In the present study we have performed Quantitative structure activity relationship (QSAR) analysis for 43bisbenzofuran derivatives to estimate the antimalarial activity using some 2D descriptors. Several significant QSAR models has been calculated for predicting the antimalarial activity (“logIC50) of these molecules by using the multiple linear regression (MLR) technique. Among the obtained QSAR models, a four parametric model was most significant having R2=0.9502. An external set was used for confirming the predictive power of the models. High correlation between experimental and predicted antimalarial activity values, was obtained in the validation approach that displayed the good modality of the derived QSAR models. Tripti Kaushal | Anita K | Bashirulla Shaik | Vijay K. Agrawal"QSAR Modeling of Bisbenzofuran Compounds using 2D-Descriptors as Antimalarial Agents" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018, URL: http://www.ijtsrd.com/papers/ijtsrd9497.pdf http://www.ijtsrd.com/chemistry/other/9497/qsar-modeling-of-bisbenzofuran-compounds-using-2d-descriptors-as-antimalarial-agents/tripti-kaushal
Study on multi-target mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen ...LucyPi1
Abstract Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang) (RERR) and Semen Persicae (Taoren) (SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.
Predictive comparative qsar analysis of as 5 nitrofuran-2-yl derivatives myco...hiij
Antitubercular activity of 5-nitrofuran-2-yl Deriva
tives series were subjected to Quantitative Struc
ture
Activity Relationship (QSAR) Analysis with an effo
rt to derive and understand a correlation between t
he
biological activity as response variable and differ
ent molecular descriptors as independent variables.
QSAR models are built using 40 molecular descriptor
dataset. Different statistical regression express
ions
were got using Partial Least Squares (PLS) ,Multip
le Linear Regression (MLR) and Principal Component
Regression (PCR) techniques. The among these techni
que, Partial Least Square Regression (PLS)
technique has shown very promising result as compar
ed to MLR technique A QSAR model was build by a
training set of 30 molecules with correlation coe
fficient (
) of 0.8484 , significant cross validated
correlation coefficient (
) is 0.0939,
is 48.5187,
for external test set (
_
)
is -0.5604,
coefficient of correlation of predicted data set
( _
) is 0.7252 and degree of freedom is 26 by
Partial Least Squares Regression technique.
Neglected infectious diseases such as tuberculosis (TB) and malaria kill millions of people annually and the oral drugs used are subject to resistance requiring the urgent development of new therapeutics. Several groups, including pharmaceutical companies, have made large sets of antimalarial screening hit compounds and the associated bioassay data available for the community to learn from and potentially optimize. We have examined both intrinsic and predicted molecular properties across these datasets and compared them with large libraries of compounds screened against Mycobacterium tuberculosis in order to identify any obvious patterns, trends or relationships. One set of antimalarial hits provided by GlaxoSmithKline appears less optimal for lead optimization compared with two other sets of screening hits we examined. Active compounds against both diseases were identified to have larger molecular weight ([similar]350–400) and logP values of [similar]4.0, values that are, in general, distinct from the less active compounds. The antimalarial hits were also filtered with computational rules to identify potentially undesirable substructures. We were surprised that approximately 75–85% of these compounds failed one of the sets of filters that we applied during this work. The level of filter failure was much higher than for FDA approved drugs or a subset of antimalarial drugs. Both antimalarial and antituberculosis drug discovery should likely use simple available approaches to ensure that the hits derived from large scale screening are worth optimizing and do not clearly represent reactive compounds with a higher probability of toxicity in vivo.
Study on multi-target mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen ...LucyPi1
Abstract Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang) (RERR) and Semen Persicae (Taoren) (SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.
Predictive comparative qsar analysis of as 5 nitrofuran-2-yl derivatives myco...hiij
Antitubercular activity of 5-nitrofuran-2-yl Deriva
tives series were subjected to Quantitative Struc
ture
Activity Relationship (QSAR) Analysis with an effo
rt to derive and understand a correlation between t
he
biological activity as response variable and differ
ent molecular descriptors as independent variables.
QSAR models are built using 40 molecular descriptor
dataset. Different statistical regression express
ions
were got using Partial Least Squares (PLS) ,Multip
le Linear Regression (MLR) and Principal Component
Regression (PCR) techniques. The among these techni
que, Partial Least Square Regression (PLS)
technique has shown very promising result as compar
ed to MLR technique A QSAR model was build by a
training set of 30 molecules with correlation coe
fficient (
) of 0.8484 , significant cross validated
correlation coefficient (
) is 0.0939,
is 48.5187,
for external test set (
_
)
is -0.5604,
coefficient of correlation of predicted data set
( _
) is 0.7252 and degree of freedom is 26 by
Partial Least Squares Regression technique.
Neglected infectious diseases such as tuberculosis (TB) and malaria kill millions of people annually and the oral drugs used are subject to resistance requiring the urgent development of new therapeutics. Several groups, including pharmaceutical companies, have made large sets of antimalarial screening hit compounds and the associated bioassay data available for the community to learn from and potentially optimize. We have examined both intrinsic and predicted molecular properties across these datasets and compared them with large libraries of compounds screened against Mycobacterium tuberculosis in order to identify any obvious patterns, trends or relationships. One set of antimalarial hits provided by GlaxoSmithKline appears less optimal for lead optimization compared with two other sets of screening hits we examined. Active compounds against both diseases were identified to have larger molecular weight ([similar]350–400) and logP values of [similar]4.0, values that are, in general, distinct from the less active compounds. The antimalarial hits were also filtered with computational rules to identify potentially undesirable substructures. We were surprised that approximately 75–85% of these compounds failed one of the sets of filters that we applied during this work. The level of filter failure was much higher than for FDA approved drugs or a subset of antimalarial drugs. Both antimalarial and antituberculosis drug discovery should likely use simple available approaches to ensure that the hits derived from large scale screening are worth optimizing and do not clearly represent reactive compounds with a higher probability of toxicity in vivo.
Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Mode...Sean Ekins
Slides from SERMACS 2015 meeting in Memphis 2015 describing a collaborative project with SRI International and Rutgers. The work was published in PLOS ONE http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141076
Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact...Mahendra Kumar Trivedi
The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups.
This lecture outlines the different strategies for finding a fragment hit and the subsequent elaboration strategies used in order to increase potency to develop a lead compound in drug discovery.
The Role of Bioinformatics in The Drug Discovery ProcessAdebowale Qazeem
The Role of Bioinformatics in The Drug Discovery Process, is an undergraduate seminar presentation in the department of Biochemistry, Faculty of life Sciences, University of Ilorin, Ilorin.
A Framework for Improving the Performance of MANET by Controlling Data Traffi...rahulmonikasharma
A mobile ad-hoc network is a category of wireless network which does not depend on a predefined network structure or topology. Ad hoc networks require no centralized administration or fixed network infrastructure such as base stations or access points, and can be quickly and inexpensively set up as needed. Two mobile nodes can exchange data directly if they are in the defined range of each other. If not, nodes can communicate via a multi-hop route with the help of other mobile nodes. This paper proposed an approach to improve data transmission by reducing the data traffic and it also increase data availability in the mobile ad-hoc network. In the proposed approach, MANET is server client based network, means a mobile host acts as a server and fulfill the others node’s request. Each mobile node has a buffer for temporarily storing data fragment for a specific time, If a mobile node requests for a particular data fragment and the request is multi hoped, then first request is sent to its neighbor node, neighbor node first match requested data fragment with stored data, if it is matched the request will be responded by this neighbor otherwise request will be routed to mobile server. In this way the overhead of the server and server traffic will be reduced. The proposed method reduces time consumed by data fetching directly from server routing through multiple nodes and thus, it also enhances data availability.
