The Human Genome Project (HGP) determines the sequence of nucleotide.pdfanton291
The Human Genome Project (HGP) determines the sequence of nucleotide base pairs of human
DNA, It is used to identifies and mapping all of the genes of the human genome.HGP was
proposed by Robert Sinshelmer in May1884. This project formally launched in 1990, and it was
completed in 2003. The goal of HGP is to identify the DNA sequence of entire human genome. 3
billion DNA base pairs are found in DNA that make up the human genome. Because of HGP, the
name and bases of nitrogenous bases are known.
US government through the National Institutes of Health (NIH) provide the fund for the project.
In 1990 DOE and NIH, shows interest to developed a memorandum of understanding and give
support and coordinate plans and set the clock to initiate the Project in 1990. David Galas was
Director of the renamed “Office of Biological and Environmental Research” in the U.S.
Department of Energy’s Office of Science and James Watson headed the NIH Genome Program.
In 1993, U.S. National Institutes of Health (NIH) and National Center for Human Genome
Research ( now known as National Human Genome Research Institute) worked on the project.
The United States, the United Kingdom, France, Germany, Japan and China are participated to
complete this project.
The genomic sequencing was conducted at numerous universities and research center given
below:-
The time period of this project is 13-years. It is initiated in 1990 and completed in 2003. Robert
Sinsheimer proposed this project in May 1985, President Regan\'s in 1988 submitted budget for
this project. In 1990,DOE and NIH, provided the fund for the project. In 2000 working draft of
the genome was announced and in the February 2001, papers were published . And more
sequence were identified and lateron, complete draft was published in 2003, and genome
\"finishing\" work continued for more than a decade. It was published on May 27, 2004 with
99.99% accurate sequence.
The research techniques that play major role in this project are Mapping the human genome,
sequencing the genome. Mapping the human genome includes two types of map:-A gene linkage
map and physical map.
Solution
The Human Genome Project (HGP) determines the sequence of nucleotide base pairs of human
DNA, It is used to identifies and mapping all of the genes of the human genome.HGP was
proposed by Robert Sinshelmer in May1884. This project formally launched in 1990, and it was
completed in 2003. The goal of HGP is to identify the DNA sequence of entire human genome. 3
billion DNA base pairs are found in DNA that make up the human genome. Because of HGP, the
name and bases of nitrogenous bases are known.
US government through the National Institutes of Health (NIH) provide the fund for the project.
In 1990 DOE and NIH, shows interest to developed a memorandum of understanding and give
support and coordinate plans and set the clock to initiate the Project in 1990. David Galas was
Director of the renamed “Office of Biological and Environmental Research” in the U.S.
.
The Human Genome Project (HGP) determines the sequence of nucleotide.pdfanton291
The Human Genome Project (HGP) determines the sequence of nucleotide base pairs of human
DNA, It is used to identifies and mapping all of the genes of the human genome.HGP was
proposed by Robert Sinshelmer in May1884. This project formally launched in 1990, and it was
completed in 2003. The goal of HGP is to identify the DNA sequence of entire human genome. 3
billion DNA base pairs are found in DNA that make up the human genome. Because of HGP, the
name and bases of nitrogenous bases are known.
US government through the National Institutes of Health (NIH) provide the fund for the project.
In 1990 DOE and NIH, shows interest to developed a memorandum of understanding and give
support and coordinate plans and set the clock to initiate the Project in 1990. David Galas was
Director of the renamed “Office of Biological and Environmental Research” in the U.S.
Department of Energy’s Office of Science and James Watson headed the NIH Genome Program.
In 1993, U.S. National Institutes of Health (NIH) and National Center for Human Genome
Research ( now known as National Human Genome Research Institute) worked on the project.
The United States, the United Kingdom, France, Germany, Japan and China are participated to
complete this project.
The genomic sequencing was conducted at numerous universities and research center given
below:-
The time period of this project is 13-years. It is initiated in 1990 and completed in 2003. Robert
Sinsheimer proposed this project in May 1985, President Regan\'s in 1988 submitted budget for
this project. In 1990,DOE and NIH, provided the fund for the project. In 2000 working draft of
the genome was announced and in the February 2001, papers were published . And more
sequence were identified and lateron, complete draft was published in 2003, and genome
\"finishing\" work continued for more than a decade. It was published on May 27, 2004 with
99.99% accurate sequence.
The research techniques that play major role in this project are Mapping the human genome,
sequencing the genome. Mapping the human genome includes two types of map:-A gene linkage
map and physical map.
