This document analyzes public health trends in metro Atlanta neighborhoods. It finds that while overall health has generally improved due to declining mortality rates, some issues remain problems. Diabetes rates and low birthweight births are increasing in many counties. Place and race are common factors for worse health outcomes. Areas with high poverty and non-white populations see more premature deaths, diabetes cases, and low birthweight babies. While most metro Atlanta counties rank highly for health outcomes, problem areas tend to be in southern parts of the region.
State of Homelessness in America, January 2011, authored by M William Sermons and Peter Witte of the National Alliance to End Homelessness. Download at endhomelessness.org
State of Homelessness in America, January 2011, authored by M William Sermons and Peter Witte of the National Alliance to End Homelessness. Download at endhomelessness.org
An overview of recent population trends in Illinois, its origins and potential implication. This research was compiled by Northern Illinois University researcher Brian Harger.
A brief presentation of recent population trends in Illinois from 2010 to 2017 along with related commentary. This is part of an ongoing series of presentations on topics relevant to Illinois and the U.S. midwest.
New threats to an age-old problem: How poverty varies across our generations ...ResolutionFoundation
Wednesday 22 May, 9.30-10.45am, Resolution Foundation offices, Westminster
Poverty is an age-old problem, and one that we often assume is concentrated amongst the young and old. But the nature and timing of poverty varies much more than we think between generations and over the lifecycle. Understanding these shifts is crucial if we are to make the right interventions to reduce poverty throughout society.
At what stage of one’s life is the risk of poverty greatest, and has this changed for different generations? Are specific groups particularly susceptible to certain drivers of poverty? And what are the most effective interventions to reduce poverty among children, pensioners and all other groups?
In the run-up to the launch of the Intergenerational Centre in mid-June, which is housed within the Resolution Foundation and supported by the Nuffield Foundation, our analysts presented research on poverty rates across different generations, and explored how this has evolved over time. A panel of experts then discussed how we should understand – and reduce – poverty through an intergenerational lens, before taking part in an audience Q&A.
Speakers
John Hills, Professor of Social Policy, LSE
Polly Toynbee, Columnist at The Guardian
Fahmida Rahman, Researcher at the Resolution Foundation
Torsten Bell, Director of the Resolution Foundation
ABC brought john a. powell to Rochester last summer. This is a version of his presentation. You can see the video of his presentation here
http://www.youtube.com/watch?v=vY0fsOsUzAc
This represents a 4.9 percent increase in the last year alone, and a nearly 29.0 percent increase since 2005. National vacancy rates are at their lowest levels since the 1980s.
U.S. homeownership declined to 63.4 percent, the lowest rate since 1967. Homeownership rates slide as wage growth lags and tighter standards for mortgage lending act as substantial barriers to entry.
An overview of recent population trends in Illinois, its origins and potential implication. This research was compiled by Northern Illinois University researcher Brian Harger.
A brief presentation of recent population trends in Illinois from 2010 to 2017 along with related commentary. This is part of an ongoing series of presentations on topics relevant to Illinois and the U.S. midwest.
New threats to an age-old problem: How poverty varies across our generations ...ResolutionFoundation
Wednesday 22 May, 9.30-10.45am, Resolution Foundation offices, Westminster
Poverty is an age-old problem, and one that we often assume is concentrated amongst the young and old. But the nature and timing of poverty varies much more than we think between generations and over the lifecycle. Understanding these shifts is crucial if we are to make the right interventions to reduce poverty throughout society.
At what stage of one’s life is the risk of poverty greatest, and has this changed for different generations? Are specific groups particularly susceptible to certain drivers of poverty? And what are the most effective interventions to reduce poverty among children, pensioners and all other groups?
In the run-up to the launch of the Intergenerational Centre in mid-June, which is housed within the Resolution Foundation and supported by the Nuffield Foundation, our analysts presented research on poverty rates across different generations, and explored how this has evolved over time. A panel of experts then discussed how we should understand – and reduce – poverty through an intergenerational lens, before taking part in an audience Q&A.
