Diminished ovarian reserve is common and associated with declining live birth rates with age. Biomarkers like AMH and AFC can predict poor ovarian response and live birth, but response varies and outcomes are still acceptable in younger women. While interventions aimed at promoting follicle development, like higher FSH doses or adding DHEA/testosterone, may improve response, the effect sizes are small and safety risks unclear. Improved understanding of ovarian biology could enable new approaches to intervention.
Ovarian reserve refers to the reproductive potential left within a woman's two ovaries based on number and quality of eggs. Diminished ovarian reserve is the loss of normal reproductive potential in the ovaries due to a lower count or quality of the remaining eggs
Ovarian reserve refers to the reproductive potential left within a woman's two ovaries based on number and quality of eggs. Diminished ovarian reserve is the loss of normal reproductive potential in the ovaries due to a lower count or quality of the remaining eggs
Ovarian reserve testing is important before planning IVF cycle, ovulation induction, family planning reasons, before and after chemotherapy and radiotherapy. Ovarian reserve testing such as AMH may help also in diagnosis of granulosa cell tumors and amenorrhea.
Ovarian reserve refers to the reproductive potential left within a woman's two ovaries based on number and quality of eggs. Diminished ovarian reserve is the loss of normal reproductive potential in the ovaries due to a lower count or quality of the remaining eggs
Ovarian reserve refers to the reproductive potential left within a woman's two ovaries based on number and quality of eggs. Diminished ovarian reserve is the loss of normal reproductive potential in the ovaries due to a lower count or quality of the remaining eggs
Ovarian reserve testing is important before planning IVF cycle, ovulation induction, family planning reasons, before and after chemotherapy and radiotherapy. Ovarian reserve testing such as AMH may help also in diagnosis of granulosa cell tumors and amenorrhea.
Management of poor ovarian reserve- Dr Parul KatiyarDr Parul Katiyar
Premature ovarian aging or ovarian failure is a major cause of female factor infertility. Dr Parul explains the mechanism of premature ovarian failure and discusses some simple measures to preserve/ regain fertility among women.
Role Of AMH In Infertility , Dr. Sharda Jain , Life Care Centre Lifecare Centre
Role Of AMH In Infertility , Advantage of AMH , Fecundity / Infertility & AMH , Infertility and AMH ,Prediction of pregnancy chances in couples presenting with infertility , AMH in IVF
Ovarian Reserve Testing in Infertility Dr. Jyoti Agarwal Dr. Sharda JainLifecare Centre
The Best Gametes
Give The Best Result
OVARIAN RESERVE
Plan fertility preservation
Fertility outcome
Response to ovarian stimulation
Predict pregnancy rate
Monitor fertility decline
Fertility after chemotherapy and cancer treatment
Anovulation is the main symptom of PCOS. Normal Physiology of ovulation must know before induction of ovulation. Induction of ovulation is difficult. Careful monitoring gives good success.
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Management of poor ovarian reserve- Dr Parul KatiyarDr Parul Katiyar
Premature ovarian aging or ovarian failure is a major cause of female factor infertility. Dr Parul explains the mechanism of premature ovarian failure and discusses some simple measures to preserve/ regain fertility among women.
Role Of AMH In Infertility , Dr. Sharda Jain , Life Care Centre Lifecare Centre
Role Of AMH In Infertility , Advantage of AMH , Fecundity / Infertility & AMH , Infertility and AMH ,Prediction of pregnancy chances in couples presenting with infertility , AMH in IVF
Ovarian Reserve Testing in Infertility Dr. Jyoti Agarwal Dr. Sharda JainLifecare Centre
The Best Gametes
Give The Best Result
OVARIAN RESERVE
Plan fertility preservation
Fertility outcome
Response to ovarian stimulation
Predict pregnancy rate
Monitor fertility decline
Fertility after chemotherapy and cancer treatment
Anovulation is the main symptom of PCOS. Normal Physiology of ovulation must know before induction of ovulation. Induction of ovulation is difficult. Careful monitoring gives good success.
