Daniel Romo is moving his research group from Texas A&M University to Baylor University in August 2015. His group conducts synthetic, biological, and biosynthetic studies of bioactive natural products with a focus on developing novel synthetic strategies and understanding the mode of action of natural products through activity-based proteomic profiling and molecular studies. Current projects include the total synthesis of oxazolomycin and gracillins and investigating the mechanisms of rameswaralide, ophiobolin, and agelastatin A.
Justifications for invasive experiments on animals rely on claims that such research is essential for the advancement of biomedical knowledge, for the development of cures to human diseases, or for the evaluation of the toxicity of compounds to which humans are exposed. Until recently, critical evaluations of the accuracy of such claims have been rare. However, a growing body of large-scale systematic reviews have now been published in scientific and medical journals. The outcomes have been consistent: animal experiments have contributed far less than advocates would have us believe.
This presentation summarises these recent results, and comprehensively reviews the alternatives to invasive animal use with biomedical research, toxicity testing, and education.
Published studies are available at www.AnimalExperiments.info.
Alternate animal experiments models for pre and post clinical screening of new drugs.
#Expetrimental_Pharmacology.
#Preclinical Screening methods and testing models.
#Animal_Handeling
Potential Alleviation of Chlorella vulgaris and Zingiber officinale on Lead-I...Prof. Hesham N. Mustafa
Natural products were studied to combat reproductive alterations of lead. The current work
aimed to disclose the efficacy of Chlorella vulgaris and Zingiber officinale to alleviate lead
acetate induced toxicity. Sixty adult male Wistar rats were distributed into four groups.
Group 1 was considered control, group 2 received 200 mg/l PbAc water, group 3 received 50
mg/kg/rat of C. vulgaris extract and 200 mg/l PbAc water, and group 4 received 100
mg/kg/rat of Z. officinale and 200 mg/l PbAc water for 90 days. Testis samples were subjected
to ultrastructural examination. It was observed that PbAc caused degenerative alterations in
the spermatogenic series in many tubules, with a loss of germ cells and vacuoles inside the
cytoplasm and between the germ cells. Mitochondria exhibited ballooning, with lost cristae
and widening of the interstitial tissue, while nuclear envelopes of primary spermatocytes
were broken up, and axonemes of the mid-pieces of the sperms were distorted. With the
treatment with C. vulgaris or Z. officinale, there were noticeable improvements in these
modifications. It was concluded that both C. vulgaris and Z. officinale represent convincing
medicinal components that may be used to ameliorate testicular toxicity in those exposed to
lead in daily life with superior potentials revealed by C. vulgaris due to its chelating action.
Key words: Chlorella vulgaris, lead acetate, ultrastructure, Zingiber officinale.
Justifications for invasive experiments on animals rely on claims that such research is essential for the advancement of biomedical knowledge, for the development of cures to human diseases, or for the evaluation of the toxicity of compounds to which humans are exposed. Until recently, critical evaluations of the accuracy of such claims have been rare. However, a growing body of large-scale systematic reviews have now been published in scientific and medical journals. The outcomes have been consistent: animal experiments have contributed far less than advocates would have us believe.
This presentation summarises these recent results, and comprehensively reviews the alternatives to invasive animal use with biomedical research, toxicity testing, and education.
Published studies are available at www.AnimalExperiments.info.
Alternate animal experiments models for pre and post clinical screening of new drugs.
#Expetrimental_Pharmacology.
#Preclinical Screening methods and testing models.
#Animal_Handeling
Potential Alleviation of Chlorella vulgaris and Zingiber officinale on Lead-I...Prof. Hesham N. Mustafa
Natural products were studied to combat reproductive alterations of lead. The current work
aimed to disclose the efficacy of Chlorella vulgaris and Zingiber officinale to alleviate lead
acetate induced toxicity. Sixty adult male Wistar rats were distributed into four groups.