Speakers
John Hills, Professor of Social Policy, LSE
Polly Toynbee, Columnist at The Guardian
Fahmida Rahman, Researcher at the Resolution Foundation
Torsten Bell, Director of the Resolution Foundation
ABC brought john a. powell to Rochester last summer. This is a version of his presentation. You can see the video of his presentation here
http://www.youtube.com/watch?v=vY0fsOsUzAc
This represents a 4.9 percent increase in the last year alone, and a nearly 29.0 percent increase since 2005. National vacancy rates are at their lowest levels since the 1980s.
U.S. homeownership declined to 63.4 percent, the lowest rate since 1967. Homeownership rates slide as wage growth lags and tighter standards for mortgage lending act as substantial barriers to entry.
Exploring Public Health in Georgia and Metro AtlantaARCResearch
Looks at a variety of public health data, along with socioeconomic and demographic data, to provide a context for health.Health involves so much more than just the care we receive. Socioeconomics and demographics drive health outcomes in powerful ways. Research is focused on the recently released 2013 County Health Rankings.
Overview of public health issues in the Metro Atlanta area, presented by the Atlanta Regional Commission's Research and Analytics Group and Neighborhood Nexus. Topics include COVID-19, homicide, opioids, maternal health and County Health Rankings status.
Identified the pivotal reason for the cause of death amongst the residents in US based on the age group
Forecasted the deaths in near future considering the predicted deaths and observed deaths records of previous years.
Integrated data from twitter for major death causes using Hashtags and the twitter API calls and analyzed sentiments
Diversity and Cultural Competency in Health Care Je.docxShiraPrater50
Diversity and Cultural
Competency in Health Care
Jean Gordon, RN, DBA
LEARNING OUTCOMES
After completing this chapter, the student should be able to:
☛ Define diversity.
☛ Define cultural competency.
☛ Define diversity management.
☛ Understand why changes in U.S. demographics affect the health care industry.
OVERVIEW
Demographics of the U.S. population have changed dramatically in the
past three decades. These changes directly impact the health care indus-
try in regard to the patients we serve and our workforce. By 2050, the term
“minority” will take on a new meaning. According to the U.S. Census Bureau,
by midcentury the white, non-Hispanic population will comprise less than
50 percent of the nation’s population. As such, the health care industry needs
to change and adopt new ways to meet the diverse needs of our current and
future patients and employees.
The American Heritage Dictionary of the English Language (4th ed.) defines
diversity as: “(1) the fact or quality of being diverse; difference, and (2) a point
in which things differ.” Dreachslin (1998) provided us with a more specific def-
inition of diversity. She defined diversity as “the full range of human similari-
ties and differences in group affiliation including gender, race/ethnicity, social
class, role within an organization, age, religion, sexual orientation, physi-
cal ability, and other group identities” (p. 813). For our discussions, we will
focus on the following diversity characteristics: (1) race/ethnicity, (2) age, and
(3) gender.
This chapter is presented in three parts. First, we discuss the chang-
ing demographics of the nation’s population. Second, we examine how these
changes are affecting the delivery of health services from both the patient’s
and employee’s perspectives. Because diversity challenges faced by the health
care industry are not limited to quality-of-care and access-to-care issues, in
part three of our discussions we explore how these changes will affect the
health services workforce, and more specifically the current and future leader-
ship within the industry.
15
CHAPTER 2
9781284087062_CH02_PASS02.indd 15 17/02/15 6:10 PM
CHANGING UNITED STATES POPULATION
There is no doubt that the demographic profile of the U.S. population has
undergone significant changes within the past 10 years regarding age, gender,
and ethnicity (see Table 2–1 ).
Data from the 2010 Census provide insights to our racially and ethnically
diverse nation (Humes, Jones, & Ramirez, 2011). According to the 2010 Cen-
sus, 308.7 million people resided in the United States on April 1, 2010—an
increase of 27.3 million people, or 9.7 percent, between 2000 and 2010. The
vast majority of the growth in the total population came from increases in
those who reported their race(s) as something other than White alone and
those who reported their ethnicity as Hispanic or Latino. For the first time in ...
