotic candidates, are live microbial food supplements.
o Non-pathogenic and non-toxigenic
o Retain viability during storage and survive passage through
the stomach &small bowel.
o capable of colonizing the intestinal tract to influence
human health.
Eg. Lactic Acid Bacteria ( LAB), Bifi dobacteria spp .
4/27
o Prevent potentially harmful bacteria attaching to gut
lining.
o Reduce the availability of nutrients for potentially harmful
bacteria.
o Improve mucous production form cell lining the gut.
o Ongoing support of the immune system.
o Bring down the pH in the colon.
5/27
o Improvement of lactose intolerance and other enzymatic
effects.
o Antibiotic associated diarrhoea.
o Gastroenteritis.
o Inflammatory bowel disease.
o Intestinal infections and colonisation by pathogenic bacteria.
o Traveller’s diarrhoea.
o Colon cancer.
6/27
7/27
Situation (prevention) Probiotic
Ulcerative colitis E. coli Nissle 1917
Ulcerative colitis S. boulardii
Crohn’s disease E. coli Nissle 1917
Prebiotics can be defined as non-digestible food ingredients or
fiber that beneficially affect the body by selectively
stimulating the growth and/or activity of a limited number of
bacteria in the colon.
Eg. Inulin and oligofructose
8/27
 It is assumed that a prebiotic should increase the
number or activity of bifidobacteria and lactic acid
bacteria
 The importance of the bifidobacteria and the lactic
acid bacteria (LABs) is that these groups of bacteria
may have several beneficial effects on the host,
especially in terms of improving digestion.
 prebiotics may thus also act as a bifidogenic factor and
vice versa.
 It should help in increasing the absorption of certain
minerals such as calcium and magnessium.
9/27
prebiotics probiotics
Prebiotics non-digestible food ingredients
fiber or carbohydrates
Probiotics live active microraganism that
when administered in adequate amount
will have beneficially to its host.
The powder from prebiotics can survive
heat, cold,acid and even time.
Probiotics are more fragile.they are
vulnerable to heat and stomach acid.
Prebiotics main role by nourishing the
bacteria that lives in intestines.
Probiotics fight the harmful bacterial
speices present in the gut.
Eg. Inulin and oligofructose Lactic Acid Bacteria ( LAB), Bifi dobacteria
10/27
 Prebiotics escape enzymatic digestion in the upper
gastrointestinal tract.
 Not excreted in the stools – indicating fermented by colonic flora
 Produce- a mixture of short-chain fatty acids (acetate,
propionate butyrate), L-lactate, carbon dioxide and hydrogen.
Stimulate Bifidobacteria.
11/27
 Prebiotics are classified as soluble fiber.
 These type of soluble fibers are:
1. Inulin and oligofructose.
2. Fructo-oligosaccharides (FOS).
3. Galacto-oligosaccharides (GOS).
4. Other oligosaccharides-
12/27
 Raw garlic – 17.5%
 Raw Banana – 1%
 Raw leak - 11.7%
 Raw dandelion greens -24.3%
 Raw onion - 5%
 Raw Asparagus – 5%
 Raw wheat bran - 5%
13//27
• Increase digestion of lactose metabolism.
• Increase mineral absorption.
• Increase HDL/LDL ratio.
• Decrease serum lipids and blood cholesterol.
• Decrease blood pressure.
• Decrease glycemic response.
14/27
 Fructooligosaccharides (FOS)
 The reduction of cholesterol levels and blood glucose
levels, lowering of blood pressure.
 FOS are not digested by the human gastrointestinal
tract, and when they reach the colon, they
beneficially.
 stimulate the growth and strengthening of specific
