This document summarizes a readiness assessment for a health link coalition. It highlights strengths such as regular partnership meetings and established connections within the health and social services networks. Gaps are noted around clarifying some areas, verifying statistics, and expanding partnerships outside the coalition. The document also outlines metrics to track the coalition's progress in coordinating care for complex patients, improving access to services, reducing wait times, avoiding unnecessary emergency visits and hospital admissions, and enhancing the patient experience while reducing costs. Further work is still needed to improve the accuracy and completeness of the data and ensure all relevant partners are involved.
Andrea Sutcliffe, Chief Inspector of Adult Social Care for the Care Quality Commission (CQC) presented at the National Children and Adult Services Conference (NCAS) on 4 November 2016.
Care Quality Commission: Driving improvement in the investigation of deathsCare Quality Commission
A regulators perspective: supporting learning and driving improvement in the investigations of deaths
Presentation by Kim Forrester, Mental Health Act Policy Manager, and Karen Bennet-Wilson, Head of Inspection to the Improving Quality and Learning from Investigation of Deaths in Mental Health & Learning Disability Services event, Wednesday 22 June 2016, Hallam Conference Centre, London.
• Updates on the CQC review into investigations of deaths in NHS Trusts
• Learning from Southern Health
• What should be reported to CQC
• Moving forward...
A community-based clinical liaison project to support HIV prevention and sexuality sensitive health care in General Practice and government clinics across Queensland
State of Care is our annual overview of health and adult social care in England.
For the first time, we have been able to draw on the findings of our new ratings system across all of the sectors we regulate.
Our analysis shows that, despite increasingly challenging circumstances, many services have managed to either improve or maintain quality.
Andrea Sutcliffe, Chief Inspector of Adult Social Care for the Care Quality Commission (CQC) presented at the National Children and Adult Services Conference (NCAS) on 4 November 2016.
Care Quality Commission: Driving improvement in the investigation of deathsCare Quality Commission
A regulators perspective: supporting learning and driving improvement in the investigations of deaths
Presentation by Kim Forrester, Mental Health Act Policy Manager, and Karen Bennet-Wilson, Head of Inspection to the Improving Quality and Learning from Investigation of Deaths in Mental Health & Learning Disability Services event, Wednesday 22 June 2016, Hallam Conference Centre, London.
• Updates on the CQC review into investigations of deaths in NHS Trusts
• Learning from Southern Health
• What should be reported to CQC
• Moving forward...
A community-based clinical liaison project to support HIV prevention and sexuality sensitive health care in General Practice and government clinics across Queensland
State of Care is our annual overview of health and adult social care in England.
For the first time, we have been able to draw on the findings of our new ratings system across all of the sectors we regulate.
Our analysis shows that, despite increasingly challenging circumstances, many services have managed to either improve or maintain quality.
Enabling Remote Patient Monitoring: Opportunities and Challenges at Bio2Devic...Akhsar Kharebov
Personal medical devices track an ever increasing amount of patient information away from the hospital. Coupled with quantitative self devices such as fitness trackers or calories counters, provide valuable information as the condition of a patient. Digital Health is growing a new realm of opportunities for biospace professionals. Yet challenges exist. Medical information software are archaic and siloed. Medical system is slow to adopt.
Screening for diabetes and its complications as part of the Alberta Diabetes ...Kelli Buckreus
2004 (Jan) 3rd National Conference on Diabetes and Aboriginal Peoples, National Aboriginal Diabetes Association (NADA), poster presentation by BRAID Research
How to make cash-based telepsychiatry work for youVSee
Session: Telepsychiatry Best Practices
Speaker: Chris O'Brien (TherapyWorks)
Telehealth Secrets Conference 2018 by VSee
More info here: vsee.com/conference
BiomedHealthtech is engaged in serving the healthcare industry since 1989 and now introduce Remote Monitoring Technologies (RMT) which is a new concept of Patient Monitoring designed to meet the demands of Modern Healthcare and thus reduce the Mortality Rate.
Transforming End of Life Care in Acute Hospitals PM Workshop 5: How to use th...NHS Improving Quality
Transforming End of Life Care in Acute Hospitals PM Workshop 5: How to use the revised and updated ‘Transform How to Guide’ presented by Maggie Morgan Cooke, Wendy Gray, NHS England
Together with Médecins Sans Frontières and the World Health Organisation, we hosting a two day conference on the global response to Ebola. By pulling together and sharing the collective knowledge, we're working hard to ensure that, as a team, we have a head start on any future epidemics
This presentation was by Erin Polich
Primary Care Integration for a Rural Community Behavioral Health Clinic. 2015 Washington Behavioral Healthcare Conference: Fulfilling the Promise of Integrated Care
Vancouver, WA June 19, 2015
2.5 Partnership working - Anne Forletta, Katherine HewittNHS England
Partnership working. Building partnerships with acute hospitals, voluntary and community services. Featuring examples from Birmingham and Coventry. Anne Forletta, My Healthcare Birmingham; Katherine Hewitt, Gateway Family Services, Birmingham.
