This document describes a study investigating the effects of multi-nutrient enriched diets on a mouse model of Alzheimer's disease. The study aims to examine how diets supplemented with DHA, EPA, UMP, choline, phospholipids, and vitamins impact the pathophysiology of AD. Mice are fed either a control diet, DHA+EPA enriched diet, or a multi-nutrient fortified diet. Outcome measures include 1H magnetic resonance spectroscopy to analyze neuronal and glial markers, and cerebral blood flow measurements using FAIR imaging. The goal is to determine if nutrient enriched diets can restore cerebral perfusion and protect against neurodegeneration in an APP/PS1 mouse model of Alzheimer's disease.
Alzheimer's disease is a common neurodegenerative condition associated with progressive cognitive decline. The patient is an 83-year-old female with Alzheimer's disease who has problems with medication adherence and repeatedly tells the same stories. She has multiple medical issues including atrial fibrillation and heart failure. Her son is her primary caretaker. Current FDA-approved medications for Alzheimer's disease include cholinesterase inhibitors and NMDA antagonists, which aim to treat cognitive symptoms but do not stop disease progression. Non-pharmacologic therapies and caring for caregivers are also important aspects of Alzheimer's treatment and management.
This document provides an overview of diffusion tensor imaging (DTI). It describes how DTI can be used to measure the diffusion of water molecules in tissue to determine tissue cellularity and connectivity. Key aspects covered include diffusion anisotropy, the diffusion tensor, quantitative DTI parameters like fractional anisotropy, visualization techniques like fiber tractography, limitations of DTI like issues with crossing fibers, and more advanced methods like probabilistic fiber tracking and high b-value q-space imaging.
This document discusses Alzheimer's disease and potential drug targets and strategies. It begins by introducing Alzheimer's disease and some of its key characteristics like memory loss and neuronal cell dysfunction. It then discusses amyloid beta and its role in Alzheimer's disease pathology. Several current and potential drug targets are mentioned, like acetylcholinesterase inhibitors and NMDA receptors. The document also discusses using biomarkers from sources like platelets and CSF to aid diagnosis and validate drug targets. Methodologies like proteomics and various assays are mentioned for identifying these biomarkers. Overall the goal is to identify novel targets and strategies to enhance cognition and slow disease progression.
This document summarizes several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The key points are:
1) Neurodegenerative diseases are characterized by the progressive loss of neurons affecting functional groups. The common pathologic process is the accumulation of protein aggregates in the brain.
2) Alzheimer's disease is the most common cause of dementia and is characterized by amyloid plaques and neurofibrillary tangles leading to neuronal death. Parkinson's disease results from the loss of dopamine neurons in the substantia nigra. Huntington's disease is an inherited disorder caused by a CAG repeat expansion leading to chorea.
3
This document summarizes several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The key points are:
1) Neurodegenerative diseases are characterized by the progressive loss of neurons affecting functional groups. The common pathologic process is the accumulation of protein aggregates.
2) Alzheimer's disease is the most common cause of dementia and is characterized by amyloid plaques and neurofibrillary tangles leading to neuronal death. Parkinson's disease results from the loss of dopamine neurons in the substantia nigra. Huntington's disease is an inherited disorder caused by a trinucleotide repeat expansion leading to chorea.
3)
Dr. Sadaf Khan discusses amyloidosis, a disorder caused by the deposition of abnormal protein fibrils in tissues and organs. Amyloidosis can be localized to a single organ or systemic. The type of amyloid protein deposited determines the classification, with the most common types being AL amyloidosis associated with plasma cell dyscrasias and AA amyloidosis associated with inflammatory conditions. Diagnosis involves staining biopsy samples with dyes like Congo red and examining under polarized light. Treatment depends on the type and organ involvement but may include targeting the underlying condition, chemotherapy, dialysis, or organ transplantation.
This study investigated alterations in the Ca2+/calmodulin/CaMKII/CaV1.2 signaling pathway in experimental models of Alzheimer's disease and vascular dementia. The study found that APP/PS1 mice, a model of Alzheimer's disease, exhibited deficits in hippocampal synaptic transmission, long-term potentiation, and memory associated with increased expression of Aβ 1–42. In a vascular dementia model using gerbils, cerebral ischemia reduced levels of phosphorylated CaMKII in the hippocampal CA1 region. The study provides insights into calcium signaling alterations in Alzheimer's disease and vascular dementia pathological mechanisms.
Alzheimer's disease is a common neurodegenerative condition associated with progressive cognitive decline. The patient is an 83-year-old female with Alzheimer's disease who has problems with medication adherence and repeatedly tells the same stories. She has multiple medical issues including atrial fibrillation and heart failure. Her son is her primary caretaker. Current FDA-approved medications for Alzheimer's disease include cholinesterase inhibitors and NMDA antagonists, which aim to treat cognitive symptoms but do not stop disease progression. Non-pharmacologic therapies and caring for caregivers are also important aspects of Alzheimer's treatment and management.
