The Government of India’s well-intentioned move to de-monetize currency notes of INR 500 and INR 1000, has been expected to cause near-term business disruptions across sectors. Within pharmaceuticals, this has implications for different stakeholders, ranging from pharmaceutical companies to distribution channel,
patients & physicians.
In an attempt to understand the effect of the announcement on the drug distribution network, QuintilesIMS conducted a survey across roughly 500+ chemists around the country. The objective was to understand short-term as well as potentially lingering effects of the demonetization move. Key points of investigation
ranged from the immediate impact on individual chemist sales & patient footfall to value chain-related aspects such as credit cycles, supply levels, inventory stock levels, etc. as well as measures taken by retailers to manage the effect of the demonetization announcement.
This document captures the essence of the study results
Procurement business model for a Retail Pharmacyjajoe510
Few months back, I was interviewed by a renowned International Chain of Pharmacy for their operations in Pakistan and was asked to submit a Procurement Strategy (right from the scratch) for their operations in Pakistan.
I am submitting the same for learning purpose for students, individuals, professionals and for myself also (so i can improvise through your comments / feedback)
Purchasing and Inventory control in drug store
by Mrs. Anjua Parkhe and Mrs. Priyanka Kalamkar
Assistant Professor
Sraaswathi Vidya Bhavans College Of Pharmacy, Dombivli
These slides make an argument that marketing channels in pharmacy are not limited to distribution channels. They include information, financing, and more.
How to start a wholesale pharmacy business in India? - Fossil RemediesFossil Remedies
If you are looking to start a wholesale pharmacy business in India then it is a one of the leading PCD Based Pharma Franchise Companies in India. Here you know the basic requirements to start a wholesale pharmacy business.
Procurement business model for a Retail Pharmacyjajoe510
Few months back, I was interviewed by a renowned International Chain of Pharmacy for their operations in Pakistan and was asked to submit a Procurement Strategy (right from the scratch) for their operations in Pakistan.
I am submitting the same for learning purpose for students, individuals, professionals and for myself also (so i can improvise through your comments / feedback)
Purchasing and Inventory control in drug store
by Mrs. Anjua Parkhe and Mrs. Priyanka Kalamkar
Assistant Professor
Sraaswathi Vidya Bhavans College Of Pharmacy, Dombivli
These slides make an argument that marketing channels in pharmacy are not limited to distribution channels. They include information, financing, and more.
How to start a wholesale pharmacy business in India? - Fossil RemediesFossil Remedies
If you are looking to start a wholesale pharmacy business in India then it is a one of the leading PCD Based Pharma Franchise Companies in India. Here you know the basic requirements to start a wholesale pharmacy business.
Wholesaling and its importance, Types of Wholesalers - Merchant Wholesalers, Agents and Brokers, Manufacturer’s Wholesalers, Strategic Issues in Wholesaling - Target Market Decisions, Marketing Mix Decisions Trends Shaping Wholesale Distribution - Functional Overlap, Increased Services, Pricing and Credit,, Regional Coverage Organizational Form and Size, Impact of Information Technology on Wholesaling - Challenges in Wholesaling -Inventory Management, Sales Management, Promotion Management, Financial Planning and Management - Retailing and its Importance - Importance to Consumers, Source of Employment - Evolution of Retailing and types of retailing
DSBM Chapter 3: Channels of Distribution SHIVANEE VYAS
Distribution means the process of transferring the product from the factory into the hands of its consumer. The distribution channels are the various outlets through which products move from manufacturers to consumers.
There are different channels of distribution and the selection of an appropriate one depends on the requirements of the manufacturer, the needs of the consumer, and the nature of the product.
https://youtu.be/gkyxy5zLJ74
A program that combines the study of basic and pharmaceutical sciences with marketing and management studies; and that prepares individuals for careers in pharmaceutical sales, marketing, management, and related fields within the health care industry.