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Are we giving much importance to AMH in infertility practice?Sujoy Dasgupta
Dr Sujoy Dasgupta delivered "Kamini Rao Oration" on "Are we giving much importance to AMH in infertility practice?" in East Zone Yuva FOGSI Conference organized by Imphal Obstetric and Gynaecological Society (IOGS) on 24 December, 2023
Oration delivered by Dr Sujoy Dasgupta at Yuvacon, conference organized by the BOGS (Bengal Obstetric and Gynaecological Society) held on 22-23 April, 2023
Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period.
This Presentation is made by Dr.Laxmi Shrikhande
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
1. Clinical significance of
diminished ovarian reserve
Richard A Anderson
Elsie Inglis Professor of Clinical Reproductive Science
University of Edinburgh
2. The ‘poor responder’
• What do we mean by this term?
• Is it reliable?
• What can we do about it?
• What might we be able to do about it?
3. Association between egg number
and live birth rate
Sunkara SK et al. Hum. Reprod. 2011;26:1768-1774
HFEA data: 400,000 cycles
4. The increasing gap between
women’s wishes and biology
0
5
10
15
20
25
<29 30-34 35-39 40-44 >45
Live birth
rate per ET
Templeton et al 1996 Lancet 384; 1402
0
50000
100000
150000
200000
250000
300000
<20 20-24 25-29 30-34 35-39 40-44 45+
1995
2005
OHE Compendium of Health Statistics
5. The variation as well as decline in
follicular endowment
Wallace and Kelsey 2010 PLoS One 5; e8772
Non-growing
follicle
number
Age
6. Wallace and Kelsey 2010 PLoS One 5; e8772
200/month
6.7 per day
22/month 2000/month
Calculation of
rate of follicle
activation
7. The long and hazardous road of follicle
development
From McGee and Hsueh 2000 Endocr Rev 21, 200
??? 120 Days
Primordial
Primary
Secondary
Antral
Human
(2 - 5mm)
Rat
(0.2 - 0.4mm)
Atretic
Pre-ovulatory
Follicles
OVULATION
SELECTION AND
DOMINANCE
CYCLIC
RECRUITMENT
INITIAL
RECRUITMENT
>30 Days 28 Days 2-3 Days
71 Days 14 Days
Human
Rat
Similar durations in Gougeon A 1986 Hum Reprod
On the radar
8. AMH and AFC reflect
primordial follicle number
Hansen et al 2010 Fertil Steril
Stereological analysis
following
oophorectomy, n=42
LogPrimordialfolliclenumber
9. R² = 0.6646
0
1
2
3
4
5
6
7
0 1 2 3 4 5 6
AMH(ng/ml)
Log NGF number
NGF vs AMH
R² = 0.600
1
10
100
20 30 40 50 60NGF/AMH
Age
NGF/AMH ratio vs age
Fewer antral follicles per NGF with age
Increased early selection?
The changing relationship between primordial
follicle number and AMH with age
11. ‘Bologna’ criteria for poor response
• 2 of 3:
– Advanced maternal age or other risk factor
– Previous POR (≤3 oocytes)
– Abnormal ovarian reserve test
• Or 2 episodes of POR with max stimulation
• Reproducibility in a second cycle:
– 64% of ‘unexpected’ will show a normal response
– 31% of ‘expected’ will show a normal response
(n=225, Klinkert et al 2004)
Ferraretti AP et al; ESHRE working group on Poor Ovarian Response Definition 2011
12. 69% of DOR cycles did
not result in POR
0
5
10
15
20
2004 2011
DOR live birth
POR live birth
Devine K et al Fertil Steril 2015, 3, 612
Using ‘Diminished ovarian reserve’ to predict
poor ovarian response
Diminished ovarian reserve in the United States assisted reproductive technology
population: diagnostic trends among 181,536 cycles from the Society for Assisted Reproductive
Technology Clinic Outcomes Reporting System
13. Chai J, Lee VCY, Yeung TWY, Li RWH, Ho PC, et al. (2015) Live Birth and Cumulative Live Birth Rates in Expected Poor Ovarian Responders
Defined by the Bologna Criteria Following IVF/ICSI Treatment. PLoS ONE 10(3): e0119149.
