Prenatal exposure to recreational drugs affects global motion perception in preschool children Arijit Chakraborty1, Nicola S. Anstice1, Robert J. Jacobs1, Linda L. LaGasse2, Barry M. Lester2, Trecia A. Wouldes3,* & Benjamin Thompson1,
Prenatal exposure to recreational drugs affects global motion
perception in preschool children.
A very interesting paper that adds another piece of the puzzle to the puzzle of FASD and the neurodevelopment disabilities of prenatal alcohol exposure.
I found in my practice, consistently, that those diagnosed with the neurodevelopment disabilities of fasd found relief from marijuana and tobacco. The relief had to be a neurological process that resulted in a calming of uncontrolled thoughts and emotions.
It is a tragedy that mainstream science does not see prenatal alcohol exposure as the significant tool for the investigation of brain function that it is.
Barry Stanley
It is my observation that those with FASD exist in two states,
1 -a mind of chaotic, uncontrolled and uncomfortable thoughts, usually described as being bored.
2- a mind perseverating [ super focused ], with or without physical activity.
They seek the second to escape the first.
What they perseverate on is determined by their particular set of cognitive, emotional, information processing, memory, expressive and sensory disabilities; as well as their early childhood experience and their immediate environment, including how others relate to them.
What they may perseverate on to soothe themselves extends from cutting, provoking others, to more acceptable behaviors, such as playing video games, reading and sports.
Alcohol and hard drugs are used to obliterate the 1st state of mind. Those with FASD can often stop using them providing they have an alternative focus of perseveration.
This is not true of Marijuana and Tobacco, which generally appear to have a specific action that reduces their multiple chaotic thoughts and allows them to focus on one process.
Barry Stanley
Austin Public Health is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Public Health.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances & happenings in all areas of Public Health. Austin Public Health accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of public health.
Austin Public Health strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Increased nuchal translucency thickness and risk of neurodevelopmental disorders
S. G. Hellmuth, L. H. Pedersen, C. B. Miltoft, O. B. Petersen, S. Kjærgaard, C. Ekelund, A. Tabor
Volume 49, Issue 5; Date: May (pages 592–598)
Slides prepared by Dr Maddalena Morlando (UOG Editors-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15961/full
Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
C. Scala, A. Familiari, A. Pinas, A.T. Papageorghiou, A. Bhide, B. Thilaganathan, A. Khalil
Volume 49, Issue 4, Date: April (pages 450–459)
Slides prepared by Dr Yael Raz (UOG Editor-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15943/full
Austin Public Health is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Public Health.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances & happenings in all areas of Public Health. Austin Public Health accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of public health.
Austin Public Health strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Increased nuchal translucency thickness and risk of neurodevelopmental disorders
S. G. Hellmuth, L. H. Pedersen, C. B. Miltoft, O. B. Petersen, S. Kjærgaard, C. Ekelund, A. Tabor
Volume 49, Issue 5; Date: May (pages 592–598)
Slides prepared by Dr Maddalena Morlando (UOG Editors-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15961/full
Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
C. Scala, A. Familiari, A. Pinas, A.T. Papageorghiou, A. Bhide, B. Thilaganathan, A. Khalil
Volume 49, Issue 4, Date: April (pages 450–459)
Slides prepared by Dr Yael Raz (UOG Editor-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15943/full
Fetal Alcohol Spectrum Disorder Provincial Roundtable Report
A Report from Parliamentary Assistant Granville Anderson to the Minister of Children and Youth Services
SEPTEMBER 2015.
IMO it is a comprehensive and honest report that acknowledges the importance and need for more diagnostic facilities. This is in contrast to the recent Government of Canada, Nineteenth Report of the Standing Committee on Justice and Human Rights entitled Study of the Subject Matter of Bill C-583, An Act to amend the Criminal Code (fetal alcohol spectrum disorder), tabled in the House of Commons on May 8, 2015, which made no reference to the need for increased diagnostic facilities.
