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INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES
Preventing most overdose deaths
would be easy
So, why don’t we?
Dr Chris Ford, Clinical Director
IDHDP
ISAM Conference Dundee
Physicians globally unite for health based drug policy
Reducing overdose drug related deaths: A
major challenge for Public Health
• Over 250,000 lives were lost to drug overdoses in
world (2010)
– This represents 2 million years of life lost
• 6,100 overdose deaths in Europe in 2012, 70,000 in
first decade
– 3.5% of all deaths in males under 40 in Europe
– England & Scotland highest since records began
• 41,340 deaths in overdose deaths in US
Preventing opioid overdoses in Europe EMCDDA, Lisbon,
October 2012 (revised 2014)
Prevalence of use of opioids worldwide
Reducing drug related deaths
• What increases the risk of fatal and non-fatal
overdoses?
• What can be done to reduce these?
1. Individual factors that increase the risk
of fatal and non-fatal overdose
• Type of substance used, heroin most
• Route of administration
• Health of the person
• Poly-drug use increases risk
– Particularly heroin + benzodiazepines,
antidepressants, alcohol
– non-medical use of prescribed substitution
medications and opioid analgesics
Giraudon et al., 2013
2. Environmental factors that increase risk
of drug overdose deaths
• Disruption or
discontinuation of
treatment
• After detoxification in
rehab or particularly
prison
• Inadequate through-
care between prison
and community
Zlodre and Fazel, 2012
3. Lack of response or inadequate
interventions by those witnessing
overdoses
• Poor first aid knowledge
• Inadequate access to naloxone
• Fear of legal repercussions
What we can do to reduce overdoses
1. Interventions geared towards preventing of
overdoses
2. Reducing fatal outcomes when overdoses do
occur
Frisher et al., 2012
1. Interventions geared towards
preventing of overdoses
• Increase awareness of overdose risks to the
general public particularly people who use
drugs, their family and friends
• The provision of good effective drug
treatment and therefore retention in
treatment
• Improve through-care between prison and the
community
2. Reducing fatal outcomes when
overdoses do occur
a. Supervised drug consumption rooms
"Research to prove that injecting inside drug
consumption rooms is safer than injecting
elsewhere, is like needing to prove that jumping
from a plane with a parachute is safer than
jumping without one.”
Joan Colom I Faran in Viral Hepatitis in Europe, 2014
b. Improved bystander response
• Training for all
• Increase access to
naloxone
• Involve ambulance
and police
Improved bystander response
“People likely to witness an
opioid overdose should have
access to naloxone and be
instructed in its
administration to enable
them to use it for the
emergency management of
suspected opioid overdose.”
Community management of opioid
overdose
World Health Organization 2014
Improved bystander response
Most heroin users
witness/experience an
overdose at some point:
From a sample of 155 drug
using clients:
– 46% had overdosed
themselves
– 82% had witnessed an
overdose
– 43 of which were fatal
46%
82%
43
Best D., Man LH., Gossop M., Noble A., Strang J., 2000
Part of the solution
“…naloxone is part of a comprehensive approach
to services for drug users and can reverse the
effects of opioids and prevent mortality.”
UN Resolution 55/7: Promoting measures
to prevent drug overdose, 2014
Countries which have Naloxone
Counries with naloxone
Counries without
naloxone
No data
What joins all factors that affect
overdose deaths?
INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES
Overdose deaths can be reduced
The science is easy
It’s the policies that need changing
Physicians globally unite for health based drug policy
Opportunity for doctors:
April 2016 will see the next UN General Assembly Special
Session (“UNGASS”) where future drug policy will be debated.
Until then physicians can make themselves heard and ensure
health is pushed up the drug policy agenda.
What can you do………….?
INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES
Physicians globally unite for health based drug policy
By joining IDHDP you will be adding your voice to a growing
number of physicians calling for health based drug policies.
Join at www.idhdp.com
It’s free - it’s easy and by joining you will receive our very
informative newsletter
Twitter @idhdp
INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES
Physicians globally unite for health based drug policy
INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES
Physicians globally unite for health based drug policy
Thank you
Dr Chris Ford
chris.ford@idhdp.com
www.idhdp.com
@IDHDP

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Preventing most overdose deaths would be easy So, why don’t we?