Expected Normal (562) Expected Poor (160)
No of oocytes 11 (8-15) 5 (3-8)
Cancellations 0 1 (0.6%)
Live birth 202 (35.9%) 38 (23.8%)
Fresh plus frozen LBR 323/512 (62.8%) 48/134 (35.8%)
How well do predicted poor
responders do in IVF/ICSI?
1152 women undergoing first IVF/ICSI cycle (cutoffs: age 40, AFC 6, AMH 2ng/ml)
14. SART data by diagnosis
Luke et al 2012 NEJM 366, 2483
15. ROC analysis for AMH and successful egg retrieval in DOR patients (FSH>10IU/L)
Burks HR et al Fertil Sertil 2015, 3, 643
Can we do better?
Ultrasensitive AMH assay
No egg retrievals at <100pg/ml
n=24 /group
16. What else does having a poor ovarian
reserve mean?
From McGee and Hsueh 2000 Endocr Rev 21, 200
??? 120 Days
Primordial
Primary
Secondary
Antral
Human
(2 - 5mm)
Rat
(0.2 - 0.4mm)
Atretic
Pre-ovulatory
Follicles
OVULATION
SELECTION AND
DOMINANCE
CYCLIC
RECRUITMENT
INITIAL
RECRUITMENT
>30 Days 28 Days 2-3 Days
71 Days 14 Days
Human
Rat
17. Sowers, M. R. et al. J Clin Endocrinol Metab 2008;93:3478-3483
Prediction of menopause
50 women followed prospectively
(Michigan Bone Health and
Metabolism Study)
6 annual assessments
Mean initial age 42 yr
AMH signif related to both time to and
age at FMP
Inhibin B less predictive of both
18. AMH and prediction of menopause
Broer SL et al 2011 JCE&M
257 ovulatory women, 21-46yr
Reassessed after 11 years (19% menopausal)
AMH at baseline Menopause by AMH centileLow age specific AMH
Shift towards younger
age at menopause
High age specific
AMH
Shift towards higher
age at menopause
20. 0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0 1 2 3 4 5 6
Cumulativeproportionofwomen
achievingpregnancy
Time from cessation of birth control
(cycles)
0
10
20
30
40
50
60
70
19 21 23 25 27 29 31 33 35
AMH(pmol/L)
Age (years)
AMH and fecundability
Hagen et al 2012 Fertil Steril
AMH quintiles, middle 3 combined
21. 981 women aged 30 to 44, trying to conceived max 3 months at study entry Steiner AZ et al, 2017, JAMA
Adjusted for age,
smoking,
contraception, BMI,
race, prev
pregnancy
22. Changes in ovarian reserve after
chemotherapy
Identification of post-
cancer compromised
ovarian reserve?
Ovarianreserve
23. Effects of A(B)VD and BEACOPP on
ovarian function in Hodgkin lymphoma
0
5
10
15
20
Pre chemo 2 cycles EOT 1 2 3
AMH(pmol/L) AMH
Blue: ABVD
Red: BEACOPP
(after 2 cycles of ABVD)
Years after chemotherapy
Chemotherapy
Anderson RA et al 2018 Lancet Oncol
24. AMH and pregnancy after HL
0
2
4
6
8
10
12
Pre chemo 2 cycles EOT 1 2 3
AMH(pmol/l)
During pregnancy
28. AMH and miscarriage after IVF?
Tarasconi et al Fertil Steril 2017, 108, 518
Age but not AMH predicted clinical pregnancy and live birth
29. AMH and miscarriage in natural
pregnancy?
Schumacker et al 2018 Fertil Steril 109, 1065Women (n = 533), age 30 - 44
Women with severely
diminished ovarian reserve (AMH < 0.4 ng/mL)
miscarried at over twice the rate of women
with an AMH > 1 ng/mL (HR 2.3; 1.3-4.3).
30. AMH and miscarriage in natural
pregnancy?
multivariable Cox model adjusting for
maternal age, race, obesity, and recurrent
pregnancy loss suggested that risk of
miscarriage showed a nonsignificant
trend to decrease with increasing AMH
(HR per unit increase in natural log of
AMH = 0.85; 0.72-1.01).
