This document discusses antimicrobial resistance and antibiotic use. It defines antibiotics and their classifications including site of action, mode of action, and spectrum of activity. It discusses the misuse of antibiotics and factors that can lead to drug resistance. Antimicrobial resistance has reached crisis levels and is linked to overuse of antibiotics. The document recommends educating healthcare professionals, hospitals, pharmacists, students and patients about appropriate antibiotic usage to curb rising antimicrobial resistance.
Future impacts of antibiotic resistance
Antibiotic resistance poses serious risks to global public health in the future, including the potential for 10 million deaths per year by 2050 from currently treatable infections and diseases becoming deadly again without effective treatments. Recognition of these future impacts is important for emphasizing the urgent need to change antibiotic prescription and usage. If antibiotic resistance continues to grow, global health systems will lose control over infectious diseases and see increased rates of severe infection, hospitalization, disability and death. Many medical procedures may also become riskier as common postoperative infections become difficult or impossible to treat.
Antimicrobial resistance (AMR) occurs when microorganisms change when exposed to antimicrobial drugs, becoming 'superbugs' that medicines become ineffective against, allowing infections to persist and spread. This threatens global health by making infections difficult to treat, increasing mortality and healthcare costs. The top 10 most dangerous antibiotic resistant bacteria are described, along with factors contributing to AMR like overuse and misuse of antibiotics in humans, agriculture, personal care products and the environment. Additional precautions are needed when treating infections from antibiotic resistant bacteria. Public measures like handwashing and not sharing personal items can help reduce spread.
The document discusses bacteriophages (phages), including their taxonomy, characteristics, uses in treating antibiotic resistance, and applications. Phages are viruses that infect bacteria and there are over 100 phage species. Phage therapy uses phages to treat bacterial infections and was commonly used in the early 20th century before being replaced by antibiotics. Recent interest has grown in phage therapy and other applications of phages due to increasing antibiotic resistance. Phages and their enzymes (enzybiotics) show potential for treating various infections and in industries like food processing.
The document discusses the importance of developing an antibiotic policy to improve antibiotic use and combat antibiotic resistance. It notes that overuse and misuse of antibiotics in various healthcare, agricultural, and community settings has contributed significantly to the rise of antibiotic-resistant bacteria. An antibiotic policy aims to standardize and promote best practices for antibiotic prophylaxis and treatment. It also seeks to improve education, optimize resource use, and slow the emergence and spread of resistant bacteria. Developing effective antibiotic stewardship requires coordinated efforts between clinicians, microbiologists, pharmacists, and other stakeholders. Ongoing monitoring of resistance patterns and prudent prescribing guided by local susceptibility data are also emphasized.
The document provides an overview of antibiotic resistance, including definitions of antibiotics and antibiotic resistance. It discusses mechanisms of antibiotic resistance such as enzyme modification, altered target sites, efflux pumps, and decreased membrane permeability. Causes of resistance include overuse and misuse of antibiotics in humans, agriculture, and health care settings. Management of resistance involves prudent antibiotic use, infection control, developing new antibiotics, and global cooperation. National action plans aim to combat resistance through improved awareness, surveillance, optimal antibiotic use, and investments in research.
This document discusses antimicrobial resistance and antibiotic use. It defines antibiotics and their classifications including site of action, mode of action, and spectrum of activity. It discusses the misuse of antibiotics and factors that can lead to drug resistance. Antimicrobial resistance has reached crisis levels and is linked to overuse of antibiotics. The document recommends educating healthcare professionals, hospitals, pharmacists, students and patients about appropriate antibiotic usage to curb rising antimicrobial resistance.
Future impacts of antibiotic resistance
Antibiotic resistance poses serious risks to global public health in the future, including the potential for 10 million deaths per year by 2050 from currently treatable infections and diseases becoming deadly again without effective treatments. Recognition of these future impacts is important for emphasizing the urgent need to change antibiotic prescription and usage. If antibiotic resistance continues to grow, global health systems will lose control over infectious diseases and see increased rates of severe infection, hospitalization, disability and death. Many medical procedures may also become riskier as common postoperative infections become difficult or impossible to treat.
Antimicrobial resistance (AMR) occurs when microorganisms change when exposed to antimicrobial drugs, becoming 'superbugs' that medicines become ineffective against, allowing infections to persist and spread. This threatens global health by making infections difficult to treat, increasing mortality and healthcare costs. The top 10 most dangerous antibiotic resistant bacteria are described, along with factors contributing to AMR like overuse and misuse of antibiotics in humans, agriculture, personal care products and the environment. Additional precautions are needed when treating infections from antibiotic resistant bacteria. Public measures like handwashing and not sharing personal items can help reduce spread.
The document discusses bacteriophages (phages), including their taxonomy, characteristics, uses in treating antibiotic resistance, and applications. Phages are viruses that infect bacteria and there are over 100 phage species. Phage therapy uses phages to treat bacterial infections and was commonly used in the early 20th century before being replaced by antibiotics. Recent interest has grown in phage therapy and other applications of phages due to increasing antibiotic resistance. Phages and their enzymes (enzybiotics) show potential for treating various infections and in industries like food processing.