Barry Stanley
Lancet.docx comorbidity of fetal alcohol spectrum disorder a systematic revi...BARRY STANLEY 2 fasd
Lancet. January, 2016
Comorbidity of fetal alcohol spectrum disorder: a systematic
review and meta-analysis
Dr Svetlana Popova, PhD Shannon Lange, MPH Kevin Shield, PhD Alanna Mihic, MSc Prof Albert E Chudley, MD
Raja A S Mukherjee, PhD Dennis Bekmuradov, BASc Prof Jürgen Rehm, PhD
In spite of many, and increasing, correlations the possibility/probability that pre conceptual and prenatal alcohol exposure is a key component in the CAUSE of mental illnesses has never been explored or excluded.
Slides taken from Fetal Alcohol Spectrum Disorder Symposium: Seeing The Other Perspective.
DA DWA DA DEHS NYE>S September 9, 2014
Disruption of histone methylation in developing sperm impairs offspring healt...BARRY STANLEY 2 fasd
Science
www.sciencemag.org
Published Online October 8 2015
Science 6 November 2015:
Vol. 350 no. 6261
DOI: 10.1126/science.aab2006
RESEARCH ARTICLE
Disruption of histone methylation in developing sperm impairs
offspring health transgenerationally
Keith Siklenka1,*, Serap Erkek2,3,*,†,‡, Maren Godmann4,§, Romain Lambrot4, Serge McGraw5||,
Christine Lafleur4, Tamara Cohen4, Jianguo Xia4,6, Matthew Suderman7, Michael Hallett8,
Jacquetta Trasler5,9, Antoine H. F. M. Peters2,3,*,¶, Sarah Kimmins1,4,*,¶
Alcohol is not mentioned, but is relevant to the subject.
The next step required is research into the contribution that trasgenerational epegentics of the father makes to the maternal prenatal alcohol exposure effects on the developing fetus.
Barry Stanley
Jody Crowe's Vienna presentation draws attention to the correlation between school shooters and prenatal alcohol exposure. He first made this correlation in his book, The Fatal Link. In addition his variability graphs are excellent and deserve to be adopted world wide. Barry Stanley
XXXIVth International Congress on Law and Mental Health. Vienna, 2015.
Perseveration – The Lens by Which Those Afflicted with FASD Interpret their Relationship and Environment
Biomarkers outperform symptoms in parsing psychosis subgroupsBARRY STANLEY 2 fasd
Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers Brett A. Clementz, Ph.D., John A. Sweeney, Ph.D., Jordan P. Hamm, Ph.D., Elena I. Ivleva, M.D., Ph.D., Lauren E. Ethridge, Ph.D., Godfrey D. Pearlson, M.D., Matcheri S. Keshavan, M.D., Carol A. Taming, M.D.
Perseveration – The Lens by Which Those Afflicted with FASD Interpret their Relationship and Environment
XXXIVth International Congress on Law and Mental Health. Vienna, 2015.
Perseveration – The Lens by Which Those Afflicted with FASD Interpret their Relationship and Environment.
XXXIVth International Congress on Law and Mental Health. Vienna, 2015.
Letter to the Editors: Alcohol Exposure in Utero and Breast Cancer. Richard G. Stevens and Leena Hilakivi- Clarke
Alcohol and Alcoholism Vol.36, No.3, pp.276-277, 2001
An article by Ricardo Haussmann regarding concerns about the role of evidence-based policies.
with comments relating to prenatal alcohol exposure and DSM psychiatric diagnoses.
Submission to the Ontario Select Committee on developmental services. BARRY STANLEY 2 fasd
Submission to the Ontario Select Committee on developmental services. Jan. 2014: relating to the needs of those with FASD and the families who support them.
Screening Tool for Developmental Disorders in ChildrenApollo Hospitals
Developmental problems are a diverse group of conditions that affect and limit children and their life-chances. A ready reference for a Paediatrician would be the first six chapters of the latest edition (18th) of the Nelson Textbook of Pediatrics (The Field of Pediatrics, Growth & Development, Psychological Disorders, Social Issues, Children with Special Health Needs and Nutrition and Human Genetics and Metabolic Diseases).
Fetal Alcohol Spectrum Disorder Provincial Roundtable Report
A Report from Parliamentary Assistant Granville Anderson to the Minister of Children and Youth Services
SEPTEMBER 2015.