Group 1 was considered control, group 2 received 200 mg/l PbAc water, group 3 received 50
mg/kg/rat of C. vulgaris extract and 200 mg/l PbAc water, and group 4 received 100
mg/kg/rat of Z. officinale and 200 mg/l PbAc water for 90 days. Testis samples were subjected
to ultrastructural examination. It was observed that PbAc caused degenerative alterations in
the spermatogenic series in many tubules, with a loss of germ cells and vacuoles inside the
cytoplasm and between the germ cells. Mitochondria exhibited ballooning, with lost cristae
and widening of the interstitial tissue, while nuclear envelopes of primary spermatocytes
were broken up, and axonemes of the mid-pieces of the sperms were distorted. With the
treatment with C. vulgaris or Z. officinale, there were noticeable improvements in these
modifications. It was concluded that both C. vulgaris and Z. officinale represent convincing
medicinal components that may be used to ameliorate testicular toxicity in those exposed to
lead in daily life with superior potentials revealed by C. vulgaris due to its chelating action.
Key words: Chlorella vulgaris, lead acetate, ultrastructure, Zingiber officinale.
These presentation includes the information about the replacement of animal experiments (invivo tests) with all the alternative methods like invitro tests and in-silico methods which are used in present century and made the research work easy for pre-clinical and clinical trials.
Alternative methods to animals testing are the development and implementation of test method that avoid use of live animals or use of less animals in method.
The council directive on protection of animals used for experiments and scientific purpose in article 23
“The commission and member states should encourage
research into development and validation of alternative methods which could provide the same level of information as that obtained in experiment using animals but which involves less animal”.
Alternative methods able to do:
Reduce Refine Replace
collectively called as “The 3Rs Principle”.
Needs for alternative methods
Because in laboratory animals may be:
Poisoned.
Deprived of food water and sleep.
Applied with skin and eye irritants.
Subjected to psychological stress.
Deliberately infected with the infected disease.
I would describe myself as a conscientious worker, problem solver and a dependable team player with laboratory expertise in molecular cloning, virology and immunology. I am proficient at developing small animal infection models, mammalian cell culture, proficient at working in Biosafety level -2 and 3 laboratories, developing recombinant gene constructs through primer design, restriction digestion and bacterial cloning. I am proficient at nucleic acid (DNA/RNA) extraction, quantitative PCR and RT-PCR. My technical expertise in virology and immunology include performing plaque assays and foci forming assays to quantify viremia and ELISA. I possess extensive training in working with laboratory animals and I am proficient at intra-nasal and intra-peritoneal drug administration, working with animal restraint systems like the In-TOX system and have performed nebulization studies using guinea pigs in the past. I also perform tail DNA genotyping in mice.
Wagner College Forum for Undergraduate Research, Vol. 17 No. 1Wagner College
The Fall 2018 issue contains abstracts by Kevin Lipton, John Acquaviva, Lejla Bolevic, Anna Cios, Lauren Taibi, Samantha Susi & Jack Leighton, Mara Mineo, Tamar Amirov & Vinh Phuong, Kelsey Savje & Domenick Palmieri, Oskar Sundberg & Iireyel Gittens, Ellen Reidy, Derek Avery, Zachary Pandorf & Michelle Hernandez, Piper Skinner, Matthew Barreto & Victor Ruan, Monica Valero and Gent Prelvukaj. It also contains articles by Adam O’Brien, Cathryn Cantyne, Claire Johnson & Jacqueline Otake, Jordan Gonzales, Jacquelyn Thorsen, John Badagliacca, Elena Rotzokou, Ethan Meyer and Glen MacDonald.
Scientific Research on Natural Heavy Metal ChelatorsHEAVY METAL DETOX
Our research group were commissioned by a Russian metal foundry to examine the chelating effects of these natural substances, and attempt to identify a natural compound that would be effective at chelating a number of toxic metals from Russian metal foundry workers.
Wagner College Forum for Undergraduate Research, Vol. 14 No. 2Wagner College
The Spring 2016 issue contains papers by Joseph V. Agro, Kendra Best, Katie Murphy, Jessica Catanzaro, Nicole Bianco, Sandra G. Minchala, Karina Cusumano, Avika Sagwal, Alyssa Thompson and Juliana R. Ohanian.
These presentation includes the information about the replacement of animal experiments (invivo tests) with all the alternative methods like invitro tests and in-silico methods which are used in present century and made the research work easy for pre-clinical and clinical trials.
Alternative methods to animals testing are the development and implementation of test method that avoid use of live animals or use of less animals in method.
The council directive on protection of animals used for experiments and scientific purpose in article 23
“The commission and member states should encourage
research into development and validation of alternative methods which could provide the same level of information as that obtained in experiment using animals but which involves less animal”.
Alternative methods able to do:
Reduce Refine Replace
collectively called as “The 3Rs Principle”.