The document discusses the importance of developing an antibiotic policy to improve antibiotic use and combat antibiotic resistance. It notes that overuse and misuse of antibiotics in various healthcare, agricultural, and community settings has contributed significantly to the rise of antibiotic-resistant bacteria. An antibiotic policy aims to standardize and promote best practices for antibiotic prophylaxis and treatment. It also seeks to improve education, optimize resource use, and slow the emergence and spread of resistant bacteria. Developing effective antibiotic stewardship requires coordinated efforts between clinicians, microbiologists, pharmacists, and other stakeholders. Ongoing monitoring of resistance patterns and prudent prescribing guided by local susceptibility data are also emphasized.
The document provides an overview of antibiotic resistance, including definitions of antibiotics and antibiotic resistance. It discusses mechanisms of antibiotic resistance such as enzyme modification, altered target sites, efflux pumps, and decreased membrane permeability. Causes of resistance include overuse and misuse of antibiotics in humans, agriculture, and health care settings. Management of resistance involves prudent antibiotic use, infection control, developing new antibiotics, and global cooperation. National action plans aim to combat resistance through improved awareness, surveillance, optimal antibiotic use, and investments in research.
Mechanism Antibiotic Resistance
Intrinsic (Natural)
Acquired
Chromosomal
Extra chromosomal
Intrinsic Resistance
Lack target : No cell wall; innately resistant to penicillin
2. Drug inactivation: Cephalosporinase in Klebsiella
3. Innate efflux pumps:
It is an active transport mechanism. It requires ATP.
Eg. E. coli, P. aeruginosa
Altered target sites
PBP alteration
Ribosomal target alteration
Decreased affinity by target modification
Beta-lactamase
Beta-lactamases are enzymes produced by bacteria that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems
Major resistant Pathogen
1. PRSP- Penicillin resistant Streptococcus pneumoniae2. MRSA/ORSA- Methicillin-resistant Staphylococcus Aureus (Super bug)3. VRE -Vancomycin-Resistant Enterococci4. Carbapenem resistant pseudomonas aeruginosa5. Carbapenem resistant Carbapenem resistant 6. Extended spectrum beta-lactamase (ESBL)-producing bacteria
Antibiotic resistance occurs when bacteria change in response to antibiotic use, making infections harder to treat. Bacteria, not humans or animals, become resistant. This leads to higher medical costs, prolonged hospital stays, and increased deaths. Antibiotic resistance threatens global health and can affect anyone, of any age, in any country. It occurs naturally but also because of misuse of antibiotics in humans and farm animals. This is making many infections like pneumonia, tuberculosis, and gonorrhea more difficult to treat.
This document discusses bacteriophage therapy as an alternative approach to antibiotic resistance. It begins with an introduction to antibiotic resistance and discusses the mechanisms and factors contributing to resistance. It then introduces bacteriophage or phages, describing their classification, life cycles, and mechanisms of infecting bacteria. The document outlines methods for preparing and administering phage therapy. It discusses advantages of phage therapy over antibiotics and provides examples of phage therapy applications in food and agriculture. Finally, it addresses some challenges to phage therapy including host range, bacterial debris in preparations, and lysogeny.
This document discusses multidrug-resistant and extensively drug-resistant organisms (MDROs and XDRs). It defines antibiotic resistance and how bacteria can become resistant through improper antibiotic usage and transmission of resistance genes. Common MDROs include MRSA, VRE, and carbapenem-resistant Enterobacteriaceae. XDR tuberculosis is described as being resistant to nearly all drug classes. Treatment of MDROs and XDRs is difficult as few drug options remain effective. The prevention of further resistance development requires appropriate antibiotic prescribing and hygiene practices to limit transmission.
FLOW OF THE SEMINAR
1. Definition – antibiotic resistance, Multi-resistance, cross-resistance in antibiotics
2. Evolution of resistance
3. Impact of resistance
4. The scenario of resistance: Global, India
5. Factors causing resistance
6. Mechanisms of resistance: Intrinsic and Acquired
7. Acquired mechanism of resistance
8. Quorum sensing
9. Mechanism of resistance in commonly used antibiotics
10. Methods for determining the resistance
11. Strategies to contain resistance
12. Antibiotic stewardship
13. Role of Pharmacologist
14. Initiatives undertaken by India to control resistance
Antimicrobial Resistance: A One Health Challenge for Joint ActionSIANI
Presented by Juan Lubroth at the seminar "Antimicrobial resistance; linkages between humans, livestock and water in peri-urban areas" at the World Water Week, 29th August 2016.