IMO it is a comprehensive and honest report that acknowledges the importance and need for more diagnostic facilities. This is in contrast to the recent Government of Canada, Nineteenth Report of the Standing Committee on Justice and Human Rights entitled Study of the Subject Matter of Bill C-583, An Act to amend the Criminal Code (fetal alcohol spectrum disorder), tabled in the House of Commons on May 8, 2015, which made no reference to the need for increased diagnostic facilities.
Barry Stanley
Lancet.docx comorbidity of fetal alcohol spectrum disorder a systematic revi...BARRY STANLEY 2 fasd
Lancet. January, 2016
Comorbidity of fetal alcohol spectrum disorder: a systematic
review and meta-analysis
Dr Svetlana Popova, PhD Shannon Lange, MPH Kevin Shield, PhD Alanna Mihic, MSc Prof Albert E Chudley, MD
Raja A S Mukherjee, PhD Dennis Bekmuradov, BASc Prof Jürgen Rehm, PhD
In spite of many, and increasing, correlations the possibility/probability that pre conceptual and prenatal alcohol exposure is a key component in the CAUSE of mental illnesses has never been explored or excluded.
Slides taken from Fetal Alcohol Spectrum Disorder Symposium: Seeing The Other Perspective.
DA DWA DA DEHS NYE>S September 9, 2014
Disruption of histone methylation in developing sperm impairs offspring healt...BARRY STANLEY 2 fasd
Science
www.sciencemag.org
Published Online October 8 2015
Science 6 November 2015:
Vol. 350 no. 6261
DOI: 10.1126/science.aab2006
RESEARCH ARTICLE
Disruption of histone methylation in developing sperm impairs
offspring health transgenerationally
Keith Siklenka1,*, Serap Erkek2,3,*,†,‡, Maren Godmann4,§, Romain Lambrot4, Serge McGraw5||,
Christine Lafleur4, Tamara Cohen4, Jianguo Xia4,6, Matthew Suderman7, Michael Hallett8,
Jacquetta Trasler5,9, Antoine H. F. M. Peters2,3,*,¶, Sarah Kimmins1,4,*,¶
Alcohol is not mentioned, but is relevant to the subject.
The next step required is research into the contribution that trasgenerational epegentics of the father makes to the maternal prenatal alcohol exposure effects on the developing fetus.
Barry Stanley
Jody Crowe's Vienna presentation draws attention to the correlation between school shooters and prenatal alcohol exposure. He first made this correlation in his book, The Fatal Link. In addition his variability graphs are excellent and deserve to be adopted world wide. Barry Stanley
XXXIVth International Congress on Law and Mental Health. Vienna, 2015.
Perseveration – The Lens by Which Those Afflicted with FASD Interpret their Relationship and Environment
Biomarkers outperform symptoms in parsing psychosis subgroupsBARRY STANLEY 2 fasd
Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers Brett A. Clementz, Ph.D., John A. Sweeney, Ph.D., Jordan P. Hamm, Ph.D., Elena I. Ivleva, M.D., Ph.D., Lauren E. Ethridge, Ph.D., Godfrey D. Pearlson, M.D., Matcheri S. Keshavan, M.D., Carol A. Taming, M.D.
Perseveration – The Lens by Which Those Afflicted with FASD Interpret their Relationship and Environment
XXXIVth International Congress on Law and Mental Health. Vienna, 2015.
Perseveration – The Lens by Which Those Afflicted with FASD Interpret their Relationship and Environment.
XXXIVth International Congress on Law and Mental Health. Vienna, 2015.
Letter to the Editors: Alcohol Exposure in Utero and Breast Cancer. Richard G. Stevens and Leena Hilakivi- Clarke
Alcohol and Alcoholism Vol.36, No.3, pp.276-277, 2001
An article by Ricardo Haussmann regarding concerns about the role of evidence-based policies.
with comments relating to prenatal alcohol exposure and DSM psychiatric diagnoses.
Submission to the Ontario Select Committee on developmental services. BARRY STANLEY 2 fasd
Submission to the Ontario Select Committee on developmental services. Jan. 2014: relating to the needs of those with FASD and the families who support them.
