This document discusses research methods for variables in studies. It defines what a variable is and types of variables such as numerical, categorical, ordinal and nominal. It discusses developing indicators to operationalize variables. Variables can be dependent or independent. Background variables are also discussed. The document covers questionnaire design including types of questions, sequencing questions and formatting. It discusses data sources, collection, quality control and coding. Measurement error from questionnaires, data collection methods, interviewers and respondents is explored.
types of variables in research, Dependent independent, moderator,quantitative qualitative,continuous discontinuous,demographic,extraneous, confounding,intervening, control
types of variables in research, Dependent independent, moderator,quantitative qualitative,continuous discontinuous,demographic,extraneous, confounding,intervening, control
DATA COLLECTION AND PRESENTATION IN PUBLIC HEALTH DENTISTRYPoonam Narang
The basics of data collection, from defining data types to exploring measurement scales. We discussed and outlined various sources for data collection. Text, tables, and graphs are effective communication media that present and convey data and information. They aid readers in understanding the content of research, sustain their interest, and effectively present large quantities of complex information.
Questionnaire-based Research Workshop.pdfAimanAlwadi1
• Provide overview of clinical research design and their hierarchy • Identify the difference between survey and questionnaire
• Describe the different types of survey
DATA COLLECTION AND PRESENTATION IN PUBLIC HEALTH DENTISTRYPoonam Narang
The basics of data collection, from defining data types to exploring measurement scales. We discussed and outlined various sources for data collection. Text, tables, and graphs are effective communication media that present and convey data and information. They aid readers in understanding the content of research, sustain their interest, and effectively present large quantities of complex information.
Questionnaire-based Research Workshop.pdfAimanAlwadi1
• Provide overview of clinical research design and their hierarchy • Identify the difference between survey and questionnaire
• Describe the different types of survey
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. FORMULATING VARIABLES
What is a variable?
• A VARIABLE is a characteristic of a person, object or phenomenon which
can take on different values.
• In the form of numbers (e.g., age) or
• Non-numerical characteristics (e.g., sex)
• A simple example of a variable in the form of numbers is ‘a person’s
age’
• Other examples of variables are:
• weight (expressed in kilograms or in pounds);
• home - clinic distance (expressed in kilometres or in minutes walking distance);
• monthly income (expressed in dollars, rupees, or kwachas); and
• number of children (1, 2, etc.).
3
4. What is a variable?
• Because the values of all these variables are expressed in numbers, we
call them NUMERICAL VARIABLES
• Some variables may also be expressed in categories.
• For example, the variable sex has two districts categories, groups,
male and female.
4
6. Numerical variables can either be continuous or discrete
1. Continuous
With this type of data, one can develop more and more accurate
measurements depending on the instrument used, e.g
• Height in centimeters (2.5 cm or 2.546 cm or 2.543216 cm)
• Temperature in degrees Celsius (37.20 C or 37.199990C etc.)
2. Discrete
These are variables in which numbers can only have full
values, e.g.:
• Number of visits to a clinic (0, 1, 2, 3, 4, etc.)
• Number of sexual partners (0, 1, 2, 3, 4, 5, etc.)
6
7. Categorical variables, on the other hand, can either be ordinal or
nominal
1. Ordinal variables These are grouped variables that are ordered or
ranked in
• Increasing or Decreasing order:
• High income (above 300 per month)
• Middle income (100-300 per month)
• Low income (less than 100 per month)
Other examples are:
• Disability:
• No disability,
• Partial disability,
• Serious or total disability
7
8. Categorical variables, on the other hand, can either be ordinal or
nominal
1. Ordinal variables
• Seriousness of a disease:
• Severe,
• Moderate,
• Mild
• Agreement with a statement:
• Fully agree,
• Partially agree,
• Fully disagree
• Fear of leprosy:
• Will not share food with a patient;
• Will not enter the house of a patient;
• Will not allow patient to live in the community.
8
9. Categorical variables, on the other hand, can either be ordinal or
nominal
2. Nominal variables.
The groups in these variables do not have an order or ranking
in them.
For example:
Sex: male, female
Main food crops: maize, millet, rice, etc.