This document provides an overview of diffusion tensor imaging (DTI). It describes how DTI can be used to measure the diffusion of water molecules in tissue to determine tissue cellularity and connectivity. Key aspects covered include diffusion anisotropy, the diffusion tensor, quantitative DTI parameters like fractional anisotropy, visualization techniques like fiber tractography, limitations of DTI like issues with crossing fibers, and more advanced methods like probabilistic fiber tracking and high b-value q-space imaging.
This document discusses Alzheimer's disease and potential drug targets and strategies. It begins by introducing Alzheimer's disease and some of its key characteristics like memory loss and neuronal cell dysfunction. It then discusses amyloid beta and its role in Alzheimer's disease pathology. Several current and potential drug targets are mentioned, like acetylcholinesterase inhibitors and NMDA receptors. The document also discusses using biomarkers from sources like platelets and CSF to aid diagnosis and validate drug targets. Methodologies like proteomics and various assays are mentioned for identifying these biomarkers. Overall the goal is to identify novel targets and strategies to enhance cognition and slow disease progression.
This document summarizes several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The key points are:
1) Neurodegenerative diseases are characterized by the progressive loss of neurons affecting functional groups. The common pathologic process is the accumulation of protein aggregates in the brain.
2) Alzheimer's disease is the most common cause of dementia and is characterized by amyloid plaques and neurofibrillary tangles leading to neuronal death. Parkinson's disease results from the loss of dopamine neurons in the substantia nigra. Huntington's disease is an inherited disorder caused by a CAG repeat expansion leading to chorea.
3
This document summarizes several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The key points are:
1) Neurodegenerative diseases are characterized by the progressive loss of neurons affecting functional groups. The common pathologic process is the accumulation of protein aggregates.
2) Alzheimer's disease is the most common cause of dementia and is characterized by amyloid plaques and neurofibrillary tangles leading to neuronal death. Parkinson's disease results from the loss of dopamine neurons in the substantia nigra. Huntington's disease is an inherited disorder caused by a trinucleotide repeat expansion leading to chorea.
3)
Dr. Sadaf Khan discusses amyloidosis, a disorder caused by the deposition of abnormal protein fibrils in tissues and organs. Amyloidosis can be localized to a single organ or systemic. The type of amyloid protein deposited determines the classification, with the most common types being AL amyloidosis associated with plasma cell dyscrasias and AA amyloidosis associated with inflammatory conditions. Diagnosis involves staining biopsy samples with dyes like Congo red and examining under polarized light. Treatment depends on the type and organ involvement but may include targeting the underlying condition, chemotherapy, dialysis, or organ transplantation.
This study investigated alterations in the Ca2+/calmodulin/CaMKII/CaV1.2 signaling pathway in experimental models of Alzheimer's disease and vascular dementia. The study found that APP/PS1 mice, a model of Alzheimer's disease, exhibited deficits in hippocampal synaptic transmission, long-term potentiation, and memory associated with increased expression of Aβ 1–42. In a vascular dementia model using gerbils, cerebral ischemia reduced levels of phosphorylated CaMKII in the hippocampal CA1 region. The study provides insights into calcium signaling alterations in Alzheimer's disease and vascular dementia pathological mechanisms.
This study investigated alterations in the Ca2+/calmodulin/CaMKII/CaV1.2 signaling pathway in experimental models of Alzheimer's disease and vascular dementia. The study found that APP/PS1 mice, a model of Alzheimer's disease, exhibited deficits in hippocampal synaptic transmission, long-term potentiation, and memory associated with increased expression of Aβ 1–42. In a vascular dementia model using gerbils, cerebral ischemia reduced levels of phosphorylated CaMKII in the hippocampal CA1 region. The study provides insights into calcium signaling alterations in Alzheimer's disease and vascular dementia pathological mechanisms.
This document discusses newer concepts in the renin-angiotensin-aldosterone system (RAAS), including tissue and cardiac RAAS. It describes how the RAAS was traditionally viewed as circulating in the bloodstream, but is now understood to also exist locally in tissues. Local tissue RAAS can generate angiotensin II independently of circulating RAAS through local synthesis of angiotensinogen and renin. Inhibition of tissue RAAS provides benefits like reducing endothelial dysfunction, vascular damage, and organ damage in the heart and kidneys.
Definition
Statistics of AD
A brief introduction
Signs and symptoms of AD
NMDA receptors
Classification
Causes
Risk Factors
Pathophysiology
AD… The great unknown
Treatment Options
Future Trends
This document discusses cardiac amyloidosis, specifically amyloid light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis. It defines amyloidosis as a group of diseases where misfolded proteins form fibrils that deposit in tissues. For cardiac amyloidosis, this most commonly involves immunoglobulin light chains (AL) or transthyretin (ATTR). The document reviews clinical presentation, diagnosis, treatment approaches and prognosis for these types of cardiac amyloidosis.