  • 1. INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES Preventing most overdose deaths would be easy So, why don’t we? Dr Chris Ford, Clinical Director IDHDP ISAM Conference Dundee Physicians globally unite for health based drug policy
  • 2. Reducing overdose drug related deaths: A major challenge for Public Health • Over 250,000 lives were lost to drug overdoses in world (2010) – This represents 2 million years of life lost • 6,100 overdose deaths in Europe in 2012, 70,000 in first decade – 3.5% of all deaths in males under 40 in Europe – England & Scotland highest since records began • 41,340 deaths in overdose deaths in US Preventing opioid overdoses in Europe EMCDDA, Lisbon, October 2012 (revised 2014)
  • 3. Prevalence of use of opioids worldwide
  • 4. Reducing drug related deaths • What increases the risk of fatal and non-fatal overdoses? • What can be done to reduce these?
  • 5. 1. Individual factors that increase the risk of fatal and non-fatal overdose • Type of substance used, heroin most • Route of administration • Health of the person • Poly-drug use increases risk – Particularly heroin + benzodiazepines, antidepressants, alcohol – non-medical use of prescribed substitution medications and opioid analgesics Giraudon et al., 2013
  • 6. 2. Environmental factors that increase risk of drug overdose deaths • Disruption or discontinuation of treatment • After detoxification in rehab or particularly prison • Inadequate through- care between prison and community Zlodre and Fazel, 2012
  • 7.
  • 8.
  • 9. 3. Lack of response or inadequate interventions by those witnessing overdoses • Poor first aid knowledge • Inadequate access to naloxone • Fear of legal repercussions
  • 10. What we can do to reduce overdoses 1. Interventions geared towards preventing of overdoses 2. Reducing fatal outcomes when overdoses do occur Frisher et al., 2012
  • 11. 1. Interventions geared towards preventing of overdoses • Increase awareness of overdose risks to the general public particularly people who use drugs, their family and friends • The provision of good effective drug treatment and therefore retention in treatment • Improve through-care between prison and the community
  • 12. 2. Reducing fatal outcomes when overdoses do occur a. Supervised drug consumption rooms "Research to prove that injecting inside drug consumption rooms is safer than injecting elsewhere, is like needing to prove that jumping from a plane with a parachute is safer than jumping without one.” Joan Colom I Faran in Viral Hepatitis in Europe, 2014
  • 13. b. Improved bystander response • Training for all • Increase access to naloxone • Involve ambulance and police
  • 14. Improved bystander response “People likely to witness an opioid overdose should have access to naloxone and be instructed in its administration to enable them to use it for the emergency management of suspected opioid overdose.” Community management of opioid overdose World Health Organization 2014
  • 15. Improved bystander response Most heroin users witness/experience an overdose at some point: From a sample of 155 drug using clients: – 46% had overdosed themselves – 82% had witnessed an overdose – 43 of which were fatal 46% 82% 43 Best D., Man LH., Gossop M., Noble A., Strang J., 2000
  • 16. Part of the solution “…naloxone is part of a comprehensive approach to services for drug users and can reverse the effects of opioids and prevent mortality.” UN Resolution 55/7: Promoting measures to prevent drug overdose, 2014
  • 17. Countries which have Naloxone Counries with naloxone Counries without naloxone No data
  • 18. What joins all factors that affect overdose deaths?
  • 19.