The document discusses antimicrobial resistance in bacteria. It begins by defining antimicrobial resistance as the ability of microorganisms to resist antimicrobial agents that they were previously susceptible to. The two main types are acquired resistance, which occurs when bacteria gain resistance genes, and intrinsic resistance, which refers to innate resistance in certain bacterial species. The overuse and misuse of antimicrobials is identified as the primary driver in the emergence and spread of resistant bacteria. The mechanisms by which bacteria develop resistance are explored, such as decreasing drug permeability, active drug efflux, and enzymatic inactivation or modification of drug targets. Methods for laboratory testing of bacterial resistance are also summarized.
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
This document discusses antimicrobial resistance and provides definitions, history, and mechanisms. It defines antimicrobial resistance as the ability of microorganisms like bacteria, viruses, and parasites to stop antimicrobial drugs from working against them. The discovery of antimicrobials created new treatments but microbes developed resistance over time. Factors that contribute to resistance include overuse of antibiotics, lack of sanitation, and transmission of resistant genes between bacteria. Resistance occurs via natural and acquired mechanisms, the latter being a major clinical problem. Strategies to address resistance include prudent antibiotic use, developing new drugs, and alternative approaches like phage therapy.
This document provides an antibiogram for Jindal Institute of Medical Science summarizing the types of bacterial isolates found from patient samples over a one month period and their antibiotic sensitivities. It lists the most common gram positive and gram negative isolates from urine, sputum/endotracheal secretions, pus, and blood samples. It then details the sensitivity of these isolates to various antibiotics, with E.coli and Klebsiella being highly sensitive to imipenem, amikacin and piperacillin-tazobactam according to the data. The document concludes with rates of multidrug-resistant organisms identified.
Role of the Laboratory in Antimicrobial Resistance DataAnuj Sharma
The document discusses the role of microbiology laboratories in collecting, analyzing, and circulating antimicrobial resistance data. It outlines how laboratories provide antibiograms, which summarize local bacterial susceptibility patterns to guide empiric antibiotic therapy. The data can also be used for quality improvement, infection control, outbreak detection, and surveillance of resistance trends over time. The document recommends following Clinical and Laboratory Standards Institute guidelines for generating high quality antibiograms and discusses how data can be managed and shared using software tools like WHONET.
Mechanistic View of Antibiotic Resistance
1. Antibiotic resistance occurs when bacteria no longer respond to antibiotics designed to kill them, allowing them to continue growing. 2. Resistance can be intrinsic, through natural mechanisms like efflux pumps, or acquired through genetic mutations or transfer of genes. 3. Acquired resistance is a concern as it can lead to treatment failure, increased mortality, and spread in communities.
updated statistics about antimicrobial resistance,causes and mechanism of antimicrobial resistances, national antimicrobial policy, national antimicrobial surveillance, new delhi b metallo-lactamase-1 bacteria
WHO - AMR Global Overview and Action Planmarkovingian
Diberikan dan disampaikan pada Seminar "Cegah Resistensi Antibiotik: Demi Selamatkan Manusia", kerjasama Kemenkes, WHO, dan Yayasan Orang Tua Peduli, didukung oleh React, 5 Agustus 2015
Phage therapy (PT) is also called bacteriophage therapy. It uses viruses to treat bacterial infections. Bacterial viruses are called phages or bacteriophages. They only attack bacteria; phages are harmless to people, animals, and plants. Bacteriophages are the natural enemies of bacteria.
An tibiotic policy in medical care seminardeepak deshkar
This document outlines an antibiotic policy and discusses the importance of prudent antibiotic usage to reduce antibiotic resistance. It notes that nearly half of hospitalized patients receive antibiotics. While antibiotics have been life-saving, their overuse for trivial infections, commercial pressures, and poverty have encouraged resistance. Antibiotic resistance arises from genetic changes and spread of R plasmids between bacteria. Indiscriminate antibiotic use in animals and humans has led to the spread of resistant organisms. The policy aims to reduce resistance by engaging all prescribers, restricting certain antibiotics, and ensuring adherence through surveillance and education. The roles of microbiologists, pharmacists, and continuous staff training are emphasized.
This document discusses antibiotic resistance. It begins by defining antibiotic resistance and explaining that it is a natural phenomenon accelerated by antibiotic use, allowing resistant bacterial strains to survive and multiply. It then outlines various mechanisms of resistance, including enzymatic modification of antibiotics, decreased bacterial membrane permeability, efflux pumps that remove antibiotics, alterations of antibiotic targets or cell wall precursors, overproduction of targets, and bypassing antibiotic inhibition. The document also discusses how resistance spreads between bacteria through horizontal gene transfer and provides several examples of multidrug-resistant pathogens. It emphasizes the importance of addressing antibiotic resistance due to increased mortality, costs, and few treatment options.
This document discusses antibiotic resistance and new approaches to address it. It notes that inappropriate antibiotic usage and lack of regulation have contributed to rising drug resistance. Newly identified resistant bacteria and better infection control strategies are discussed as newer approaches. These include using bacteriophages and quorum sensing inhibitors as alternatives to antibiotics. The document also highlights India's National Antibiotic Policy and the Chennai Declaration which call for restricting certain antibiotic sales and implementing antibiotic stewardship programs in hospitals.
