Rabies is an acute infectious viral disease that affects the central nervous system in humans and other mammals. It is caused by a rhabdovirus and is almost always fatal if post-exposure prophylaxis is not administered. Rabies is most commonly transmitted through bites from rabid animal hosts like foxes, bats, and dogs. Symptoms in humans include fever, headache, anxiety and eventually violent movements, hydroophobia, and death. Treatment involves immediately washing any wounds, vaccine administration, and possibly immunoglobulin depending on the severity of exposure.