This presents the resource-based theory of competitive advantage as a framework for describing, understanding, and predicting the adoption and dissemination pharmacy service innovations into routine practice. The theory argues that sustainability of any business innovation (e.g., pharmacy service) is based upon (1) the internal resources of the firm offering it, (2) the firm’s capabilities in using those resources, (3) the competitive advantage to the firm of its resources and capabilities, (4) the attractiveness of the market in which it competes, and (5) the innovation’s contribution to financial performance of the firm.
Community Pharmacy: Defined as a place where the medicines are stocked and dispensed to the patients or patient care givers under the supervision of a qualified and registered pharmacist upon the production of a prescription or when legally permitted without the prescription
Wholesaling and its importance, Types of Wholesalers - Merchant Wholesalers, Agents and Brokers, Manufacturer’s Wholesalers, Strategic Issues in Wholesaling - Target Market Decisions, Marketing Mix Decisions Trends Shaping Wholesale Distribution - Functional Overlap, Increased Services, Pricing and Credit,, Regional Coverage Organizational Form and Size, Impact of Information Technology on Wholesaling - Challenges in Wholesaling -Inventory Management, Sales Management, Promotion Management, Financial Planning and Management - Retailing and its Importance - Importance to Consumers, Source of Employment - Evolution of Retailing and types of retailing
DSBM Chapter 3: Channels of Distribution SHIVANEE VYAS
Distribution means the process of transferring the product from the factory into the hands of its consumer. The distribution channels are the various outlets through which products move from manufacturers to consumers.
There are different channels of distribution and the selection of an appropriate one depends on the requirements of the manufacturer, the needs of the consumer, and the nature of the product.
https://youtu.be/gkyxy5zLJ74
A program that combines the study of basic and pharmaceutical sciences with marketing and management studies; and that prepares individuals for careers in pharmaceutical sales, marketing, management, and related fields within the health care industry.
This presents the resource-based theory of competitive advantage as a framework for describing, understanding, and predicting the adoption and dissemination pharmacy service innovations into routine practice. The theory argues that sustainability of any business innovation (e.g., pharmacy service) is based upon (1) the internal resources of the firm offering it, (2) the firm’s capabilities in using those resources, (3) the competitive advantage to the firm of its resources and capabilities, (4) the attractiveness of the market in which it competes, and (5) the innovation’s contribution to financial performance of the firm.
Community Pharmacy: Defined as a place where the medicines are stocked and dispensed to the patients or patient care givers under the supervision of a qualified and registered pharmacist upon the production of a prescription or when legally permitted without the prescription
Why are there only 15% to 20% Women in Indian Pharma?Anup Soans
Guest Editorial - Gender Gap in Indian Pharma - An Unaddressed Issue
..............................................................................
Inside this Issue
1. A Salesforce Retention Strategy for Indian Pharma by K. Hariram
A quantitative and qualitative approach to measuring and stemming the tide of attrition in pharma sales.
2. “I Am Waiting for the Day When Pharma Hires a CEO from a Tech Company” an Interview with Salil Kallianpur
Salil Kallianpur – Executive Vice President – Primary Care at GSK shares his thoughts on Indian pharma in 2017 and beyond with MedicinMan.
3. 1st World Pharma Brand Managers Day by Prof. Suniel Deshpande and Vivek Hattangadi
A report on the 1st World Pharma Brand Managers Day which began with a Pharma CEO Conclave.
4. Pharma L&D Beyond the Classroom by Diksha Fouzdar
Real learning almost always takes place outside the classroom, but internalizing that in L&D requires a mindset change.
This presentation is just designed in public interest and also to make the term DEMONETIZATION lucid to understand. Dont forget to hit like button before you proceed to download. And stay tuned to my channel so that I can serve you better by providing you ppt on current topics............
History of Currency : Ancient Coinage, paper, Indian Rupee
Evolution Coins, to paper to Bank Money
Financial Inclusion
Reforms - Adhar cards,Jan Dhan Yojana, GST
Benefits of GST
Why demonetisation is needed?