This document discusses antimicrobial resistance, including its definition, causes, mechanisms, and impact. It notes that resistance arises naturally but is accelerated by misuse and overuse of antimicrobials in both humans and animals. Resistance occurs via several mechanisms including inactivating drugs, modifying drug targets in bacteria, exporting drugs from bacteria, reducing drug permeability, and mutating genes involved in drug mechanisms of action. It highlights several important antibiotic-resistant bacteria like MRSA, VRE, and multi-drug resistant TB. The global spread of resistance poses a major threat to modern medicine.
Multi drug resistance molecular pathogenesisAlagar Suresh
The document discusses multi-drug resistance and antibiotic resistance. It provides background on the history of antibiotics and resistance. It then covers the major topics of how antibacterial resistance develops through various mechanisms like mutations, plasmids, efflux pumps, and inactivating enzymes. The document also discusses the Indian scenario of rising drug resistance and the growing problem of NDM-1 enzyme production. It concludes by outlining some strategies to address resistance like developing new antibiotics, prudent antibiotic use, and alternative approaches like phage therapy and quorum sensing inhibition.
Environmental Consequences of Genetically-Modified Foods, Biopharming and rBGHJack Olmsted
Martin Donohoe, MD, FACP
Portland State University
Oregon Physicians for Social Responsibility
With thanks to Rick North, Project Director, Campaign for Safe Food
Oregon Physicians for Social Responsibility
The document discusses the importance of biodiversity for human health and society. It defines biodiversity as the variety of life on Earth, including genetic, species, and ecosystem diversity. Biodiversity is essential for supporting human needs like food, water, and medicine. However, human activities like habitat destruction, pollution, and climate change are causing a current mass extinction. This loss of biodiversity threatens human health by reducing food security and increasing diseases. The document outlines how protecting biodiversity benefits people through medicines, business, livelihoods, and protection from disasters. Maintaining biodiversity is crucial for sustaining a healthy society.
Mechanism Antibiotic Resistance
Intrinsic (Natural)
Acquired
Chromosomal
Extra chromosomal
Intrinsic Resistance
Lack target : No cell wall; innately resistant to penicillin
2. Drug inactivation: Cephalosporinase in Klebsiella
3. Innate efflux pumps:
It is an active transport mechanism. It requires ATP.
Eg. E. coli, P. aeruginosa
Altered target sites
PBP alteration
Ribosomal target alteration
Decreased affinity by target modification
Beta-lactamase
Beta-lactamases are enzymes produced by bacteria that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems
Major resistant Pathogen
1. PRSP- Penicillin resistant Streptococcus pneumoniae2. MRSA/ORSA- Methicillin-resistant Staphylococcus Aureus (Super bug)3. VRE -Vancomycin-Resistant Enterococci4. Carbapenem resistant pseudomonas aeruginosa5. Carbapenem resistant Carbapenem resistant 6. Extended spectrum beta-lactamase (ESBL)-producing bacteria
Antibiotic resistance occurs when bacteria change in response to antibiotic use, making infections harder to treat. Bacteria, not humans or animals, become resistant. This leads to higher medical costs, prolonged hospital stays, and increased deaths. Antibiotic resistance threatens global health and can affect anyone, of any age, in any country. It occurs naturally but also because of misuse of antibiotics in humans and farm animals. This is making many infections like pneumonia, tuberculosis, and gonorrhea more difficult to treat.
This document discusses bacteriophage therapy as an alternative approach to antibiotic resistance. It begins with an introduction to antibiotic resistance and discusses the mechanisms and factors contributing to resistance. It then introduces bacteriophage or phages, describing their classification, life cycles, and mechanisms of infecting bacteria. The document outlines methods for preparing and administering phage therapy. It discusses advantages of phage therapy over antibiotics and provides examples of phage therapy applications in food and agriculture. Finally, it addresses some challenges to phage therapy including host range, bacterial debris in preparations, and lysogeny.
This document discusses multidrug-resistant and extensively drug-resistant organisms (MDROs and XDRs). It defines antibiotic resistance and how bacteria can become resistant through improper antibiotic usage and transmission of resistance genes. Common MDROs include MRSA, VRE, and carbapenem-resistant Enterobacteriaceae. XDR tuberculosis is described as being resistant to nearly all drug classes. Treatment of MDROs and XDRs is difficult as few drug options remain effective. The prevention of further resistance development requires appropriate antibiotic prescribing and hygiene practices to limit transmission.