Diversity and Cultural Competency in Health Care Je.docxAASTHA76
Diversity and Cultural
Competency in Health Care
Jean Gordon, RN, DBA
LEARNING OUTCOMES
After completing this chapter, the student should be able to:
☛ Define diversity.
☛ Define cultural competency.
☛ Define diversity management.
☛ Understand why changes in U.S. demographics affect the health care industry.
OVERVIEW
Demographics of the U.S. population have changed dramatically in the
past three decades. These changes directly impact the health care indus-
try in regard to the patients we serve and our workforce. By 2050, the term
“minority” will take on a new meaning. According to the U.S. Census Bureau,
by midcentury the white, non-Hispanic population will comprise less than
50 percent of the nation’s population. As such, the health care industry needs
to change and adopt new ways to meet the diverse needs of our current and
future patients and employees.
The American Heritage Dictionary of the English Language (4th ed.) defines
diversity as: “(1) the fact or quality of being diverse; difference, and (2) a point
in which things differ.” Dreachslin (1998) provided us with a more specific def-
inition of diversity. She defined diversity as “the full range of human similari-
ties and differences in group affiliation including gender, race/ethnicity, social
class, role within an organization, age, religion, sexual orientation, physi-
cal ability, and other group identities” (p. 813). For our discussions, we will
focus on the following diversity characteristics: (1) race/ethnicity, (2) age, and
(3) gender.
This chapter is presented in three parts. First, we discuss the chang-
ing demographics of the nation’s population. Second, we examine how these
changes are affecting the delivery of health services from both the patient’s
and employee’s perspectives. Because diversity challenges faced by the health
care industry are not limited to quality-of-care and access-to-care issues, in
part three of our discussions we explore how these changes will affect the
health services workforce, and more specifically the current and future leader-
ship within the industry.
15
CHAPTER 2
9781284087062_CH02_PASS02.indd 15 17/02/15 6:10 PM
CHANGING UNITED STATES POPULATION
There is no doubt that the demographic profile of the U.S. population has
undergone significant changes within the past 10 years regarding age, gender,
and ethnicity (see Table 2–1 ).
Data from the 2010 Census provide insights to our racially and ethnically
diverse nation (Humes, Jones, & Ramirez, 2011). According to the 2010 Cen-
sus, 308.7 million people resided in the United States on April 1, 2010—an
increase of 27.3 million people, or 9.7 percent, between 2000 and 2010. The
vast majority of the growth in the total population came from increases in
those who reported their race(s) as something other than White alone and
those who reported their ethnicity as Hispanic or Latino. For the first time in.
The Graying Job Market in the Atlanta Region & The Economic Impact This PortendsARCResearch
Not only is the population growing older, so is the workforce. This simple fact has vast ramifications for the region as the 65 and older age cohort is increasing its economic strength by staying in the workforce longer and earning more while doing it.
The U.S. Census Bureau released a report in 2014 detailing the growth of the aging population. The senior population, defined as those 65 and older, comprised 13% of the total U.S. population in 2010. That number is expected to rise to nearly 21% by 2050. For the full report, visit http://www.census.gov/content/dam/Census/library/publications/2014/demo/p23-212.pdf. For more about the Professional Development in Gerontology Certificate, visit ccpe.kennesaw.edu/gerontology.
COVID19 presentation of data and analysis by Radius Energy Solutions. We plot regional, country and state trends as well as model the US States using Mortality Rate as the variable.
