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Management of Poor Ovarian response
Definition ,[object Object],[object Object],[object Object],[object Object]
Normal ovarian response DAYS FROM LH PEAK LH FSH 10  15  20  25  0  5  10  15 ,[object Object],[object Object]
Reserve ,[object Object]
[object Object],[object Object]
[object Object]
Poor response ,[object Object],[object Object]
Poor response & Monofollicular induction
Gold Standard: Clomiphene Citrate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Expected conception rate on clomiphene citrate ,[object Object],[object Object],[object Object]
Clomiphene citrate failure ,[object Object],[object Object],[object Object],[object Object],[object Object]
CC Resistant ,[object Object]
No ovulation: ,[object Object],[object Object],[object Object]
The   Aromatase   Inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Prolactin Reducing Medications ,[object Object],[object Object],[object Object],[object Object],[object Object]
Metformin ,[object Object],[object Object]
gonadotrophins ,[object Object],[object Object],[object Object],[object Object]
Ovarian Drilling ,[object Object],[object Object],[object Object]
Cochrane Review ,[object Object]
Poor response & Multifollicular induction IVF/ICSI
Protocols for IVF  GnRH Antagonist Protocols GnRH  Agonist Protocols   225 IU per day (150 IU Europe) Individualized Dosing of FSH/HMG 250   g per day antagonist Individualized Dosing of FSH/HMG GnRHa 1.0 mg per day  up to 21 days 0.5 mg per day of GnRHa 225 IU per day (150 IU Europe) Day 6 of  FSH/HMG Day of  hCG Day 1  of FSH/HMG Day 6 of  FSH/HMG Day of hCG 7 – 8 days after estimated ovulation Down regulation Day 2 or 3 of menses Day 1  FSH/HMG OCP
What is poor response in IVF ,[object Object],[object Object],[object Object]
What to do  ,[object Object]
Cancellation ,[object Object],[object Object],[object Object]
In subsequent cycles ,[object Object]
[object Object],[object Object]
Protocols for IVF  GnRH Antagonist Protocols GnRH  Agonist Protocols   225 IU per day (150 IU Europe) Individualized Dosing of FSH/HMG 250   g per day antagonist Individualized Dosing of FSH/HMG GnRHa 1.0 mg per day  up to 21 days 0.5 mg per day of GnRHa 225 IU per day (150 IU Europe) Day 6 of  FSH/HMG Day of  hCG Day 1  of FSH/HMG Day 6 of  FSH/HMG Day of hCG 7 – 8 days after estimated ovulation Down regulation Day 2 or 3 of menses Day 1  FSH/HMG OCP
Protocols for poor responders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Short (flare up protocol): ,[object Object],[object Object]
Ultra-short protocol ,[object Object],[object Object],[object Object]
[object Object]
Growth hormone ,[object Object],[object Object]
NC ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
Prediction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
AMH ,[object Object],[object Object],[object Object],[object Object]
Poor response TI/IUI Gonadotrophins Modified natural cycle ” Antagonist “ IVM” IVF

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Management of poor ovarian response

  • 1. Management of Poor Ovarian response
  • 2.
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  • 8. Poor response & Monofollicular induction
  • 9.
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  • 20. Poor response & Multifollicular induction IVF/ICSI
  • 21. Protocols for IVF GnRH Antagonist Protocols GnRH Agonist Protocols 225 IU per day (150 IU Europe) Individualized Dosing of FSH/HMG 250  g per day antagonist Individualized Dosing of FSH/HMG GnRHa 1.0 mg per day up to 21 days 0.5 mg per day of GnRHa 225 IU per day (150 IU Europe) Day 6 of FSH/HMG Day of hCG Day 1 of FSH/HMG Day 6 of FSH/HMG Day of hCG 7 – 8 days after estimated ovulation Down regulation Day 2 or 3 of menses Day 1 FSH/HMG OCP
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27. Protocols for IVF GnRH Antagonist Protocols GnRH Agonist Protocols 225 IU per day (150 IU Europe) Individualized Dosing of FSH/HMG 250  g per day antagonist Individualized Dosing of FSH/HMG GnRHa 1.0 mg per day up to 21 days 0.5 mg per day of GnRHa 225 IU per day (150 IU Europe) Day 6 of FSH/HMG Day of hCG Day 1 of FSH/HMG Day 6 of FSH/HMG Day of hCG 7 – 8 days after estimated ovulation Down regulation Day 2 or 3 of menses Day 1 FSH/HMG OCP
  • 28.
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  • 38.
  • 39.
  • 40. Poor response TI/IUI Gonadotrophins Modified natural cycle ” Antagonist “ IVM” IVF