The influences of rooting media and hormone applications on rooting percentag...inventionjournals
ABSTRACT : Schefflera arboricola is used as an indoor plant in many places across the world besides the area it covers naturally. Therefore, it is produced intensely. However, it is usually produced through body cutting, which damages rootstock and allows obtaining only few cuttings from a plant. This study makes an attempt to determine the influences of rooting media and hormone applications on rooting percentage and some root morphological characters in cuttings taken from Schefflera arboricola in small amounts without damaging rootstock to the contrary of common practice. In this study, cuttings were treated with 1000 ppm, 3000 ppm, and 5000 ppm doses of IAA, IBA, NAA, and GA3 hormones, and rooting trials were carried out in sand, pearlite, and peat media. The research results show that the employed methods are significantly influential on rooting percentage and root morphological characters, and rooting percentage can be increased up to 75%.
Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Mode...Sean Ekins
Slides from SERMACS 2015 meeting in Memphis 2015 describing a collaborative project with SRI International and Rutgers. The work was published in PLOS ONE http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141076
Spectroscopic Characterization of Chloramphenicol and Tetracycline: An Impact...Mahendra Kumar Trivedi
The present study was aimed to evaluate the impact of biofield treatment for spectroscopic characterization of chloramphenicol and tetracycline using FT-IR and UV-Vis spectroscopy.Methods: The study was performed in two groups (control and treatment) of each antibiotic. The control groups remained as untreated, and biofield treatment was given to treatment groups.
This lecture outlines the different strategies for finding a fragment hit and the subsequent elaboration strategies used in order to increase potency to develop a lead compound in drug discovery.
The Role of Bioinformatics in The Drug Discovery ProcessAdebowale Qazeem
The Role of Bioinformatics in The Drug Discovery Process, is an undergraduate seminar presentation in the department of Biochemistry, Faculty of life Sciences, University of Ilorin, Ilorin.
A Framework for Improving the Performance of MANET by Controlling Data Traffi...rahulmonikasharma
A mobile ad-hoc network is a category of wireless network which does not depend on a predefined network structure or topology. Ad hoc networks require no centralized administration or fixed network infrastructure such as base stations or access points, and can be quickly and inexpensively set up as needed. Two mobile nodes can exchange data directly if they are in the defined range of each other. If not, nodes can communicate via a multi-hop route with the help of other mobile nodes. This paper proposed an approach to improve data transmission by reducing the data traffic and it also increase data availability in the mobile ad-hoc network. In the proposed approach, MANET is server client based network, means a mobile host acts as a server and fulfill the others node’s request. Each mobile node has a buffer for temporarily storing data fragment for a specific time, If a mobile node requests for a particular data fragment and the request is multi hoped, then first request is sent to its neighbor node, neighbor node first match requested data fragment with stored data, if it is matched the request will be responded by this neighbor otherwise request will be routed to mobile server. In this way the overhead of the server and server traffic will be reduced. The proposed method reduces time consumed by data fetching directly from server routing through multiple nodes and thus, it also enhances data availability.
The influences of rooting media and hormone applications on rooting percentag...inventionjournals
ABSTRACT : Schefflera arboricola is used as an indoor plant in many places across the world besides the area it covers naturally. Therefore, it is produced intensely. However, it is usually produced through body cutting, which damages rootstock and allows obtaining only few cuttings from a plant. This study makes an attempt to determine the influences of rooting media and hormone applications on rooting percentage and some root morphological characters in cuttings taken from Schefflera arboricola in small amounts without damaging rootstock to the contrary of common practice. In this study, cuttings were treated with 1000 ppm, 3000 ppm, and 5000 ppm doses of IAA, IBA, NAA, and GA3 hormones, and rooting trials were carried out in sand, pearlite, and peat media. The research results show that the employed methods are significantly influential on rooting percentage and root morphological characters, and rooting percentage can be increased up to 75%.
PREDICTIVE COMPARATIVE QSAR ANALYSIS OF AS 5-NITROFURAN-2-YL DERIVATIVES MYCO...hiij
Antitubercular activity of 5-nitrofuran-2-yl Derivatives series were subjected to Quantitative Structure
Activity Relationship (QSAR) Analysis with an effort to derive and understand a correlation between the
biological activity as response variable and different molecular descriptors as independent variables.
QSAR models are built using 40 molecular descriptor dataset. Different statistical regression expressions
were got using Partial Least Squares (PLS) ,Multiple Linear Regression (MLR) and Principal Component
Regression (PCR) techniques. The among these technique, Partial Least Square Regression (PLS)
technique has shown very promising result as compared to MLR technique A QSAR model was build by a
training set of 30 molecules with correlation coefficient (
) of 0.8484 , significant cross validated
correlation coefficient (
) is 0.0939, is 48.5187,
for external test set (
_
) is -0.5604,
coefficient of correlation of predicted data set (
_
) is 0.7252 and degree of freedom is 26 by
Partial Least Squares Regression technique.
Comparing Genetic Evolutionary Algorithms on Three Enzymes of HIV-1: Integras...CSCJournals
In this work, we utilized Quantitative Structure-Activity Relationship (QSAR) techniques to develop predictive models for inhibitors of the HIV-1 enzymes Integrase, HIV-Protease, and Reverse Transcriptase. Each predictive model was composed of quantitative drug characteristics that were selected by genetic evolutionary algorithms, such as Genetic Algorithm (GE), Differential Evolutionary Algorithm (DE), Binary Particle Swarm Optimization (BPSO), and Differential Evolution with Binary Particle Swarm Optimization (DE-BPSO). After characteristic selection, each model was tested with machine-learning algorithms such as Multiple Linear Regression (MLR), Support Vector Machine (SVM), and Multi-Layer Perceptron neural networks (MLP/ANN). We found that a combination of DE-BPSO combined with Multi-Layer Perceptron produced the most accurate predictive models as measured by R2, the statistical measure of proportion of variance in prediction values, and root-mean-square-error (RMSE) of prediction values compared to observed values. As for the models themselves: the best predictors for Integrase inhibitor included mass-weighted centred Broto-Moreau autocorrelation values, Moran autocorrelations, and eigenvalues of Burden matrices weighted by I-states; the best predictors for HIV-Protease inhibitors included the second Zagreb index value, the normalized spectral positive sum from Laplace matrix, and the connectivity-like index of order 0 from edge adjacency mat; and the best predictors for Reverse Transcriptase inhibitors included the number of hydrogen atoms, the molecular path count of order 7, the centred Broto-Moreau autocorrelation of lag 2 weighted by Sanderson electronegativity, the P_VSA-like on ionization potential, and the frequency of C – N bonds at topological distance 3.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
A Semi-empirical based QSAR study of indole휷- Diketo acid, Diketo acid and Ca...iosrjce
In this study, a set of novel synthesized indole훽- diketo acid, diketo acid and carboxamide
derivativeswas investigated by quantitative structure–activity relationship (QSAR) analysis using semiempirical
(PM3) based descriptors. The best molecular descriptors identified were LogP, polar area
corresponding to absolute values of electrostatic potential greater than 75 (P-area(75)), Energy (E), Minimum
values of electrostatic potential (as mapped onto an electron density surface) (MinEIPot), Polar surface area
and Maximum values of electrostatic potential (as mapped onto an electron density surface) (MaxEIPot) that
contributed to the anti-HIV activity of the indole훽- diketo acid, diketo acid and carboxamide derivatives as
independent factors. The correlation of these descriptors with their anti-HIV activity increases indicating their
importance in studying biological activity. Quantitative structure activity relationship (QSAR) analysis was
applied to 37 of the above mentioned derivatives using physicochemical and structural molecular descriptors
obtained by the semi-empirical method by employing PM3 basis set. By using the multiple linear regression
(MLR) technique several QSAR models have been drown up with the help these calculated descriptors and the
anti-HIV activity of indole훽- diketo acid, diketo acid and carboxamide derivatives. The regression method was
used to derive the most significant models as a calibration model for predicting the LogIC50 of this class of
compounds. Among the obtained QSAR models presented in the study from the MLR method, statistically the
most significant one is the last model with the squared correlation coefficient 0.8932, Q = 3.1854 and F=
27.8644 that could be useful to predict the biological activity of indole훽- diketo acid, diketo acid and carboxamide derivatives as Potent HIV-1 Drugs.