bacteria in the intestine.
15/27
 Stimulation of the immune system of the host.
 Constipation relief.
 Decreased risk of osteoporosis.
 A reduced risk of atherosclerosis.
 Increasing stool weight in bowel movements.
 Increasing the frequency of bowel movements.
 Inulin has anticarcinogenic properties.
16/27
 Polydextrose is partially fermented in the large
intestine.
 Stimulating effect on the growth of Bifidobacterium .
 The addition of the inulin/GOS mixture were
demonstrated in several studies with infants and
children as the in creasing of the faecal percentage
of Bifidobacteria.
17/27
 Promotes the proliferation of bifidobacteria and the
reduction of deteriorating bacteria .
 Thus causing beneficial effects to human health,
such as liver detoxification by the reduction of toxic
metabolites .
 Prevention of pathogenic diarrhea.
 On abdominal pain.
18/27
 Effects on the intestinal flora.
 Most species of Lactobacillus used XOS, including
Lactobacillus Fermentum.
 Incresing digestibility.
 Function and nutritional parameters in elderly.
patients suggested a XOS
19/27
 In a study of the incorporation of 0.5% of lactulose in
formulations for infants.
 Long-standing liver cirrhosis, the administrationof
milk fermented with bifidobacteria and lactulose
resulted in the re-stabilization of beneficial
microbiota
 Reduction of ammonia and free phenols in the
blood.
 Used in the treatment of hepatic encephalopathy.
20/27
 Lack of fiber will create more problems.
 For making prebiotics for the elderly suffer mainly
from constipation,lactose intolerance and calcium
absorption.
 The main thing prebiotics do is feed the probiotics
bacteria thus keeps our diagestive system healthy and
increase the immunity of the body.
21/27
 Many baby food manufactures are adding prebiotics
and probiotics to food.
 Infection cause in infant is diarrhea.
 They can be cured by brest milk contain the
bifidobacterium which is good for growth of good
bacteria in the colon.
 Prebiotics product can be given to the infant after the
doctor recommendation.
22/27
 Dairy products
 Breads
 Fruit juices
 Margarine
 Pasta
 Icecreams
 Milk,
 Biscuits
 Soft drinks in general
23/27
BRAND NAME MANUFACTURER
GUTMESTER Powder Dr. Tobias ultimate prebiotic
PREBIOTHERIVE powder Gundry MD
Healthy Track Prebiotic, 60 Liquid Soft-
Gels
Irwin Naturals
60 Capsules Prebiotic INLIFE™ helthcare
Pre-Probiotic Daily Health 60 Capsules Healthvit Pre-Probiotic
DR. FORMULATED ORGANIC PREBIOTIC Garden of life
24/27
 The various studies in clinical nutrition conducted over
the past 20 years have established the indirect prebiotic
ingredients in promoting healthy and balanced intestinal
microbita.
 The administration of prebiotics reduce blood lipids and
blood pressure, increases the synthesis and absorption of
nutrients and has anti-carcinogenic.
 Prebiotics show interesting properties that have
implications for the food processing industry.
25/27
1 Monica jain et,al,.(2014) Malaya Journal of Bioscience
181-195 1 (3)
2 Glenn R Gibson (2007) Functional foods:.
Prebiotic and Probiotic 1-5
3 Sherif M. Abed et.al., (2016) International
Journal of Agriculture Innovations & Research
1319-1473 1 (5)
4 Biplab Bandyopadhyay and Narayan C. Mandal
(2014) International Journal Of Current Microbiology
& Applied Science. 410-420 3(3)
5 P. Marteau et.al., (2002) British Journal of Nutrition
153-157 87
26/27
27