Religion: Christian, Muslims, Hindu, Buddhism, etc
9
10. Variables
• When you selected the variables for your study, you did so
with the assumption that they either would help to define
your problem (dependent variables) and its different
components or that they were contributory factors to your
problem (independent variables)
• The purpose of data analysis is to identify whether these
assumptions were correct or not, and to highlight
possible new views on the problem under study
• The ultimate purpose of analysis is to answer the research
questions outlined in the objectives with your data
10
11. Operationalizing variables by choosing appropriate
indicators
• Note that the different values of many of the variables
presented up to now can easily be determined
• However, for some variables it is sometimes not possible
to find meaningful categories unless the variables are
made operational with one or more precise INDICATORS
• Operationalizing variables means that you make them
‘measurable’
11
12. Operationalizing variables by choosing appropriate indicators
• If you want to determine the level of knowledge concerning a
specific issue in order to find out to what extent the factor
‘poor knowledge’
• The variable ‘level of knowledge’ cannot be measured as such.
• You would need to develop a series of questions, for example
on pre-natal care and risk factors related to pregnancy
• The answers to these questions form an indicator of
someone’s knowledge on this issue, which can then be
categorized
• If 10 questions were asked, you might decide that the
knowledge of those with:
- 0 to 3 correct answers is poor,
-4 to 6 correct answers is reasonable, and
- 7 to 10 correct answers is good.
12
13. Operationalizing variables by choosing appropriate
indicators
• Nutritional status of under-5 year olds: widely used indicators
for nutritional status include:
-Weight in relation to age (W/A)
- Weight in relation to height (W/H)
-Height in relation to age (H/A)
-Upper-arm circumference (UAC)
• For the classification of nutritional status, internationally
accepted categories already exist, which are based on so-called
standard growth curves.
• For the indicator ‘Weight/Age’, for example, children are:
- well-nourished if they are above 80% of the standard,
- moderately malnourished if they are between 60% and 80%,
13
14. Operationalizing variables by choosing appropriate
indicators
• When defining variables on the basis of the problem
analysis diagram, it is important to realize which variables
are measurable as such and which ones need indicators
• Once appropriate indicators have been identified we know
exactly what information we are looking for
• This makes the collection of data as well as the analysis
more focused and efficient
14
15. Defining variables and indicators of variables
• To ensure that everyone understands exactly what has
been measured and to ensure that there will be
consistency in the measurement, it is necessary to clearly
define the variables (and indicators of variables)
• For example, to define the indicator ‘waiting time’ it is
necessary to decide what will be considered the starting
point of the ‘waiting period’ e.g., is it when the patient
enters the front door, or when he has been registered and
obtained his card?
15
16. Dependent and independent variables
• Because in health systems research you often look for
causal explanations, it is important to make a distinction
between dependent and independent variables
• The variable that is used to describe or measure the
problem under study is called the DEPENDENT (outcome)
variable
• The variables that are used to describe or measure the
factors that are assumed to cause or at least to influence
the problem are called the INDEPENDENT variables
16
17. Dependent and independent variables
• In a study of the relationship between smoking and lung
cancer, ‘suffering from lung cancer’ (with the values yes, no)
would be the dependent variable and ‘smoking’ is the
independent variable
• Whether a variable is dependent or independent is determined
by the statement of the problem and the objectives of the
study.
• It is therefore important when designing an analytical study to
clearly state which variable is the dependent and which are the
independent ones
• Note that if a researcher investigates why people smoke,
‘smoking’ is the dependent variable, and ‘pressure from peers
to smoke’ could be an independent variable.
• In the lung cancer study ‘ smoking’ was the independent
17
18. Background variables
• In almost every study, BACKGROUND VARIABLES, such as
age, sex, educational level, socioeconomic status, marital
status and religion, should be considered
• These background variables are often related to a number
of independent variables, so that they influence the
problem indirectly (hence they are called background
variables)
• Background variables are notorious ‘confounders’.