7 synthesis, characterisation and antimicrobial activity of schiff base of 7 ...BIOLOGICAL FORUM
ABSTRACT: Compounds having 2-quinolone moiety are associated with interesting biological activities. In the present study, we synthesized Schiff bases of 7-hydroxy-3-methyl-2-quinolone and their antibacterial activity was evaluated by wells diffusion method. Schiff bases of 7-hydroxy-3-methyl-2-quinolone (1 to 5 named as Q2aa-Q2ae) were prepared by refluxing 7-hydroxy-3-methyl-2-quinolone with substituted aromatic aldehydes. The final test compounds were purified and characterized by IR, 1HNMR and Mass Spectral studies. M.P. of these compounds was confirmed by open capillary method instrument chemline cl 725. They were evaluated for antibacterial activity. Compounds were active against Klebsiella pneumonia and Enterococcus faecalis. While ciprofloxacin was used as standards.
Oxadiazole and its tested derivatives with diverse pharmacological activities come under an important class of compounds in new drug development. The novel oxadiazole derivatives synthesized and investigated for their chemical and biological behavior has showed more importance in the recent era. In the previous studies, it was found that synthetic modification of oxadiazole ring has higher efficacy with improved potency and lesser toxicity. The present review provides an overview on the work done so far on oxadiazole and its biological activities (2008-2018).
UV Spectrophotometric Method Development and Validation for Quantitative Esti...Sagar Savale
U.V Spectrophotometric method have been widely employed in determination of Curcumin in a mixture or fixed dose combination. For the ternary mixture containing Curcumin, no spectrophotometric method for evaluation has been reported so far. Thus our aim is to develop method for Curcumin estimation in ternary mixture using U.V spectrophotometry.
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
Similar to QSAR Modeling of Bisbenzofuran Compounds using 2D-Descriptors as Antimalarial Agents (20)
‘Six Sigma Technique’ A Journey Through its Implementationijtsrd
The manufacturing industries all over the world are facing tough challenges for growth, development and sustainability in today’s competitive environment. They have to achieve apex position by adapting with the global competitive environment by delivering goods and services at low cost, prime quality and better price to increase wealth and consumer satisfaction. Cost Management ensures profit, growth and sustainability of the business with implementation of Continuous Improvement Technique like Six Sigma. This leads to optimize Business performance. The method drives for customer satisfaction, low variation, reduction in waste and cycle time resulting into a competitive advantage over other industries which did not implement it. The main objective of this paper ‘Six Sigma Technique A Journey Through Its Implementation’ is to conceptualize the effectiveness of Six Sigma Technique through the journey of its implementation. Aditi Sunilkumar Ghosalkar "‘Six Sigma Technique’: A Journey Through its Implementation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64546.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64546/‘six-sigma-technique’-a-journey-through-its-implementation/aditi-sunilkumar-ghosalkar
Edge Computing in Space Enhancing Data Processing and Communication for Space...ijtsrd
Edge computing, a paradigm that involves processing data closer to its source, has gained significant attention for its potential to revolutionize data processing and communication in space missions. With the increasing complexity and data volume generated by modern space missions, traditional centralized computing approaches face challenges related to latency, bandwidth, and security. Edge computing in space, involving on board processing and analysis of data, offers promising solutions to these challenges. This paper explores the concept of edge computing in space, its benefits, applications, and future prospects in enhancing space missions. Manish Verma "Edge Computing in Space: Enhancing Data Processing and Communication for Space Missions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64541.pdf Paper Url: https://www.ijtsrd.com/computer-science/artificial-intelligence/64541/edge-computing-in-space-enhancing-data-processing-and-communication-for-space-missions/manish-verma
Dynamics of Communal Politics in 21st Century India Challenges and Prospectsijtsrd
Communal politics in India has evolved through centuries, weaving a complex tapestry shaped by historical legacies, colonial influences, and contemporary socio political transformations. This research comprehensively examines the dynamics of communal politics in 21st century India, emphasizing its historical roots, socio political dynamics, economic implications, challenges, and prospects for mitigation. The historical perspective unravels the intricate interplay of religious identities and power dynamics from ancient civilizations to the impact of colonial rule, providing insights into the evolution of communalism. The socio political dynamics section delves into the contemporary manifestations, exploring the roles of identity politics, socio economic disparities, and globalization. The economic implications section highlights how communal politics intersects with economic issues, perpetuating disparities and influencing resource allocation. Challenges posed by communal politics are scrutinized, revealing multifaceted issues ranging from social fragmentation to threats against democratic values. The prospects for mitigation present a multifaceted approach, incorporating policy interventions, community engagement, and educational initiatives. The paper conducts a comparative analysis with international examples, identifying common patterns such as identity politics and economic disparities. It also examines unique challenges, emphasizing Indias diverse religious landscape, historical legacy, and secular framework. Lessons for effective strategies are drawn from international experiences, offering insights into inclusive policies, interfaith dialogue, media regulation, and global cooperation. By scrutinizing historical epochs, contemporary dynamics, economic implications, and international comparisons, this research provides a comprehensive understanding of communal politics in India. The proposed strategies for mitigation underscore the importance of a holistic approach to foster social harmony, inclusivity, and democratic values. Rose Hossain "Dynamics of Communal Politics in 21st Century India: Challenges and Prospects" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64528.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/history/64528/dynamics-of-communal-politics-in-21st-century-india-challenges-and-prospects/rose-hossain
Assess Perspective and Knowledge of Healthcare Providers Towards Elehealth in...ijtsrd
Background and Objective Telehealth has become a well known tool for the delivery of health care in Saudi Arabia, and the perspective and knowledge of healthcare providers are influential in the implementation, adoption and advancement of the method. This systematic review was conducted to examine the current literature base regarding telehealth and the related healthcare professional perspective and knowledge in the Kingdom of Saudi Arabia. Materials and Methods This systematic review was conducted by searching 7 databases including, MEDLINE, CINHAL, Web of Science, Scopus, PubMed, PsycINFO, and ProQuest Central. Studies on healthcare practitioners telehealth knowledge and perspectives published in English in Saudi Arabia from 2000 to 2023 were included. Boland directed this comprehensive review. The researchers examined each connected study using the AXIS tool, which evaluates cross sectional systematic reviews. Narrative synthesis was used to summarise and convey the data. Results Out of 1840 search results, 10 studies were included. Positive outlook and limited knowledge among providers were seen across trials. Healthcare professionals like telehealth for its ability to improve quality, access, and delivery, save time and money, and be successful. Age, gender, occupation, and work experience also affect health workers knowledge. In Saudi Arabia, healthcare professionals face inadequate expert assistance, patient privacy, internet connection concerns, lack of training courses, lack of telehealth understanding, and high costs while performing telemedicine. Conclusions Healthcare practitioners telehealth perceptions and knowledge were examined in this systematic study. Its collection of concerned experts different personal attitudes and expertise would help enhance telehealths implementation in Saudi Arabia, develop its healthcare delivery alternative, and eliminate frequent problems. Badriah Mousa I Mulayhi | Dr. Jomin George | Judy Jenkins "Assess Perspective and Knowledge of Healthcare Providers Towards Elehealth in Saudi Arabia: A Systematic Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64535.pdf Paper Url: https://www.ijtsrd.com/medicine/other/64535/assess-perspective-and-knowledge-of-healthcare-providers-towards-elehealth-in-saudi-arabia-a-systematic-review/badriah-mousa-i-mulayhi
The Impact of Digital Media on the Decentralization of Power and the Erosion ...ijtsrd