Enabling Remote Patient Monitoring: Opportunities and Challenges at Bio2Devic...Akhsar Kharebov
Personal medical devices track an ever increasing amount of patient information away from the hospital. Coupled with quantitative self devices such as fitness trackers or calories counters, provide valuable information as the condition of a patient. Digital Health is growing a new realm of opportunities for biospace professionals. Yet challenges exist. Medical information software are archaic and siloed. Medical system is slow to adopt.
Screening for diabetes and its complications as part of the Alberta Diabetes ...Kelli Buckreus
2004 (Jan) 3rd National Conference on Diabetes and Aboriginal Peoples, National Aboriginal Diabetes Association (NADA), poster presentation by BRAID Research
How to make cash-based telepsychiatry work for youVSee
Session: Telepsychiatry Best Practices
Speaker: Chris O'Brien (TherapyWorks)
Telehealth Secrets Conference 2018 by VSee
More info here: vsee.com/conference
BiomedHealthtech is engaged in serving the healthcare industry since 1989 and now introduce Remote Monitoring Technologies (RMT) which is a new concept of Patient Monitoring designed to meet the demands of Modern Healthcare and thus reduce the Mortality Rate.
Transforming End of Life Care in Acute Hospitals PM Workshop 5: How to use th...NHS Improving Quality
Transforming End of Life Care in Acute Hospitals PM Workshop 5: How to use the revised and updated ‘Transform How to Guide’ presented by Maggie Morgan Cooke, Wendy Gray, NHS England
Together with Médecins Sans Frontières and the World Health Organisation, we hosting a two day conference on the global response to Ebola. By pulling together and sharing the collective knowledge, we're working hard to ensure that, as a team, we have a head start on any future epidemics
This presentation was by Erin Polich
Primary Care Integration for a Rural Community Behavioral Health Clinic. 2015 Washington Behavioral Healthcare Conference: Fulfilling the Promise of Integrated Care
Vancouver, WA June 19, 2015
2.5 Partnership working - Anne Forletta, Katherine HewittNHS England
Partnership working. Building partnerships with acute hospitals, voluntary and community services. Featuring examples from Birmingham and Coventry. Anne Forletta, My Healthcare Birmingham; Katherine Hewitt, Gateway Family Services, Birmingham.
Presentation by Auditor General - Caroline Spencer, An audit of access to State-managed adult mental health services.
Presented at the Western Australian Mental Health Conference 2019.
NatCon 2018 Presentation: Pay for Success and Social Impact Bondscommteam
Faith Richie, SVP of Development at Telecare, as well as Shannon Mong, Director of Innovation Initiatives at Telecare, provided an insider’s perspective on the planning and implementation of our “pay for success” behavioral health program, Partners in Wellness. This community-based program in San Jose, California, establishes performance incentives that align clinical goals and social impact regarding reducing expensive utilization of wraparound services.
The Better Care Fund is a pooled budget for health and social care spending in the city which is shared between NHS Sheffield Clinical Commissioning Group and Sheffield City Council.
This set of slides talks Health and Wellbeing Board members through plans for the Better Care Fund in 2016/17. The slides were presented at the Health and Wellbeing Board meeting on 31 March 2016.
The paper which supports these slides can be read and downloaded at: http://sheffielddemocracy.moderngov.co.uk/ieListDocuments.aspx?CId=366&MId=5996&Ver=4.
PIHCI programmatic grants webinar (en) for circulationAlexandra Enns
These are the slides from CIHR’s webinar providing information for the upcoming PIHCI Network Programmatic Grant funding opportunity.
The complete instructions are on ResearchNet: https://www.researchnet-recherchenet.ca/rnr16/vwOpprtntyDtls.do?prog=2734&view=currentOpps&org=CIHR&type=EXACT&resultCount=25&sort=program&next=1&all=1&masterList=true
Medicare and Medicaid In-Patient service' s provided within Nursing Homes for the Mental disabled. These service;s are avaliable through out the United States in every State.Contact us for more information?
Making Seven Day Services a reality, pop up uni, 2 pm, 3 september 2015NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
Geraldine Strathdee and Jen Hyatt: Technology innovation for supporting patie...Nuffield Trust
Geraldine Strathdee, Oxleas NHS Foundation Trust,and Jen Hyatt, Big White Wall, present in a breakout session on using technology to support people with mental health issues at home.
The COVID-19 pandemic has created several challenges for our country’s health care infrastructure, and the community health center workforce is no exception. Join us as we describe strategies to get patients back into dental care. Along with these strategies, participants will learn how to recognize challenges in dental practices, as well as how to engage the interdisciplinary care team through role redesign and integration to increase access to comprehensive care.
Using simulation to drive changes in health and care - long term conditions Year of Care model
Bev Matthews and Claire Cordeaux
Presentation from Day 1 of the Health and Care Innovation Expo 2014, Manchester Central
Practical considerations in enabling new models of care, pop up uni, 10am, 3 ...NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
Tips to engage stakeholders in 7 day servicesNHS England
NHS England’s Sustainable Improvement team are hosting a series of free sharing and learning webinars to support organisations implement seven day services (7DS).