Suggested by Dr. Ambedkar
Benefits - Unearthing Black Money, Revenue to Govt., Shift to Bank Money
welcomed globally.
Short-term pains
5 Megatrends in Learning and DevelopmentAnup Soans
Embedding a Culture of Learning and Development in Pharma by Diksha Fouzdar
How pharma can make learning and development deliver real value to employees and become a part of the company’s DNA.
Pharma Front-line Manager - How to Inspire Peak PerformanceAnup Soans
Inside this Issue
1. The Dead Sea Effect in Talent Management by K. Hariram
How to avert the flight of top talent from your organization.
2. The Audit Mindset: The Key to Successful Implementation of Compliance Practices in Pharma by Diksha Fouzdar
For companies to become and stay compliant, a thorough change in mindset is needed – from an adhoc approach to a systems approach.
3. Emotional Marketing: From ‘Needs’ to ‘Wants’ by Vivek Hattangadi
Different emotions trigger different actions – a look into different emotional states and how they can be put to use in pharma marketing.
4. Top 20 Things Every Digital Health Marketer Should Know by Dr. Ashwin Bonde
The importance of preparing for the next level of your career by acquiring the requisite knowledge, skills and attitude before you get there.
To date, the Indian pharma market has been dominated by the trade/retail segment. This is unlike most mature
markets globally which usually operate in a multi-channeled business model involving
not only trade outlets, but also hospitals, over-the-counter and retail chains. However, in light of the increasing demand for quality care in hospitals, as well as
increased government spending and recent regulatory changes, India is slowly evolving
into a multi-channel market. The most striking aspect of this shifting paradigm is the
increasing dominance of the hospital segment.
The Indian Government, in November 2016, decided to demonetize its high-value currency. Given over 85% of all currency in circulation were high-value currency, there was clearly a short-term impact as a result of this move. What are the long-term implications of demonetization? Learn more in this infographic
Global pharmaceutical companies are modeled with a supply chain, which ensures that the right drug reaches the right people at the right time and in the right condition. The supply chain also ensures 100% product availability at optimum cost by carrying huge inventory, which maintains 100% fill rate. Manufacturers are trying to cut down development time to save costs. For example, a drug manufacturer who can trim development time by 19% can save up to USD 100 million. But if a drug is getting delayed to reach the market, the time delay costs the company around USD 1 million a day. So, pharmaceutical companies today are designing the supply chain to be as responsive as possible to reduce entry time to the market thereby increasing profit margins.
Consumer health: time for a regulatory re-think? is a report by RB in association with PAGB, written by the Economist Intelligence Unit. It looks at the changing healthcare environment and the role self-care plays and efforts at regulatory harmonisation, the barriers they have encountered, and prospects for the future.
McKinsey Sağlık Tedarik Zinciriyle, FMCG Tedarik Zinciri karşılaştırıyor. Sağlık Tedarik Zincirindeki iyileştirme fırsatına ve toplumsal boyutuna dikkat çekiyor.
Discussion Therapy for Clients With Personality DisordersClient.docxmadlynplamondon
Discussion: Therapy for Clients With Personality Disorders
Clients with personality disorders often find it difficult to overcome their problems and function in daily life. Even when these clients are aware that they have a dysfunction with their personality and are open to counseling, treatment can be challenging for both the client and the therapist. For this Discussion, as you examine personality disorders, consider therapeutic approaches you might use with clients.
Learning Objectives
Students will:
· Analyze therapeutic approaches to treating clients with personality disorders
To prepare:
· Review this week’s Learning Resources and reflect on the insights they provide.
· Select one of the personality disorders from the DSM-5.
By Day 3
Post
· A description of the personality disorder you selected. (personality disorder).
· Explain a therapeutic approach (including psychotropic medications if appropriate) you might use to treat a client presenting with this disorder,
· including how you would share your diagnosis of this disorder to the client in order to avoid damaging the therapeutic relationship.
· Support your approach with evidence-based literature.