18
20. Questionnaire designs and data sources
• Questionnaire design
• Types of questions
• Steps in Designing a questionnaire
• Consideration to write Open or Closed
• Formatting interpreting questionnaires
• Data sources
• Data collection
• Data quality control
20
21. Questionnaire design
• The quality of research depends to a large extent on the
quality of the data collection tools
• Designing good ‘questioning tools’ forms an important and
time-consuming phase in the development of most
research proposals
• Questionnaires are an inexpensive way to gather data from
a potentially large number of respondents
21
22. Questionnaire …
• Points to be considered before designing questionnaire
1. What exactly do we want to know (i.e. the objectives)
2. Is Questionnaire the right technique to obtain all answers
3. Who will be the respondents
4. What techniques will we use
5. How large is the sample that will be interviewed
22
23. Types of questions
1. Open-ended questions: permit free response
• Important to explore in-depth information on
1. Issues with which the researcher is not familiar
2. Opinion, attitudes, or sensitive questions
2. Closed questions: supplies the respondent with two or more
specified alternative responses
23
24. Steps in designing a questionnaire
1. Content : take objectives and variables as a starting point
2. Formulating questions: formulate one or more questions that will provide
the information needed for each variable
3. Sequencing the questions: Design your interview or questionnaire to be
‘informant friendly’.
4. Formatting the questionnaire
5. Translation
6. Check Reliability (Pre‐ test)
24
25. Writing the Questionnaire
• Points to be Considered to write open or closed format and interpreting
questionnaires
1. Clarity: questions must be clear
2. Leading Questions: A leading question is one that forces or implies a
certain type of answer
3. Phrasing of questions
4. Embarrassing Questions
5. Hypothetical Questions, eg If I were a him ……
25
26. Types of Data
• Data may be classified as
1. Cross-sectional data: are collected at one point in time
2. Time series, or panel data: are collected on repeated occasions
26
27. Types of data…
• Based on Type of Research Methods: data can be classified into
1. Quantitative data : is that which can be easily measured and recorded
in numerical form
1. Qualitative data : is information that is represented by means other
than numbers
27
28. Data sources
• Major Data Sources of Population
– Census
– Vital statistics
– Surveys
– Medical/administrative records
• Data may be collected from
– Primary source eg. Interview
– Secondary sources eg. Records
28
29. Data collection
Types of data collection
• Interviewing
• Self‐ administered questionnaire
• Observation
• Focus group discussion
• Using secondary data
• Routine records
• Database from previous studies etc…
29
30. Factors that affect data collection methods
• Resource (human and financial)
• Ethical issues
• Sensitivity of the information gathered
• Geographic accessibility
• Time
• Language
• Study design
• Study participants
30
31. Field staff recruitment
• Select data collectors in a way to minimize bias
• Every one who will be participating in the field work should be trained
• Pre‐test is usually done as part of the training of field staffs
•At the end of the training data collectors and supervisors go to
the field to test the data collection instrument
•Pre‐test is usually done on similar population but in an area
different from the actual survey
31
32. Purpose of pre‐test
• Check the clarity of instruments
• Assess the level of understanding of data collectors and supervisors
• Do data collectors understand the questions and thus administer
properly
• Correction of the instruments before the actual study
• To estimate the time and budget needed for the actual data collection
32
33. Quality control at field level
• Ensure appropriate administration of the data collection instrument
• Monitoring and supervision of field activities:
– Supervision should be done during data collection
– Intensive supervision is especially needed at the beginning of data
collection
33
34. Monitoring at the field
• Adherence to the study protocol
• Consistency of protocol implementation
• Appropriate implementation of ethical issues
• Completeness of questionnaires
34
35. Quality control at data entry and processing
• Questionnaires should be manually edited before entering data into
computer software
• Proper design of the data entry template
• Double entry to check consistency
• Preparing Data dictionary is mandatory
• Data cleaning
• Always save the master database on a separate file before doing any
coding and categorizing
35
36. Quality control for Qualitative studies
• Triangulation of data using different methods
• Proper labelling and documenting of data base
– Labelling tapes
– Interview notes
– Observations
36
37. Data processing
• It refers to data entry into a computer, and data
checks and correction
• The purpose of this process is to produce a
relatively clean data set
37
38. Coding Data
• Computers are at their best with numbers
• Some statistical packages cannot analyse
alphabetical codes
• Code: a numerical and/or alphabetical system for
classifying information
• Coding: translation of information: E.g.