Needs for alternative methods
Because in laboratory animals may be:
Poisoned.
Deprived of food water and sleep.
Applied with skin and eye irritants.
Subjected to psychological stress.
Deliberately infected with the infected disease.
I would describe myself as a conscientious worker, problem solver and a dependable team player with laboratory expertise in molecular cloning, virology and immunology. I am proficient at developing small animal infection models, mammalian cell culture, proficient at working in Biosafety level -2 and 3 laboratories, developing recombinant gene constructs through primer design, restriction digestion and bacterial cloning. I am proficient at nucleic acid (DNA/RNA) extraction, quantitative PCR and RT-PCR. My technical expertise in virology and immunology include performing plaque assays and foci forming assays to quantify viremia and ELISA. I possess extensive training in working with laboratory animals and I am proficient at intra-nasal and intra-peritoneal drug administration, working with animal restraint systems like the In-TOX system and have performed nebulization studies using guinea pigs in the past. I also perform tail DNA genotyping in mice.
Wagner College Forum for Undergraduate Research, Vol. 17 No. 1Wagner College
The Fall 2018 issue contains abstracts by Kevin Lipton, John Acquaviva, Lejla Bolevic, Anna Cios, Lauren Taibi, Samantha Susi & Jack Leighton, Mara Mineo, Tamar Amirov & Vinh Phuong, Kelsey Savje & Domenick Palmieri, Oskar Sundberg & Iireyel Gittens, Ellen Reidy, Derek Avery, Zachary Pandorf & Michelle Hernandez, Piper Skinner, Matthew Barreto & Victor Ruan, Monica Valero and Gent Prelvukaj. It also contains articles by Adam O’Brien, Cathryn Cantyne, Claire Johnson & Jacqueline Otake, Jordan Gonzales, Jacquelyn Thorsen, John Badagliacca, Elena Rotzokou, Ethan Meyer and Glen MacDonald.
Scientific Research on Natural Heavy Metal ChelatorsHEAVY METAL DETOX
Our research group were commissioned by a Russian metal foundry to examine the chelating effects of these natural substances, and attempt to identify a natural compound that would be effective at chelating a number of toxic metals from Russian metal foundry workers.
Wagner College Forum for Undergraduate Research, Vol. 14 No. 2Wagner College
The Spring 2016 issue contains papers by Joseph V. Agro, Kendra Best, Katie Murphy, Jessica Catanzaro, Nicole Bianco, Sandra G. Minchala, Karina Cusumano, Avika Sagwal, Alyssa Thompson and Juliana R. Ohanian.
SAMSUNG Wireless LAN solution grows with new tools and devices (new AP controller and new APs 802.11ac).
Look at the new brochure coming from official SAMSUNG Business site: https://www.samsungbusiness.com/business/pages/main/downloads/brochures.aspx
Estrategia y planificación - No presentado - Taller Internet PyME EARTHPaul Fervoy
Esta presentación habla acerca del proceso de planificación de la presencia web. No se vio durante el Taller.
Por Paul Fervoy para Universidad EARTH en al Cuarto Taller para Pequeños Productores y Organizaciones. Noviembre 28, 29 y 30 en EARTH Guápiles Costa Rica. Para más información sobre el Taller, contácte Jan Axelsson (jaxelsson@earth.ac.cr).
Cómo diseñar innovaciones desde el análisis de las tendencias de consumo.
Comment concevoir des innovations à partir de l'analyse des tendances de consommation.
How to design innovations from the analysis of consumer trends.
En este curso de 12 horas aprenderá la importancia que hoy tiene la generación de comunidad y la administración mediante el conocido sistema de gerencia de relaciones con el cliente (CRM), con la importante implicación que representa la comunicación social por medio de los usuarios del ecosistema digital de la empresa. Además, conocerá las principales herramientas y aplicaciones para ejercer la actividad de seguimiento de sus clientes.
El docente del curso es Pablo Di Meglio, reconocido especialista y conferencista en temas relacionados al Marketing Digital y Social Media, y con más de 6 años de experiencia implementando estrategias en redes sociales para empresas como DIRECTV, SAP, CABLEVISION, SAP MILLER y Nextel entre otras.
Acxiom’s Retail Consumer Dynamics Study provides a consumer-centric snapshot of the UK retail market based on current consumer thinking and behaviour underpinned by a wealth of demography and lifestyle intelligence.
