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Rabies
A deadly viral disease transmitted by the
most beautiful beings.
Submitted to:Dr.Ghulam Shabbir
Presented by: Uzma Shireen
Introduction
01 02 03
04 05 06
Table of contents
Case Study
Symptoms & Diagnosis
Conclusion
Life Cycle & Stages Pathogenesis
07 09
08
Structure
Public awareness
& control
Treatment
Definition:
Rabies is a zoonotic viral disease of mammals which
is caused by Rabies virus ( Family Rhabdovirus,
Genus Lyssavirus ).
• Rabies virus is a Bullet shaped, RNA enveloped virus.
Introduction
Transmission:
This disease is transmitted by the Saliva
of infected animals generally known as Rabid animals
( most often by bites).
Transmitter:
Following are the transmitters of Rabies;
• Dogs
• Bats
• Cats
• Carnivores( Skunk ,Racoon ,Fox).
Case Study
● Rabies is known from over 4000 years.
● It was reduced in 20th century due to the introduction of
rabies vaccine.
● It is found in most countries but with exception of naturally
protected regions.
● Currently, Belgium, Australia, Netherland and UK are free of
Rabies.
● In Asia, upto 31000 children die annually due to rabies.
● In Indo-Pak, endemic 55000 cases are found in dogs annually.
● First Vaccination was done by Louis Pasteur in 1885.
Structure
•Rabies virus is approximately 180nm long and with a cross-
section of 75 nm.
• Rabies virus comprises of 5 different kinds of protein.
• It also contains RNA polymerase and its cofactor for
replication and translation
Structural
G
M
R
P
Functional
L
Rabies Viral Genome
● Rabies viral genome consist of 5 genes of
about 12kilobp in total.
● Out of which 4 code for structural protein
and 1 for functional protein.
● Rabies genome is negative sense ssRNA.
Life Cycle at Cellular Level
3. Acute Neurogical
Phase
It can stay avg 30-90 days.
1cm/day.
Virus enters CNS and
symptoms appear stays
for 2-10 days.
Stages of Rabies in Body
4. Coma
Virus have reached the
brain and is causing
inflammation.
Severe symptoms appear
which are irreversible.
Brain affected completly
leading to death.
5. Death
1. Incubation 2. Prodormal
Pathogensis
5.Enters salivary
Glands and other
organs.
2.Virus enters
Peripheral Nervous
System
4.Reaches Brain
causing Inflammation
in Thalammus, Brain
Stem & Spinal cord.
3.Virus ascend from
spinal cord.
1. Virus enters
through bite.
Diagnosis
DFA test.
•It is not detected at
early stage.
•DFA
•Saliva Test.
•MRI
•Blood Test.
In Animals
In Humans
Headache
Fatigue
Increased Saliva
Symptoms
Hydrophobic
Behavior
Seizures
Insomnia Aggression
Partial Paralysis Hyperventilation
Treatment
• After the rabid animal bite, consult health care
provider .
• Wash the wound with soap and water.
• Provider will provide Fast-shot vaccine or
Human Rabies Immuno Globulin.
• If the virus is reached to the brain there is no
medication or treatment.
Public Awareness & Control
• Make sure pets vaccination is up to date.
• Leave wildlife alone.
• Don’t let your pet roam without supervision.
• If you find a bat in your room, consider it and seek medical
help,
• This is because bat bites are faded and small.
• Get regular vaccination ( Pre-exposure prophylaxis).
• Proper awareness of disease by government health sectors.
Conclusions
•Rabies is a deadly viral disease.
• It is eliminated from a number of
countries.
•It caused by warm blooded animals.
• It is caused by RNA enveloped virus.
•It attacks the nervous system of body.
•It is uncurable if reached to the Brain
•Adequate measures should be taken to
Control the spread.
