The opioid epidemic in Philadelphia has intensified, largely due to increased prescriptions and the emergence of fentanyl, resulting in a significant rise in overdose deaths. The Mayor's Task Force reviewed various elements of this crisis, emphasizing the need for enhanced treatment access, public education, and comprehensive data monitoring to combat opioid misuse and its societal impacts. Recommendations include improving healthcare provider education, expanding medicated-assisted treatment, and addressing homelessness among opioid users.