questionnaire responses, into numbered categories
38
39. Coding data …
• Example, instead of using male and female for the variable sex, it can
be coded as 1=male and 2=female
• The meaning of the codes will depend on the level of measurement of
the variable
• Nominal: codes are just indications of the category
• Ordinal: codes are indications of ordering
• Interval/Ratio: codes are the actual numerical value
39
40. Coding data …
• Before entering data into a computer for processing
develop a code that indicates how each variable is
coded (whether it is actual or coded values) and in
what field it appears
• Assign a unique ID for each study subject or
questionnaire
• The ID number can direct the person back to the
original data for correction
• Used for follow-up
40
41. Data entry
• It concerns the transfer of data from questionnaire
into a computer file
• Converting data in to that can be read and
manipulated by computers used in quantitative data
analysis
• Data entry may be possible to begin anytime
anywhere
41
42. Data Cleaning
• Data cleaning/editing is the process of identifying values in
your data that are unusual or unexpected and examining
them to decide if the data is correct or if there is an error
• Before we analyse data we need to clean errors may have
occurred in data collection, coding, or data entry
• The purpose of this process is to produce a clean set of
data for statistical analysis
42
44. Measurement
• Measurements vary from questions asked about:
• Symptoms during history-taking,
• Physical examinations and Tests,
• laboratory tests,
• imaging techniques,
• Self-report questionnaires,
44
45. Characteristics of measurements
• From diagnosis to outcome measurements
• From clinician-based to patient-based measurements
• From objective to subjective measurements
• From unidimensional to multidimensional characteristics
• From observable to non-observable characteristics
45
47. Measurement Error
• Measurement error is the difference between the recorded response
to a question and the ‘true’ value.
• Measurement error occurs as part of data collection,
• It may arise from four sources:
1. The questionnaire,
2. The data collection method,
3. The interviewer, and
4. The respondent
47
48. Sources of Measurement Error
1. Questionnaire Effects
1.1. Specification problems:
• Error can occur because the data specification is
inadequate and/or inconsistent with what the survey
requires
• Specification problems can occur due to poorly worded
questionnaires and survey instructions, or may occur due
to the difficulty of measuring the desired concept
• These problems exist because of inadequate specifications
of uses and needs, concepts, and individual data elements
48
49. 1. Questionnaire Effects
1.2. Question wording:
• The designer wants the respondent to interpret the question as
the designer would interpret the question
The potentials for error are many
• First, the questionnaire designer may not have a clear formulation
of the concept he/she is trying to measure
• Next, even if he/she has a clear concept, it may not be clearly
represented in the question
• Even if the concept is clear and faithfully reproduced, the
respondent may not interpret the request as intended
• Not all respondents will understand the request for information,
due to language or cultural differences, affective response to the
wording, or differences in experience and context between the
questionnaire author and the respondent
49
50. 1. Questionnaire Effects
1.3. Length of the questions
• The questionnaire designer is faced with the dilemma of
keeping questions short and simple while assuring
sufficient information is provided to respondents so they
are able to answer a question accurately and completely.
• Common sense and good writing practice tell us that
keeping questions short and simple will lead to clear
interpretation.
• Research, however, suggests that longer questions
actually yield more accurate detail from respondents than
shorter questions, at least as they relate to behavioral
reports of symptoms and doctors’ visits
50
51. 1. Questionnaire Effects
1.4. Length of the questionnaire
• Long questionnaires may introduce error due to respondent
fatigue or loss of concentration.
• Length of the questionnaire may also be related to non-
response error.
• There is always a tension between the desire to ask as many
questions as possible and the awareness that error may be
introduced if the questionnaire is too long
51
52. 1. Questionnaire Effects
1.5. Open and closed formats
• Question formats in which respondents are asked to
respond using a specified set of options (closed format)
may yield different responses than when respondents are
not given categories (open format).
• A given response is less likely to be volunteered by a
respondent in an open format than when included as an
option in a closed format.
• The closed format may remind respondents of something
they may not have otherwise remembered to include.
• The response options to a question cue the respondent as
to the level or type of responses considered appropriate
52
53. 1. Questionnaire Effects
1.6. Data Collection Mode Effects
Face-to-face interviewing
• Face-to-face interviewing is the mode in which an interviewer
administers a structured questionnaire to respondents.