More Related Content

What's hot

Health benefits of fermented foods
Health benefits of fermented foodsHealth benefits of fermented foods
Health benefits of fermented foods
Deepak Verma
 
Starter Culture
Starter CultureStarter Culture
Starter Culture
HIMANSHU JAIN
 
Starter culture definition, starter culture selection, starter culture inhibi...
Starter culture definition, starter culture selection, starter culture inhibi...Starter culture definition, starter culture selection, starter culture inhibi...
Starter culture definition, starter culture selection, starter culture inhibi...
Adamou MAMOUDOU ANZA
 
Probiotics
ProbioticsProbiotics
Probiotics
Prof.Louay Labban
 
Use of probiotics and prebiotics
Use of probiotics and prebioticsUse of probiotics and prebiotics
Use of probiotics and prebiotics
RITTWIK DASH
 
Nutrceuticals
NutrceuticalsNutrceuticals
Culturelle Probiotic
Culturelle ProbioticCulturelle Probiotic
Culturelle Probiotic
Raga C
 
Lactic acid bacteria in food industry
Lactic acid bacteria in food industryLactic acid bacteria in food industry
Lactic acid bacteria in food industry
Adamou MAMOUDOU ANZA
 
Prebiotics : Characteristics and usage in food industry
Prebiotics : Characteristics and usage in food industryPrebiotics : Characteristics and usage in food industry
Prebiotics : Characteristics and usage in food industry
Adamou MAMOUDOU ANZA
 
Pro and prebiotics
Pro and prebioticsPro and prebiotics
Pro and prebiotics
sajid ali
 
Probiotics
ProbioticsProbiotics
Probiotics
Nyles Bauer
 
3. Classification of nutraceuticals.pptx
3. Classification of nutraceuticals.pptx3. Classification of nutraceuticals.pptx
3. Classification of nutraceuticals.pptx
SandeepSinghrana7
 
health benifits of Fermented food
health benifits of Fermented foodhealth benifits of Fermented food
health benifits of Fermented foodShumailah Nayab
 
Preservatives
PreservativesPreservatives
Preservatives
Sharjil Mahmood
 
Probiotics
ProbioticsProbiotics
Probiotics
Atharva Chintawar
 
Classification of Lactic acid bacteria
Classification of Lactic acid bacteriaClassification of Lactic acid bacteria
Classification of Lactic acid bacteria
Bishal Kashyap
 
Tempeh production
Tempeh productionTempeh production
Tempeh production
EstherShoba1
 

What's hot (20)

Health benefits of fermented foods
Health benefits of fermented foodsHealth benefits of fermented foods
Health benefits of fermented foods
 
Starter Culture
Starter CultureStarter Culture
Starter Culture
 
Yogurt
YogurtYogurt
Yogurt
 
Synbiotics
SynbioticsSynbiotics
Synbiotics
 
Starter culture definition, starter culture selection, starter culture inhibi...
Starter culture definition, starter culture selection, starter culture inhibi...Starter culture definition, starter culture selection, starter culture inhibi...
Starter culture definition, starter culture selection, starter culture inhibi...
 
Probiotics
ProbioticsProbiotics
Probiotics
 
Use of probiotics and prebiotics
Use of probiotics and prebioticsUse of probiotics and prebiotics
Use of probiotics and prebiotics
 
Nutrceuticals
NutrceuticalsNutrceuticals
Nutrceuticals
 
Culturelle Probiotic
Culturelle ProbioticCulturelle Probiotic
Culturelle Probiotic
 
Lactic acid bacteria in food industry
Lactic acid bacteria in food industryLactic acid bacteria in food industry
Lactic acid bacteria in food industry
 
fermented food products
fermented food productsfermented food products
fermented food products
 
Prebiotics : Characteristics and usage in food industry
Prebiotics : Characteristics and usage in food industryPrebiotics : Characteristics and usage in food industry
Prebiotics : Characteristics and usage in food industry
 
Pro and prebiotics
Pro and prebioticsPro and prebiotics
Pro and prebiotics
 
Probiotics
ProbioticsProbiotics
Probiotics
 
3. Classification of nutraceuticals.pptx
3. Classification of nutraceuticals.pptx3. Classification of nutraceuticals.pptx
3. Classification of nutraceuticals.pptx
 
health benifits of Fermented food
health benifits of Fermented foodhealth benifits of Fermented food
health benifits of Fermented food
 
Preservatives
PreservativesPreservatives
Preservatives
 
Probiotics
ProbioticsProbiotics
Probiotics
 
Classification of Lactic acid bacteria
Classification of Lactic acid bacteriaClassification of Lactic acid bacteria
Classification of Lactic acid bacteria
 
Tempeh production
Tempeh productionTempeh production
Tempeh production
 

Similar to Sachin sem 2 ppt

Prebiotics and probiotics
Prebiotics and probioticsPrebiotics and probiotics
Prebiotics and probiotics
NivyaEM
 