Schumacker et al 2018 Fertil Steril 109, 1065
31. Can we intervene to promote follicle
development?
From McGee and Hsueh 2000 Endocr Rev 21, 200
??? 120 Days
Primordial
Primary
Secondary
Antral
Human
(2 - 5mm)
Rat
(0.2 - 0.4mm)
Atretic
Pre-ovulatory
Follicles
OVULATION
SELECTION AND
DOMINANCE
CYCLIC
RECRUITMENT
INITIAL
RECRUITMENT
>30 Days 28 Days 2-3 Days
71 Days 14 Days
Human
Rat
32. Local and gonadotrophic regulation of
follicle growth
Scaramuzzi R et al 1993 Reprod Fertil Develop 5: 459-478
Local
FSH
33. Does giving more FSH help?
N=501 Standard 150 IU 225 or 450 IU
Oocytes retrieved 6.5 7.6
Cancelled first cycle 21% 7%
LBR first cycle 18% 18%
Cumulative LBR 44.8% 42.4%
van Tilborg et al 2017 Hum Reprod 32, 2496
OPTIMIST trial: predicted poor responders (AFC ≤7, 8-10)
Outcome: ongoing pregnancy/LB within 18 months
34. RECOMMENDATIONS
In patients who are classified as poor responders and pursuing
IVF, strong consideration should be given to a mild ovarian-
stimulation protocol (low-dose gonadotropins [≤150IU/d] with or
without oral agents) due to lower costs and comparable low
pregnancy rates compared with traditional IVF stimulation protocols.
35. Adding growth hormone?
N=130 rGH +FSH FSH only
LBR 11% 14%
Hart RJ et al Curr Opin Obstet Gynecol 2017
LIGHT study
rGH group had more egg recoveries and 1 day less ovarian stimulation
Recruitment stopped early
a benefit for the use of the adjunct GH, with a reduction in the duration of ovarian
stimulation required for oocyte retrieval, the collection of a greater number of oocytes
than placebo, and an improvement in many of the early clinical parameters; however,
there was no evidence of an increased chance of a live birth for the use of GH
36. Local and gonadotrophic regulation of
follicle growth
Scaramuzzi R et al 1993 Reprod Fertil Develop 5: 459-478
Local
Gns
37. By size
Vendola KA et al 1998 J Clin Invest 12, 2622
Androgens stimulate early follicular
growth in the primate
Rhesus monkey
Treated with T or DHT
38. DHEA pretreatment and LBR/ongoing
pregnancy
Nagels HE et al Cochrane Database Syst Rev. 2015:CD009749
OR 1.81, 95% CI 1.25 to 2.62
(8 RCTs, N = 878)
39. Testosterone pretreatment and LBR/ongoing
pregnancy
Nagels HE et al Cochrane Database Syst Rev. 2015:CD009749
OR 2.60, 95% CI 1.30 to 5.20
(four RCTs, N = 345)
40. Novel loci to impact follicle development
From McGee and Hsueh 2000 Endocr Rev 21, 200
??? 120 Days
Primordial
Primary
Secondary
Antral
Human
(2 - 5mm)
Rat
(0.2 - 0.4mm)
Atretic
Pre-ovulatory
Follicles
OVULATION
SELECTION AND
DOMINANCE
CYCLIC
RECRUITMENT
INITIAL
RECRUITMENT
>30 Days 28 Days 2-3 Days
71 Days 14 Days
Human
Rat
AMH
Regulation of
growth activation
sensitivity to
FSH/selection
41. Campbell BK et al. Endocrinology 2012;153:4533-4543
Immunisation against AMH
promotes follicle progression
in sheep
Intraovarian AMH antibody increases the number of
antral follicles at midcycle
and primates
Xu J et al. Hum. Reprod. 2016;31:1522-1530
Control +AMH antibody
42. Conclusions
• Diminished ovarian reserve is common but we
aren’t very good at predicting poor response
• But still has acceptable outcomes in younger
women
• Can we improve response and outcomes?
– Yes, but effect size and safety/risks unclear
– Improved understanding of ovarian function
will allow new developments