• Using a paper questionnaire or via computer assisted personal
interviewing, the interviewer completes the questionnaire by asking
questions of the respondent.
• One problem for face-to-face interviewing is the effect of
interviewers on respondents’ answers to questions, resulting in
increases to the variances of survey estimates.
• Another possible source of measurement error is the presence of
other household members who may affect the respondent’s
answers. T
• his is especially true for topics viewed as sensitive by the
respondents.
• Measurement error may also occur because respondents are
reluctant to report socially undesirable traits or acts
53
54. 1. Questionnaire Effects
1.7. Skipping pattern
• while use skipping pattern the interviewer and/or
interviewee may use the advantage of the skipping and
follow the pattern that shorten the time of the question
by choosing the response that let them jump to other
question.
1.8. Reference period:
• The length the reference period at which the problems
occurs may affect the response of the respondents.
• If it is so long the respondents may not exactly recall the
problem (telescoping bias )
54
55. 2. Respondent Effects
• Survey respondents vary considerably in their abilities and
willingness to provide accurate answers to questions
regarding to their behaviors.
• Respondent behaviors can be understood within the
framework of the generally accepted cognitive model of survey
response, which recognizes four basic tasks required from
respondents when they are answering each survey question.
a) question interpretation,
(b) memory retrieval,
(c) judgment formation,
(d) response editing
• This is a useful model for understanding how variability across
respondents may influence the quality of self-reported
information
55
56. 2. Respondent Effects
2.1. Question Interpretation
• Respondents sometimes employ terminology that differs from that
employed in research questionnaires.
• A related concern is the degree to which respondent cultural
background may influence the interpretation and/or comprehension of
survey questions.
• Some disease patterns and risk practices are known to vary cross-
culturally and those varied experiences and beliefs regarding the
problem can also be expected to influence respondent knowledge and
familiarity with the topic in general and related terminology in
particular.
• Experienced researchers, of course, recognize the importance of
investigating and addressing these potential problems by employing
focus groups discussion
56
57. 2. Respondent Effects
2.2. Memory Retrieval
• The accuracy of respondent recall has been the focus of
much attention.
• Poorly worded survey questions may present respondents
with difficult cognitive challenges in terms of the effort
necessary to retrospectively retrieve specific and/or
detailed information that may not be readily accessible in
memory
57
58. 2. Respondent Effects
2.3. Response Editing
• Once respondents have successfully interpreted a survey
question and retrieved the relevant information necessary to
form an answer, they must decide whether that answer is to
be accurately shared with the researcher.
• Given the illicit and sometimes stigmatizing nature of
behaviors, conventional wisdom often suggests that some
respondents will make conscious decisions to underreport, or
deny altogether, any such behavior.
• That survey respondents will sometimes attempt to present
themselves in a favourable, albeit not completely accurate,
light during survey interviews is well understood and is
commonly referred to as social desirability bias 58
59. 2. Respondent Effects
2.4. Recall bias
• if the presence of disease influences the perception of its
causes (rumination bias) or the search for exposure to the
putative cause (exposure suspicion bias), or in a trial if
the patient knows what they receive may influence their
answers (participant expectation bias)
59
60. 2. Respondent Effects
2.5. Reporting bias; participants can ‘‘collaborate’’ with
researchers and give answers in the direction they perceive
are of interest (obsequiousness bias), or the existence of a
case triggers family information (family aggregation bias)
60
61. 3. Interviewer Effects
• Because of individual differences, each interviewer
handles the survey situation in a different way, that is, in
asking questions, probing and recording answers, or
interacting with the respondent, some interviewers appear
to obtain different responses from others.
• The interviewer situation is dynamic and relies on an
interviewer establishing rapport with the respondent.
• Interviewers may not ask questions exactly as worded,
follow skip patterns correctly or probe for answers non
directivity.
• They may not follow directions exactly, either
purposefully or because those directions have not been
made clear enough.
• Interviewers may vary their inflection, tone of voice, or
61
62. 3. Interviewer Effects
• Errors, both over reports and underreports, can occur for each
interviewer.
• When over reporting and underreporting of approximately the
same magnitude occurs, small interviewer bias will result.
• However, these individual interviewer errors may be large and
in the same direction, resulting in large errors for individual
interviewers Another possible mechanism that may account
for interviewer effects involves social distance.