42861
4286142861
42861
milu1312
 
Probiotics&prebiotics
Probiotics&prebioticsProbiotics&prebiotics
Probiotics&prebiotics
Dr.kritika singh
 
Probiotics&prebiotic
Probiotics&prebioticProbiotics&prebiotic
Probiotics&prebiotic
Dr.kritika singh
 
PRE & PROBIOTICS
PRE & PROBIOTICSPRE & PROBIOTICS
PRE & PROBIOTICS
Dr Sachin Pawar
 
Symptomatic treatment of Dysbacteriosis & Gaseous bowel
Symptomatic treatment of Dysbacteriosis & Gaseous bowelSymptomatic treatment of Dysbacteriosis & Gaseous bowel
Symptomatic treatment of Dysbacteriosis & Gaseous bowel
Eneutron
 
Probiotics
Probiotics Probiotics
Probiotics
HamzaHussain749078
 
Probiotics and prebiotics mohit shakya
Probiotics and prebiotics mohit shakyaProbiotics and prebiotics mohit shakya
Probiotics and prebiotics mohit shakya
MohitShakya12
 
Prebiotic and probiotic.
Prebiotic and probiotic.Prebiotic and probiotic.
Prebiotic and probiotic.
151212345
 
lecture_1._probiotics_prebiotics_lecture.ppt
lecture_1._probiotics_prebiotics_lecture.pptlecture_1._probiotics_prebiotics_lecture.ppt
lecture_1._probiotics_prebiotics_lecture.ppt
ZainabMohammed74
 
Probiotics and Healthy life by Dr.C P Prince
Probiotics and Healthy life by Dr.C P PrinceProbiotics and Healthy life by Dr.C P Prince
Probiotics and Healthy life by Dr.C P Prince
DR.PRINCE C P
 
Probiotic activities of fungus
Probiotic activities of fungusProbiotic activities of fungus
Probiotic activities of fungus
Md. Saiful Islam
 
Difference Between Prebiotic and Probiotic
Difference Between Prebiotic and ProbioticDifference Between Prebiotic and Probiotic
Difference Between Prebiotic and Probiotic
Raga C
 
Probiotics by Akash Raza
Probiotics by Akash RazaProbiotics by Akash Raza
Probiotics by Akash Raza
akash raza
 
Probiotics1 12766811034852-phpapp01
Probiotics1 12766811034852-phpapp01Probiotics1 12766811034852-phpapp01
Probiotics1 12766811034852-phpapp01akash raza
 
Pro and prebiotics
Pro and prebioticsPro and prebiotics
Pro and prebiotics
Muhammad iqbal
 
Pre por and pae dr.niteen141014183151-conversion-gate01
Pre por and pae dr.niteen141014183151-conversion-gate01Pre por and pae dr.niteen141014183151-conversion-gate01
Pre por and pae dr.niteen141014183151-conversion-gate01
drnitin120
 
Prebiotics and Probiotics
Prebiotics and ProbioticsPrebiotics and Probiotics
Prebiotics and Probiotics
Rinisha Sinha
 
Gut flora probiotic
Gut flora probiotic Gut flora probiotic
Probiotics
ProbioticsProbiotics
Probiotics
Pharmacism
 

Similar to Sachin sem 2 ppt (20)

Prebiotics and probiotics
Prebiotics and probioticsPrebiotics and probiotics
Prebiotics and probiotics
 
42861
4286142861
42861
 
Probiotics&prebiotics
Probiotics&prebioticsProbiotics&prebiotics
Probiotics&prebiotics
 
Probiotics&prebiotic
Probiotics&prebioticProbiotics&prebiotic
Probiotics&prebiotic
 
PRE & PROBIOTICS
PRE & PROBIOTICSPRE & PROBIOTICS
PRE & PROBIOTICS
 
Symptomatic treatment of Dysbacteriosis & Gaseous bowel
Symptomatic treatment of Dysbacteriosis & Gaseous bowelSymptomatic treatment of Dysbacteriosis & Gaseous bowel
Symptomatic treatment of Dysbacteriosis & Gaseous bowel
 