The impact of digital media on the distribution of power and the weakening of traditional gatekeepers has gained considerable attention in recent years. The adoption of digital technologies and the internet has resulted in declining influence and power for traditional gatekeepers such as publishing houses and news organizations. Simultaneously, digital media has facilitated the emergence of new voices and players in the media industry. Digital medias impact on power decentralization and gatekeeper erosion is visible in several ways. One significant aspect is the democratization of information, which enables anyone with an internet connection to publish and share content globally, leading to citizen journalism and bypassing traditional gatekeepers. Another aspect is the disruption of conventional media industry business models, as traditional organizations struggle to adjust to the decrease in advertising revenue and the rise of digital platforms. Alternative business models, such as subscription models and crowdfunding, have become more prevalent, leading to the emergence of new players. Overall, the impact of digital media on the distribution of power and the weakening of traditional gatekeepers has brought about significant changes in the media landscape and the way information is shared. Further research is required to fully comprehend the implications of these changes and their impact on society. Dr. Kusum Lata "The Impact of Digital Media on the Decentralization of Power and the Erosion of Traditional Gatekeepers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64544.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/political-science/64544/the-impact-of-digital-media-on-the-decentralization-of-power-and-the-erosion-of-traditional-gatekeepers/dr-kusum-lata
Online Voices, Offline Impact Ambedkars Ideals and Socio Political Inclusion ...ijtsrd
This research investigates the nexus between online discussions on Dr. B.R. Ambedkars ideals and their impact on social inclusion among college students in Gurugram, Haryana. Surveying 240 students from 12 government colleges, findings indicate that 65 actively engage in online discussions, with 80 demonstrating moderate to high awareness of Ambedkars ideals. Statistically significant correlations reveal that higher online engagement correlates with increased awareness p 0.05 and perceived social inclusion. Variations across colleges and a notable effect of college type on perceived social inclusion highlight the influence of contextual factors. Furthermore, the intersectional analysis underscores nuanced differences based on gender, caste, and socio economic status. Dr. Kusum Lata "Online Voices, Offline Impact: Ambedkar's Ideals and Socio-Political Inclusion - A Study of Gurugram District" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64543.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/political-science/64543/online-voices-offline-impact-ambedkars-ideals-and-sociopolitical-inclusion--a-study-of-gurugram-district/dr-kusum-lata
Problems and Challenges of Agro Entreprenurship A Studyijtsrd
Noting calls for contextualizing Agro entrepreneurs problems and challenges of the agro entrepreneurs and for greater attention to the Role of entrepreneurs in agro entrepreneurship research, we conduct a systematic literature review of extent research in agriculture entrepreneurship to overcome the study objectives of complications of agro entrepreneurs through various factors, Development of agriculture products is a key factor for the overall economic growth of agro entrepreneurs Agro Entrepreneurs produces firsthand large scale employment, utilizes the labor and natural resources, This research outlines the problems of Weather and Soil Erosions, Market price fluctuation, stimulates labor cost problems, reduces concentration of Price volatility, Dependency on Intermediaries, induces Limited Bargaining Power, and Storage and Transportation Costs. This paper mainly devoted to highlight Problems and challenges faced for the sustainable of Agro Entrepreneurs in India. Vinay Prasad B "Problems and Challenges of Agro Entreprenurship - A Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64540.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64540/problems-and-challenges-of-agro-entreprenurship--a-study/vinay-prasad-b
Comparative Analysis of Total Corporate Disclosure of Selected IT Companies o...ijtsrd
Disclosure is a process through which a business enterprise communicates with external parties. A corporate disclosure is communication of financial and non financial information of the activities of a business enterprise to the interested entities. Corporate disclosure is done through publishing annual reports. So corporate disclosure through annual reports plays a vital role in the life of all the companies and provides valuable information to investors. The basic objectives of corporate disclosure is to give a true and fair view of companies to the parties related either directly or indirectly like owner, government, creditors, shareholders etc. in the companies act, provisions have been made about mandatory and voluntary disclosure. The IT sector in India is rapidly growing, the trend to invest in the IT sector is rising and employment opportunities in IT sectors are also increasing. Therefore the IT sector is expected to have fair, full and adequate disclosure of all information. Unfair and incomplete disclosure may adversely affect the entire economy. A research study on disclosure practices of IT companies could play an important role in this regard. Hence, the present research study has been done to study and review comparative analysis of total corporate disclosure of selected IT companies of India and to put forward overall findings and suggestions with a view to increase disclosure score of these companies. The researcher hopes that the present research study will be helpful to all selected Companies for improving level of corporate disclosure through annual reports as well as the government, creditors, investors, all business organizations and upcoming researcher for comparative analyses of level of corporate disclosure with special reference to selected IT companies. Dr. Vaibhavi D. Thaker "Comparative Analysis of Total Corporate Disclosure of Selected IT Companies of India" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64539.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64539/comparative-analysis-of-total-corporate-disclosure-of-selected-it-companies-of-india/dr-vaibhavi-d-thaker
The Impact of Educational Background and Professional Training on Human Right...ijtsrd
This study investigated the impact of educational background and professional training on human rights awareness among secondary school teachers in the Marathwada region of Maharashtra, India. The key findings reveal that higher levels of education, particularly a master’s degree, and fields of study related to education, humanities, or social sciences are associated with greater human rights awareness among teachers. Additionally, both pre service teacher training and in service professional development programs focused on human rights education significantly enhance teacher’s knowledge, skills, and competencies in promoting human rights principles in their classrooms. Baig Ameer Bee Mirza Abdul Aziz | Dr. Syed Azaz Ali Amjad Ali "The Impact of Educational Background and Professional Training on Human Rights Awareness among Secondary School Teachers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64529.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/64529/the-impact-of-educational-background-and-professional-training-on-human-rights-awareness-among-secondary-school-teachers/baig-ameer-bee-mirza-abdul-aziz
A Study on the Effective Teaching Learning Process in English Curriculum at t...ijtsrd
“One Language sets you in a corridor for life. Two languages open every door along the way” Frank Smith English as a foreign language or as a second language has been ruling in India since the period of Lord Macaulay. But the question is how much we teach or learn English properly in our culture. Is there any scope to use English as a language rather than a subject How much we learn or teach English without any interference of mother language specially in the classroom teaching learning scenario in West Bengal By considering all these issues the researcher has attempted in this article to focus on the effective teaching learning process comparing to other traditional strategies in the field of English curriculum at the secondary level to investigate whether they fulfill the present teaching learning requirements or not by examining the validity of the present curriculum of English. The purpose of this study is to focus on the effectiveness of the systematic, scientific, sequential and logical transaction of the course between the teachers and the learners in the perspective of the 5Es programme that is engage, explore, explain, extend and evaluate. Sanchali Mondal | Santinath Sarkar "A Study on the Effective Teaching Learning Process in English Curriculum at the Secondary Level of West Bengal" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd62412.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/62412/a-study-on-the-effective-teaching-learning-process-in-english-curriculum-at-the-secondary-level-of-west-bengal/sanchali-mondal
The Role of Mentoring and Its Influence on the Effectiveness of the Teaching ...ijtsrd
This paper reports on a study which was conducted to investigate the role of mentoring and its influence on the effectiveness of the teaching of Physics in secondary schools in the South West Region of Cameroon. The study adopted the convergent parallel mixed methods design, focusing on respondents in secondary schools in the South West Region of Cameroon. Both quantitative and qualitative data were collected, analysed separately, and the results were compared to see if the findings confirm or disconfirm each other. The quantitative analysis found that majority of the respondents 72 of Physics teachers affirmed that they had more experienced colleagues as mentors to help build their confidence, improve their teaching, and help them improve their effectiveness and efficiency in guiding learners’ achievements. Only 28 of the respondents disagreed with these statements. With majority respondents 72 agreeing with the statements, it implies that in most secondary schools, experienced Physics teachers act as mentors to build teachers’ confidence in teaching and improving students’ learning. The interview qualitative data analysis summarized how secondary school Principals use meetings with mentors and mentees to promote mentorship in the school milieu. This has helped strengthen teachers’ classroom practices in secondary schools in the South West Region of Cameroon. With the results confirming each other, the study recommends that mentoring should focus on helping teachers employ social interactions and instructional practices feedback and clarity in teaching that have direct measurable impact on students’ learning achievements. Andrew Ngeim Sumba | Frederick Ebot Ashu | Peter Agborbechem Tambi "The Role of Mentoring and Its Influence on the Effectiveness of the Teaching of Physics in Secondary Schools in the South West Region of Cameroon" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64524.pdf Paper Url: https://www.ijtsrd.com/management/management-development/64524/the-role-of-mentoring-and-its-influence-on-the-effectiveness-of-the-teaching-of-physics-in-secondary-schools-in-the-south-west-region-of-cameroon/andrew-ngeim-sumba