This document discusses the management of intracranial pressure and cerebral edema in neurocritical care patients. It covers topics such as how patients typically present with brain injuries, important caveats in neurological examinations, principles of cerebral resuscitation, mechanisms of primary and secondary brain injury, the pathophysiology over time, imaging techniques including CT scans and MRI, monitoring techniques like intracranial pressure monitoring, and treatment approaches like the use of hyperosmolar therapy with mannitol or hypertonic saline. The goal is to prevent secondary brain injury after the initial primary injury occurs.
amyloidosis(including history,physical and chemical properties, classification, variants, staining characteristics, lab diagnosis,morphological patterns according to organ involved ,), basically for undergraduates and residents in pathology
This document provides an overview of amyloidosis, including:
- Amyloidosis involves the abnormal deposition of amyloid protein fibrils in tissues.
- It can be classified based on the type of precursor protein and can be either systemic or localized.
- Common clinical manifestations involve the heart, kidneys, liver, and nervous system.
- Diagnosis involves staining tissue samples with Congo red or using immunohistochemistry to identify the type of amyloid protein. Organ involvement is also evaluated through imaging and laboratory tests.
CARDIAC AMYLOIDOSIS a brief review – sameer.pptxpurraSameer
The document describes two case scenarios of patients presenting with cardiac symptoms. The first case involves a 70-year-old man diagnosed with cardiac amyloidosis based on positive Congo red staining on endomyocardial biopsy showing amyloid deposits. Imaging and labs revealed cardiac involvement including heart failure and abnormal cardiac markers. The second case involves a 42-year-old man initially diagnosed with NSTEMI but later found to have malabsorption syndrome based on abnormal labs and imaging. Both cases demonstrate the challenges in diagnosing cardiac amyloidosis.
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
This document provides an overview of amyloidosis, including:
- Amyloidosis is caused by the extracellular deposition of misfolded proteins forming fibrils. There are different types classified by the precursor protein involved.
- Systemic forms include AL amyloidosis associated with plasma cell disorders and AA amyloidosis associated with inflammatory conditions.
- Diagnosis involves biopsy of tissues like fat pad or organs stained with Congo red to identify amyloid deposits. Immunohistochemistry identifies the precursor protein type.
- Organ involvement varies but kidney, heart, liver and spleen are commonly affected. Clinical manifestations depend on the organs involved and may include proteinuria, heart failure, hepatomegaly or neurological symptoms.
The passage discusses the pathophysiology of Alzheimer's disease, outlining several hypotheses for its causes including the amyloid hypothesis, vascular hypothesis, glutamatergic hypothesis, and cholinergic hypothesis. It notes risk factors like age, neurotransmitter deficiencies, head trauma, and genetics. The amyloid hypothesis suggests abnormal amyloid protein precursor cleavage leads to amyloid plaques and neurofibrillary tangles, while other hypotheses implicate vascular factors, glutamate receptor activation, and acetylcholine loss in neuronal death and cognitive impairment.
This document discusses drugs used to treat angina pectoris and myocardial infarction. It describes the pathophysiology and types of angina pectoris. The main drug classes discussed are nitrates, calcium channel blockers, and beta blockers. Specific drugs mentioned include nitroglycerin, nifedipine, metoprolol, and propanolol. The mechanisms of action, effects, indications, dosages, and side effects of these drugs are summarized. Risk factor modification and lifestyle changes are also mentioned as important principles in the treatment of angina pectoris.
1. Alzheimer's disease is a progressive brain disorder that causes memory loss and cognitive decline, and is the most common form of dementia.
2. It results from an increase in beta-amyloid proteins in the brain that leads to nerve cell death. The disease is incurable and causes impairment in memory, reasoning, language, and perception.
3. Risk factors include age over 65, genetics, hypertension, high cholesterol, diabetes, smoking, alcohol use, and mild cognitive impairment. The disease is characterized by two lesions - neuritic plaques containing beta-amyloid protein and neurofibrillary tangles containing tau protein.
This document summarizes key information about amyloidosis from an autopsy report and additional explanatory text. Amyloidosis is a heterogeneous group of disorders where abnormal proteins form insoluble fibrils that deposit in tissues, damaging organs. The autopsy findings identified cardiac amyloidosis as the cause of death. Amyloid deposits were found throughout the organs. Treatment aims to reduce amyloid protein production and promote deposit clearance while managing organ dysfunction, but amyloidosis generally has a poor long-term prognosis.
This document provides information about multiple myeloma. It begins by describing multiple myeloma as a malignant proliferation of plasma cells from a single clone that most commonly affects bone. It then discusses the incidence, risk factors, clinical features, recurrent infections, renal failure, anemia, classifications, diagnostic features, laboratory findings, radiology, and management of multiple myeloma. In summary, it provides an overview of multiple myeloma including its causes, symptoms, diagnostic criteria, staging systems, and treatment options.