MC_forecasts_finals series 17_feb2024.pdfARCResearch
Final summary slide deck for Series 17 population, employment by sector, age group forecasts for MPO region, counties, and smaller areas...February 2024
33N Blog Housing MAS 2023 Slide DeckpdfARCResearch
Results of housing-related questions from the 2023 Metro Atlanta Speaks survey--focus on affordability locally and regionally, as well as on policy perceptions
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Public Health in Metro Atlanta
1. Atlanta Regional Commission
For more information, contact:
mcarnathan@atlantaregional.com
Public Health in Metro Atlanta:
Exploring How Healthy Our Neighborhoods Are
2. Public Health issues are often reflective of the social and
economic state of a community and can say a lot about
its overall wellbeing. In this Snapshot, we will explore
public health issues and trends in the region’s
neighborhoods and the Metro area as a whole.
Specifically, we analyze data about:
• Mortality (i.e. how long people live), from OASIS (GA
Dept. of Public Health).
• Morbidity (i.e. how healthy people feel), from OASIS
(GA Dept. of Public Health).
• 2015 County Health Rankings, which include the
above plus more.
• Demographics from Neighborhood Nexus.
Measuring Public Health
3. • Based on Years of Potential Life Lost (YPLL), public health generally
seems to be improving in most counties over the past decade or
so. There are some notable exceptions, though.
• The latest County Health Rankings also show that health is
generally improving across metro Atlanta, but again, there are
some notable exceptions in mostly the same places.
• We also took a quick look into the state of cardiovascular disease,
as it is the number one public health threat in the U.S. It is also on
the decline in metro Atlanta.
A Closer Look at Public Health in Metro Atlanta
• There are some areas that haven’t seen the same levels of overall improvement. Low Birthweight Births
and Diabetes are outliers in the general improvement of public health in the Atlanta area.
• Place matters. As suspected, there seems to be a common denominator among the increasing public health
threats in Atlanta. Years of Potential Life Lost, Diabetes and Low Birthweight all are correlated with where
poverty levels are highest in metro Atlanta.
• Race Matters. Race also appears to be a common denominator among the increasing health threats in
Metro Atlanta. Both Low Birthweight Rates and Diabetes discharges are also correlated with race.
4. Years of Potential Life Lost under age 75
(A Measure of Premature Death)
Years of Potential Life Lost before the age of 75 is
a measure of premature death. The measure
simply adds up the difference between actual age
of death and age 75. So, for example, if a person
dies at age 65, that is 10 years of potential life
lost. This calculation is then performed for every
death in an area.
When compared to the rest of the state, Metro
Atlanta has some of the lowest Years of Potential
Life Lost rates. (Blues are highest rates; Yellows
are lowest rates)
Source: Georgia Department of Public Health (OASIS) via Neighborhood Nexus
5. The chart illustrates an improving trend in metro Atlanta. Here we are comparing the number of years of
potential life lost before the age of 75 (YPLL) between 2000-2002 to 2011-2013. The chart shows that YPLL has
decreased significantly in every county, with the exception of Spalding and Walton. But, as the chart shows, the
increases in these two counties are very small. Still, Spalding does have the highest levels of premature death in
the 20-county region.
Years of Potential Life Lost under age 75
(A Measure of Premature Death)
Source: Georgia Department of Public Health (OASIS)
0.00
2,000.00
4,000.00
6,000.00
8,000.00
10,000.00
12,000.00
TPLL 2000-2002 TPLL 2011-2013YPLL, 2000-2002 YPLL, 2011-2013
Total Years of
Potential Life Lost
6. Place matters. While YPLL is on the decline as a whole, there are several neighborhoods that still have high
levels of premature death. Here we compare poverty rates (map on the left) to YPLL (map on the right). There
are clusters of neighborhoods that stand out when comparing the two maps. South DeKalb and Fulton, North
Clayton, and outer counties like Bartow, Hall, Carroll all have high levels of poverty and premature deaths.