Design Simulation and Hardware Construction of an Arduino Microcontroller Bas...ijtsrd
This study primarily focuses on the design of a high side buck converter using an Arduino microcontroller. The converter is specifically intended for use in DC DC applications, particularly in standalone solar PV systems where the PV output voltage exceeds the load or battery voltage. To evaluate the performance of the converter, simulation experiments are conducted using Proteus Software. These simulations provide insights into the input and output voltages, currents, powers, and efficiency under different state of charge SoC conditions of a 12V,70Ah rechargeable lead acid battery. Additionally, the hardware design of the converter is implemented, and practical data is collected through operation, monitoring, and recording. By comparing the simulation results with the practical results, the efficiency and performance of the designed converter are assessed. The findings indicate that while the buck converter is suitable for practical use in standalone PV systems, its efficiency is compromised due to a lower output current. Chan Myae Aung | Dr. Ei Mon "Design Simulation and Hardware Construction of an Arduino-Microcontroller Based DC-DC High-Side Buck Converter for Standalone PV System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64518.pdf Paper Url: https://www.ijtsrd.com/engineering/mechanical-engineering/64518/design-simulation-and-hardware-construction-of-an-arduinomicrocontroller-based-dcdc-highside-buck-converter-for-standalone-pv-system/chan-myae-aung
Sustainable Energy by Paul A. Adekunte | Matthew N. O. Sadiku | Janet O. Sadikuijtsrd
Energy becomes sustainable if it meets the needs of the present without compromising the ability of future generations to meet their own needs. Some of the definitions of sustainable energy include the considerations of environmental aspects such as greenhouse gas emissions, social, and economic aspects such as energy poverty. Generally far more sustainable than fossil fuel are renewable energy sources such as wind, hydroelectric power, solar, and geothermal energy sources. Worthy of note is that some renewable energy projects, like the clearing of forests to produce biofuels, can cause severe environmental damage. The sustainability of nuclear power which is a low carbon source is highly debated because of concerns about radioactive waste, nuclear proliferation, and accidents. The switching from coal to natural gas has environmental benefits, including a lower climate impact, but could lead to delay in switching to more sustainable options. “Carbon capture and storage” can be built into power plants to remove the carbon dioxide CO2 emissions, but this technology is expensive and has rarely been implemented. Leading non renewable energy sources around the world is fossil fuels, coal, petroleum, and natural gas. Nuclear energy is usually considered another non renewable energy source, although nuclear energy itself is a renewable energy source, but the material used in nuclear power plants is not. The paper addresses the issue of sustainable energy, its attendant benefits to the future generation, and humanity in general. Paul A. Adekunte | Matthew N. O. Sadiku | Janet O. Sadiku "Sustainable Energy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64534.pdf Paper Url: https://www.ijtsrd.com/engineering/electrical-engineering/64534/sustainable-energy/paul-a-adekunte
Concepts for Sudan Survey Act Implementations Executive Regulations and Stand...ijtsrd
This paper aims to outline the executive regulations, survey standards, and specifications required for the implementation of the Sudan Survey Act, and for regulating and organizing all surveying work activities in Sudan. The act has been discussed for more than 5 years. The Land Survey Act was initiated by the Sudan Survey Authority and all official legislations were headed by the Sudan Ministry of Justice till it was issued in 2022. The paper presents conceptual guidelines to be used for the Survey Act implementation and to regulate the survey work practice, standardizing the field surveys, processing, quality control, procedures, and the processes related to survey work carried out by the stakeholders and relevant authorities in Sudan. The conceptual guidelines are meant to improve the quality and harmonization of geospatial data and to aid decision making processes as well as geospatial information systems. The established comprehensive executive regulations will govern and regulate the implementation of the Sudan Survey Geomatics Act in all surveying and mapping practices undertaken by the Sudan Survey Authority SSA and state local survey departments for public or private sector organizations. The targeted standards and specifications include the reference frame, projection, coordinate systems, and the guidelines and specifications that must be followed in the field of survey work, processes, and mapping products. In the last few decades, there has been a growing awareness of the importance of geomatics activities and measurements on the Earths surface in space and time, together with observing and mapping the changes. In such cases, data must be captured promptly, standardized, and obtained with more accuracy and specified in much detail. The paper will also highlight the current situation in Sudan, the degree to which survey standards are used, the problems encountered, and the errors that arise from not using the standards and survey specifications. Kamal A. A. Sami "Concepts for Sudan Survey Act Implementations - Executive Regulations and Standards" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63484.pdf Paper Url: https://www.ijtsrd.com/engineering/civil-engineering/63484/concepts-for-sudan-survey-act-implementations--executive-regulations-and-standards/kamal-a-a-sami
Towards the Implementation of the Sudan Interpolated Geoid Model Khartoum Sta...ijtsrd
The discussions between ellipsoid and geoid have invoked many researchers during the recent decades, especially during the GNSS technology era, which had witnessed a great deal of development but still geoid undulation requires more investigations. To figure out a solution for Sudans local geoid, this research has tried to intake the possibility of determining the geoid model by following two approaches, gravimetric and geometrical geoid model determination, by making use of GNSS leveling benchmarks at Khartoum state. The Benchmarks are well distributed in the study area, in which, the horizontal coordinates and the height above the ellipsoid have been observed by GNSS while orthometric heights were carried out using precise leveling. The Global Geopotential Model GGM represented in EGM2008 has been exploited to figure out the geoid undulation at the benchmarks in the study area. This is followed by a fitting process, that has been done to suit the geoid undulation data which has been computed using GNSS leveling data and geoid undulation inspired by the EGM2008. Two geoid surfaces were created after the fitting process to ensure that they are identical and both of them could be counted for getting the same geoid undulation with an acceptable accuracy. In this respect, statistical operation played an important role in ensuring the consistency and integrity of the model by applying cross validation techniques splitting the data into training and testing datasets for building the geoid model and testing its eligibility. The geometrical solution for geoid undulation computation has been utilized by applying straightforward equations that facilitate the calculation of the geoid undulation directly through applying statistical techniques for the GNSS leveling data of the study area to get the common equation parameters values that could be utilized to calculate geoid undulation of any position in the study area within the claimed accuracy. Both systems were checked and proved eligible to be used within the study area with acceptable accuracy which may contribute to solving the geoid undulation problem in the Khartoum area, and be further generalized to determine the geoid model over the entire country, and this could be considered in the future, for regional and continental geoid model. Ahmed M. A. Mohammed. | Kamal A. A. Sami "Towards the Implementation of the Sudan Interpolated Geoid Model (Khartoum State Case Study)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63483.pdf Paper Url: https://www.ijtsrd.com/engineering/civil-engineering/63483/towards-the-implementation-of-the-sudan-interpolated-geoid-model-khartoum-state-case-study/ahmed-m-a-mohammed
Activating Geospatial Information for Sudans Sustainable Investment Mapijtsrd