This study investigated alterations in the Ca2+/calmodulin/CaMKII/CaV1.2 signaling pathway in experimental models of Alzheimer's disease and vascular dementia. The study found that APP/PS1 mice, a model of Alzheimer's disease, exhibited deficits in hippocampal synaptic transmission, long-term potentiation, and memory associated with increased expression of Aβ 1–42. In a vascular dementia model using gerbils, cerebral ischemia reduced levels of phosphorylated CaMKII in the hippocampal CA1 region. The study provides insights into calcium signaling alterations in Alzheimer's disease and vascular dementia pathological mechanisms.
This document discusses newer concepts in the renin-angiotensin-aldosterone system (RAAS), including tissue and cardiac RAAS. It describes how the RAAS was traditionally viewed as circulating in the bloodstream, but is now understood to also exist locally in tissues. Local tissue RAAS can generate angiotensin II independently of circulating RAAS through local synthesis of angiotensinogen and renin. Inhibition of tissue RAAS provides benefits like reducing endothelial dysfunction, vascular damage, and organ damage in the heart and kidneys.
Definition
Statistics of AD
A brief introduction
Signs and symptoms of AD
NMDA receptors
Classification
Causes
Risk Factors
Pathophysiology
AD… The great unknown
Treatment Options
Future Trends
This document discusses cardiac amyloidosis, specifically amyloid light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis. It defines amyloidosis as a group of diseases where misfolded proteins form fibrils that deposit in tissues. For cardiac amyloidosis, this most commonly involves immunoglobulin light chains (AL) or transthyretin (ATTR). The document reviews clinical presentation, diagnosis, treatment approaches and prognosis for these types of cardiac amyloidosis.
This document discusses the management of intracranial pressure and cerebral edema in neurocritical care patients. It covers topics such as how patients typically present with brain injuries, important caveats in neurological examinations, principles of cerebral resuscitation, mechanisms of primary and secondary brain injury, the pathophysiology over time, imaging techniques including CT scans and MRI, monitoring techniques like intracranial pressure monitoring, and treatment approaches like the use of hyperosmolar therapy with mannitol or hypertonic saline. The goal is to prevent secondary brain injury after the initial primary injury occurs.
amyloidosis(including history,physical and chemical properties, classification, variants, staining characteristics, lab diagnosis,morphological patterns according to organ involved ,), basically for undergraduates and residents in pathology
This document provides an overview of amyloidosis, including:
- Amyloidosis involves the abnormal deposition of amyloid protein fibrils in tissues.
- It can be classified based on the type of precursor protein and can be either systemic or localized.
- Common clinical manifestations involve the heart, kidneys, liver, and nervous system.
- Diagnosis involves staining tissue samples with Congo red or using immunohistochemistry to identify the type of amyloid protein. Organ involvement is also evaluated through imaging and laboratory tests.
CARDIAC AMYLOIDOSIS a brief review – sameer.pptxpurraSameer
The document describes two case scenarios of patients presenting with cardiac symptoms. The first case involves a 70-year-old man diagnosed with cardiac amyloidosis based on positive Congo red staining on endomyocardial biopsy showing amyloid deposits. Imaging and labs revealed cardiac involvement including heart failure and abnormal cardiac markers. The second case involves a 42-year-old man initially diagnosed with NSTEMI but later found to have malabsorption syndrome based on abnormal labs and imaging. Both cases demonstrate the challenges in diagnosing cardiac amyloidosis.
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
This document provides an overview of amyloidosis, including:
- Amyloidosis is caused by the extracellular deposition of misfolded proteins forming fibrils. There are different types classified by the precursor protein involved.
- Systemic forms include AL amyloidosis associated with plasma cell disorders and AA amyloidosis associated with inflammatory conditions.
- Diagnosis involves biopsy of tissues like fat pad or organs stained with Congo red to identify amyloid deposits. Immunohistochemistry identifies the precursor protein type.
- Organ involvement varies but kidney, heart, liver and spleen are commonly affected. Clinical manifestations depend on the organs involved and may include proteinuria, heart failure, hepatomegaly or neurological symptoms.
The passage discusses the pathophysiology of Alzheimer's disease, outlining several hypotheses for its causes including the amyloid hypothesis, vascular hypothesis, glutamatergic hypothesis, and cholinergic hypothesis. It notes risk factors like age, neurotransmitter deficiencies, head trauma, and genetics. The amyloid hypothesis suggests abnormal amyloid protein precursor cleavage leads to amyloid plaques and neurofibrillary tangles, while other hypotheses implicate vascular factors, glutamate receptor activation, and acetylcholine loss in neuronal death and cognitive impairment.
This document discusses drugs used to treat angina pectoris and myocardial infarction. It describes the pathophysiology and types of angina pectoris. The main drug classes discussed are nitrates, calcium channel blockers, and beta blockers. Specific drugs mentioned include nitroglycerin, nifedipine, metoprolol, and propanolol. The mechanisms of action, effects, indications, dosages, and side effects of these drugs are summarized. Risk factor modification and lifestyle changes are also mentioned as important principles in the treatment of angina pectoris.
1. Alzheimer's disease is a progressive brain disorder that causes memory loss and cognitive decline, and is the most common form of dementia.