Class Rules
A clear purpose statement (The purpose of this paper is to...) is required in the introduction of all writings.
you are required to cite scholarly resources including peer-review journals and current practice guidelines
Please, all bullets points, bold, red and highlighted area must be attended to.
As the rapid growth of emerging markets gives millions of
consumers new spending power, those consumers are encountering
a marketing environment every bit as complex and swiftly evolving
as its counterpart in developed countries. Product choices and
communication channels are exploding; so is the potential of digital
platforms; and, as everywhere, consumer empowerment is on the
rise.
The impact of these changes has been so profound in developed
markets that three years ago, our colleague David Court and his
coauthors proposed a new approach for understanding consumer
behavior.1 On the basis of research involving 20,000 consumers
across five industries and three continents, our colleagues suggested
replacing the traditional metaphor of a “funnel” in which consumers
start at the wide end, with a number of potential brands in mind,
before narrowing their choices down to a final purchase. Envisioning
Companies that harness word-of-mouth effects, emphasize
in-store execution, and get their brands onto shoppers’
short lists for initial consideration are more likely to capture the
loyalty of emerging-market consumers.
Building brands in emerging
markets
Yuval Atsmon, Jean-Frederic Kuentz, and Jeongmin Seong
1 See David Court, Dave Elzinga, Susan Mulder, and Ole Jørgen Vetvik, “The consumer
decision journey,” mckinseyquarterly.com, June 2009.
S E P T E M B E R 2 0 1 2
m a r k e t i n g & s a l e s p r a c t i c e
2
consumer behavio ...
Taking the Red Pill - How Can OTC Drug Brands Penetrate More HouseholdsTwentify
A look at the Canadian OTC drugs market, and examples on how market research can help brands in this market on differentiating themselves to get ahead of the competition.
How can OTC drug brands get ahead of the competition and differentiate themselves in the market using market research?
An Infectious Disease Specialist, Dr Mandar Kubal Speaks to Pharma on How it ...Anup Soans
Key Point from the Q &A with Dr. Mandar Kubal, Mumbai
Telemedicine has become a very useful tool for clinicians to manage their patients.
Given the ever changing contours of Covid19 treatment, doctors have to check daily for online resources.
It would be wonderful if pharma can provide every specialty the latest developments in treating Covid19 with pre existing conditions instead of sending their unvaccinated field force to give brand reminders.
Pharma should seek frontline worker status for Medical Reps and Field Managers as they are critical to maintain the drug supply chain.
Treat the Field Force as an asset and protect them, instead of pushing them onto the field without vaccination.
And many more insights from a clinician at the frontlines of treating Covid19 patients.
Now on MedicinMan YouTube Channel - https://youtu.be/J_p3paeO_eg
Key Challenges Facing Pharma Industry and the Way ForwardAnup Soans
Suresh Subramanian, pharma veteran discusses Key Challenges Facing Pharma Industry and the Way Forward on Saturday, 27th March at 6 PM on https://www.credoweb.in/discussion/630/key-challenges-facing-pharma-industry-and-the-way-forward
MedicinMan CEO Roundtable 2021 is here... Saturday, Feb 27thAnup Soans
Covid-19 has hugely affected the modes of interaction between physicians and pharma Sales Force.
As of February 2021, most pharma companies in India re-started their F2F visits even though most corporate hospitals have restricted access to salesforce
What is keeping most CEOs awake – How to respond to customer expectations and adjust the content and format accordingly.
How to track complexities of implementation of a new model into marketing & sales teams.
Many research reports have indicated that a hybrid (mixed model) that includes face to face and digital interactions are favoured by most respondent Physicians.
The other challenge is the need to change the outdated traditional digital model, which is overused and creates digital noise into an innovative interactive model.
Register Now: https://lnkd.in/gmJK8et
Key Account Management - Time for India Pharma to Adopt KAMAnup Soans
Pharma's 40-year Model of Pitching to the HCPs is Over says Hanno Wolfram author of Key Account Management in Pharma...