Probiotics
Probiotics Probiotics
Probiotics
 
Probiotics and prebiotics mohit shakya
Probiotics and prebiotics mohit shakyaProbiotics and prebiotics mohit shakya
Probiotics and prebiotics mohit shakya
 
Prebiotic and probiotic.
Prebiotic and probiotic.Prebiotic and probiotic.
Prebiotic and probiotic.
 
lecture_1._probiotics_prebiotics_lecture.ppt
lecture_1._probiotics_prebiotics_lecture.pptlecture_1._probiotics_prebiotics_lecture.ppt
lecture_1._probiotics_prebiotics_lecture.ppt
 
Probiotics and Healthy life by Dr.C P Prince
Probiotics and Healthy life by Dr.C P PrinceProbiotics and Healthy life by Dr.C P Prince
Probiotics and Healthy life by Dr.C P Prince
 
Probiotic activities of fungus
Probiotic activities of fungusProbiotic activities of fungus
Probiotic activities of fungus
 
Difference Between Prebiotic and Probiotic
Difference Between Prebiotic and ProbioticDifference Between Prebiotic and Probiotic
Difference Between Prebiotic and Probiotic
 
Probiotics by Akash Raza
Probiotics by Akash RazaProbiotics by Akash Raza
Probiotics by Akash Raza
 
Probiotics1 12766811034852-phpapp01
Probiotics1 12766811034852-phpapp01Probiotics1 12766811034852-phpapp01
Probiotics1 12766811034852-phpapp01
 
Pro and prebiotics
Pro and prebioticsPro and prebiotics
Pro and prebiotics
 
Pre por and pae dr.niteen141014183151-conversion-gate01
Pre por and pae dr.niteen141014183151-conversion-gate01Pre por and pae dr.niteen141014183151-conversion-gate01
Pre por and pae dr.niteen141014183151-conversion-gate01
 
Prebiotics and Probiotics
Prebiotics and ProbioticsPrebiotics and Probiotics
Prebiotics and Probiotics
 
Gut flora probiotic
Gut flora probiotic Gut flora probiotic
Gut flora probiotic
 
Probiotics
ProbioticsProbiotics
Probiotics
 

Recently uploaded

Getting started with Amazon Bedrock Studio and Control Tower
Getting started with Amazon Bedrock Studio and Control TowerGetting started with Amazon Bedrock Studio and Control Tower
Getting started with Amazon Bedrock Studio and Control Tower
Vladimir Samoylov
 
International Workshop on Artificial Intelligence in Software Testing
International Workshop on Artificial Intelligence in Software TestingInternational Workshop on Artificial Intelligence in Software Testing
International Workshop on Artificial Intelligence in Software Testing
Sebastiano Panichella
 
Bitcoin Lightning wallet and tic-tac-toe game XOXO
Bitcoin Lightning wallet and tic-tac-toe game XOXOBitcoin Lightning wallet and tic-tac-toe game XOXO
Bitcoin Lightning wallet and tic-tac-toe game XOXO
Matjaž Lipuš
 
Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...
Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...
Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...
Orkestra
 
Announcement of 18th IEEE International Conference on Software Testing, Verif...
Announcement of 18th IEEE International Conference on Software Testing, Verif...Announcement of 18th IEEE International Conference on Software Testing, Verif...
Announcement of 18th IEEE International Conference on Software Testing, Verif...
Sebastiano Panichella
 
Bonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdf
Bonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdfBonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdf
Bonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdf
khadija278284
 
0x01 - Newton's Third Law: Static vs. Dynamic Abusers
0x01 - Newton's Third Law:  Static vs. Dynamic Abusers0x01 - Newton's Third Law:  Static vs. Dynamic Abusers
0x01 - Newton's Third Law: Static vs. Dynamic Abusers
OWASP Beja
 
Doctoral Symposium at the 17th IEEE International Conference on Software Test...
Doctoral Symposium at the 17th IEEE International Conference on Software Test...Doctoral Symposium at the 17th IEEE International Conference on Software Test...
Doctoral Symposium at the 17th IEEE International Conference on Software Test...
Sebastiano Panichella
 
somanykidsbutsofewfathers-140705000023-phpapp02.pptx
somanykidsbutsofewfathers-140705000023-phpapp02.pptxsomanykidsbutsofewfathers-140705000023-phpapp02.pptx
somanykidsbutsofewfathers-140705000023-phpapp02.pptx
Howard Spence
 