  • 20. INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES Overdose deaths can be reduced The science is easy It’s the policies that need changing Physicians globally unite for health based drug policy
  • 21. Opportunity for doctors: April 2016 will see the next UN General Assembly Special Session (“UNGASS”) where future drug policy will be debated. Until then physicians can make themselves heard and ensure health is pushed up the drug policy agenda. What can you do………….? INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES Physicians globally unite for health based drug policy
  • 22. By joining IDHDP you will be adding your voice to a growing number of physicians calling for health based drug policies. Join at www.idhdp.com It’s free - it’s easy and by joining you will receive our very informative newsletter Twitter @idhdp INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES Physicians globally unite for health based drug policy
  • 23. INTERNATIONAL DOCTORS FOR HEALTHIER DRUG POLICIES Physicians globally unite for health based drug policy Thank you Dr Chris Ford chris.ford@idhdp.com www.idhdp.com @IDHDP

Editor's Notes

  1. 1
  2. Rise in deaths UK = 5th highest rate in EU of deaths/million population. Mortality due to drug-induced deaths in EU, Croatia, Turkey and Norway (European Monitoring committee for Drugs and Drug Addiction 2013) Asia – poor data Austrlia high South Americaa – low but low opiods
  3. Large part of deaths are opioid deaths: Most overdose deaths are linked to the use of opioids, primarily the injection of heroin 27 million users of opioids worldwide (0.6% world pop) 1.3 million users of opioids in Europe
  4. Siobhan’s story
  5. Type of substance used Route of administration Health of the person – older sicker – in Europe and England many deaths in over 40 all have an impact on the risk of overdose Most overdose deaths are linked to opioid use, mainly heroin Polydrug use increases risk, particularly heroin + Benzodiazepines, Antidepressants, alcohol non-medical use of prescribed substitution medications and opioid analgesics Giraudon et al., 2013
  6. Treatment is protective but only when in Reduced tolerance and result they are at particularly high risk of overdosing. Inadequate through-care between prison and community is important environmental risk factor Farrell and Marsden’s study of more than 48,000 prison releases found that injecting drug users were eight times more likely to die in the two weeks that followed release from prison than at any other time in their lives; 87% of these deaths involved opiate drugs.
  7. Fear of legal repercussions, increases the risk of an overdose event having a fatal outcome
  8. Several interventions are recommended to help reduce the high numbers of overdose deaths among former prisoners in the period shortly after leaving prison (Merrall et al., 2010; Binswanger et al., 2013). (Merrall et al., 2010; Binswanger et al., 2013). These include pre-release education on overdose risks and prevention, continuation and initiation of substitution treatment and improved referral to aftercare and community treatment services (WHO, 2010). A randomised trial (N-ALIVE trial) is under way to test the hypothesis that giving naloxone on release to prisoners with a history of heroin injecting will reduce heroin overdose deaths in this population during the most risky period — the first 12 weeks after release (Strang et al., 2013). Increasing awareness of and information about overdose risks to PUDs Training in all settings Screening for overdose risk by those treating heroin users may contribute to reductions in overall mortality (Darke et al., 2011) overdose risk assessment interventions can assist the early identification of high-risk individuals Provision of effective drug treatment and retention in treatment Opioid substitution treatment (OST) substantially reduces the risk of mortality, as long as doses are sufficient and continuity of treatment is maintained (e.g. Degenhardt et al., 2011) A prospective observational cohort study conducted in Edinburgh recently confirmed that survival is increased by cumulative exposure to treatment (Kimber et al., 2010 Retention in drug treatment is a protective factor against overdose deaths, increasing access to and coverage of treatment services should be a priority implementation of good treatment practice, which involves the use of clinical guidelines and training doctors in prescribing practices (including benzodiazepine prescribing). Improving throughcare between prison and community pre-release education on overdose risks and prevention continuation and initiation of substitution treatment improved referral to aftercare and community treatment services (WHO, 2010) giving naloxone on release to prisoners with a history of heroin injecting, especially in the first 12 weeks after release (Bird and Strang et al., 2014) Paper this month in Addiction: Following the introduction of a prison-based opioid substitution therapy (OST) policy in Scotland, the rate of drug-related deaths in the 12 weeks following release fell by two-fifths. However, the proportion of deaths that occurred in the first 14 days did not change appreciably, suggesting that in-prison OST does not reduce early deaths after release. Indefinite maintenance on drugs like methadone is the only approach that has been proven to reduce the risk of overdose death by 75%