Read on to find out more.
Presentació de El Portal de la Recerca de Catalunya a les 4es Jornades sobre Gestió de la Informació Científica (JGIC 2015) dels dies 21 i 22 de maig del 2015, a cárrec d'Enric Canela (UB) i Lluís Anglada (CSUC) amb el suport de Sandra Reoyo (CSUC), Ricard de la Vega (CSUC) i Ramon Ros (CSUC).
Mike generously is sharing this slide set which he presented at the 250th meeting of the ACS 2015 so that others who think they can not afford to run drug discovery can consider this economical distributed, virtual model….and to see CDD Vault in action.
A retrospective cohort study on the efficacy of homeopathy compared to homeop...home
Hypertension currently affects nearly one billion people
worldwide. It is a major cause of global morbidity
and mortality, as well as a major risk factor of various
chronic and fatal diseases. Individuals suffering from hypertension
have increased over the years yet the rate of
controlled blood pressure (<140/90 mmHg) remains
poor. While the demand for traditional, complementary
and alternative medicine (T/CAM) is on the rise, more evidence
is needed to evaluate whether the clinical use of
homeopathy will bring any beneficial effects to the community
at large. T
38 experts on bpa panel consensus statement. effects in animals and potential...ricguer
Un conjunto de 38 prestigiados científicos de todo el mundo alertan sobre el potencial nocivo y los impactos de exposición al Bisphenol A para la salud humana.
1. January 2015
Daniel Romo, Professor & Director of the Natural Products LINCHPIN Laboratory
[***Moving to Baylor University, August 2015***]
Synthetic, Biomechanistic, and Biosynthetic Studies of Bioactive Natural Products (Chemical
Biology); Asymmetric Synthesis, Novel Transformations, and Applications of β-Lactones
(Synthetic Methodology); Natural Product Mode of Action Studies (Chemical Genetics)
Rm 304, (979) 845-9571, "romo@tamu.edu", FAX (979) 862-4880; WEB page:
http://www.chem.tamu.edu/rgroup/romo
At the heart of our research interests is the chemistry and biology of natural products. These are unique and
often structurally complex molecules that are designed to interact in highly specific ways with various cellular
receptors and by homology those found in humans.
Thus, all our projects begin with natural products
encompassing development of novel synthetic
strategies towards these naturally occurring
compounds or derivatives that in turn serve as useful
leads for inquiries into cell biology.
‘Bioactivity-guided Retrosynthesis.’ This is a new
approach toward the pursuit of natural product total
synthesis that enables a synthetic chemist, if
interested, to get involved with MS-based methods
for activity based proteomic profiling at the early
stages of the total synthesis effort. Natural products
in this category that are currently being pursued include oxazolomycin and the gracillins. (No papers in this
area yet, however we are preparing our initial paper that describes this new strategy for total synthesis. In
addition, our recently described Diels-Alder Lactonization organocascade is being applied to the gracillins.
Thus, we attempt to make use of our methodology to access natural products that we in fact plan to pursue
further in terms of biological studies. In this case, toward activity based proteomic profiling with these
electrophilic natural products and as a further application of bioactivity-guided retrosynthesis. Biological
studies of the gracillins and
spongiolactone/oxaxolomycin are
supported by excellent collaborations
with Prof. Luis Botana (Spain) and Prof.
Stephan Sieber (Germany), respectively.
Exploiting the potential of chiral
unsaturated acylammonium salts. We
recently discovered and are continuing to
mine the rich potential of this readily
available chiral intermediate readily
derived from commercially available acid
chlorides and catalysts. Numerous other
organocascade processes are waiting to be
discovered that make full use of the triple
reactivity of this versatile intermediate!