2. It results from an increase in beta-amyloid proteins in the brain that leads to nerve cell death. The disease is incurable and causes impairment in memory, reasoning, language, and perception.
3. Risk factors include age over 65, genetics, hypertension, high cholesterol, diabetes, smoking, alcohol use, and mild cognitive impairment. The disease is characterized by two lesions - neuritic plaques containing beta-amyloid protein and neurofibrillary tangles containing tau protein.
This document summarizes key information about amyloidosis from an autopsy report and additional explanatory text. Amyloidosis is a heterogeneous group of disorders where abnormal proteins form insoluble fibrils that deposit in tissues, damaging organs. The autopsy findings identified cardiac amyloidosis as the cause of death. Amyloid deposits were found throughout the organs. Treatment aims to reduce amyloid protein production and promote deposit clearance while managing organ dysfunction, but amyloidosis generally has a poor long-term prognosis.
This document provides information about multiple myeloma. It begins by describing multiple myeloma as a malignant proliferation of plasma cells from a single clone that most commonly affects bone. It then discusses the incidence, risk factors, clinical features, recurrent infections, renal failure, anemia, classifications, diagnostic features, laboratory findings, radiology, and management of multiple myeloma. In summary, it provides an overview of multiple myeloma including its causes, symptoms, diagnostic criteria, staging systems, and treatment options.
This document discusses techniques for photographing retinoblastoma in children using various camera types. It notes that while newer digital cameras and smartphones aim to produce beautiful photos, their features like flash reduction can interfere with detecting leukocoria. The "Granny Test" is described as the standard approach using an analog camera with flash in a dim room from different angles. However, cell phone cameras are not always successful due to their LED flashes. The document emphasizes that any detected leukocoria requires examination, and that fundoscopy remains the gold standard.
This document summarizes research on foveal sparing in patients with Stargardt disease. It finds that 13 of 149 Stargardt patients showed foveal sparing. Most had late onset of symptoms after age 50 and initial vision loss. Genetic analysis found various mutations in the ABCA4 gene in these patients. Imaging like autofluorescence and OCT scans revealed atrophy surrounding the spared fovea. Possible causes of foveal sparing discussed are milder mutations, influence of modifier genes, anatomical differences in the fovea, and roles of Muller cells and photoreceptor distribution. The findings provide insight into pathogenic pathways in foveal sparing Stargardt disease.
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdfMalak Abu Hammad
Discover how MongoDB Atlas and vector search technology can revolutionize your application's search capabilities. This comprehensive presentation covers:
* What is Vector Search?
* Importance and benefits of vector search
* Practical use cases across various industries
* Step-by-step implementation guide
* Live demos with code snippets
* Enhancing LLM capabilities with vector search
* Best practices and optimization strategies
Perfect for developers, AI enthusiasts, and tech leaders. Learn how to leverage MongoDB Atlas to deliver highly relevant, context-aware search results, transforming your data retrieval process. Stay ahead in tech innovation and maximize the potential of your applications.
#MongoDB #VectorSearch #AI #SemanticSearch #TechInnovation #DataScience #LLM #MachineLearning #SearchTechnology
OpenID AuthZEN Interop Read Out - AuthorizationDavid Brossard
During Identiverse 2024 and EIC 2024, members of the OpenID AuthZEN WG got together and demoed their authorization endpoints conforming to the AuthZEN API
Ivanti’s Patch Tuesday breakdown goes beyond patching your applications and brings you the intelligence and guidance needed to prioritize where to focus your attention first. Catch early analysis on our Ivanti blog, then join industry expert Chris Goettl for the Patch Tuesday Webinar Event. There we’ll do a deep dive into each of the bulletins and give guidance on the risks associated with the newly-identified vulnerabilities.
How to Interpret Trends in the Kalyan Rajdhani Mix Chart.pdfChart Kalyan
A Mix Chart displays historical data of numbers in a graphical or tabular form. The Kalyan Rajdhani Mix Chart specifically shows the results of a sequence of numbers over different periods.
AI 101: An Introduction to the Basics and Impact of Artificial IntelligenceIndexBug
Imagine a world where machines not only perform tasks but also learn, adapt, and make decisions. This is the promise of Artificial Intelligence (AI), a technology that's not just enhancing our lives but revolutionizing entire industries.
How to Get CNIC Information System with Paksim Ga.pptxdanishmna97
Pakdata Cf is a groundbreaking system designed to streamline and facilitate access to CNIC information. This innovative platform leverages advanced technology to provide users with efficient and secure access to their CNIC details.
Monitoring and Managing Anomaly Detection on OpenShift.pdfTosin Akinosho
Monitoring and Managing Anomaly Detection on OpenShift
Overview
Dive into the world of anomaly detection on edge devices with our comprehensive hands-on tutorial. This SlideShare presentation will guide you through the entire process, from data collection and model training to edge deployment and real-time monitoring. Perfect for those looking to implement robust anomaly detection systems on resource-constrained IoT/edge devices.