Solution
The Human Genome Project (HGP) determines the sequence of nucleotide base pairs of human
DNA, It is used to identifies and mapping all of the genes of the human genome.HGP was
proposed by Robert Sinshelmer in May1884. This project formally launched in 1990, and it was
completed in 2003. The goal of HGP is to identify the DNA sequence of entire human genome. 3
billion DNA base pairs are found in DNA that make up the human genome. Because of HGP, the
name and bases of nitrogenous bases are known.
US government through the National Institutes of Health (NIH) provide the fund for the project.
In 1990 DOE and NIH, shows interest to developed a memorandum of understanding and give
support and coordinate plans and set the clock to initiate the Project in 1990. David Galas was
Director of the renamed “Office of Biological and Environmental Research” in the U.S.
.
Human genome project is the coordinated , comprehensive and internat.pdfdeepua8
Human genome project is the coordinated , comprehensive and international effort with an
ultimate aim to map the entire genome by determining the complete nucleotide sequence of DNA
of each chromosome ( 22 autosomal and X and Y sex chromosome)
In US a project to map and sequence the human genome was proposed in 1986, and in 1988,
National Institute of Health directed by Francis Collins and US Department of Energy headed by
Arizona Patrick created a joint committee to develop a plan for the project. Human go Genome
Project was launched on October 1, 1990.
Purpose of human genome project : Different goals of human genome project are;
1. To determine the nucleotide sequence of 3 billion base pairs in human genome.
2. To store this genetic information obtained from sequencing g human genome in computer
databases .
3. To identify the functions of different genes.
4. To point out genes responsible for different kinds of genetic disorders .
5. To address ethical, legal, and social issues (ELSI) that may arise from this project.
Future research on human genome project stresses upon the aim to understand the genetic make
up of human species and to enhance the basic understanding about human genetics . The various
areas that could benefit from human genome project are;
1. Health care: Human genome project can provide vast amount of genetic information about the
genes responsible for genetic disorders which will help in preventing g inherited diseases.
2. Cancer: Efforts are in progress to determine genes that will cause reversion of cancerous cells
to normal cells.
Solution
Human genome project is the coordinated , comprehensive and international effort with an
ultimate aim to map the entire genome by determining the complete nucleotide sequence of DNA
of each chromosome ( 22 autosomal and X and Y sex chromosome)
In US a project to map and sequence the human genome was proposed in 1986, and in 1988,
National Institute of Health directed by Francis Collins and US Department of Energy headed by
Arizona Patrick created a joint committee to develop a plan for the project. Human go Genome
Project was launched on October 1, 1990.
Purpose of human genome project : Different goals of human genome project are;
1. To determine the nucleotide sequence of 3 billion base pairs in human genome.
2. To store this genetic information obtained from sequencing g human genome in computer
databases .
3. To identify the functions of different genes.
4. To point out genes responsible for different kinds of genetic disorders .
5. To address ethical, legal, and social issues (ELSI) that may arise from this project.
Future research on human genome project stresses upon the aim to understand the genetic make
up of human species and to enhance the basic understanding about human genetics . The various
areas that could benefit from human genome project are;
1. Health care: Human genome project can provide vast amount of genetic information about the
genes responsible for genetic d.
Prof Richard Gibbs - Director, Baylor College of Medicine Human Genome Sequencing Centre
Wofford Cain Professor of Human & Molecular Genetics. http://www.garvan.org.au/news-events/leaders-in-science-and-society
A document containing extensive research on the Human Genome Project- inclding the history behind it , various landmarks in the study of genes and our genome , the scale of the project , the methods used and the new methods developed to successfully execute it and the vrious applications of its discoveries in science and industry today
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.
Human Genome Project (HGP)
Main objectives Human Genome Project (HGP)
Goals for the HGP
Medical Implications
Applications of HGP
Timeline of HGP
Technical aspects in HGP
Mapping strategies
Sequencing strategies
. Shotgun sequencing method
Sanger sequencing method
Outcomes of HGP
Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional
Human genome project is the coordinated , comprehensive and internat.pdfdeepua8
Human genome project is the coordinated , comprehensive and international effort with an
ultimate aim to map the entire genome by determining the complete nucleotide sequence of DNA
of each chromosome ( 22 autosomal and X and Y sex chromosome)
In US a project to map and sequence the human genome was proposed in 1986, and in 1988,
National Institute of Health directed by Francis Collins and US Department of Energy headed by
Arizona Patrick created a joint committee to develop a plan for the project. Human go Genome
Project was launched on October 1, 1990.