Sudan is witnessing an acceleration in the processes of development and transformation in the performance of government institutions to raise the productivity and investment efficiency of the government sector. The development plans and investment opportunities have focused on achieving national goals in various sectors. This paper aims to illuminate the path to the future and provide geospatial data and information to develop the investment climate and environment for all sized businesses, and to bridge the development gap between the Sudan states. The Sudan Survey Authority SSA is the main advisor to the Sudan Government in conducting surveying, mappings, designing, and developing systems related to geospatial data and information. In recent years, SSA made a strategic partnership with the Ministry of Investment to activate Geospatial Information for Sudans Sustainable Investment and in particular, for the preparation and implementation of the Sudan investment map, based on the directives and objectives of the Ministry of Investment MI in Sudan. This paper comes within the framework of activating the efforts of the Ministry of Investment to develop technical investment services by applying techniques adopted by the Ministry and its strategic partners for advancing investment processes in the country. Kamal A. A. Sami "Activating Geospatial Information for Sudan's Sustainable Investment Map" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63482.pdf Paper Url: https://www.ijtsrd.com/engineering/information-technology/63482/activating-geospatial-information-for-sudans-sustainable-investment-map/kamal-a-a-sami
Educational Unity Embracing Diversity for a Stronger Societyijtsrd
In a rapidly changing global landscape, the importance of education as a unifying force cannot be overstated. This paper explores the crucial role of educational unity in fostering a stronger and more inclusive society through the embrace of diversity. By examining the benefits of diverse learning environments, the paper aims to highlight the positive impact on societal strength. The discussion encompasses various dimensions, from curriculum design to classroom dynamics, and emphasizes the need for educational institutions to become catalysts for unity in diversity. It highlights the need for a paradigm shift in educational policies, curricula, and pedagogical approaches to ensure that they are reflective of the diverse fabric of society. This paper also addresses the challenges associated with implementing inclusive educational practices and offers practical strategies for overcoming barriers. It advocates for collaborative efforts between educational institutions, policymakers, and communities to create a supportive ecosystem that promotes diversity and unity. Mr. Amit Adhikari | Madhumita Teli | Gopal Adhikari "Educational Unity: Embracing Diversity for a Stronger Society" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64525.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/64525/educational-unity-embracing-diversity-for-a-stronger-society/mr-amit-adhikari
Integration of Indian Indigenous Knowledge System in Management Prospects and...ijtsrd
The diversity of indigenous knowledge systems in India is vast and can vary significantly between different communities and regions. Preserving and respecting these knowledge systems is crucial for maintaining cultural heritage, promoting sustainable practices, and fostering cross cultural understanding. In this paper, an overview of the prospects and challenges associated with incorporating Indian indigenous knowledge into management is explored. It is found that IIKS helps in management in many areas like sustainable development, tourism, food security, natural resource management, cultural preservation and innovation, etc. However, IIKS integration with management faces some challenges in the form of a lack of documentation, cultural sensitivity, language barriers legal framework, etc. Savita Lathwal "Integration of Indian Indigenous Knowledge System in Management: Prospects and Challenges" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63500.pdf Paper Url: https://www.ijtsrd.com/management/accounting-and-finance/63500/integration-of-indian-indigenous-knowledge-system-in-management-prospects-and-challenges/savita-lathwal
DeepMask Transforming Face Mask Identification for Better Pandemic Control in...ijtsrd
The COVID 19 pandemic has highlighted the crucial need of preventive measures, with widespread use of face masks being a key method for slowing the viruss spread. This research investigates face mask identification using deep learning as a technological solution to be reducing the risk of coronavirus transmission. The proposed method uses state of the art convolutional neural networks CNNs and transfer learning to automatically recognize persons who are not wearing masks in a variety of circumstances. We discuss how this strategy improves public health and safety by providing an efficient manner of enforcing mask wearing standards. The report also discusses the obstacles, ethical concerns, and prospective applications of face mask detection systems in the ongoing fight against the pandemic. Dilip Kumar Sharma | Aaditya Yadav "DeepMask: Transforming Face Mask Identification for Better Pandemic Control in the COVID-19 Era" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64522.pdf Paper Url: https://www.ijtsrd.com/engineering/electronics-and-communication-engineering/64522/deepmask-transforming-face-mask-identification-for-better-pandemic-control-in-the-covid19-era/dilip-kumar-sharma
Streamlining Data Collection eCRF Design and Machine Learningijtsrd
Efficient and accurate data collection is paramount in clinical trials, and the design of Electronic Case Report Forms eCRFs plays a pivotal role in streamlining this process. This paper explores the integration of machine learning techniques in the design and implementation of eCRFs to enhance data collection efficiency. We delve into the synergies between eCRF design principles and machine learning algorithms, aiming to optimize data quality, reduce errors, and expedite the overall data collection process. The application of machine learning in eCRF design brings forth innovative approaches to data validation, anomaly detection, and real time adaptability. This paper discusses the benefits, challenges, and future prospects of leveraging machine learning in eCRF design for streamlined and advanced data collection in clinical trials. Dhanalakshmi D | Vijaya Lakshmi Kannareddy "Streamlining Data Collection: eCRF Design and Machine Learning" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63515.pdf Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/63515/streamlining-data-collection-ecrf-design-and-machine-learning/dhanalakshmi-d
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
QSAR Modeling of Bisbenzofuran Compounds using 2D-Descriptors as Antimalarial Agents
1. @ IJTSRD | Available Online @ www.ijtsrd.com
ISSN No: 2456
International
Research
QSAR Modeling of Bisbenzofuran Compounds
as Antimalarial Agents
Tripti Kaushal
Department of Chemistry, Technocrats Institute of
Technology and Science, Bhopal, Madhya Pradesh
Bashirulla Shaik
Dept. of Applied Science, National Institute of
Technical Teachers Training and Research, Shamla
Hills, Bhopal, Madhya Pradesh, India
ABSTRACT
In the present study we have performed
structure activity relationship (QSAR) analysis for
43bisbenzofuran derivatives to estimate the
antimalarial activity using some 2D descriptors.
Several significant QSAR models has bee
for predicting the antimalarial activity (
these molecules by using the multiple linear
regression (MLR) technique. Among the obtained
QSAR models, a four parametric model was most
significant having R2
=0.9502. An external set was
used for confirming the predictive power of the
models. High correlation between experimental and
predicted antimalarial activity values, was obtained in
the validation approach that displayed the good
modality of the derived QSAR models.
Keywords; bisbenzofuran derivatives, antimalarial
activity, 2D descriptors, QSAR, MLR
Introduction
According to the World Health Organization (WHO),
malaria is globally recognized as serious problem of
public health, mainly in the tropical and subtropical
regions of the world. Thus Malaria is an infectious
disease which is caused by the protozoa of the genus
Plasmodium. Commonly four species of the parasite
cause infection, i.e., Plasmodium ovale
malariaeand P. Falciparum. Among them P
@ IJTSRD | Available Online @ www.ijtsrd.com | Volume – 2 | Issue – 2 | Jan-Feb 2018
ISSN No: 2456 - 6470 | www.ijtsrd.com | Volume
International Journal of Trend in Scie
Research and Development (IJTSRD)
International Open Access Journal
f Bisbenzofuran Compounds using 2
s Antimalarial Agents
Department of Chemistry, Technocrats Institute of
Technology and Science, Bhopal, Madhya Pradesh
Anita K
Department of Chemistry, Career College,
Bhopal, Madhya Pradesh
Dept. of Applied Science, National Institute of
Technical Teachers Training and Research, Shamla
Hills, Bhopal, Madhya Pradesh, India
Vijay K. Agrawal
Department of Chemistry, APS University,
Rewa, Madhya Pradesh,
In the present study we have performed Quantitative
structure activity relationship (QSAR) analysis for
43bisbenzofuran derivatives to estimate the
some 2D descriptors.
Several significant QSAR models has been calculated
for predicting the antimalarial activity (–logIC50) of
these molecules by using the multiple linear
regression (MLR) technique. Among the obtained
QSAR models, a four parametric model was most
=0.9502. An external set was
used for confirming the predictive power of the
models. High correlation between experimental and
predicted antimalarial activity values, was obtained in
the validation approach that displayed the good
zofuran derivatives, antimalarial
According to the World Health Organization (WHO),
malaria is globally recognized as serious problem of
public health, mainly in the tropical and subtropical
world. Thus Malaria is an infectious
disease which is caused by the protozoa of the genus
. Commonly four species of the parasite
Plasmodium ovale, P. vivax, P.
Among them P.
