The document discusses UNODC's mandate related to drug use, treatment, rehabilitation, and HIV issues. It notes that UNODC works with the Commission on Narcotic Drugs and the Commission on Crime Prevention and Criminal Justice on these topics. It then discusses why drug dependence treatment and rehabilitation are important, noting the high rates of HIV and tuberculosis in prison populations. The document advocates for integrating drug treatment, HIV prevention, and healthcare and supports expanded treatment and rehabilitation options.