This document summarizes a seminar on promoting physiotherapy leadership to reduce sedentary behavior in clinical populations. The seminar objectives are to review the state of research on sedentary behavior and physical activity among key clinical groups, present findings from physiotherapy-delivered interventions, and provide practical advice for implementing interventions. The structure includes an overview of sedentary behavior recommendations and research, followed by four presentations of physiotherapist-led multi-modal interventions, and a question and answer session with panelists. The goal is to communicate relevant messages to delegates on how physiotherapists can help break cycles of prolonged sitting and inactivity in clinical settings.