Key Topics Covered
1. Introduction to Anomaly Detection
- Understand the fundamentals of anomaly detection and its importance in identifying unusual behavior or failures in systems.
2. Understanding Edge (IoT)
- Learn about edge computing and IoT, and how they enable real-time data processing and decision-making at the source.
3. What is ArgoCD?
- Discover ArgoCD, a declarative, GitOps continuous delivery tool for Kubernetes, and its role in deploying applications on edge devices.
4. Deployment Using ArgoCD for Edge Devices
- Step-by-step guide on deploying anomaly detection models on edge devices using ArgoCD.
5. Introduction to Apache Kafka and S3
- Explore Apache Kafka for real-time data streaming and Amazon S3 for scalable storage solutions.
6. Viewing Kafka Messages in the Data Lake
- Learn how to view and analyze Kafka messages stored in a data lake for better insights.
7. What is Prometheus?
- Get to know Prometheus, an open-source monitoring and alerting toolkit, and its application in monitoring edge devices.
8. Monitoring Application Metrics with Prometheus
- Detailed instructions on setting up Prometheus to monitor the performance and health of your anomaly detection system.
9. What is Camel K?
- Introduction to Camel K, a lightweight integration framework built on Apache Camel, designed for Kubernetes.
10. Configuring Camel K Integrations for Data Pipelines
- Learn how to configure Camel K for seamless data pipeline integrations in your anomaly detection workflow.
11. What is a Jupyter Notebook?
- Overview of Jupyter Notebooks, an open-source web application for creating and sharing documents with live code, equations, visualizations, and narrative text.
12. Jupyter Notebooks with Code Examples
- Hands-on examples and code snippets in Jupyter Notebooks to help you implement and test anomaly detection models.
Main news related to the CCS TSI 2023 (2023/1695)Jakub Marek
An English 🇬🇧 translation of a presentation to the speech I gave about the main changes brought by CCS TSI 2023 at the biggest Czech conference on Communications and signalling systems on Railways, which was held in Clarion Hotel Olomouc from 7th to 9th November 2023 (konferenceszt.cz). Attended by around 500 participants and 200 on-line followers.
The original Czech 🇨🇿 version of the presentation can be found here: https://www.slideshare.net/slideshow/hlavni-novinky-souvisejici-s-ccs-tsi-2023-2023-1695/269688092 .
The videorecording (in Czech) from the presentation is available here: https://youtu.be/WzjJWm4IyPk?si=SImb06tuXGb30BEH .
Project Management Semester Long Project - Acuityjpupo2018
Acuity is an innovative learning app designed to transform the way you engage with knowledge. Powered by AI technology, Acuity takes complex topics and distills them into concise, interactive summaries that are easy to read & understand. Whether you're exploring the depths of quantum mechanics or seeking insight into historical events, Acuity provides the key information you need without the burden of lengthy texts.
Best 20 SEO Techniques To Improve Website Visibility In SERPPixlogix Infotech
Boost your website's visibility with proven SEO techniques! Our latest blog dives into essential strategies to enhance your online presence, increase traffic, and rank higher on search engines. From keyword optimization to quality content creation, learn how to make your site stand out in the crowded digital landscape. Discover actionable tips and expert insights to elevate your SEO game.
For the full video of this presentation, please visit: https://www.edge-ai-vision.com/2024/06/building-and-scaling-ai-applications-with-the-nx-ai-manager-a-presentation-from-network-optix/
Robin van Emden, Senior Director of Data Science at Network Optix, presents the “Building and Scaling AI Applications with the Nx AI Manager,” tutorial at the May 2024 Embedded Vision Summit.
In this presentation, van Emden covers the basics of scaling edge AI solutions using the Nx tool kit. He emphasizes the process of developing AI models and deploying them globally. He also showcases the conversion of AI models and the creation of effective edge AI pipelines, with a focus on pre-processing, model conversion, selecting the appropriate inference engine for the target hardware and post-processing.
van Emden shows how Nx can simplify the developer’s life and facilitate a rapid transition from concept to production-ready applications.He provides valuable insights into developing scalable and efficient edge AI solutions, with a strong focus on practical implementation.
5th LF Energy Power Grid Model Meet-up SlidesDanBrown980551
5th Power Grid Model Meet-up
It is with great pleasure that we extend to you an invitation to the 5th Power Grid Model Meet-up, scheduled for 6th June 2024. This event will adopt a hybrid format, allowing participants to join us either through an online Mircosoft Teams session or in person at TU/e located at Den Dolech 2, Eindhoven, Netherlands. The meet-up will be hosted by Eindhoven University of Technology (TU/e), a research university specializing in engineering science & technology.
Power Grid Model
The global energy transition is placing new and unprecedented demands on Distribution System Operators (DSOs). Alongside upgrades to grid capacity, processes such as digitization, capacity optimization, and congestion management are becoming vital for delivering reliable services.