Obesity causes and management and associated medical conditions
Obesity causes and management and associated medical conditionsObesity causes and management and associated medical conditions
Obesity causes and management and associated medical conditions
Faculty of Medicine And Health Sciences
 
Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...
Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...
Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...
OECD Directorate for Financial and Enterprise Affairs
 
Acorn Recovery: Restore IT infra within minutes
Acorn Recovery: Restore IT infra within minutesAcorn Recovery: Restore IT infra within minutes
Acorn Recovery: Restore IT infra within minutes
IP ServerOne
 
Eureka, I found it! - Special Libraries Association 2021 Presentation
Eureka, I found it! - Special Libraries Association 2021 PresentationEureka, I found it! - Special Libraries Association 2021 Presentation
Eureka, I found it! - Special Libraries Association 2021 Presentation
Access Innovations, Inc.
 

Recently uploaded (13)

Getting started with Amazon Bedrock Studio and Control Tower
Getting started with Amazon Bedrock Studio and Control TowerGetting started with Amazon Bedrock Studio and Control Tower
Getting started with Amazon Bedrock Studio and Control Tower
 
International Workshop on Artificial Intelligence in Software Testing
International Workshop on Artificial Intelligence in Software TestingInternational Workshop on Artificial Intelligence in Software Testing
International Workshop on Artificial Intelligence in Software Testing
 
Bitcoin Lightning wallet and tic-tac-toe game XOXO
Bitcoin Lightning wallet and tic-tac-toe game XOXOBitcoin Lightning wallet and tic-tac-toe game XOXO
Bitcoin Lightning wallet and tic-tac-toe game XOXO
 
Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...
Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...
Sharpen existing tools or get a new toolbox? Contemporary cluster initiatives...
 
Announcement of 18th IEEE International Conference on Software Testing, Verif...
Announcement of 18th IEEE International Conference on Software Testing, Verif...Announcement of 18th IEEE International Conference on Software Testing, Verif...
Announcement of 18th IEEE International Conference on Software Testing, Verif...
 
Bonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdf
Bonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdfBonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdf
Bonzo subscription_hjjjjjjjj5hhhhhhh_2024.pdf
 
0x01 - Newton's Third Law: Static vs. Dynamic Abusers
0x01 - Newton's Third Law:  Static vs. Dynamic Abusers0x01 - Newton's Third Law:  Static vs. Dynamic Abusers
0x01 - Newton's Third Law: Static vs. Dynamic Abusers
 
Doctoral Symposium at the 17th IEEE International Conference on Software Test...
Doctoral Symposium at the 17th IEEE International Conference on Software Test...Doctoral Symposium at the 17th IEEE International Conference on Software Test...
Doctoral Symposium at the 17th IEEE International Conference on Software Test...
 
somanykidsbutsofewfathers-140705000023-phpapp02.pptx
somanykidsbutsofewfathers-140705000023-phpapp02.pptxsomanykidsbutsofewfathers-140705000023-phpapp02.pptx
somanykidsbutsofewfathers-140705000023-phpapp02.pptx
 
Obesity causes and management and associated medical conditions
Obesity causes and management and associated medical conditionsObesity causes and management and associated medical conditions
Obesity causes and management and associated medical conditions
 
Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...
Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...
Competition and Regulation in Professional Services – KLEINER – June 2024 OEC...
 