Falciparum being the most virulent to humans. The
introduction of parasites in human organism can be
through the bite of a female Anopheles
it can also be injection or transfusion of infected
blood and through the hypodermic syringes. It effects
40% population of more than a hundred countries and
considered as one of the diseases that caused already
great damage to millions of people [1
about 300 million cases and at least one million
consequent deaths are estimated annually. About 40%
of malaria cases are registered in the world and about
90% deaths are mainly caused due to
For the treatment of malaria drugs such as
chloroquine, mefloquine, pyrimethamine, dapsone,
and cycloguanil are being used for years. But the
resistance against malaria parasite strain is increasing
continuously producing a big obstacle to
chemotherapy of malaria disease[6
use of classical antimalarials promoted fast selection
of drug–resistant strains of
requires an urgent development of new antimalarial
drugs. Soidentification and design of novel drug
molecules specifically affecting these targets could
lead to better treatment of malaria. Recently the
antimalarial activity of bisbenzofuran has generated
interest among the drug researchers which has
displayed activityagainst several strains of malaria. It
has limited role to treat the diseases because of
Feb 2018 Page: 769
6470 | www.ijtsrd.com | Volume - 2 | Issue – 2
Scientific
(IJTSRD)
International Open Access Journal
sing 2D-Descriptors
Anita K
Department of Chemistry, Career College,
pal, Madhya Pradesh
Vijay K. Agrawal
of Chemistry, APS University,
Rewa, Madhya Pradesh, India
most virulent to humans. The
introduction of parasites in human organism can be
Anopheles mosquito, and
it can also be injection or transfusion of infected
blood and through the hypodermic syringes. It effects
f more than a hundred countries and
considered as one of the diseases that caused already
great damage to millions of people [1-5]. Due to this
about 300 million cases and at least one million
consequent deaths are estimated annually. About 40%
cases are registered in the world and about
90% deaths are mainly caused due toP. falciparum.
For the treatment of malaria drugs such as
chloroquine, mefloquine, pyrimethamine, dapsone,
and cycloguanil are being used for years. But the
alaria parasite strain is increasing
continuously producing a big obstacle to
chemotherapy of malaria disease[6-15].The massive
use of classical antimalarials promoted fast selection
resistant strains of P. falciparum, which
lopment of new antimalarial
identification and design of novel drug
molecules specifically affecting these targets could
lead to better treatment of malaria. Recently the
bisbenzofuran has generated
researchers which has
displayed activityagainst several strains of malaria. It
has limited role to treat the diseases because of
2. International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470
@ IJTSRD | Available Online @ www.ijtsrd.com | Volume – 2 | Issue – 2 | Jan-Feb 2018 Page: 770
protonation of its amidine group at physiological pH,
pentamidineand also shows low oral availability.
Drugrequiresparentral administration which makes the
treatment less practical in rural areas. Pentamidine is
tolerated by most patients in spite of some reported
serious adverse effects [16, 17, 18].In this context it is
very appropriate to search for options to find a potent
antimalarial compound with improved potency and
oral availability. Computational chemistry is an
important tool to rational drug design. The
quantitative structure-activity relationship (QSAR)
approach by Hansch et al. helps to correlate the
specific biological activities of compounds with the
molecular properties of the compounds. The authors
have successfully reported use of topological
parameters for modeling antimalarial activity of 4-
pyridones against P. falciparum T9-96 strains[ 19].
Materials and Methods
In the present work an attempt was made to find out a
mathematical model which correlates the possible
structural requirements and biological activity of in
order to design of new and more potent compounds
with strengthened biological activities. An analysis
using the MLR method is applied to a series of
43bisbenzofurans derivatives with known biological
activity[20].The biological activity has been given in
terms of negative log of IC50 in order to convert the
data into free energy change related values.
Structural details of the compound having
antimalarial activity (bisbenzofurancation) used in
present studyare given in Table-1.The parameters
used for modeling the activity are VE1_D,
VE1_B(e), GATS7p, GATS8p , CATS2D_04_DA,
CATS2D_06_PL, B10[N-N], F08[C-C], DLS_07 ,
Psychotic-80 and cRo5. Here DLS_07 , Psychotic-80 ,
cRo5 are Drug-like indices descriptors,
CATS2D_04_DA, CATS2D_06_PL, B10[N-N],
F08[C-C] are 2D Atom Pairs parameters, GATS7p,
GATS8p are 2D- autocorrelation parameters [21]and
VE1_D, VE1_B(e) are 2D matrix-based descriptors.
All these have been calculated using DRAGON
software[22] and for regression purpose NCSS was
used [23]. The calculated values along with biological
activity –log IC50are given inTable-2.The entire data
set given in table 1 has been divided into training and
test set and efforts have been made for obtaining the
best suitable model for modeling the -log IC50 value.
We have taken 31 compounds for training set and 12
compounds as test set. The generation of training and
test sets is done on random basis. For statistical
validation, variety of statistical parameters was
calculated. All these statistically significant
correlation models for the training set have been
reported below along with their statistical parameters.
RESULT AND DISCUSSION:
The correlation matrixes of these parameters
arereportedin Table-3 which clearly reveals that
F08[C-C] is highly correlated with VE1_D and
similarly B10[N-N] is highly correlated with
CATS2D_06_PL and Psychotic-80 is highly
correlated F08[C-C]. Hence while dealing with these
parameters the collinearity defect should be checked.
Now, we will discuss the results obtained in
successive regression analysis. It is pertinent to
mention that the parameter which are auto-correlated
should not be used in multiparametric analysis
because they may result in to some defect in the
model.
Through variable selection four parameters were
selected and the data presented in Table-2 was
subjected to regression analysis which yields
significant models. These models along with their
quality are reported in Table-5.
ONE-PARAMETRIC MODEL:
Among all the models, the best one parametric model
contains B10 [N-N], having R2
value equal to 0.8459.
The model is as below:
-logIC50=2.0051(±0.1589) B10[N-N]+0.1149
(4.1.1)
N=31, Se = 0.1563, R2
= 0.8459, R2
Adj= 0.8406, F-
ratio = 159.185, Q =5.8830
Here and here after N is total number of compounds ;
Se is the standard error of estimation;R2
is the square
of correlation coefficient;R2
Adj is the adjusted R2
;F is
the Fisher’s ratio and Q is the Pogliani’s quality
factor[24] which is the ration of R/Se (Pogliani,
1994,1996)
TWO-PARAMETRIC MODEL:
When cRo5 is added to the mono-parametric model,
two parametric models are resulted with improved R2
value. For this model R2
comes out to be 0.9211and
R2
Adj also enhances from0.8406 to 0.9154. The model
is reported as under
IC50=2.0531(±0.1161) B10[N-N]-0.2881(±0.0558)
cRo5+0.3550 (2)
N=31 , Se = 0.1138, R2
= 0.9211, R2
Adj=0.9154, F-
ratio = 163.392 , Q =8.4292
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THREE-PARAMETRIC MODEL:
F08[C-C] has also been found to be an effective
parameter in modeling log IC50. When higher
parametric models were tried with B10_N_N_,
F08[C-C]as correlating parameters along with VE1_D
in modeling the antimalarial activity, a improvement
in the quality of the model is observed. For this
model, R2
comes out to be 0.9318.The value of R2
Adj
changes from 0.9154 to 0.9242 suggesting that the
added parameter is favorable .The model is given
below:
IC50=2.1541(±0.1176) B10_N_N_+0.0241(±0.0044)
F08[C-C]-0.5575(±0.1052) VE1_D+2.2910
(3)
N= 31, Se = 0.1078, R2
= 0.9318, R2
Adj= 0.9242, F-
ratio = 122.890, Q =8.9532
FOUR -PARAMETRIC MODEL:
Finally, by adding 2D- autocorrelation
parametersGATS7p atetra - parametric model having
R2
=0.9502 is found to be the best model for modeling
IC50 activity. The model contains B10 [N-N], F08[C-
C], GATS7p and VE1_D as correlating parameter.
The lowest values of SE and also highest value of F-
ratio and Q-value further confirm our results.