  9. Reach marginalised high-risk drug users and connect to wider care Reduce acute risks of diseases and overdose death associated with injecting or inhalative drug use, and to reduce public drug use (EMCDDA, 2015) Provide a safer drug use environment, advice on safer injecting and medical supervision, and are equipped to manage drug overdoses Reduce related morbidity and mortality Reduction in overdose mortality at population level in the local area e.g. Vancouver (Marshall et al., 2011) (EMCDDA Perspectives on Drugs, 2015) a. a. Drug Consumption Rooms In 2014 there are now 88 drug consumption rooms (DCRs) operating worldwide. DCRs form a vital part of harm reduction services in some parts of Western Europe, allowing people who use drugs to inject in a safe space and under medical supervision. Outside of Europe two DCRs are in operation, one in Australia and one in Canada. In Western Europe, Denmark saw the implementation of five DCRs, and both Spain and Switzerland, who had previous DCRs in operation increased their site provision by six each. Between 2012-2014 a DCR was also opened in Greece but closed due to political pressures, and a reduction of DCRs has been seen in Germany with a decrease of 3 between 2012 to 2014, and the Netherlands, which saw a decrease of 10 in the same time period. Supervised drug consumption rooms A total of 74 facilities for supervised drug consumption operate across five Member States and Norway, serving specific subgroups of highly marginalised and homeless drug users. Supervised drug consumption facilities aim to reach marginalised high-risk drug users and connect them to the wider network of care, to reduce acute risks of diseases and overdose death associated with injecting or inhalative drug use, and to reduce public drug use (EMCDDA, 2015). Consumption rooms are highly targeted services, usually integrated within facilities that offer a broad range of other health and social services. They provide a safer drug use environment, advice on safer injecting and medical supervision, and are equipped to manage drug overdoses and reduce related morbidity and mortality. Millions of injections have been supervised and no overdose fatalities have occurred in the facilities. Evidence from robust studies document increased access to health and social services among clients of supervised drug consumption facilities as well as decreased public drug use and associated nuisance. A reduction in overdose mortality at population level was documented in the local area in the city of Vancouver, where a supervised injecting facility operates (Marshall et al., 2011). See also, Drug consumption rooms (EMCDDA Perspectives on Drugs, 2015).
  10. Fear of legal repercussions, increases the risk of an overdose event having a fatal outcome
  11. . These human networks, with appropriate training and awareness raising, can be utilised to prevent overdose deaths. Interventions that aim to improve bystander responses consist of training peers and family members of drug users in overdose prevention, recognition and response. In their new guidelines on community management of opioid overdose, the Word Health Organization recommends that people likely to witness an opioid overdose should have access to naloxone — an effective antidote that can reverse opioid intoxication — and should be instructed in its administration (WHO, 2014). Evidence shows that educational and training interventions for peers and family members, complemented by take-home naloxone, help decrease overdose-related mortality (EMCDDA, 2015). In October 2014, the EMCDDA brought together naloxone projects for a Europe-wide exchange of knowledge and experience.
  12. The sample of drug using clients was from a study in South London in 2000 Most overdoses occur when others are present and most injecting drug users have witnessed or experienced overdoses. Therefore, drug users themselves, or their friends and family, are likely to be both bystanders and potential first responders in emergency overdose situations (Strang et al., 2008).
  13. . These human networks, with appropriate training and awareness raising, can be utilised to prevent overdose deaths. Interventions that aim to improve bystander responses consist of training peers and family members of drug users in overdose prevention, recognition and response. In their new guidelines on community management of opioid overdose, the Word Health Organization recommends that people likely to witness an opioid overdose should have access to naloxone — an effective antidote that can reverse opioid intoxication — and should be instructed in its administration (WHO, 2014). Evidence shows that educational and training interventions for peers and family members, complemented by take-home naloxone, help decrease overdose-related mortality (EMCDDA, 2015). In October 2014, the EMCDDA brought together naloxone projects for a Europe-wide exchange of knowledge and experience. This is my biggest problem with all the efforts to promote naloxone - couldn't we do more to stop people overdosing in the first place?! It's like suggesting that rather than prescribe aspirin to prevent heart attacks we shouldn't bother and we should put defibs on every corner instead. (Might use that line somewhere.) Grrrrrr. 
  14. IDHDP survey results found in 21 countries Denmark, Germany, Italy, Romania, United Kingdom, Afghanistan, Australia, Canada, China, India, Italy, Kazakhstan, Kyrgyzstan, Tajikistan, Thailand, United Kingdom, United States, Ukraine and Vietnam report the existence of naloxone programmes The measure is regarded as a low-cost approach that can empower healthcare workers and people who use drugs to save lives Why not more available -stigma? Deaths from anaphylaxis/allergy:
  15. 20
  16. 23