Watch the webinar on Digital Excellence Pharma Academy today at 6 PM to know more - https://lnkd.in/gjZRN6q
How can Pharma Use Digital to Engage Doctors and Understand PatientsAnup Soans
Doctors and patients are already using digital for many healthcare needs. Telemedicine is a prime example.
A Webinar by Dr. Shenoy Robinson today at 6 PM on - https://www.credoweb.in/discussion/604/how-can-pharma-use-digital-to-engage-doctors-and-understand-patients
How can Pharma Use Digital to Engage Doctors and Understand Patients
Why Indian Pharma Needs to Enable Managers to Develop TalentAnup Soans
People need the support of their leaders and organisations processes to develop their talents.
Deep Bhandari delves deep into the topic of Talent Development and its impact on individuals and organisations.
Digital Excellence Pharma Academy Certification ProgramAnup Soans
Now on YouTube: Gartner's Top Five Priorities for Pharma Business Leaders and @Hariram K's Key Learning Points on Leadership
25-minute discussion with Deep Bhandari on the Gartner Report and Leadership Imperatives by Hariram Krishnan on How the DEPA Certification Program Can Make Pharma Professionals Future Proof
https://lnkd.in/gHiT_WU via @YouTube
Architecture To Develop Pharma Business Leaders For Today and Tomorrow Anup Soans
4 Factors of Digital Transformation
1. Leadership Mindset for Digital Transformation
2. Digital Transformation - Why and How to Do it Right
3. Sales and Sales Management - Challenges & Solutions
4. Customer/Patient Centricity - Why and How to Do it Right
What is Indian Pharma Thinking about Digital? A Research ProjectAnup Soans
First Ever Indian Pharma Centric Survey: A CredoWeb India – #MedicinMan Research Project
As a part of Digital Excellence Pharma Academy , we initiated a research project with a detailed survey to understand the current status and issues faced by Indian Pharma companies in adopting digital to bridge the pharma – physicians disconnect.
You can know more about the scope and scale of this research project and survey at https://lnkd.in/gR5JMer
Digital Excellence Pharma Academy - Webinar & Online Certification ProgramAnup Soans
Ready for the next Webinar on Digitalisation of Pharma Marketing?
Digital Excellence Pharma Academy a partnership between MedicinMan and CredoWeb not only equips pharma/devices/diagnostics/disposable company employees with KA$H (you’ll learn about KA$H soon in the future webinars), but offers you the ability to adopt the digital platform to communicate and engage your customers and create lasting experiences to build your relationship with customers.
To know more on how to engage doctors via digital, attend 40+ webinars brought to you by CredoWeb in partnership with MedicinMan - follow 3 simple steps:
Go to www.credoweb.in
Create your “Pharma professional” registration
Follow Digital Excellence Pharma Academy page and stay tuned for our webinars for which you will be cordially invited
The Mankind Pharma Story by Dr. Sumit GhoshalAnup Soans
Mankind was established in 1991, almost a decade after the industry leaders of today including Dr.Reddy’s and Sun Pharma, but has grown considerably faster than its contemporaries...
One reason for this is that unlike major drug makers who have a large portfolio of hundreds of products, mankind prefers to concentrate on a much smaller number of high value products. “they don’t bother with smaller products with a potential value of less than Rs.5 crore,” says a long-time industry watcher. thus Health OK, their OTC product, which is a combination of vitamins and nutritional medicines was able to generate Rs.50 crore in revenue within a year of its launch in 2014-15.
This is also the approach adopted by some multinationals like Sanofi, whose CEO Chris Viebacher said, that his company obtained a lion’s share of its revenue from just 15 top selling patented products...
Indian Pharma and Retail Pharmacies - Sales View PollAnup Soans
The Sales View poll concluded with valuable information on several key aspects of the Indian Pharmaceutical field force, especially in the strategies employed by medical sales reps to obtain marketing intelligence. With sales force considered to be a strong pillar of the pharmaceutical industry, gaining pointers on their day-to-day operations, and challenges faced, is indeed an asset in improving the pharma industry.