Computational studies in collaboration
with Prof. Dean Tantillo (UC Davis) and
mechanistic studies (e.g. In situ IR, LC-
MS) are being pursued in conjunction
with our methodological studies. •Mass
Spectrometry Based-Profiling of the
Cancer Proteome with Anticancer Natural Products. Using numerous cancer cell lysates that are now
commercially available, we will study the interactions of several, putative natural product-based covalent
modifiers of cellular proteins that are being synthesized in the lab. These in vitro experiments will provide
initial data regarding protein targets of these natural products. Further experiments to validate these targets
including the use of isotopically labelled proteomes (SILAC) and over-expression of putative targets in cell
lines will be conducted in the laboratories of collaborators and students would have the opportunity to visit
for short stays (e.g. with Prof. Jun Liu, Johns Hopkins University, Dept. of Pharmacology or Prof. Stephan
Graduate Students Christian Chalheine
Mikail Abbasov Weixu Kong
Natalie Harvey
Khoi Van
Yongfeng Tao
Post-Doctoral Students
Dr. Paul Gladen
Dr. Morgan Jounneau
Dr. Sreekumar Vellalath
LINCHPIN Lab: Dr. Ken Hull (co-Director)
Dr. Mingzhao Zhu
Dr. Haoran Xu
Dr. Omar Robles
TAMU Undergrad MiniPharma
Protein Conjugation Group: Wali Kahn
(Group and Team Ldr), Lorna Min;
Molecular Modeling Team: Emily
Brackhahn (Group Ldr), Asuka Orr, Adam
Burkhard; Synthesis: Julia
Taylor (Team Ldr), Kacey Ortiz
Fungal Group: Jennifer
Cuaderes (Group Ldr); Hannah
Bolton, Lauren Davis (intern).
N
N
H
N
N
H2N
O
N
HN
Cl
NH2
H
H2N
palau'amine
HO
N
NH
HN
HN
Cl
OH
NHR
MeO
HN
NH
NHR
axinellamine D
(R = 2,3-dibromoacylpyrrole)
H
H
H
O
H
O
H O
H
OH
CO2Me
H
H
OH
rameswaralide
•anti-inflammatory
agelastatin A
•Antitumor/cytotoxic agent
N
O
Me
H
OH OMe
H
N
MeO Me
OH
O
Me Me Me
N
O
OH
oxazolomycin A
O
scabrolide A
O
H
O
OH
H
Me
O
O
H
H
H
Me
OH
H
MeHO
O
H
Me
O
O
H
zedoarondiol H
Me
OMe
H
HO
HO
Me
O
O
chinesin II
N
NH
O O
O
H
N
ONH
HO
O
HO
O
O
O
N
NH2
NH2
O
O
HO
suomilide
O
OCH3
O3SO
Current Natural Product Topics (Synthesis and Biology) in the Romo Group
R =
H
N
O
Br
Br
O
H
OC(O)CH2CH(CH3)2
spongiolactone
O
caulolactone A
•antitumor/antibiotic
Me
O
H
H
OAc
Me
Me Me
OAc
gracilin A
N
NH
NH
N O
Me
HO
Br
O
H
H H
Me
Me Me
O
H
H
O
O
OAc
H
Me
tetrahydroaplysulphurin-1
2. Sieber, Tech. Univ. of Munich, Germany, or with Prof. Ben Cravatt, Scripps, CA). Molecular level mode of
action studies of natural products. We bring to bear the full range of organic methods including microscale
derivatizations developed in our group (with microscale purification and characterization enabled by a new
Bruker LC-SPE-NMR) and total synthesis to fully understand the mechanism of action of a bioactive natural
product including detailed structure-activity relationships and the use of either affinity chromatography or
activity-based proteomic profiling. Current pursuits in this area include rameswaralide, ophiobolin, and
agelastatin A (all nanomolar inhibitors of various cancer cell lines). These studies are greatly bolstered by
interactions with scientists working in the Natural Products LINCHPIN Laboratory and a fruitful long term
collaboration with Jun Liu (Johns Hopkins) and more recent collaboration with Prof. Alex Kornienko (Texas
State U.). Natural Products LINCPHIN Laboratory. This Collaboration Center is focused on the application of
strategies being developed in our group to more rapidly couple a natural product with its cellular protein
target. In addition LINCHPIN scientists assist in translating novel drug leads to therapeutic lead compounds
and diagnostics by assistance with scale-up and further SAR studies. Importantly, students in my group
interact frequently with research scientists in this laboratory including co-Director, Dr. Ken Hull, who has >20
years pharma experience.
SELECTED RECENT PUBLICATIONS (out of 114)
Stout, E. P.; Wang, Y.-G.; Romo, D.; Molinski, T. F. “Pyrrole-Aminoimidazole Alkaloid Metabiosynthesis with
Marine Sponges Agelas Conifera and Stylissa Caribica” Angew. Chem. Int. Ed. 2012, 51, 4877.