Addition of GATS7p is justified as R2
Adj changes
from 0.9242 to 0.9425. The model is found as under:
IC50= 1.9399 (±0.1235) B10[N-N]+0.0197
(±0.0041) F08[C-C]-0.9062(±0.2920)
GATS7p -0.5498(±0.0916) VE1_D+3.3488
(4)
N=31, Se =0.0939, R2
=0.9502, R2
Adj= 0.9425, F-ratio
=124.031, Q =10.3859
A close look at this model revels that out of four
parameters contained, two (GATS7p, VE1_D) are
having negative coefficients, while two of them are
positive (B10 [N-N], F08[C-C]). The predictive
potential of the model has been obtained by plotting a
graph between observed and estimated activity values
and such graph is demonstrated in Fig. 1.
PREDICTIVE POWER BASED ON CROSS
VALIDATION:
Leave –one –out cross (leave –one –out) validation
procedure”(Chaterjeeet al .,2000) is being widely
used to examine the suitability of predictive power of
the model[25]. The obtained results are reported in
Table-6 .As stated earlier the predicted residual sum
of square (PRESS) is the most important cross-
validation parameter accounting for good estimate of
the real predictive error of the model. Its value less
than SSY (sum of squares of response value) indicates
that the model predicts better than the chance and can
be considered statically significant. In our study, the
value of PRESS is much lower than SSY indicating
that all the models obtained are statically significant.
The ration of PRESS/SSY can be used to calculate
approximate confidence intervals of prediction of new
compounds. To be a reasonable and significant QSAR
model, the ratio PRESS/SSY should be less than 0.4
(PRESS/SSY < 0.4) and the value of this ratio 0.1
indicates an excellent model. A close observation of
Table-6 shows that except the one parametric model
(model1, Table4)all other models have the
PRESS/SSY ratio more or less or nearer to 0.1
indicating thereby all the proposed models are having
best predicting capacity.
R2
cv is the cross validation squared correlation
coefficient. The highest R2
cv values 0.948 for four
parametric model [(Model-30 and Table-4);Fig.1]
confirms our findings. The two important cross-
validation parameters uncertainty in prediction
(SPRESS) and predictive squared error (PSE) were also
calculated. For this model, the value of SSY is
highest, whereas, the values of PRESS, PRESS/SSY,
SPRESS, and PSE have been lowest, conforming our
findings.
Final confirmation is obtained by calculating the
estimated values of -log IC50 for the entire set of
compounds using tetra parametric model and the
same has been reported in Table-5.These values are in
good agreement with the estimated value. Further
confirmation is obtained by plotting a graph between
observed and estimated -log IC50 values using four
parametric model, the predictive power for the model
comes out to be 0.9502, suggesting that 95 % variance
in the data could be explained using this model.
Therefore, this is the best model for modeling -
iogIC50 values of the compound used in this study.
The external predictive power of the model is
assessed by predicting pIC50 value of the 9 test set
molecules, which are not included in the QSAR
model development.
Further, VIF (variance inflation factor), Eigen values
(λi), condition number (k), tolerance (T) for all the
independent parameters have been calculated or all
the independent parameters used in the proposed
models and they are reported in Table-7.The
collinearity is observed if the value of VIF is greater
than 10. In the table all the combination have VIF less
4. International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470
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than 10 means all the proposed models are free from
collinearity. And if λi, (Eigen value) is found to be
greater than 5 then the model will suffer from
collinearity. Here all the models have λi value less
than 5 so all the models are free from the defect of
collinearity. Condition number is another test
forcollinearity if its value is found to be >100 then the
collinearity exists but results indicate that values
always <100 likewise. . Tolerance value equal to 1 or
less indicates absence of collinearity Table-7 indicates
that all the above mentioned parameters or models
discussed in the study are free from multi-collinearity.
The ridge traces are recorded in fig.-2 and fig.-3
respectively.
CONCLUSION:
1. Positive coefficient of B10[N-N] suggests that
presence/absence of N - N at topological distance 10
plays a dominant role in deciding the antimalarial
activity of present set of compounds.
2. The coefficient of both the GATS7p and VE1_D
parameters are negative. Therefore molecules having
higher value of polarizability and topological distance
matrix should be avoided in designing synthesizing
new compounds for better activity. Compounds with
low value of these parameters will certainly give
better activity.
Table 1 Structures of bisbenzofurancation used in the present study
1
O
O
NH
NH2
NH
NH2
2
O
NH N H
O
NH
NH
3
O
NH N H
O
NH
NH
4
OO
N H
NH 2
NH 2
N H
5
O
O
NH NH
NH
NH
6
O
O
N
H
N
NNH
7
O
O
NNH
8
O
O
NH2 NH
NH2
NH
N
N
H
9
O
O
NHNH
NH
NH
10
O
O
N
H
N
NHN
11
O
O
NH
NH2
NH
NH2
12
O
O
NH
NH
NH
NH
13
O
O
N
NH
N
H
N
14
O
O
NH
NH2NH
NH2
15
O
O
NH
NH
NH
NH
5. International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470
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16
O
O
NH
N
NHN
17
O
O
NH2NH
NH2
NH
18
O
O
NHNH
NH
NH
19
O
O NH
NH2
N
H
N
20
O
O NH
NH2
NH
NH2
21
O
O NH
NH
NH
NH
22
O
O
NH
N N
NH
23
O
NH
N H 2
O
NH 2
N H
24
O
NH
NH
O
NH
NH
25
O
O
N
N H
N
N H
26
O
O
NH2
NH
NH
NH2
27
O
O
NH
NH
NH
NH
28
O
O
N
N
H
N
H
N
29
O
O
N H
N H 2
NH 2
N H
30
O
O
NH
NH
NH
NH
31
O
O
N
N H
N
N H
32
O
O
NH
N H 2
NH
N H 2
O
O
33
O
O
NH
N H
NH
N H
O
O
34 35 36
6. International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470
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O
O
N
N H
N
N H
O
O
O
O
NH2
NH
NH
NH2
O
O
NH
NH
NH
NH
37
O
O
N
H
N
N
N
H
38
O
O
NH
N H 2
NH 2
N H
39
O
O
NH
N H 2
NH 2
N H
40
O
O
NH
N H 2
NH 2
N H
41
O
O
NH
N H 2
NH 2
N H
42
O
O
NH
N H 2
NH 2
N H
43
O
O
NH
N H 2
NH 2
N H
13. International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470
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Table 6 Cross validated parameters for the best obtained models
Model
no
Parameters used PRESS SSY PRESS/SSY R2
cv SPRESS PSE
10 B10[N-N] 0.709 3.891 0.182 0.818 0.156 0.071
16 B10[N-N]
cRo5
0.363 4.236 0.086 0.914 0.114 0.061
22 B10[N-N]
VE1_D
F08_C_C_
0.314 4.286 0.073 0.927 0.108 0.059
30 B10_N_N_
F08_C_C_
VE1_D
GATS7p
0.229 4.37 0.052 0.948 0.094 0.055
Table 7 Ridge regression parameters for the best obtained models.
Model no Parameters used VIF T λi K
10 B10[N-N] 1.0000 1.0000 1.0000 1.0000
16 B10[N-N]
cRo5
1.0065
1.0065
0.9936
0.9936
1.080064
0.919936
1.00
1.17
22 B10[N-N]
VE1_D
F08_C_C_
1.1520
2.0735
2.2741
0.8680
0.4823
0.4397
1.895320
0.840262
0.264419
1.00
2.26
7.17
30 B10[N-N]
F08_C_C_
VE1_D
GATS7p
1.6753
2.5824
2.0750
1.5276
0.5969
0.3872
0.4819
0.6546
1.903822
1.420041
0.449074
0.227063
1.00
1.34
4.24
8.38
VIF = Variance Inflation Factor
T = Tolerance
λi = Eigen values
k = Condition number
14. International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470
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Fig.2 Ridge trace for four variable model
Fig. 3 VIF plot for four-variable model
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