FLOW OF THE SEMINAR
1. Definition – antibiotic resistance, Multi-resistance, cross-resistance in antibiotics
2. Evolution of resistance
3. Impact of resistance
4. The scenario of resistance: Global, India
5. Factors causing resistance
6. Mechanisms of resistance: Intrinsic and Acquired
7. Acquired mechanism of resistance
8. Quorum sensing
9. Mechanism of resistance in commonly used antibiotics
10. Methods for determining the resistance
11. Strategies to contain resistance
12. Antibiotic stewardship
13. Role of Pharmacologist
14. Initiatives undertaken by India to control resistance
Antimicrobial Resistance: A One Health Challenge for Joint ActionSIANI
Presented by Juan Lubroth at the seminar "Antimicrobial resistance; linkages between humans, livestock and water in peri-urban areas" at the World Water Week, 29th August 2016.
The document discusses antimicrobial resistance in bacteria. It begins by defining antimicrobial resistance as the ability of microorganisms to resist antimicrobial agents that they were previously susceptible to. The two main types are acquired resistance, which occurs when bacteria gain resistance genes, and intrinsic resistance, which refers to innate resistance in certain bacterial species. The overuse and misuse of antimicrobials is identified as the primary driver in the emergence and spread of resistant bacteria. The mechanisms by which bacteria develop resistance are explored, such as decreasing drug permeability, active drug efflux, and enzymatic inactivation or modification of drug targets. Methods for laboratory testing of bacterial resistance are also summarized.
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
This document discusses antimicrobial resistance and provides definitions, history, and mechanisms. It defines antimicrobial resistance as the ability of microorganisms like bacteria, viruses, and parasites to stop antimicrobial drugs from working against them. The discovery of antimicrobials created new treatments but microbes developed resistance over time. Factors that contribute to resistance include overuse of antibiotics, lack of sanitation, and transmission of resistant genes between bacteria. Resistance occurs via natural and acquired mechanisms, the latter being a major clinical problem. Strategies to address resistance include prudent antibiotic use, developing new drugs, and alternative approaches like phage therapy.
This document provides an antibiogram for Jindal Institute of Medical Science summarizing the types of bacterial isolates found from patient samples over a one month period and their antibiotic sensitivities. It lists the most common gram positive and gram negative isolates from urine, sputum/endotracheal secretions, pus, and blood samples. It then details the sensitivity of these isolates to various antibiotics, with E.coli and Klebsiella being highly sensitive to imipenem, amikacin and piperacillin-tazobactam according to the data. The document concludes with rates of multidrug-resistant organisms identified.
Role of the Laboratory in Antimicrobial Resistance DataAnuj Sharma
The document discusses the role of microbiology laboratories in collecting, analyzing, and circulating antimicrobial resistance data. It outlines how laboratories provide antibiograms, which summarize local bacterial susceptibility patterns to guide empiric antibiotic therapy. The data can also be used for quality improvement, infection control, outbreak detection, and surveillance of resistance trends over time. The document recommends following Clinical and Laboratory Standards Institute guidelines for generating high quality antibiograms and discusses how data can be managed and shared using software tools like WHONET.
Mechanistic View of Antibiotic Resistance
1. Antibiotic resistance occurs when bacteria no longer respond to antibiotics designed to kill them, allowing them to continue growing. 2. Resistance can be intrinsic, through natural mechanisms like efflux pumps, or acquired through genetic mutations or transfer of genes. 3. Acquired resistance is a concern as it can lead to treatment failure, increased mortality, and spread in communities.
updated statistics about antimicrobial resistance,causes and mechanism of antimicrobial resistances, national antimicrobial policy, national antimicrobial surveillance, new delhi b metallo-lactamase-1 bacteria
WHO - AMR Global Overview and Action Planmarkovingian
Diberikan dan disampaikan pada Seminar "Cegah Resistensi Antibiotik: Demi Selamatkan Manusia", kerjasama Kemenkes, WHO, dan Yayasan Orang Tua Peduli, didukung oleh React, 5 Agustus 2015
Phage therapy (PT) is also called bacteriophage therapy. It uses viruses to treat bacterial infections. Bacterial viruses are called phages or bacteriophages. They only attack bacteria; phages are harmless to people, animals, and plants. Bacteriophages are the natural enemies of bacteria.
An tibiotic policy in medical care seminardeepak deshkar
This document outlines an antibiotic policy and discusses the importance of prudent antibiotic usage to reduce antibiotic resistance. It notes that nearly half of hospitalized patients receive antibiotics. While antibiotics have been life-saving, their overuse for trivial infections, commercial pressures, and poverty have encouraged resistance. Antibiotic resistance arises from genetic changes and spread of R plasmids between bacteria. Indiscriminate antibiotic use in animals and humans has led to the spread of resistant organisms. The policy aims to reduce resistance by engaging all prescribers, restricting certain antibiotics, and ensuring adherence through surveillance and education. The roles of microbiologists, pharmacists, and continuous staff training are emphasized.
