The document discusses how organizations can prepare for inevitable changes. It recommends assessing organizational readiness, focusing on people, and applying program management best practices. The key steps are: 1) assessing readiness by evaluating sponsorship, resistance, and gaps; 2) engaging people as change agents, sponsors, and targets; 3) sanctioning the effort as a formal program and applying scope, communication, reporting and risk management. An Enterprise Project Management Office can help with methodology, training, coaching and reporting.