• It is possible that the social distance between respondents and
interviewers may influence respondent willingness to report
sensitive behaviors
• Interviewer-respondent familiarity with one another may also
influence the quality of self-reported behaviours or practice 62
63. 3. Interviewer Effects
• Helping the respondents in different ways (even with
gestures), putting emphases in different questions,
misreading questions, failing to probe answers correctly, not
following other elements of standardized survey protocols
• Social distance: if the interviewer varies from interviewee by
sex, culture, education, age, and dressing; the respondents
may not feel comfort to genuinely and freely respond about
their morbidity and other contributing factors.
• Interviewer-respondent familiarity with one another may also
influence the quality of self-reported behaviours or practice
• Between interviewer bias: variability in terms of knowledge,
profession experience may influence the result.
• Language barrier; if the interviewers are not fluent speakers of
the language of respondents, he/she cannot explain the
question in case the respondents unable to understand the
questionnaire
63
64. 4. Context Effects
• Various aspects of the social and physical environment within
which survey data are collected may also influence the quality
of the information collected
• One aspect of the social environment that has received
attention is the absence or presence of other individuals
during the interview, as this is believed to influence the social
desirability demands or pressures that respondents may
perceive.
• In general, the presence of others during survey interviews is
known to be associated with lower reporting of sensitive
behaviors
• The physical context within which interviews take place may
also influence social desirability pressures and self-report
quality 64
65. 5. Processing Errors.
• Once data collection is complete, the construction of a final
survey data set requires the implementation of numerous
coding and editing rules.
• The integrity of these rules is particularly critical in surveys, as
they typically involve assumptions about the reporting
intentions of respondents
5.1. Data Entry Errors
• Data entry errors occur in the process of transferring collected
data to an electronic medium.
• The frequency of these errors varies by the types of
information collected (e.g., numeric versus character) and the
mode of data collection.
• For example, with paper and pencil enumeration, survey data
are key-entered after the survey interview takes place
65
66. 5. Processing Errors.
5.2.Key entry errors
• Double key entry is an effective technique for minimizing
key-entry errors in paper and pencil instruments.
• With this technique, key-entered data are independently
keyed a second time, usually by a different key-entry
operator, and the resulting two data sets are compared.
• Discrepancy reports identifying cases and survey items
for which differences exist are then reviewed, and
erroneous data are corrected.
• In some cases only a sample of questionnaires is verified
to test the accuracy of the key-entry process and of
individual key-entry personnel
66
67. 5. Processing Errors.
5.3. Pre-Edit Coding Errors
• Most surveys require some type of pre-edit coding of the survey
returns before they can be further processed in edit, imputation,
and summary systems.
• The required coding is generally of two types—unit and item
response coding.
• The unit response coding assigns and records the status of the
interview.
• It is designed to indicate the response status of the return for a
sampled unit so that it can be appropriately handled in
subsequent processing.
67
68. 5. Processing Errors.
5.3. Pre-Edit Coding Errors
• Item response coding is the more commonly discussed
form of questionnaire coding
• This can involve coding an actual response for a survey
question into a category
• This situation occurs for questions that elicit open-ended
responses.
• For example, sometimes one of the responses in categorical
questions is “other-specify,” which results in a free-text
response.
• In other surveys, the respondent may be asked by design
to provide an open-ended response
68
69. 5. Processing Errors.
5.3. Pre-Edit Coding Errors
• The recoding of open-ended responses into a categorical
variable is performed by coders who interpret and catalogue
each response.
• This process can result in error or bias, since different coders are
likely to interpret and code some responses differently.
• Even the same coders may change the way they code as they gain
more experience or get bored. Another problem with open-
ended responses is that respondents sometimes supply more
than one answer to the question
• A technique employed to measure and reduce coding errors is
the use of multiple coders for the same set of responses.
• This is analogous to double key entry.
• Once both sets of coders have completed the coding, a
69
70. 5. Processing Errors.
5.4. Editing Errors
• Editing is a procedure designed and used for detecting
erroneous and/or questionable survey data (survey response
data or identification type data) with the goal of correcting
(manually and/or via electronic means) as much erroneous
data (not necessarily all of the questioned data) as possible,
usually prior to data imputation and summary procedures
• Editing generally occurs at various points in the survey
processing and can, in itself, generate errors at each juncture.