Purpose of human genome project : Different goals of human genome project are;
1. To determine the nucleotide sequence of 3 billion base pairs in human genome.
2. To store this genetic information obtained from sequencing g human genome in computer
databases .
3. To identify the functions of different genes.
4. To point out genes responsible for different kinds of genetic disorders .
5. To address ethical, legal, and social issues (ELSI) that may arise from this project.
Future research on human genome project stresses upon the aim to understand the genetic make
up of human species and to enhance the basic understanding about human genetics . The various
areas that could benefit from human genome project are;
1. Health care: Human genome project can provide vast amount of genetic information about the
genes responsible for genetic disorders which will help in preventing g inherited diseases.
2. Cancer: Efforts are in progress to determine genes that will cause reversion of cancerous cells
to normal cells.
Solution
Human genome project is the coordinated , comprehensive and international effort with an
ultimate aim to map the entire genome by determining the complete nucleotide sequence of DNA
of each chromosome ( 22 autosomal and X and Y sex chromosome)
In US a project to map and sequence the human genome was proposed in 1986, and in 1988,
National Institute of Health directed by Francis Collins and US Department of Energy headed by
Arizona Patrick created a joint committee to develop a plan for the project. Human go Genome
Project was launched on October 1, 1990.
Purpose of human genome project : Different goals of human genome project are;
1. To determine the nucleotide sequence of 3 billion base pairs in human genome.
2. To store this genetic information obtained from sequencing g human genome in computer
databases .
3. To identify the functions of different genes.
4. To point out genes responsible for different kinds of genetic disorders .
5. To address ethical, legal, and social issues (ELSI) that may arise from this project.
Future research on human genome project stresses upon the aim to understand the genetic make
up of human species and to enhance the basic understanding about human genetics . The various
areas that could benefit from human genome project are;
1. Health care: Human genome project can provide vast amount of genetic information about the
genes responsible for genetic d.
Prof Richard Gibbs - Director, Baylor College of Medicine Human Genome Sequencing Centre
Wofford Cain Professor of Human & Molecular Genetics. http://www.garvan.org.au/news-events/leaders-in-science-and-society
A document containing extensive research on the Human Genome Project- inclding the history behind it , various landmarks in the study of genes and our genome , the scale of the project , the methods used and the new methods developed to successfully execute it and the vrious applications of its discoveries in science and industry today
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.
Human Genome Project (HGP)
Main objectives Human Genome Project (HGP)
Goals for the HGP
Medical Implications
Applications of HGP
Timeline of HGP
Technical aspects in HGP
Mapping strategies
Sequencing strategies
. Shotgun sequencing method
Sanger sequencing method
Outcomes of HGP
Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional
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Presentation (14).pptx
1. Timeline
• 1986 the U.S. Dept of Energy
and the National Institute of
Health came forward to fund
the Human Genome Project..
• 1985- Robert Sinsheimer at UCSC
proposed the idea of sequencing
the human genome.
2. • 1994 - HGP's Human genetic
mapping goal was achieved.
• 2003 finished version of
human genome sequence was
completed. HGP ended with all
the goals achieved.
• 1990-HGP was officially launched
with James Watson as its Project
Director. the 1st gene to be mapped
was BRCA1 which is the gene for
breast cancer.
3. PIONEERS OF HUMAN GENOME
PROJECT
Robert Sinsheimer proposed the
idea of sequencing the human
genome in the year 1985.
Charles Delisi and David Smith
proposed the budget for Human
Genome Project.
James Watson headed the NIH
Genome Program
4. CONTENT
• Francis Collins succeeded James Watson in
1993 as the overall Project Head and the
Director of the NIH
Jim Kent, developed a software, Gig Asseblemr,
that allowed the publicly funded Human
Genome Project to assemble and publish the
human genome sequence
5. STRATEGIES/TECHNICAL ASPECTS OF
HGP
GENE MAPPING
The graphical representation of
arrangement of gene or DNA sequences in
a chromosome.
Physical mapping
A physical map is an ordered of set of DNA
fragments express in physical units (base
pair)
Physical mapping uses molecular biology
techniques to examine DNA molecules
directly in order to construct maps showing
6. • Genetic Maps A genetic map is based on
the frequencies of recombination between
adjacent genes during crossover of
homologous chromosomes .
Genetic markers are invaluable for genome
mapping
A genetic marker is a gene or DNA
sequence with a known location on a
chromosome that can be used identify
individuals or species . An example of a
marker includes restriction Fragment
length polymorphisms (RFLP).
