This document presents a research proposal on assessing post-harvest losses and handling of tomatoes in Offinso-North Municipality, Ghana. The proposal outlines the problem of high post-harvest losses reducing farmer profits. It aims to examine tomato varieties grown, harvesting techniques, and handling at primary, secondary and tertiary levels. The methodology will involve random sampling of 55 people across the supply chain to collect data through questionnaires, interviews and observations, which will be analyzed using graphs, charts and tables to identify relationships between variables. The expected outcome is solutions to minimize losses and improve farmer returns in a major tomato producing region of Ghana.