References
● https://www.cdc.gov/rabies/diagnosis/index.html
● https://www.ncbi.nlm.nih.gov/pmc/articles/PMC948
6443/
● https://www.cdc.gov/rabies/index.html
● https://www.mayoclinic.org/diseases-
conditions/history-disease-outbreaks-vaccine-
timeline/rabies
● https://my.clevelandclinic.org/health/diseases/1384
8-rabies
CREDITS: This presentation template was created by Slidesgo,
and includes icons by Flaticon, and infographics & images by
Freepik
Thank you
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Rabies ,a deadly viral disease transmitted by the most beautiful beings. by Uzma Shireen.pptx

  • 1. Rabies A deadly viral disease transmitted by the most beautiful beings. Submitted to:Dr.Ghulam Shabbir Presented by: Uzma Shireen
  • 2. Introduction 01 02 03 04 05 06 Table of contents Case Study Symptoms & Diagnosis Conclusion Life Cycle & Stages Pathogenesis 07 09 08 Structure Public awareness & control Treatment
  • 3. Definition: Rabies is a zoonotic viral disease of mammals which is caused by Rabies virus ( Family Rhabdovirus, Genus Lyssavirus ). • Rabies virus is a Bullet shaped, RNA enveloped virus. Introduction
  • 4. Transmission: This disease is transmitted by the Saliva of infected animals generally known as Rabid animals ( most often by bites). Transmitter: Following are the transmitters of Rabies; • Dogs • Bats • Cats • Carnivores( Skunk ,Racoon ,Fox).
  • 5. Case Study ● Rabies is known from over 4000 years. ● It was reduced in 20th century due to the introduction of rabies vaccine. ● It is found in most countries but with exception of naturally protected regions. ● Currently, Belgium, Australia, Netherland and UK are free of Rabies. ● In Asia, upto 31000 children die annually due to rabies. ● In Indo-Pak, endemic 55000 cases are found in dogs annually. ● First Vaccination was done by Louis Pasteur in 1885.
  • 6. Structure •Rabies virus is approximately 180nm long and with a cross- section of 75 nm. • Rabies virus comprises of 5 different kinds of protein. • It also contains RNA polymerase and its cofactor for replication and translation Structural G M R P Functional L
  • 7. Rabies Viral Genome ● Rabies viral genome consist of 5 genes of about 12kilobp in total. ● Out of which 4 code for structural protein and 1 for functional protein. ● Rabies genome is negative sense ssRNA.
  • 8. Life Cycle at Cellular Level
  • 9. 3. Acute Neurogical Phase It can stay avg 30-90 days. 1cm/day. Virus enters CNS and symptoms appear stays for 2-10 days. Stages of Rabies in Body 4. Coma Virus have reached the brain and is causing inflammation. Severe symptoms appear which are irreversible. Brain affected completly leading to death. 5. Death 1. Incubation 2. Prodormal
  • 10. Pathogensis 5.Enters salivary Glands and other organs. 2.Virus enters Peripheral Nervous System 4.Reaches Brain causing Inflammation in Thalammus, Brain Stem & Spinal cord. 3.Virus ascend from spinal cord. 1. Virus enters through bite.
  • 11. Diagnosis DFA test. •It is not detected at early stage. •DFA •Saliva Test. •MRI •Blood Test. In Animals In Humans
  • 13. Treatment • After the rabid animal bite, consult health care provider . • Wash the wound with soap and water. • Provider will provide Fast-shot vaccine or Human Rabies Immuno Globulin. • If the virus is reached to the brain there is no medication or treatment.
  • 14. Public Awareness & Control • Make sure pets vaccination is up to date. • Leave wildlife alone. • Don’t let your pet roam without supervision. • If you find a bat in your room, consider it and seek medical help, • This is because bat bites are faded and small. • Get regular vaccination ( Pre-exposure prophylaxis). • Proper awareness of disease by government health sectors.
  • 15. Conclusions •Rabies is a deadly viral disease. • It is eliminated from a number of countries. •It caused by warm blooded animals. • It is caused by RNA enveloped virus. •It attacks the nervous system of body. •It is uncurable if reached to the Brain •Adequate measures should be taken to Control the spread.
  • 16. References ● https://www.cdc.gov/rabies/diagnosis/index.html ● https://www.ncbi.nlm.nih.gov/pmc/articles/PMC948 6443/ ● https://www.cdc.gov/rabies/index.html ● https://www.mayoclinic.org/diseases- conditions/history-disease-outbreaks-vaccine- timeline/rabies ● https://my.clevelandclinic.org/health/diseases/1384 8-rabies
  • 17. CREDITS: This presentation template was created by Slidesgo, and includes icons by Flaticon, and infographics & images by Freepik Thank you