This document discusses antibiotic resistance. It begins by defining antibiotic resistance and explaining that it is a natural phenomenon accelerated by antibiotic use, allowing resistant bacterial strains to survive and multiply. It then outlines various mechanisms of resistance, including enzymatic modification of antibiotics, decreased bacterial membrane permeability, efflux pumps that remove antibiotics, alterations of antibiotic targets or cell wall precursors, overproduction of targets, and bypassing antibiotic inhibition. The document also discusses how resistance spreads between bacteria through horizontal gene transfer and provides several examples of multidrug-resistant pathogens. It emphasizes the importance of addressing antibiotic resistance due to increased mortality, costs, and few treatment options.
This document discusses antibiotic resistance and new approaches to address it. It notes that inappropriate antibiotic usage and lack of regulation have contributed to rising drug resistance. Newly identified resistant bacteria and better infection control strategies are discussed as newer approaches. These include using bacteriophages and quorum sensing inhibitors as alternatives to antibiotics. The document also highlights India's National Antibiotic Policy and the Chennai Declaration which call for restricting certain antibiotic sales and implementing antibiotic stewardship programs in hospitals.
This document discusses antimicrobial resistance, including its definition, causes, mechanisms, and impact. It notes that resistance arises naturally but is accelerated by misuse and overuse of antimicrobials in both humans and animals. Resistance occurs via several mechanisms including inactivating drugs, modifying drug targets in bacteria, exporting drugs from bacteria, reducing drug permeability, and mutating genes involved in drug mechanisms of action. It highlights several important antibiotic-resistant bacteria like MRSA, VRE, and multi-drug resistant TB. The global spread of resistance poses a major threat to modern medicine.
Multi drug resistance molecular pathogenesisAlagar Suresh
The document discusses multi-drug resistance and antibiotic resistance. It provides background on the history of antibiotics and resistance. It then covers the major topics of how antibacterial resistance develops through various mechanisms like mutations, plasmids, efflux pumps, and inactivating enzymes. The document also discusses the Indian scenario of rising drug resistance and the growing problem of NDM-1 enzyme production. It concludes by outlining some strategies to address resistance like developing new antibiotics, prudent antibiotic use, and alternative approaches like phage therapy and quorum sensing inhibition.
Environmental Consequences of Genetically-Modified Foods, Biopharming and rBGHJack Olmsted
Martin Donohoe, MD, FACP
Portland State University
Oregon Physicians for Social Responsibility
With thanks to Rick North, Project Director, Campaign for Safe Food
Oregon Physicians for Social Responsibility
The document discusses the importance of biodiversity for human health and society. It defines biodiversity as the variety of life on Earth, including genetic, species, and ecosystem diversity. Biodiversity is essential for supporting human needs like food, water, and medicine. However, human activities like habitat destruction, pollution, and climate change are causing a current mass extinction. This loss of biodiversity threatens human health by reducing food security and increasing diseases. The document outlines how protecting biodiversity benefits people through medicines, business, livelihoods, and protection from disasters. Maintaining biodiversity is crucial for sustaining a healthy society.
Biodiversity refers to the variety of plant and animal life in a particular habitat. It is essential for healthy ecosystems and human well-being. Loss of biodiversity can negatively impact food/water security, medicine development, business/livelihoods, and protection from disasters. The main threats are habitat loss, pollution, overexploitation, invasive species, and climate change. Preserving biodiversity is crucial to ensure continued ecosystem services and human health.
One Health approaches to different problems: Work at the International Livest...ILRI
The document discusses One Health approaches used by the International Livestock Research Institute (ILRI). ILRI takes a One Health approach to address problems at the human-animal-environment interface. It works on projects related to zoonotic diseases, food safety issues like aflatoxins, and increasing sustainable livestock production to meet the growing global demand for animal proteins. ILRI aims to find solutions that improve food security and public health while minimizing environmental impacts.
1. The document discusses biological agents that can be used as weapons against humans, animals, and plants. It describes how biological weapons are intentionally used to cause disease and death.
2. It provides examples of bacteria, viruses, and toxins that have been used or considered for use as biological weapons, and discusses their characteristics like contagiousness, lethality, and treatability. Smallpox, anthrax, plague, and influenza are highlighted.
3. The document outlines the history of biological weapons development and alleged uses over time. It also discusses the potential threats posed by different agents and considerations for their strategic use.
Prof. Michael Depledge discusses global megatrends related to the environment, health, and well-being. He notes trends including rising temperatures increasing disease risks, growing chemical pollution from plastics and pollutants, and increasing antibiotic resistance. However, he argues that many megatrends can be redirected through lifestyle changes, renewable energy, recycling, sustainable chemical use, and new technologies. Interpreting megatrends locally and facilitating awareness can help enable beneficial behavior changes to improve both global and individual well-being.
Pesticides Used for Food Production as a Health and Safety IssueUN SPHS
By Dr. Tadesse Amera, Co-Chair, IPEN and Director, Pesticide Action Nexus (PAN)-Ethiopia delivered at the Global Forum 2020 Food Safety and Risk Assessment session.