Power Grid Model is an open source project from Linux Foundation Energy and provides a calculation engine that is increasingly essential for DSOs. It offers a standards-based foundation enabling real-time power systems analysis, simulations of electrical power grids, and sophisticated what-if analysis. In addition, it enables in-depth studies and analysis of the electrical power grid’s behavior and performance. This comprehensive model incorporates essential factors such as power generation capacity, electrical losses, voltage levels, power flows, and system stability.
Power Grid Model is currently being applied in a wide variety of use cases, including grid planning, expansion, reliability, and congestion studies. It can also help in analyzing the impact of renewable energy integration, assessing the effects of disturbances or faults, and developing strategies for grid control and optimization.
What to expect
For the upcoming meetup we are organizing, we have an exciting lineup of activities planned:
-Insightful presentations covering two practical applications of the Power Grid Model.
-An update on the latest advancements in Power Grid -Model technology during the first and second quarters of 2024.
-An interactive brainstorming session to discuss and propose new feature requests.
-An opportunity to connect with fellow Power Grid Model enthusiasts and users.
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?Speck&Tech
ABSTRACT: A prima vista, un mattoncino Lego e la backdoor XZ potrebbero avere in comune il fatto di essere entrambi blocchi di costruzione, o dipendenze di progetti creativi e software. La realtà è che un mattoncino Lego e il caso della backdoor XZ hanno molto di più di tutto ciò in comune.
Partecipate alla presentazione per immergervi in una storia di interoperabilità, standard e formati aperti, per poi discutere del ruolo importante che i contributori hanno in una comunità open source sostenibile.
BIO: Sostenitrice del software libero e dei formati standard e aperti. È stata un membro attivo dei progetti Fedora e openSUSE e ha co-fondato l'Associazione LibreItalia dove è stata coinvolta in diversi eventi, migrazioni e formazione relativi a LibreOffice. In precedenza ha lavorato a migrazioni e corsi di formazione su LibreOffice per diverse amministrazioni pubbliche e privati. Da gennaio 2020 lavora in SUSE come Software Release Engineer per Uyuni e SUSE Manager e quando non segue la sua passione per i computer e per Geeko coltiva la sua curiosità per l'astronomia (da cui deriva il suo nickname deneb_alpha).
1. Multi nutrient enriched diets restore cerebral
perfusion and protect against neurodegeneration in a
mouse model for Alzheimer’s disease
Valerio Zerbi1,2, D. Jansen1, X. Fang1, M. Wiesmann1, M. Mutsaers1, P.J. Dederen1,
I.Arnoldussen1, A. Veltien2, S. Van Asten2, A. Heerschap2 and A.J. Kiliaan1
1 Dept. Anatomy, Donders Centre for Neuroscience, Radboud University Nijmegen Medical
Centre, Nijmegen, the Netherlands
2 Dept. Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
2. Introduction
Alzheimer’s Disease (AD)
AD affects more than 24 million people world wide
Age is the major risk factor for AD: 47% of people older
than 85 years affected
80 million affected in 2040
Clinical phenotype: gradual episodic memory impairment
Neuropathological changes:
• Presence of plaque and tangle pathology
• Massive loss neuronal cells and synapses
• Neurodegeneration / white matter pathology
3. Introduction
Genetics & risk factors
1. Sporadic AD (late onset) Epidemiology (end of 20th century)
Causes unclear Risk factors for Alzheimer’s disease
Risk factors
Ageing
Presence of APOEε4 allele
Hypertension
Congestive heart failure
2. Familial AD (early onset) Atrial fibrillation
Mutations in amyloid precursor Atherosclerosis
Smoking
protein (APP), presenilin (PS)-1
High intake of saturated fat
or -2 genes Diabetes mellitus
contribute to increased Stroke
Sedentary lifestyle
Aβ production Overweight
White matter lesions
De la Torre JC (2002), Stroke
4. Introduction
Regulation of β-amyloid production / clearance
Physiological situation
β-amyloid Microglial cells
γ-secretase
β-secretase
Energy
supply
Blood flow
5. Introduction
Regulation of β-amyloid production / clearance
• Abnormal cleavage of APP by
γ- and β-secretase
β-amyloid Activated
•monomers • Decrease Aβ clearance by
•dimers Microglial cells reduced cerebral blood flow
γ-secretase •trimers
•Aβ oligomers and plaques
β-secretase
• Vascular amyloid deposition
(CAA)
β-amyloid
β-amyloid plaques • Chronic inflammatory
oligomers response
• Energy crisis
Energy
supply
Blood flow • Neurodegeneration
