This document presents a research proposal that will analyze the cost benefit of producing lettuce with organic versus inorganic fertilizers in Techiman Municipality, Ghana. The study will evaluate the costs of production per acre and yields under different fertilizer treatments. Specifically, the research will compare the effects of poultry manure, NPK fertilizer, and combinations on lettuce growth and yields. Data on plant characteristics and economic costs will be collected and analyzed to determine which fertilizer method provides the highest benefit.