Dr. Laura Kahn - One Health and The Politics of Antimicrobial ResistanceJohn Blue
One Health and The Politics of Antimicrobial Resistance - Dr. Laura Kahn, Research Scholar, Princeton University, from the 2017 NIAA Antibiotic Symposium - Antibiotic Stewardship: Collaborative Strategy for Animal Agriculture and Human Health, October 31 - November 2, 2017, Herndon, Virginia, USA.
More presentations at http://www.swinecast.com/2017-niaa-antibiotic-symposium-antibiotic-stewardship
Dr. Peter Davies - Antibiotic Use In Swine Production - Where Is It At And Wh...John Blue
This document discusses antibiotic use in the swine industry and resistance. It notes that resistance generated in animals can spread to humans and cause harm, but evidence of this is minimal. It discusses calls for measuring antibiotic use to support stewardship efforts. Voluntary monitoring programs are being developed to provide representative data while maintaining confidentiality. Overall it examines balancing prudent antibiotic use with animal health and food safety.
Transforming Agri-food Systems to Achieve Healthy Diets for AllCGIAR
Challenges: Why Agri-Food Systems Need to Be Transformed
Opportunities: What Science Can Offer to Address these Challenges
The CGIAR partnership: Our Contribution to achieving the UN’s Sustainable Development Targets
Dr. Lonnie King - Keynote - One Health Approach to Antimicrobial Resistance a...John Blue
Keynote - One Health Approach to Antimicrobial Resistance and Use - Dr. Lonnie King, Dean, The Ohio State University, College of Veterinary Medicine, from the 2012 NIAA One Health Approach to Antimicrobial Resistance and Use Symposium, October 26-27, 2012, Columbus, OH, USA.
More presentations at:
http://www.trufflemedia.com/agmedia/conference/2012-one-health-to-approach-antimicrobial-resistance-and-use
Mr. Somu Kumar Speaker at Knowledge day 2015Poultry India
The document discusses the debate around antimicrobial resistance (AMR) and antibiotic use. It covers several topics:
- The complexity of the debate involving animal welfare, ethics, science, sustainability, and consumer perceptions.
- Categories of antibiotics including those shared between human and animal medicine, animal-only, and human-only.
- Risk analysis and the human health risks of acquiring antibiotic-resistant infections from food animals treated with antibiotics.
- Global classification systems for antibiotics from organizations like WHO and FDA based on importance for human medicine.
(01) BIODIVERSITY AND THE HEALTHY SOCIETY.pptxMaryRoseNaboa1
Biodiversity refers to the variety of plant and animal life on Earth. It is essential for healthy ecosystems and human well-being. Loss of biodiversity due to habitat destruction, pollution, climate change and other human impacts threatens both the environment and human societies. When ecosystems are compromised by loss of biodiversity, they can no longer support human needs for food, water, medicine and other resources to maintain health. Biodiversity also underpins global economies and provides livelihoods for many people. Its loss therefore has significant negative impacts on both environmental and human health.
The document discusses the importance of biodiversity for human health and society. It defines biodiversity as the variety of life on Earth, including genetic, species, and ecosystem diversity. Biodiversity is essential for providing food, medicine, clean water and shelter. However, human activities like habitat destruction, pollution and climate change are causing a sixth mass extinction. This impacts human health by reducing access to resources and increasing disease transmission. The document outlines how preserving biodiversity benefits business, livelihoods and protects from disasters. Overall, the health of human societies is interrelated with and dependent on biodiversity and ecosystem health.
BIODIVERSITY AND HEALTHY SOCIETY BY GROUP 1KaliAndres
Biodiversity supports human and societal needs, including food and nutrition security, energy, development of medicines and pharmaceuticals and freshwater, which together underpin good health. It also supports economic opportunities, and leisure activities that contribute to overall wellbeing.
The document discusses how the world is changing rapidly due to factors like globalization, increasing population and urbanization, technological advances, and environmental changes. It highlights challenges like emerging infectious diseases, food and water security issues, and the interconnected relationship between human, animal and environmental health. The presentation aims to raise awareness of these issues and provide tools to help navigate ongoing changes, emphasizing local empowerment and collective action to address global challenges.
Similar to Antimicrobial Resistance (AMR): A global and Multisectoral issue of concern to all (20)
Agenda of the 5th NENA Soil Partnership meetingFAO
The Fifth meeting of the Near East and North African (NENA) Soil Partnership will take place from 1-2 April 2019 in Cairo, Egypt. The objectives of the meeting are to consolidate the NENA Soil Partnership, review the work plan, organize activities to establish National Soil Information Systems, agree to launch a Regional Soil Laboratory for NENA, and strengthen networking. The meeting agenda includes discussions on soil information systems, a soil laboratory network, and implementing the Voluntary Guidelines for Sustainable Soil Management. The performance of the NENA Soil Partnership will also be assessed and future strategies developed.