Acorn Recovery: Restore IT infra within minutes
Acorn Recovery: Restore IT infra within minutesAcorn Recovery: Restore IT infra within minutes
Acorn Recovery: Restore IT infra within minutes
 
Eureka, I found it! - Special Libraries Association 2021 Presentation
Eureka, I found it! - Special Libraries Association 2021 PresentationEureka, I found it! - Special Libraries Association 2021 Presentation
Eureka, I found it! - Special Libraries Association 2021 Presentation
 

Sachin sem 2 ppt

  • 1. ROLE OF PREBIOTICS IN HUMAN HEALTH Presented BY MR. Sachin M. Uttarwar M. Pharm. Sem-II Department of Phrmaceutics 1/27
  • 2.  Introduction  Probiotics  Functions of probiotics  Applications of probiotics  Prebiotic  Functions of prebiotics  Prebiotic vs probiotics  Types of prebiotics  Applications of prebiotics  Marketed formulations  Conclusion  Reference 2/27
  • 3. o The concept of of prebiotic was introduced by Gibbson & Roberfroid in 1995 . o Probiotics and prebiotics in the diet can modify the composition and metabolic activites of microflora. o Prebiotics can be defined as non-digestible food ingredients or fiber that beneficially affect the body by selectively stimulating the growth and/or activity of a limited number of bacteria in the colon. o Microflora of the intestine complete digestion through fermantation, protect against pathogenic bacteria and stimulate the immune system 3/27
  • 4. o Probiotic candidates, are live microbial food supplements. o Non-pathogenic and non-toxigenic o Retain viability during storage and survive passage through the stomach &small bowel. o capable of colonizing the intestinal tract to influence human health. Eg. Lactic Acid Bacteria ( LAB), Bifi dobacteria spp . 4/27
  • 5. o Prevent potentially harmful bacteria attaching to gut lining. o Reduce the availability of nutrients for potentially harmful bacteria. o Improve mucous production form cell lining the gut. o Ongoing support of the immune system. o Bring down the pH in the colon. 5/27
  • 6. o Improvement of lactose intolerance and other enzymatic effects. o Antibiotic associated diarrhoea. o Gastroenteritis. o Inflammatory bowel disease. o Intestinal infections and colonisation by pathogenic bacteria. o Traveller’s diarrhoea. o Colon cancer. 6/27
  • 7. 7/27 Situation (prevention) Probiotic Ulcerative colitis E. coli Nissle 1917 Ulcerative colitis S. boulardii Crohn’s disease E. coli Nissle 1917
  • 8. Prebiotics can be defined as non-digestible food ingredients or fiber that beneficially affect the body by selectively stimulating the growth and/or activity of a limited number of bacteria in the colon. Eg. Inulin and oligofructose 8/27
  • 9.  It is assumed that a prebiotic should increase the number or activity of bifidobacteria and lactic acid bacteria  The importance of the bifidobacteria and the lactic acid bacteria (LABs) is that these groups of bacteria may have several beneficial effects on the host, especially in terms of improving digestion.  prebiotics may thus also act as a bifidogenic factor and vice versa.  It should help in increasing the absorption of certain minerals such as calcium and magnessium. 9/27
  • 10. prebiotics probiotics Prebiotics non-digestible food ingredients fiber or carbohydrates Probiotics live active microraganism that when administered in adequate amount will have beneficially to its host. The powder from prebiotics can survive heat, cold,acid and even time. Probiotics are more fragile.they are vulnerable to heat and stomach acid. Prebiotics main role by nourishing the bacteria that lives in intestines. Probiotics fight the harmful bacterial speices present in the gut. Eg. Inulin and oligofructose Lactic Acid Bacteria ( LAB), Bifi dobacteria 10/27
  • 11.  Prebiotics escape enzymatic digestion in the upper gastrointestinal tract.  Not excreted in the stools – indicating fermented by colonic flora  Produce- a mixture of short-chain fatty acids (acetate, propionate butyrate), L-lactate, carbon dioxide and hydrogen. Stimulate Bifidobacteria. 11/27
  • 12.  Prebiotics are classified as soluble fiber.  These type of soluble fibers are: 1. Inulin and oligofructose. 2. Fructo-oligosaccharides (FOS). 3. Galacto-oligosaccharides (GOS). 4. Other oligosaccharides- 12/27