Number of Years of Potential Life Lost before
75 years of age, 2009-2013
Percent of Population in Poverty, 2009-2013
Source: Georgia Department of Public Health (OASIS), ACS- 2009-2013 via Neighborhood Nexus
People in Poverty and Years of Potential Life Lost
7. The County Health Rankings breaks down overall health into two basic categories – Outcomes and Factors. “Outcomes” include
premature death and how healthy one feels while alive. “Factors” include a myriad of other things like behaviors (smoking, drinking
alcohol, etc.), quality of clinical care, and social/economic/physical characteristics. Once all of these are considered, each county is
given a rank, 1-159, where “1” is the healthiest county in the state, and “159” is the least healthy county in the state.
As can be seen, most counties in the Atlanta area have a relatively low rank, meaning they are among the healthiest counties in the
state. This is particularly true for the relatively wealthy counties of Cherokee, Cobb, Fayette and Forsyth. There are exceptions,
however. Clayton County, even though it has a relatively good rank for Outcomes, ranks among the lowest in the state for Factors,
meaning that, eventually, these factors will begin to drag down Clayton residents overall health outlook. Spalding, again, is an outlier
in the region, ranking poorly on both Outcomes and Factors.
Counties in Metro Atlanta Generally Healthy
Source: County Health Rankings
40
63
56
6
38
4
9
19
27
3 1
20
2
17
21
49
14 15
135
42
70
42
52
7
137
6
10
22
35
2 3
25
9
23
15
50
11
32
112
28
0
20
40
60
80
100
120
140
160
Health Outcomes Health Factors
Rank,outof159(1=healthiest
8. Factors Outcomes
Metro Atlanta is a healthy place when compared to the rest of the state, and especially the southern half.
However, in the Factors map, Spalding and Clayton counties stand out as poorly ranked counties within the metro area
with rankings of 137 and 112 respectively.
How Metro Atlanta Compares
Source: 2015 County Health Rankings via Neighborhood Nexus
9. Cardiovascular Disease in Georgia
One of the biggest NATIONAL public health
threats is cardiovascular disease. This map
shows how this disease is distributed
throughout the state, with blues representing
the highest rates, and yellows representing
the lowest.
As illustrated in the map, Metro Atlanta has
the lowest cardiovascular rates when
compared to the state as a whole, with
Spalding, again, being a notable exception.
Discharge rate, per 100,000, Major Cardiovascular
Diseases, (deduplicated), 2011-2013
Source: Georgia Department of Public Health (OASIS) via Neighborhood Nexus
10. Cardiovascular Disease Over the Years…
Within metro Atlanta, the hospital discharge rate for cardiovascular diseases has declined in every county between the
2000-2002 and 2011-2013 periods. On average, the cardiovascular discharge rate has decreased from 1,203.8 per
100,000 people during the 2000-2002 period, to 1,017.8 between 2011-2013. Even though in decline, it is still important
to pay close attention to counties that still have high Cardiovascular Disease rates like Spalding, Carroll, Bartow, and
Barrow.
0.00
500.00
1,000.00
1,500.00
2,000.00
2,500.00
Cardiovascular Disease Discharge Rates, Deduplicated, per 100,000 people
2000-2002 2011-2013
Source: Georgia Department of Public Health (OASIS)
11. Overall Health Improving, Except for…
As previously discussed, overall health is improving in metro Atlanta. However, unlike the cardiovascular-related
diseases, hospital discharges for diabetes are increasing in many counties. Fifteen out of the 20 counties have higher
discharge rates for diabetes today (2011-2013) than in the 2000-2002 period. As a whole, metro Atlanta has gone
from an average discharge rate of 108.7 per 100,000 people from 2000-2002 to 119.54 from 2011-2013. Clayton has
seen an increase of 59.9 discharges per 100,000, the highest increase in metro Atlanta. Diabetes is related to
nutrition, so this increase could be due to less-healthy diets or increasingly limited access to healthy foods.