Such weekly and monthly data analysis by IQVIA and leading pharma KOLs will help you understand market dynamics better. Do participate in our polls and keep up with the latest opinions and trends on IQVIA Sales View.
Healthcare's Future will be Patient ExperienceAnup Soans
With healthcare reform now opening the door to more insured patients, it is not overwhelming what we hear nowadays that market access is dead and patient access is the new prescription for healthcare marketing.
Patient access helps when there is precariousness in the benefits, which will never be fully known until a product is used in the real world and over a period of time.
A patient access centered mindset aims to understand the patient and provider pathways, with the ultimate objective that all those patients who can optimally benefit from a product can have the access to the product.
Instead of a win/lose mindset at the core of market access, patient access tries to create win/win/win solutions that lead to value for patients, companies, and the healthcare system at large.
In such a scenario, several issues that should deal with patient access should be addressed such as:
Patient access as a guiding principle across all functions
Developing a clear and compelling value proposition for each stakeholder group
Creating a formal framework for understanding the impact of decisions on patient access
Getting payer input and advice early on
Enhanced patient satisfaction
Improved communication through shared data
Unethical Practices in Pharma - Interesting Study from Pakistan Anup Soans
This study clarifies the current pharmaceutical drug promotion and prescribing practices in Pakistan. The majority of prescribers and national pharmaceutical firms and to some extent the multinational pharmaceuticals are involved in unethical practices in drug promotion and prescribing. Alarming policies governing the drug promotion and prescribing are required to be implemented by the concerned regulatory authorities to avoid unnecessary harm to the patient’s life and pocket through the unethical drug promotion. The prescribers should not accept any incentives, gifts of financial value from any pharmaceutical companies in return for an increase in prescribing selected brand. On the other hand, pharmaceutical companies must compete in the market on the basis of the drug quality and do not offer any valuable gift and incentives to the prescribers. The interaction between doctors and phar- maceutical firms should be restricted within acceptable boundaries and the authorities must be prepared to play an active role. Strengthening the regulatory machinery and formulating policies in this regard in neces- sary. It is essential that a health care professional such as a pharmacist can play an important role in this process since he/she is an expert in the pharmaceutical field as well as more aware of the outcomes of unethical drug prescribing practices such as polypharmacy and adverse drug reactions.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Retail Sales of Drugs - Impact of Demonetization
1. Demonetization: Impact on Drug Distribution @ Pharmacy
The Government of India’s well-intentioned move to de-monetize currency notes of INR 500 and INR 1000,
has been expected to cause near-term business disruptions across sectors. Within pharmaceuticals, this
has implications for different stakeholders, ranging from pharmaceutical companies to distribution channel,
patients & physicians. QuintilesIMS shared a report on 28th
November on the effect of demonetization @
distributors and stockists.
In an attempt to understand the effect of the announcement on the drug distribution network, QuintilesIMS’
conducted a survey across roughly 500+ chemists around the country. The objective was to understand
short-term as well as potentially lingering effects of the demonetization move. Key points of investigation
ranged from the immediate impact on individual chemist sales & patient footfall to value chain-related
aspects such as credit cycles, supply levels, inventory stock levels, etc. as well as measures taken by
retailers to manage the effect of the demonetization announcement.
This document captures the essence of the study results.
Impact on Chemists
Sales Impact: Overall
As expected, Demonetization has had a downward impact on overall chemist sales. Our team of field
auditors across the country carried out a quick survey where over 60% of all chemists reported a decrease
in month-on-month sales (End Nov vs End Oct). The impact was starker among smaller retailers, as 75%
of these have seen a fall in sales. This may be attributed to a larger share of cash transactions in their
business. Almost 50% large retailers, however, reported limited impact. The extent of sales decline varied,
going as high as 30% in some cases.