Reyes, J.C.P.; Romo, D. “Bioinspired Total Synthesis of AgelastatinA” Angew. Chem. Int. Ed. 2012, 51, 6870.
(Highlighted in Synfacts 2012)
J. Li, J. S. Cisar, C. Zhou, B. Vera, H. Williams, A. D. Rodríguez, B. F. Cravatt, and D. Romo. “Simultaneous
structure-activity studies and arming of natural products via CH amination reveal the cellular targets of
eupalmerin acetate” Nature Chem. 2013, 5, 510-517.
G. Liu, M. A. Shirley, K. N. Van, R. McFarlin, D. Romo “Rapid Assembly of Complex Cyclopentanes
Employing Chiral, α,β−Unsaturated Acyl Ammonium Intermediates” Nature Chem. 2013, 5, 1049-1057.
(Highlighted in Chem. Eng. News, BioNews Texas, and Synform.)
S. Vellalath, K. N. Van, D. Romo “Direct Catalytic Asymmetric Synthesis of N-Heterocycles from
Commodity Acid Chlorides Employing α,β-Unsaturated Acylammonium Salts” Angew. Chem. Int. Ed. 2013,
52, 13688-13692. (Highlighted in Synfacts 2013, twice!)
Abbasov, M.E.; Hudson, B.M.; Tantillo, D.J.; Romo, D. “Acylammonium Salts as Dienophiles in Diels-Alder-
Lactonization Organocascades” J. Am. Chem. Soc. 2014, 136, 4492-4495. (Featured in JACS Highlights, Synfacts
2014, Advances in Engineering)
Harvey, N. L.; Krysiak, J.; Chamni, S.; Cho, S. W.; Sieber, S. A.; Romo, D. “Synthesis of (±)-Spongiolactone
Enabling Discovery of a More Potent Derivative” Eur. J. Chem. 2014, on-line.
CURRENT POSITIONS OF FORMER GROUP MEMBERS
Graduate Students (20 Ph.D.; 5 M.S.): Dr. Robert M. Rzasa (PhD, 1998): Amgen, Thousand Oaks, CA; Dr. William Schmitz
(PhD, 1998): Bristol-Myers-Squibb, Wallingford, CT; Dr. Hong Woon Yang (PhD, 1998): GlycoMimetics, Gaithersburg, MD: OK;
Dr. Cunxiang Zhao (PhD 1999): Kalypsys, Inc., San Diego, CA; Stephen Cohn (MS, 1999); Ingrid Buchler (MS, 2000); Reginald
Tennyson (MS, 2001): Encysive Inc.; Dr. Yingcai Wang (PhD, 2002) Res. Prof. Purdue, USA; Dr. Anja Dilley (PhD 2002); Dr.
Karine Poullennec (PhD 2003), Selcia Inc., UK; Min Zhou (MS, 2003); Francisco Franco-Torres (MS, 2007); Dr. Ke Kong (Ph.D
2007), Post-doc w/John Wood, Colorado State Univ., Res. Scientist, Amgen, Thousand Oaks, USA; Dr. Richard Duffy (PhD 2007),
Post-doc w/Mike Doyle, University of Maryland; Dr. Shaohui Wang, (PhD 2007), BeiGene, Beijing, China; Dr. Andrew T. Mitchell
(Ph.D. 2008), Asst. Prof., Illinois State Univ.; Dr. Sungwook Cho (Ph.D. 2007), Samsung, Korea; Andrea Matla (MS, 2008),
Teacher, Houston, TX; Dr. Vikram Purohit (Ph.D. 2008), TEVA, Malvern, PA; Dr. Kay Morris (Ph.D. 2010), Haliburton, Houston,
TX, USA; Dr. Changsuk Lee (Ph.D. 2009) Post-doc, Texas Christian Univ.; Dr. Manuel Zancanella (Ph.D. 2010), Amgen Inc., San
Francisco, CA, USA; Dr. Supakarn Chamni (Ph.D. 2011), Asst. Prof., Chulalongkorn Univ., Thailand; Dr. Gang Liu (Ph.D. 2011)
Res. Scientist, M.D. Anderson Cancer Center, Houston, TX. Dr. Morgan E. Shirley (Ph.D. 2013) Res. Scientist, Chevron, San
Francisco, CA.
Romo Group
Chemistry
Highlighted
On Cover Art