The next in the series focuses on stakeholder engagement, as feedback from the service has indicated that good stakeholder engagement is a key factor in successfully implementing 7DS.
This webinar will showcase practical tried and tested approaches supported by Trust examples. There will be opportunities for peer to peer connections, learning and for participants to share their own practice.
During this session you will hear about examples from:
University Hospital Southampton NHS Foundation Trust: Whole System: Engaging commissioners, clinicians and Patients for 7DS with Dr Juliane Kause, Care Group Lead Emergency Care, Lead Consultant Out of Hours Care and Seven Day Services.
Oxford University Hospitals NHS Foundation Trust: Spreading the word and resources to help clinicians: Portal for Oxford 7DS Guide with Belinda Boulton, Director of Transformation and Ruth McNamara, Integrated Care Projects Lead.
Maidstone and Tunbridge Wells NHS Trust: Getting it right from the start: engaging internal stakeholders for 7DS clinical leadership and planning with Lynne Sheridan, Head of Delivery Development
Similar to Readiness Template - South Renfrew Health Link - Julia Atkinson (20)
A brief update on the Physical Activity Network Strategic and Sustainability direction, our connection and contribution to the Healthy Community Partnership, community action projects and updates.
Presentation shared at Linking Healthy Communities - Building from Within - Toronto, Nov. 1-2, 2011. Focus on the strength of assets based initiatives and collective impact / strength of effective collaboration and co-ordinated effort.
Lindsay Legari was one of 12 youth delegates at the Healthy Children Healthy Spaces event. Based on her inspiration at HCHS, Lindsay developed an initiative that is youth lead and community supported. Your Inner Child builds on the expertise and recommendations developed by the youth delegates and is being implemented by Lindsay in the Ottawa region.
Jamie Nicholls is a practicing landscape architect in Montreal. His area of expertise is in design and policy for provision of children's play spaces. Let the Children Play builds on the work of the 7 Cs - www.childcareoptions.ca/pdfs/7Cs.pdf
Catherine O'Brien links children's mobility, sustainable happiness with active transportation, healthy communities, environmental sustainability, travel to and from school and our children'sl health and well being. Catherine's presentation at HCHS supported the critical need to teach and support sustainable happiness in our schools.
Dr. Andrew Pipe provided a keynote presentation to the Healthy Children Healthy Spaces Initiative in Ottawa in November, 2010. As the Medical Director of Prevention and Rehab at the University of Ottawa Heart Institute, Dr Pipe speaks to the critical need to shift our children away from sedentary screen based time to outdoor, active, unstructured play.
Tim Gill, keynote speaker at Healthy Children Healthy Spaces, is one of the UK's leading thinkers on childhood and an effective advocate for change. His work focuses on children's play and free time. Tim's presentation supports the resilience, capability, creativity and ability of children to grow and learn in environments that offer them opportunity.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. Summary
Strengths Gaps
• regular meetings that include
multiple members
• well-established connections
within the health link and the LHIN
and reaching out to other LHINs,
health links
• highlighted areas need
clarification, verification or statistics
• electronic linkages between
partners
• how we work with organizations
outside out SRHL and LHIN
3. A Broad Coalition and
Diverse Leadership Models
19 early-adopter Health Links providing care to almost one million
people, through the co-operation of 18 hospitals, 42 primary care groups and
over 60 community service providers
S Cross section of partners
S Mental Health Agencies
S Public Health Units
S Food Banks
S Emergency Medical Services
S Educational Providers
S Community Social Service
Providers
S Long Term Care Facilities
S Police Services
S Cross section of coordinators
S 4 Hospitals
S 2 CCACs
S 8 primary care (FHT/FHO)
S 4CHCs
S 1 Community Services
Organization
4. Metrics for Health Links
– as per Business Plan template
S Operational Metrics (Setting the Stage for Coordinated Care Straightaway)
S 1. Ensure the development of coordinated care plans for all complex patients
S 2. Increase the number of complex patients and seniors with regular and timely access to a primary
care provider
S Results based Metrics(Moving the Needle)
S 1. Reduce the time from primary care referral to specialist consultation
S 2. Reduce the number of 30 day readmissions to hospital
S 3. Reduce the number of avoidable ED visits for patients with conditions best managed elsewhere
S 4. Reduce time from referral to home care visit
S 5. Reduce unnecessary admissions to hospitals
S 6. Ensure primary care follow-up within 7 days of discharge from an acute care setting
S Evaluation Based Metrics (How you’ll know you’ve arrived)
S 1. Enhance the health system experience for patients with the greatest health care needs.
S 2. Achieve an ALC rate of 9 per cent or less
S 3. Reduce the average cost of delivering health services to patients without compromising the
quality of care
5. Work still to be done
S Accuracy of current data
S Missing data
S Missing partners
S Francophone
S Aboriginal
S Results oriented
