Acute trauma of the spine
Acute spinal trauma refers to any injury to the spinal cord that happens suddenly. It can be a very serious condition, as it can damage the nerves that carry messages between the brain and the rest of the body. This can lead to loss of movement, feeling, and even paralysis.
There are many different causes of acute spinal trauma, including:
Car accidents
Falls
Diving accidents
Sports injuries
Violence
the symptoms of acute spinal trauma will vary depending on the severity of the injury and the location of the injury. Some common symptoms include:
Pain in the back or neck
Weakness or paralysis in the arms or legs
Numbness or tingling in the arms or legs
Loss of bladder or bowel control
Difficulty breathing
Acute trauma of the spine
Acute spinal trauma refers to any injury to the spinal cord that happens suddenly. It can be a very serious condition, as it can damage the nerves that carry messages between the brain and the rest of the body. This can lead to loss of movement, feeling, and even paralysis.
There are many different causes of acute spinal trauma, including:
Car accidents
Falls
Diving accidents
Sports injuries
Violence
the symptoms of acute spinal trauma will vary depending on the severity of the injury and the location of the injury. Some common symptoms include:
Pain in the back or neck
Weakness or paralysis in the arms or legs
Numbness or tingling in the arms or legs
Loss of bladder or bowel control
Difficulty breathing
Kummell's disease was first described by Kummell in 1895, who reported a series of patients presenting with delayed vertebral collapse after seemingly minor trauma
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Kummell's disease was first described by Kummell in 1895, who reported a series of patients presenting with delayed vertebral collapse after seemingly minor trauma
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Background:
Fractures of the vertebral column are important not
only because of the structures involved but also
because of the complications that may arise affecting
the spinal cord.
Constituting approximately 3% to 6% of all skeletal
injuries, fractures of the vertebral column are most
commonly encountered in people between the ages
of 20 and 50 years, with the majority of cases (80%)
being seen in males.
Most spinal fractures occur at the thoracic and
lumbar level.
3. Injury to the cervical area has a greater potential risk for
spinal cord damage.
Automobile accidents, sports-related activities (e.g.,
diving, skiing), and falls from heights are usually the
circumstances in which spinal injuries are sustained.
The spine is composed of 33 vertebrae: 7 cervical, 12
thoracic, 5 lumbar, a sacrum of 5 fused segments, and a
coccyx of 4 fused segments.
With the exception of the first and second cervical
vertebrae (C1 and C2), the vertebral bodies are separated
from each other by intervertebral disks.
Patients complaining of back pain after motor vehicle
accidents or falls from significant heights should be
considered to have spinal injuries until proven otherwise.
18. Cervical spine should remain immobilized
until the patient has been cleared either no
injury or the extent of injury has been
determined.
19.
20. Lateral view. (A) For the erect lateral view of the cervical spine, the patient is
standing or seated, with the head straight in the neutral position. The central
be am is directed horizontally to the center of the C4 vertebra (at the level of
the chin).
(B) For the cross-tab le lateral view, the patient is supine on the radiographic
table. The radiographic cassette (a grid cassette to obtain a clearer image) is
adjusted to the side of the neck, and the central be am is directed
horizontally to a point (red dot) approximately 2.5 to 3 cm caudal to the
mastoid tip.
21.
22. (C) The radiograph in this projection clearly shows the vertebral bodies,
apophyseal joints, spinous processes, and intervertebral disk spaces. It is
mandatory to demonstrate the C7 vertebra. (Continue d)
C
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57. The most severe fracture of the cervical
spine, often causing anterior cervical
cord syndrome and quadriplegia.
58.
59.
60.
61.
62.
63.
64.
65.
66. Burst Fracture
•C3-C7.
• Theory - compressed disc bulges into
inferior endplate causing VB to
explode from the inside.
• Usually with injury to spinal canal.
• ALL, disc, posterior column intact.
• STABLE.
67.
68.
69.
70.
71.
72.
73.
74.
75. Lumbar spine trauma.
Drawing of the primary
force involved in
compression burst injury of
the lumbar spine.
The vertical force is directed
into the central portion of
the lumbar endplate
(arrow).
The force results in both
downward and axial
displacement of fragments
of the vertebral body
endplate
76. Lumbar spine trauma. Drawing of the mechanism of injury of the lumbar spine
burst injury is compared with an axial CT image.
The centrally applied vertical force results in radial expansion of the vertebral body
endplate. The posterior margin of the endplate may be displaced into the spinal
canal (arrow)
85. Lumbar spine trauma. Axial T1-weighted MRI in a patient with lumbar spine
compression burst injury.
A comminuted fracture of the lumbar spine endplate (arrow) results in spinal
canal narrowing.
86. Lumbar spine trauma. Axial CT (right) and axial MRI (left) images of an upper
lumbar spine burst injury.
While the CT image presents better detail concerning the bone injury, the MRI
image fully illustrates the position of the conus
87. Lumbar spine trauma. A 35-year-old man presented to the emergency
department after a motor vehicle accident. He complained of back pain without
paresthesias or weakness of his lower extremities.
Findings on the sagittal T2-weighted MRI confirms edema in the posterior L1
vertebral body (white arrow), while stenosis is noted posterior and inferior to
the L1 (yellow arrow)
88.
89. •Lumbar spine trauma. Lateral
radiograph demonstrates an L3 spinal
compression fracture.
•Note the downward compression of the
superior endplate of the L3 (yellow
arrow).
•The anterior portion of the L3 vertebral
body has been displaced forward (white
arrow).
90. Sagittal T2W
image of 23yr old
male showing
burst fracture
with anterior
wedging(arrow)
of L1 vertebra.
91.
92. A 35-year-old man presented to the
emergency department after a motor vehicle
accident. He complained of back pain
without paresthesias or weakness of his
lower extremities.
Sagittal reformatted CT image
demonstrates fracture of the anterior L1
vertebral body with a posterior fragment
displaced into the spinal canal (black
arrow).
The fracture extended into the spinous
process (yellow arrow).
A second fracture in the L3 vertebral body is
noted in the posterior aspect of the inferior
endplate of the L3 (white arrow).
93. Sagittal T2-weighted MRI of an L2 compression
fracture. Relatively little deformity of the L2
vertebral body is shown, with less than 5° of
kyphotic forward angulation.
Compression fractures with little angulation
often are associated with significant posterior
ligamentous trauma (arrow).
94. Lumbar spine trauma. Sagittal T2-weighted
gradient-echo MRI demonstrates a
compression fracture of the L1 vertebral body
with a small bony fragment displaced into
the spinal canal
95. Lumbar spine trauma. Three-dimensional reconstruction of a CT scan of the
thoracic and lumbar spine in a patient with complex injury.
The L1 vertebral body is compressed with a severe rotation of the L1 vertebral body
under the T12. This injury was associated with a severe neurologic injury to the
conus and cauda equina
96.
97. A Chance fracture or a modified
compression fracture of the upper lumbar
spine may occur when the weight of the
upper body moves forward (red arrow)
while the person's waist and upper body are
fixed in position by the seatbelt or steering
wheel of an automobile (pink arrows).
The resulting fixed-position stress results in
a fracture
98.
99. Lumbar spine trauma. Sagittal reformatted
CT image in a patient with lumbar vertebral
body distraction (arrow).
Distraction injury commonly is associated
with injury to the conus of the distal spinal
cord