Similar to Prenatal exposure to recreational drugs affects global motion perception in preschool children Arijit Chakraborty1, Nicola S. Anstice1, Robert J. Jacobs1, Linda L. LaGasse2, Barry M. Lester2, Trecia A. Wouldes3,* & Benjamin Thompson1,
Screening Tool for Developmental Disorders in ChildrenApollo Hospitals
Developmental problems are a diverse group of conditions that affect and limit children and their life-chances. A ready reference for a Paediatrician would be the first six chapters of the latest edition (18th) of the Nelson Textbook of Pediatrics (The Field of Pediatrics, Growth & Development, Psychological Disorders, Social Issues, Children with Special Health Needs and Nutrition and Human Genetics and Metabolic Diseases).
The Indo-American Journal of Life Sciences and BioTechnology is a premier online platform that serves as a nexus for cutting-edge research at the intersection of life sciences and biotechnology. Our site fosters the exchange of innovative ideas, scholarly articles, and breakthrough discoveries in these dynamic fields. With a commitment to promoting scientific excellence, the journal provides a global forum for researchers, academics, and industry professionals to share their insights and advancements. Navigate through a wealth of diverse content, ranging from molecular biology to bioprocess engineering, as we strive to advance knowledge and propel the frontiers of life sciences and biotechnology. Join us in the pursuit of scientific excellence and stay abreast of the latest developments in this ever-evolving landscape.
The Indo American Journal of Life Sciences and Biotechnology is a leading scholarly publication dedicated to advancing research at the intersection of life sciences and biotechnology. With a focus on fostering interdisciplinary collaboration, this journal provides a platform for cutting-edge research and innovations in areas such as molecular biology, genetics, bioinformatics, and bioprocessing. Featuring rigorous peer-reviewed articles, the journal serves as a valuable resource for scientists, researchers, and professionals in the field, promoting the dissemination of knowledge and the development of groundbreaking technologies that contribute to the advancement of life sciences and biotechnology.
Intrauterine alcohol exposure and offspring mental health: A systematic reviewBARRY STANLEY 2 fasd
2
Abstract
Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear
on the association of alcohol use in pregnancy and offspring mental health disorders. We conducted a systematic review to evaluate studies examining this association.
Methods: Studies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and
offspring mental health at age 3 or older as an outcome. We excluded non-English language publications, and studies of foetal alcohol syndrome.
Results: Thirty-three studies were included and were categorised by mental health outcomes: anxiety/depression, emotional problems, total internalising problems, total
problem score, and conduct disorder. Over half of the analyses reported a positive association of intrauterine alcohol exposure and negative offspring mental health outcomes.
Conclusions: Our review suggests that maternal alcohol use during pregnancy is associated with negative offspring mental health outcomes, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference are needed to further investigate if these associations shown are causal.
Randomized, Controlled Trial of an Intervention forToddlersW.docxmakdul
Randomized, Controlled Trial of an Intervention for
ToddlersWith Autism: The Early Start DenverModel
WHAT’SKNOWNONTHISSUBJECT: Previous studies on the
efficacy of early behavioral intervention for improving outcomes
for preschool-aged childrenwith autismhave yieldedpromising
results. However, no randomized clinical trials of early
developmental behavioral intervention designed for toddlerswith
autismhavebeen conducted to date.
WHATTHISSTUDYADDS: This study assessed the efficacy of the
Early Start DenverModel, a comprehensive developmental
behavioral intervention, for improving outcomesof toddlerswith
ASD. The intervention,whichwas initiatedwhen childrenwere
less than 21⁄2 years, resulted in significant improvements in IQ,
language, adaptive behavior, andautismdiagnosis.
abstract
OBJECTIVE: To conduct a randomized, controlled trial to evaluate the
efficacy of the Early Start DenverModel (ESDM), a comprehensive de-
velopmental behavioral intervention, for improving outcomes of tod-
dlers diagnosedwith autismspectrumdisorder (ASD).
METHODS: Forty-eight children diagnosed with ASD between 18 and 30
monthsof agewere randomly assigned to 1of 2 groups: (1) ESDM inter-
vention,which isbasedondevelopmentalandappliedbehavioralanalytic
principlesanddeliveredby trained therapistsandparents for2years;or
(2)referraltocommunityprovidersforinterventioncommonlyavailablein
thecommunity.
