Probiotics are live microorganisms that provide health benefits when consumed. They help restore balance between good and bad bacteria in the gut. Specific probiotic strains like Lactobacilli and Bifidobacteria produce antimicrobial substances, improve gut barrier function, and modulate the immune system. Probiotics show promise for treating conditions like antibiotic-associated diarrhea, high cholesterol, and inflammatory bowel diseases. However, large doses can cause temporary gas and bloating in some people.

1. G. HARICHANDANA
17DM1R0026
B. pharm
BY

2.  WHAT ARE PROBIOTICS
 WHO NEED PROBIOTICS
 MODE OF ACTION OF PROBIOTICS
 INTRODUCTION
 CHARCTERSTICS
 ACTIONS OF PROBIOTICS
 USED IN CLINICAL CONDITIONS
 ADVANTAGES
 DISADVANTAGES

3.  The world health organization defines probiotics
as live microorganisms, which when administered in
adequate amounts confer a health benefit on a host.
 The term probiotic comes from the Latin or Greek
pro,“before, forward”, and bios, or “life” — thus
probiotics are life-promoting. In this case, we use
the term probiotics to refer to beneficial bacteria.
 The most common types of these beneficial bacteria
are Lactobacilli and Bifidobacteria.

4.  Probiotic - Probiotics defined as microorganisms
that have a beneficial effect on the host intestinal
microbial balance.
 Probiotic organisms are live microorganisms
thought to be beneficial to the host organism.
 According to the currently adopted definition by
FAO/WHO, probiotics are: "Live micro
organisms which when administered in adequate
amounts confer a health benefit on the host".

5.  People who suffer from yeast infections of any
kind,including athlete's foot, jock itch, vaginal yeast
infections and nail fungus.
 People with weak immune sytems, frequent
respiratory infections and congestion.
 People with food or respiratory allergies.
 People suffering from inflammatory bowel
disorders, constipation or intestinal infections

6.  Production of low-molecular-weight antibacterial
substance that inhibits both gram-positive and gram
negative enteric bacteria.
 Also use enzymatic mechanisms to modify toxin
receptors and block toxin-mediated pathology.
 Also prevent colonization of pathogenic
microorganisms by competitive inhibition for
microbial adhesion sites

7. It should be safe to the host.
It should not produce any pathogenic or toxic effect.
It must be resistance to hydrochloric acid, bile and
pancreatic juice.
 It should have anti-carcinogenic activity
It should stimulate the immune system of the body.
It should have the ability to colonize the gastrointestinal tract.

8.  Restore the balance b/w ‘Good’ and ‘bad’ bacteria in
gut
 secrete bactericidal proteins
 ↓ses the pH
• Block the attachment & invasion of epithelium by
pathogens
• Improve epithelial barrier function
 ↑ mucus production
 ↑ barrier integrity

9.  Alter host immune responses
 stimulate IgA production
 Inhibits the proinflmatory cytokinens
 Produce β-galactosidase, so digest lactose
 ↓ production of carcinogenic metabolites

10.  Probiotics were identified to beneficially affect the
host by improving its intestinal microbial balance,
thus inhibiting pathogens and toxin producing
bacteria.
 Today, specific health effects are being
investigated and documented including alleviation
of chronic intestinal inflammatory diseases,
prevention and treatment of pathogen-induced
diarrhoea, urogenital infections, and atopic diseases.

11. 1. Antibiotic associated diarrhea
2. Probiotics and Cancer
3. Hepatic Diseases
4. Helicobacter pylori Infections
5. Treat high cholesterol
6. Use of probiotics beyond GIT (Allergy)

12. 1. Taking them in larger amounts might produce
digestive issues, such as gas and bloating, but they
are usually temporary.
2. treating lactobacillus septicaemia which is a
potentially fatal disease caused by the consumption
of probiotics.
3. Discomfort in the gastrointestinal tract

13.  Probiotics bacteria confer health benefits by
blostering protective, structural and metabolic
functions in the human body.
 Not all probiotics are equal
 Probiotics are appear promising for the management
of gut conditions, such as inflammatory bowel
diseases