In an interesting development, as many as 46% corporate chain outlets saw an increase in sales,
although other outlets such as hospital pharmacies or standalone stores are have reflected decreased
revenues. Further investigation reveals that in general, corporate chains have seen the least pressure
on patient footfall (it actually increased for every third corporate chain outlet) as compared to other chemist
outlets.
2. Also, almost half the number of corporate chain outlets surveyed saw a surge in sales of chronic
therapy drugs (e.g. those targeting hypertension or other blood/heart-related ailments, diabetes,
depression & other neurological disorders). Typically, these drugs are for long-term/lifetime use, and it may
be inferred that offtake temporarily increased due to buyers stocking up on drug supply for future use, with
the available window of opportunity to buy drugs with older currency notes.
The ability of corporate chains to better cope with the after-effects of demonetization may also be a natural
consequence of their ability to offer cashless payment options. This is confirmed through a deeper analysis
carried out using survey results. An overwhelming majority of corporate chain outlets offer the option
of payment using cards, which would put them at a clear advantage in the situation that has emerged
post the demonetization announcement.
3. Geographical trends
It is worth note that patient footfall was most affected in North India (71% chemists reported a decline), with
the least impact seen in the West (29%), and wide variation between them.
This may be attributed to the reluctance of chemists in the North to offer extended credit, or accept old
notes. Only 23% retailers offered extended credit to buyers in North India, as opposed to 40% or more in
the East & West. Almost 50% retailers in the North did not accept old notes. Patients here may have thus
resorted to a drug purchase only when absolutely necessary, in the face of a cash crunch, resulting in a
clearer impact on footfall. Those in the West were particularly proactive on both fronts, and this may have
ensured that patients there were least likely to postpone/forgo discretionary, or “less serious” drug
purchases. This contrast is demonstrated in the exhibits below.
4. Effect on the value chain: credit cycles, supply continuity & inventory stock levels
Credit cycles
Demonetisation has, as expected, affected the credit cycles in the pharmaceutical value chain.
Responses from chemists indicate that some stockists have extended credit cycles to allow retailers to
settle payments, in a bid to protect revenue.
Supply continuity
A majority of retailers have indicated no impact of the demonetization move on stockist supply. This is true
especially in South India, where almost none of the retailers surveyed expressed a supply crunch. However,
North India again represents a contrast; 45% retailers have been experiencing supply issues.
5. Inventory stock levels - Retailers
In line with a largely undisturbed supply pattern, inventory levels of retailers have also not seen a large
impact. 75% retailers in the survey reported unchanged inventory levels.
Summary
In essence, a clear impact of demonetization is seen, specifically on sales, and also to some extent on the
pharmaceutical value chain.
Revenue-related events, such as overall decrease in sales after the demonetisation announcement, or
spurt in some pockets in sales of chronic drugs maybe assumed to be a passing phase, largely driven by
a cash crunch or as a means of dispensing available old notes, which will be restored in the long run.
The positive sales response seen by corporate chains is interesting, and equally intriguing would be the
market’s reaction to it. One key determinant of revenue growth for these chains has been availability of a
cashless payment option. It would be interesting to see if this encourages other retailers to adopt similar
trade practices.
As far as the value chain is concerned, supply patterns & inventory levels have been largely undisturbed.
Credit cycles have been disturbed, but this is also expected to be a transient occurrence; unlikely to last for
a long time.
If a cashless ecosystem is to materialize & sustain itself in the long term, both stakeholders in the
distribution system as well as consumers at the end of it need to first have the need for it, and then get
into the habit of using it. The demonetization move has certainly provided the need, however temporary. It
would now be interesting to see if the positive experience of those using cashless transactions inculcates
a habit, which might then sustain it in the long term.
Overall, the demonetization lever, while triggering a potentially short term sales revenue dip, has kick
started, albeit in a small way, some welcome practices in the direction of a cashless ecosystem. It would
be interesting to see if, within the drug distribution landscape, this vision of a cashless ecosystem
materializes in the wake of the bitter pill of demonetization.