Shannon Williams, a 33-year-old female, presented with abdominal pain and diarrhea for the past month. She experienced crampy pain in her right lower quadrant that was worse after meals. Her abdomen became distended during cramps and her pain improved when not eating or after bowel movements. She had watery stools 6 times per day with fatigue, 10-pound weight loss, and low-grade fevers. Testing revealed anemia, elevated white blood cell count and erythrocyte sedimentation rate. Colonoscopy showed erythema and an ulcerated stricture in her terminal ileum was seen on biopsy.

1. Clinical Case Study
Digestive System
Prepared by Marc Walters, M.D., Portland Community College
Shannon Williams is a 33-year old female who presented to her physician a chief complaint of abdominal pain and
diarrhea. She said that she had felt well until one month ago when she began suffering from crampy abdominal pain
in the right lower quadrant. The pain was worse after meals. When Shannon suffered from the cramps she noticed
that her abdomen became distended. Her pain improved under two conditions: if she did not eat and following bowel
movements. She said that her stools were watery and occurred about six times per day. Shannon also complained of
fatigue, a ten-pound weight loss, and low-grade fevers. She did not drink milk or consume many dairy products
except for yogurt, which did not seem to bother her. Shannon stated that she had not travelled recently outside her
home of Portland, Oregon and that she was not a hiker.
Hint: Checking out this web site might help you learn more.
http://digestive.niddk.nih.gov
QUESTIONS
Answer the questions below to demonstrate your knowledge.
Answers are available in the Instructor Resources section of this site.
This activity contains 5 questions.
Family History:
Shannon Williams has an identical twin who also had some intermittent abdominal pain and
diarrhea, but had not sought medical attention.
Habits:
She does not smoke or drink.
Physical Exam:
Revealed a thin female in no obvious distress at the time of the exam.
Temperature: 99.6. Pulse: 80. Respirations: 12. Blood Pressure: 100/70.
Eyes: No scleral icterus.
Mouth: Contained two 5-mm aphthous ulcers on the inside of her lower lip.
Abdomen: Mildly distended. Suggestion of a mass in the right lower quadrant.
Rectal: No palpable masses, stool was hemoccult negative.
Laboratory Data:
Hematocrit: 32. Mean Corpuscular Volume: 105
White Blood Cell Count: 11,500 with a normal differential count
Erythrocyte Sedimentation Rate: 35 mm/hr (Normal 0-20 mm/hr)
An Upper GI series pictured above revealed a stricture of the terminal ileum.
Colonoscopy revealed a normal rectum, sigmoid, and descending colon. The transverse colon
had two separate patches of erythema. The ascending colon was normal. The cecum had a
patch of erythema. The terminal ileum was entered through the ileocecal valve. However, the
colonoscope could not be advanced any further into the ileum due to an ulcerated stricture just
proximal to the ileocecal valve. A biopsy of the stricture was obtained. Pathology report
revealed non-caseating granulomas, areas of ulceration, and a lymphocytic cellular infiltrate in
the lamina propria.
1. What is the normal hematocrit for females? What is the normal mean corpuscular volume
for red blood cells? Based on this information, would you say that Shannon has a
microcytic or macrocytic anemia?
2. Explain the value of knowing that Shannon's symptoms were not related to dairy
products or the fact that she had not traveled recently.

2. 3. Shannon's case has two major clues that implicate a specific vitamin deficiency causing
her anemia. What are the clues?
4. What abdominal or pelvic organs might produce right lower quadrant pain?
5. What is the name of the disease that Shannon has in her intestines? Give evidence to
support your diagnosis.