1. Andrés Felipe Restrepo Ramírez
Medical student
III Semester
Molecular Biology
August 24, 2013

4. The transcription process
its really important to copy
the DNA exactly in cells
The control in this process
is really important to
determine the function of all
cells
INTRODUCTION

5. Researches identify key transcription factor linked
whit treatment-resistant prostate cancer
News-medical, August 20-2013
Prostate cancer have the
growth and spread in
the body
by androgens, which
have been the
target of treatment
against this all this time

6. Researches identify key transcription factor linked whit
treatment-resistant prostate cancer
News-medical, August 20-2013
http://www.purdue.edu/newsroom/general/
2011/110608LowRatliffProstate.html
In this process plays an
important role the
transcription process, since it
has found a key transcription
factor that stimulates output
of androgen receptors to the
cell surface called MED1

7. Researches identify key transcription factor linked whit
treatment-resistant prostate cancer
News-medical, August 20-2013
In rat models that simulate
human prostate cancer, it was
discovered that over-expression
of MED1, causing resistance to
treatment is given by the
hyperactivity of the kinases ERK
and PI3K/AKT

8. Researches identify key transcription factor linked whit
treatment-resistant prostate cancer
News-medical, August 20-2013
Now researchers suggest that this finding has encuenta
this transcription factor for therapeutic targets and thus
avoid resistance to known treatments

9. PERSONAL OPINION
I think this discovery will
open new doors to treating
prostate cancer, providing
a new molecular target for
treatment-resistant and
poor prognosis avoiding
them
http://pma507pty.com/2012/08/07/votarian-
por-ellos/hombre-pensando1/

10. Study shows enhancer RNA molecules may open
new avenues for gene therapy
August 14, 2013
Enhancers are molecules that
regulate gene expression with
promoters, these molecules
are located at many base pairs
away from the gene that
regulates

11. Study shows enhancer RNA molecules may open
new avenues for gene therapy
August 14, 2013
The researchers
demonstrated that
inflammatory processes
are new production
enhancers, used this
new formation of
enhancers to describe
the production process
the eRNA is first
activated and then
starts the methylation
of histone, methylated
histones H3K4me 1
and 2 are markers
that's the enhancer
sequence.

12. Study shows enhancer RNA molecules may open
new avenues for gene therapy
August 14, 2013
Methylation-dependent
methyltransferases enzymes
Mll1, mLL2 / 4 and MLL3, it was
found that the eRNA transcript
arresting stops histone
methylation and thus does not
express the enhancer
http://wordlesstech.com/2012/08/23/molec
ular-visualizations-of-dna/

13. Study shows enhancer RNA molecules may open
new avenues for gene therapy
August 14, 2013
This creates an
extension cord term
epigenetic change in
the cells, which
involves the
introduction of new
treatments for the
diseases.

14. This news gives us an
idea that the regulation
of gene expression can
be the key to the
control of many
diseases, discovering
the mechanisms of
calcification of action of
enhancers can achieve
this goal
PERSONAL OPINION
http://elblogdeltaller.wordpress.com/para-
debatir/pensando-en-la-lectura/

15. MEDICAL UTILITY
To reach this objective a
medical benefit, you must
have better knowledge on the
topic about transcriptional
regulation and the factors
influencing it more this
process is activated or not

16. MEDICAL UTILITY
To do this the researchers found their own news both
triggers, in the case of prostate cancer, ERK and PI3K/AKT
kinases

17. MEDICAL UTILITY
in the case of transcription
regulation methyltransferase
enzymes and their relationship to
RNA gene transcription, which
can be converted in order to study
different pathologies therapies

18. MEDICAL UTILITY
These findings are of high
value as it may in the future
have better mechanisms for
treatment of chronic or not
yet express themselves and
be more close to the ultimate
cure prostate cancer
http://2011symposium.crg.es/noticias/preve
nting-dangerous-nonsense-in-human-
gene-expression/

19. BIBLIOGRAPHY
· •Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB. Facultad de
Medicina, 2012. 78-84.P
· Kaikkonen , Minna U. Glass Christopher. Study shows enhancer RNA
molecules may open new avenues for gene therapy. News-medical, (online
magzine), 2013(august 14). Available online: http://www.news-
medical.net/news/20130814/Study-shows-enhancer-RNA-molecules-may-open-
new-avenues-for-gene-therapy.aspx?page=2
· Fondell Joseph, Jin Feng, Researches identify key transcription factor linked
with treatment-resistant prostate cáncer. News, (Online Magazine), 2013(August
20). Available online: http://www.news-
medical.net/news/20130820/Researchers-identify-key-transcription-factor-linked-
with-treatment-resistant-prostate-cancer.aspx?page=2