This document summarizes the proceedings of the first meeting of the Global Soil Laboratory Network (GLOSOLAN). GLOSOLAN was established to harmonize soil analysis methods and strengthen the performance of laboratories through standardized protocols. The meeting discussed the role of National Reference Laboratories in promoting harmonization, and how GLOSOLAN is structured with regional networks feeding into the global network. Progress made in 2018 included registering over 200 laboratories, assessing capacities and needs, and establishing regional networks. The work plan for 2019 includes further developing regional networks, standard methods, a best practice manual, and the first global proficiency testing. The document concludes by outlining next steps to launch the regional network for North Africa and the Near East.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
How to Fix the Import Error in the Odoo 17Celine George
An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
How to Add Chatter in the odoo 17 ERP ModuleCeline George
In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
2. One of the most important discoveries of the 20th century
1928
Sir Alexander Fleming discovered
ANTIBIOTICS
3. One of the most important discoveries of the 20th century
1928
Sir Alexander Fleming discovered
ANTIBIOTICS
4. Transformation of Life and Livelihoods
THE INTRODUCTION OF ANTIBIOTICS
RAPIDLY EXTENDED LIFE EXPECTANCY
1945 = 50 years
Today = 80 years
(developed countries)
Increase of 30 years
within 50 years
5. Transformation of Life and Livelihoods
THE INTRODUCTION OF ANTIBIOTICS
RAPIDLY EXTENDED LIFE EXPECTANCY
1945 = 50 years
Today = 80 years
(developed countries)
Increase of 30 years
within 50 years
6. Transformation of Life and Livelihoods
THE INTRODUCTION OF ANTIBIOTICS
RAPIDLY IMPROVED...
PRODUCTION INCOME LIVELIHOOD
7. Transformation of Life and Livelihoods
THE INTRODUCTION OF ANTIBIOTICS
RAPIDLY IMPROVED...
PRODUCTION INCOME LIVELIHOOD
8. Transformation of Life and Livelihoods
There is the danger, that the ignorant
man may easily underdose himself
and by exposing his microbes to
non-lethal quantities of the drug make
them resistant.
Alexander Fleming
9. Transformation of Life and Livelihoods
Today, Resistance is emerging and spreading
faster than new drugs are being developed
There is the danger, that the ignorant
man may easily underdose himself
and by exposing his microbes to
non-lethal quantities of the drug make
them resistant.
Alexander Fleming
10. Costs and Consequences
INAPPROPRIATE USE has
a negative impact on:
HUMAN HEALTH
and PRODUCTION
LIVELIHOOD
ECONOMY
11. Costs and Consequences
INAPPROPRIATE USE has
a negative impact on:
HUMAN HEALTH
and PRODUCTION
LIVELIHOOD
ECONOMY
13. Anti-Microbial Resistance
Deaths/year
• 25,000 - EU
• 500,000 - Global
(est.)
USA - health care costs
• $ 20 bn/yr
Lost productivity
• USA $ 35 billion/yr
• EU € 1.5 billion/yr
Socio-economic consequences
14. HUMAN ANIMALS
MAKAE m AultMiseRcto Aral aMndO GRloEba lC prOobMlemPLEX CHALLENGE
FOOD ENVIRORMENT
23. HOW FAO CAN SUPPORT MEMBERS COUNTRIES
Policy
Regulatory support
AMR detection, monitoring of trends -
laboratory capacity support
Standards setting – Codex, OIE
Guidance
24. HOW FAO CAN SUPPORT MEMBERS COUNTRIES
Policy
Regulatory support
AMR detection, monitoring of trends -
laboratory capacity support
Standards setting – Codex, OIE
Guidance
25. HOW FAO CAN SUPPORT PRODUCERS
GOOD PRACTICES
ANIMAL HEALTH,
HUSBANDRY,
BIOSECURITY MEASURES
PARTICIPATION
IN TRADE
ACCESS TO MARKETS
STANDARDS AND
REQUIREMENTS
VETERINARY DRUGS
26. HOW FAO CAN SUPPORT PRODUCERS
PROMOTE
GOOD PRACTICES
ANIMAL HEALTH,
HUSBANDRY,
BIOSECURITY MEASURES
IMPROVE
PARTICIPATION
IN TRADE
ACCESS TO MARKETS
STANDARDS AND
REQUIREMENTS
REDUCE
VETERINARY DRUGS
28. GLOBAL PARTNERSHIPS
Global Action Plan for AMR
Global Health Security Agenda
FAO/WHO/OIE Tripartite
need holistic One Health approach addressing AMR in all sectors
(human, animal and environment) and all stages of the continuum from
food production to consumption
EU, World Bank, OECD etc
Private Sector
29. GLOBAL PARTNERSHIPS
Global Action Plan for AMR
Global Health Security Agenda
FAO/WHO/OIE Tripartite
need holistic One Health approach addressing AMR in all sectors
(human, animal and environment) and all stages of the continuum
from food production to consumption
EU, World Bank, OECD etc
Private Sector