0
50
100
150
200
250
Diabetes: Discharge Rate per 100,000 Population
Discharge rate, per 100,000, for diabetes, deduplicated, 2000-2002 Discharge rate, per 100,000 for diabetes, deduplicated , 2011-2013
Source: Georgia Department of Public Health (OASIS)
12. 0
10
20
30
40
50
60
70
Diabetes Discharge Rates for Children <18 years of Age (per 100,000 population <18)
DISCHARGE RATE, 2000-2002 DISCHARGE RATE, 2011-2013
Diabetes doesn’t just affect adults…
Adults are not the only people who fall victim to Diabetes. Diabetes among children has increased in many counties
particularly in Spalding and Rockdale. Rockdale has increased by 34.1 and Spalding has increase by 40.5 children per
100,000 people. Overall, the average county in the region has only increased by 4.4 cases per 100,000.
13. Like YPLL, these maps explore the relationship between diabetes and poverty. The distribution of diabetes (discharge
rate) between 2009-2013 looks similar to the distribution of poverty in metro Atlanta. The highest rate of diabetes
discharge rates are found in southern DeKalb and Fulton and most of Clayton county. These rates reflect the highest
rates of poverty in the core of Metro Atlanta.
Percent of Population in Poverty, 2009-2013
Diabetes Discharge Rates, per 100,000, 2009-
2013
Source: Georgia Department of Public Health (OASIS) & Neighborhood Nexus, ACS-2009-2013
Diabetes is Also Related to Income…
14. Along with poverty, race also seems to have a strong relationship to public health issues in Metro
Atlanta. This chart is indicates that African Americans are disproportionately affected by diabetes, as
their discharge rate per county is significantly higher for EVERY county, with the exception of Douglas.
79.4
186.1
0.00
50.00
100.00
150.00
200.00
250.00
300.00
Diabetes Discharge Rates, per 1000,000, by Race, 2011-2013
White Black
Source: Georgia Department of Public Health (OASIS)
And Diabetes is Related to Race…
15. Overall Birth Rates are on the Decline…
0
10
20
30
40
50
60
70
Birth Rate, 2000-2002 BIRTH RATE, 2010-2012
Source: Georgia Department of Public Health (OASIS)
Changing course a bit, here we explore maternal health and find that, overall, birth rates are declining in every
county in the Atlanta region.
Births per 1,000
women age 10-55
16. …but Low Birthweight Births are Increasing
Birthweight is an good indicator of overall public health in an area. A low birthweight birth can be representative of
the child and mother’s health and even of the overall health system in an area. It can also have everlasting
behavioral and physical health effects on a child, particularly for educational achievement.
As we can see, low birth weight is increasing in every county with the exception of Barrow and Carroll and are the
highest in Clayton, Fulton, and Spalding counties. Douglas has seen 29% increase in the low birthweight rate from
2000-2002 to 2010-2012. Metro Atlanta as a whole has seen the average low birthweight rate increase from 7.9%
between the 2000-2002 period to 9.0% during 2010-2012 period.
0
2
4
6
8
10
12
14
16
% Low Birthweight Births, 2000-2002 % all births that are low birth weight, 2010-2012
Source: Georgia Department of Public Health (OASIS)
% of births that were
Low Birthweight
17. Low Birthweight Births <2,500 grams Per
100,000 2008-2012
On a neighborhood level, Low Birthweight Births are primarily concentrated in lower income areas, such as south
Atlanta, South Fulton, South DeKalb, and other southern counties like Rockdale, Clayton, Spalding, and Newton
counties. The City of Atlanta is almost identical in terms of poverty rate and low birthweight birth rates.
% Population in Poverty, 2009-2013
And, Of Course, Low Birthweight Births and Poverty Are Related
Source: Georgia Department of Public Health (OASIS) & American Community Survey, 2009-2013, via Neighborhood Nexus
18. Low Birthweight Birth rates tell a similar story. As the chart indicates, the disparity between black and
white low birthweight babies is significant in EVERY county. Overall, there is about a 5.7 percentage
point difference in the Atlanta region between White births and Black births.
7.1
12.8
0
5
10
15
20
25
Low Birthweight Birth Rates According to Race, 2010-2012
White Black
Source: Georgia Department of Public Health (OASIS)
And Low Birthweight Births are also Related to Race…