6. Introduction
Regulation of β-amyloid production / clearance
• Abnormal cleavage of APP by
γ- and β-secretase
β-amyloid Activated
•monomers • Decrease Aβ clearance by
•dimers Microglial cells reduced cerebral blood flow
γ-secretase •trimers
•Aβ oligomers and plaques
β-secretase
• Vascular amyloid deposition
(CAA)
β-amyloid
β-amyloid plaques • Chronic inflammatory
oligomers response
• Energy crisis
Energy
supply
Blood flow • Neurodegeneration
7. Introduction
Prevention strategies
• Immunotherapy Targeting Aβ
Still need to prove their efficacy on clinical trials
• “classic” vascular risk factors Prevention vascular disease
(statins, aspirin, NSAIDs) No beneficial effect on Alzheimer pathology
Improving neuronal connectivity
Improvement of neuronal membrane fluidity
• Docosahexaenoic acid (DHA) Improves vascular status and reduces
atherosclerosis
Decrease Aβ levels
Beneficial effect in patients with mild AD #
•*AD2000 collaborative group. Lancet Neurology 2008;7:41-49
•#Freund- levi et al arch neurol 2008
8. Introduction
Prevention strategies
• Immunotherapy Targeting Aβ
Still need to prove their efficacy on clinical trials
• “classic” vascular risk factors Prevention vascular disease
(statins, aspirin, NSAIDs) No beneficial effect on Alzheimer pathology
Improving neuronal connectivity
Improvement of neuronal membrane fluidity
• Docosahexaenoic acid (DHA) Improves vascular status and reduces
atherosclerosis
Decrease Aβ levels
Beneficial effect in patients with mild AD #
•*AD2000 collaborative group. Lancet Neurology 2008;7:41-49
•#Freund- levi et al arch neurol 2008
9. Introduction
Prevention strategies
• Immunotherapy Targeting Aβ
Still need to prove their efficacy on clinical trials
• “classic” vascular risk factors Prevention vascular disease
(statins, aspirin, NSAIDs) No beneficial effect on Alzheimer pathology
Improving neuronal connectivity
Improvement of neuronal membrane fluidity
• Docosahexaenoic acid (DHA) Improves vascular status and reduces
atherosclerosis
Decrease Aβ levels
Beneficial effect in patients with mild AD #
•*AD2000 collaborative group. Lancet Neurology 2008;7:41-49
•#Freund- levi et al arch neurol 2008
10. Aim of the study
Aim of the study
“to investigate the effects of DHA enriched diet on the
pathophysiology of Alzheimer’s Disease”
11. Material and methods
Animal model
• 12 months old male mice
– Transgenic strain resembling familial AD:
APP695swe/PS1∆E9 [APP/PS1]
(Dr. D. Borchelt, Baltimore, MD, USA)
– C57BL/6J [wild type] control mice
12. Material and methods
Diets
Starting from 2 months of age…
(Control) (DHA+) (Fortasyn)
5% soy oil DHA DHA
EPA EPA
Standard UMP UMP
control diet Choline
Phospholipids
B-vitamins
Anti-oxidants
Kamphuis PJ and Scheltens P (2010),
Wurtman RJ (2008)
13. Material and methods
Delatour et al., In Vivo Imaging Biomarkers in Mouse Models of Alzheimer’s
Disease: Are We Lost in Translation or Breaking Through? J Alzh dis 2010
23. Methods – Diffusion Tensor imaging
Anisotropy
• Directionally dependent
• Restriction in diffusion direction
– Because of axonal membrane
• Water molecules diffuse approximately 8 µm
in ~40 ms diffusion time.
26. Results – Diffusion Tensor imaging
Fractional anisotropy (FA, p < 0.05)
Change in APP compared to WT
corpus callosum ventricles optic tract hippocampus
FA ↓↓ ↓ ↓ -
27. Results – Diffusion Tensor imaging
Radial diffusivity (RD, p < 0.05)
Change in APP compared to WT
corpus callosum ventricles optic tract hippocampus
RD ↓ ↑↑ ↑ ↑
28. Summary
Summary
MR Control DHA+ Fortasyn
Hypothesis
Technique diet diet diet
1H metabolic
MRS
alterations
FAIR - ASL Cerebral perfusion
White matter
DT-MRI degeneration and
neuronal loss
29. Acknowledgements
Acknowledgements
Radboud Univ Nijmegen EU consortium 7th framework LipidiDiet
Medical Centre, Nijmegen,
the Netherlands (RUNMC) • Univ of Saarland (USAAR), Germany
Hartmann & Fassbender
Anatomy • Univ of Kuopio (KU), Finland
Amanda Kiliaan Tanila & Soininen
Diane Jansen • Univ of Szeged (USZEG), Hungary
Carola Janssen Penke
Maartje Mutsaers • Tel Aviv University (UTA), Israel
Jos Dederen Michaelson
Ilse Arnoldussen •Göteborgs Universitet (GU), Sweden
Xiaotian Fang Skoog & Gustafson
Maximilian Wiesmann • Danone Research B.V., the Netherlands
Michiel Kleinnijenhuis Broersen
•Karolinska Institutet (KAU), Sweden
Radiology Wahlund
Arend Heerschap •Institute of Physiology (ASCR),
Andor Veltien Czech Republic
Sjaak Van Asten Dolezal
Alan Wright •VU University Medical Centre (VUMC),
the Netherlands
Scheltens
Support: European Community’s Seventh •University of Bonn (UKB), Germany
Framework Programme (FP7/2007-2013) Lütjohann
Under grant agreement no 202167