2. INTRODUCTION
• Creams are defines as “a semisolid dosage
• form containing one or more drug substances
• dissolved or dispersed in a suitable base”
• Creams are semi-solid emulsions of oil and
• water.
• They are of a softer consistency & lighter
• body than true ointment.
• semisolid creams of either O/W or W/O
• type.
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3. TYPES
• Oil in Water (O/W) Cream
• Water in Oil (W/O) Cream
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4. A- oil-in-water (O/W) creams:
• oil-in-water (O/W) creams which are composed of
small
• droplets of oil dispersed in a continuous phase.
• More comfortable and cosmetically acceptable as they
are
• less greasy and more easily washed off using water.
• Emulsifying agents of natural origins( bees wax, wool
• alcohols, wool fat).
• Emollient and creamy, white or translucent and stiff.
• E.g. Vanishing Cream
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5. water-in-oil (W/O) creams:
• water-in-oil (W/O) creams which are composed of
• small droplets of water dispersed in a continuous
• oily phase.
• More difficult to handle but many drugs which are
• incorporated into creams are hydrophobic and will
• be released more readily from a W/O cream than
• an O/W cream.
• More moisturizing as they provide an oily barrier
• which reduces water loss from the stratum
• corneum, the outermost layer of the skin.
• e.g. Cold Cream 5
6. Advantage of cream
• They gives prolong contact in their site of
• application than any other pharmaceutical
semisolid
• dosage forms.
• Injured area can be dried quickly by creams than
• other semi-solid preparations.
• Non-irritating when applied to the skin.
• Easily water washable. Easy to wipe away.
• Less greasy compared to ointment.
• Easy to spread on the skin's surface (i.e. easy to
• apply). 6
7. Disadvantage of cream
• Stability is not as good as ointment.
• They are less hydrophobic than other semisolid
• preparation, so risk of contamination is
• high than the others.
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8. Ideal characteristics
• It should liquefy at body temperature.
• It should penetrate the epidermis (via natural
• opening).
• Its viscosity should be low enough to permit easy
• spreading.
• It should be non-toxic.
• It should be non-irritant.
• It should be non-inflammatory.
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9. USES
• The provision of a barriers to skin
• This may be a physical barriers or a chemical
barrier as with sunscreens
• To aid in the retention of moisture(especially
O/w cream)
• Cleansing and emollient effects
• As a vehicle for drug substance such as local
anaesthetics, Anti-inflammatories
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10. PURPOSES OF CREAM
• All-Purpose Cream: True to its name, all-purpose
cream is a flexible and versatile type of cream that
can be used for both your savoury and sweet
creations. The cream is pourable at room
temperature but is also able to be easily whipped
when chilled. To prevent infection in some sensitive
organ. To aid in the retention of moisture.
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11. MANUFACTURING PROCESS
• Preparation of the oil phase: Flake / powder
ingredients sometimes dry blended in adverse, are
dispersed mineral oil or silicone oil. Heating may
be required to melt some ingredients
• Hydration of aqueous phase ingredient: Emulsifiers
thickeners and stabilizers are dispersed into water
in a separate vessel. Heating May required
accelerating hydration.
• Forming the emulsion: The two phase under
vigorous agitation to form the emulsion.
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12. PACKAGING, LEBELING AND STORAGE
• An ideal container protect the product
from the external atmosphere such heat,
humidity, and particulates be nonreactive
with the product components and be
easy to use, light in weight economic.
Usually cream is packed in metallic
collapsible tubes or plastic container.
Pressurized packages expel the product
through a valve. 12
13. REFERENCES
• Govt.of India ,Indian pharmacopoeia ,Controller of
publication Delhi.Vol.1,Edition 1996, page No.540
• 2. Jain .S.K, Gupta. G.D Modern; Dispensing
Pharmacy press, Hyderabad, Page .No 85
• 3. Osborne, D.W., 2008. Review of changes in topical
drug classification. Pharm. Tech. 32, 66–74.
• 4. Margarita M, Topical and transdermal drug
product. The united State Pharmacopeia
Convention and 12-25.
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