  • 13.  Raw garlic – 17.5%  Raw Banana – 1%  Raw leak - 11.7%  Raw dandelion greens -24.3%  Raw onion - 5%  Raw Asparagus – 5%  Raw wheat bran - 5% 13//27
  • 14. • Increase digestion of lactose metabolism. • Increase mineral absorption. • Increase HDL/LDL ratio. • Decrease serum lipids and blood cholesterol. • Decrease blood pressure. • Decrease glycemic response. 14/27
  • 15.  Fructooligosaccharides (FOS)  The reduction of cholesterol levels and blood glucose levels, lowering of blood pressure.  FOS are not digested by the human gastrointestinal tract, and when they reach the colon, they beneficially.  stimulate the growth and strengthening of specific bacteria in the intestine. 15/27
  • 16.  Stimulation of the immune system of the host.  Constipation relief.  Decreased risk of osteoporosis.  A reduced risk of atherosclerosis.  Increasing stool weight in bowel movements.  Increasing the frequency of bowel movements.  Inulin has anticarcinogenic properties. 16/27
  • 17.  Polydextrose is partially fermented in the large intestine.  Stimulating effect on the growth of Bifidobacterium .  The addition of the inulin/GOS mixture were demonstrated in several studies with infants and children as the in creasing of the faecal percentage of Bifidobacteria. 17/27
  • 18.  Promotes the proliferation of bifidobacteria and the reduction of deteriorating bacteria .  Thus causing beneficial effects to human health, such as liver detoxification by the reduction of toxic metabolites .  Prevention of pathogenic diarrhea.  On abdominal pain. 18/27
  • 19.  Effects on the intestinal flora.  Most species of Lactobacillus used XOS, including Lactobacillus Fermentum.  Incresing digestibility.  Function and nutritional parameters in elderly. patients suggested a XOS 19/27
  • 20.  In a study of the incorporation of 0.5% of lactulose in formulations for infants.  Long-standing liver cirrhosis, the administrationof milk fermented with bifidobacteria and lactulose resulted in the re-stabilization of beneficial microbiota  Reduction of ammonia and free phenols in the blood.  Used in the treatment of hepatic encephalopathy. 20/27
  • 21.  Lack of fiber will create more problems.  For making prebiotics for the elderly suffer mainly from constipation,lactose intolerance and calcium absorption.  The main thing prebiotics do is feed the probiotics bacteria thus keeps our diagestive system healthy and increase the immunity of the body. 21/27
  • 22.  Many baby food manufactures are adding prebiotics and probiotics to food.  Infection cause in infant is diarrhea.  They can be cured by brest milk contain the bifidobacterium which is good for growth of good bacteria in the colon.  Prebiotics product can be given to the infant after the doctor recommendation. 22/27
  • 23.  Dairy products  Breads  Fruit juices  Margarine  Pasta  Icecreams  Milk,  Biscuits  Soft drinks in general 23/27
  • 24. BRAND NAME MANUFACTURER GUTMESTER Powder Dr. Tobias ultimate prebiotic PREBIOTHERIVE powder Gundry MD Healthy Track Prebiotic, 60 Liquid Soft- Gels Irwin Naturals 60 Capsules Prebiotic INLIFE™ helthcare Pre-Probiotic Daily Health 60 Capsules Healthvit Pre-Probiotic DR. FORMULATED ORGANIC PREBIOTIC Garden of life 24/27
  • 25.  The various studies in clinical nutrition conducted over the past 20 years have established the indirect prebiotic ingredients in promoting healthy and balanced intestinal microbita.  The administration of prebiotics reduce blood lipids and blood pressure, increases the synthesis and absorption of nutrients and has anti-carcinogenic.  Prebiotics show interesting properties that have implications for the food processing industry. 25/27
  • 26. 1 Monica jain et,al,.(2014) Malaya Journal of Bioscience 181-195 1 (3) 2 Glenn R Gibson (2007) Functional foods:. Prebiotic and Probiotic 1-5 3 Sherif M. Abed et.al., (2016) International Journal of Agriculture Innovations & Research 1319-1473 1 (5) 4 Biplab Bandyopadhyay and Narayan C. Mandal (2014) International Journal Of Current Microbiology & Applied Science. 410-420 3(3) 5 P. Marteau et.al., (2002) British Journal of Nutrition 153-157 87 26/27
  • 27. 27