• The editing process, in general, allows survey managers to
review each report for accuracy an activity that usually results
in a feeling of control over the process while obtaining a sense
of the data
70
71. 5. Processing Errors
5.4. Editing Errors
• While, indeed, there are benefits from editing, recent
studies documented by various survey organizations have
shown that data are often over-edited.
• This over editing unnecessarily uses valuable resources
and can actually add more error to the data than it
eliminates.
• Processing error can also arise during edit processing due
to edit model failure in an automated system.
• Whether the editing is based on a very sophisticated
mathematical model or on simple range checks, the
manner in which erroneous data are flagged, and how
they are handled, can introduce processing error
71
73. RELIABILITY
Reliability is defined as ‘the degree to which the
measurement is free from measurement error
• In full this is ‘the extent to which scores for patients who
have not changed are the same for repeated
measurement under several conditions:
• internal consistency
• test–retest
• inter-rater
• intra-rater
73
74. Types of Reliability
• Parameters of reliability for continuous variables
1. Intraclass correlation coefficients for single measurements
2. Pearson’s r
• Parameters of measurement error for continuous variables
1. Standard error of measurement
2. Coefficient of variation
• Parameters of reliability for categorical variables
1. Cohen’s kappa for nominal variables
• No parameters of measurement error for categorical variables
• It can be examined, however, which percentage of the
measurements are classified in the same categories. We call this
the percentage of agreement
• Cronbach’s alpha as a reliability parameter
74
75. Validity
Define: ‘the degree to which an instrument truly measures
the construct(s) it purports to measure’
Types of validity
1. Content validity (including face validity): is the degree to
which the content of a measurement instrument is an
adequate reflection of the construct to be measured’
• If the construct we want to measure is body weight, a weighing
scale is sufficient.
• To measure the construct of obesity, defined as a body mass
index (BMI = weight/height2 ) > 30 kg/m2 , a weighing scale
and a measuring rod are needed.
75
76. Types of validity
A. Face validity :A first aspect of content validity is face
validity. ‘the degree to which a measurement
instrument, indeed, looks as though it is an adequate
reflection of the construct to be measured’
It is a subjective assessment and, therefore, there are no
standards with regard to how it should be assessed, and it cannot
be quantified.
B. Content validity; When an instrument has passed the
test of face validation, we have to consider its content
in more detail
• The purpose of a content validation study is to assess
whether the measurement instrument adequately represents
the construct under study.
• We again emphasize the importance of a good description of
the construct to be measured. 76
77. 2. Criterion validity; ‘the degree to which the scores of a
measurement instrument are an adequate reflection of a gold
standard’
• This implies that criterion validity can only be assessed when a
gold standard (i.e. a criterion) is available.
3. Construct validity: In situations in which a gold standard is
lacking, construct validation should be used to provide evidence of
validity.
• Construct validity was defined as the degree to which the scores of
a measurement instrument are consistent with hypotheses, e.g.
with regard to internal relationships, relationships with scores of
other instruments or differences between relevant groups
• Construct validation is often considered to be less powerful than
criterion validation
77
78. 4. Cross-cultural: is defined as ‘the degree to which the performance
of the items
on a translated or culturally adapted PRO instrument are an
adequate reflection of the performance of items in the original
version of the instrument’
• This is often assessed after the translation of a questionnaire.
• Apart from differences induced by the translations, there may
also be differences in cultural issues
• Some items in a questionnaire may be irrelevant in other
cultures
• Cross-cultural validation starts with an accurate translation
process
• After the translation, or cultural adaptation, the real cross-
cultural validation takes place.
78
79. Validity and reliability
• The four boxes in this figure reflect
various combinations of validity and
reliability.
• The dots represent multiple
measurements of one patient, and the
cross within the circle represents the true
score:
• The dots in cell A correspond to
valid and quite reliable scores
• The dots in cell B correspond to
mostly invalid, and definitely
unreliable scores
• The dots in cell C correspond to
invalid, but quite reliable scores and
• The dots in cell D correspond to invalid
and unreliable scores
79