RESULTS: Comparedwithchildrenwhoreceivedcommunity-intervention,
childrenwhoreceivedESDMshowedsignificantimprovementsinIQ,adap-
tivebehavior,andautismdiagnosis.Twoyearsafterenteringintervention,
theESDMgrouponaverageimproved17.6standardscorepoints(1SD:15
points)comparedwith7.0pointsinthecomparisongrouprelativetobase-
linescores.TheESDMgroupmaintaineditsrateofgrowthinadaptivebehav-
iorcomparedwithanormativesampleoftypicallydevelopingchildren.Incon-
trast, over the2-yearspan, thecomparisongroupshowedgreaterdelays in
adaptivebehavior.ChildrenwhoreceivedESDMalsoweremorelikelytoexpe-
rienceachange indiagnosis fromautismtopervasivedevelopmentaldisor-
der,nototherwisespecified,thanthecomparisongroup.
CONCLUSIONS: This is thefirst randomized, controlled trial todemon-
strate theefficacyofacomprehensivedevelopmentalbehavioral inter-
vention for toddlers with ASD for improving cognitive and adaptive
behavior and reducing severity of ASDdiagnosis. Results of this study
underscore the importance of early detection of and intervention in
autism.Pediatrics 2010;125:e17–e23
AUTHORS: GeraldineDawson, PhD,a,b,c Sally Rogers,
PhD,d JeffreyMunson, PhD,e,fMilani Smith, PhD,e Jamie
Winter, PhD,e JessicaGreenson, PhD,e AmyDonaldson,
PhD,g and Jennifer Varley,MSe
aAutismSpeaks; bDepartment of Psychiatry, University of North
Carolina, Chapel Hill, North Carolina; cDepartment of Psychology,
eUniversity ofWashington AutismCenter, Center onHuman
Development andDisability, and fDepartment of Psychiatry and
Behavioral Sciences, University ofWashington, Seattle,
Washington; dMIND Institute, Departmen ...
Autism Spectrum Disorder and Particulate Matter Air Pollution before, during ...joaquin_project
Pregnant women may nearly double their risk of giving birth to a child with autism by inhaling smog spewed by vehicles or smoke stacks, according to a new Harvard study that could help unlock the deepest autism mysteries.
The research fortifies previous scientific findings that linked air pollution to autism. And it offers fresh insights by showing women in their third trimesters seem most vulnerable if they breathe in elevated levels of tiny airborne particles emitted by power plants, fires and automobiles.
Sacral Neuromodulation in Children with Neurogenic Bladder DysfunctionCrimsonpublisherssmoaj
Sacral Neuromodulation (SN) is a therapy consisting of electrical stimulation of sacral nerves at S3 level delivered by a cylindrical electrode connected to a full-implantable neurostimulation device. SN in adult patients for urinary tract dysfunctions other than neurogenic modulates cortical and subcortical structures involved in urination, beside modulating structures with an important role in awareness of the rate of urination and filling of the bladder. A possible explanation for SN’s therapeutic effect is due to the activation and inhibition of supraspinal brain areas by the spinal cord, which normalizes urinating functions. An important benefit of SN is that it is a minimally invasive and reversible treatment option, which includes a test phase before permanent implantation [1,2].
Screening Children with Autism by Developing Smart Toy CarsIJRES Journal
Autistic spectrum disorders are categorized under developmental disorders and lead into a wide range of symptoms in the patients. They are referred to as autism spectrum, since the intensity and the extent of their symptoms vary person to person based on disorder's intensity. In this study, a smart toy car was developed for screening children with autism. In making the toy car, field-programmable gate array was exploited which is an integrated circuit capable of high-speed planning. Appropriate selected features were the ones that identified repetitive and stereotypical motions in movement, which are normally comprised of 9 features. Finally, in the most appropriate conditions, the classification of aforementioned features was carried out using support vector machine algorithm with polynomial kernel with an order of 5. Autistic children screening was carried out with an accuracy of 100%
Rai, D., Lee, B. K., Dalman, C., Golding, J., Lewis, G., & Magnuss.docxmakdul
Rai, D., Lee, B. K., Dalman, C., Golding, J., Lewis, G., & Magnusson, C. (2013). Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: Population based case-control study. BMJ : British Medical Journal (Online), 346 doi:http://dx.doi.org.saintleo.idm.oclc.org/10.1136/bmj.f2059
Parental depression, maternal antidepressant use
during pregnancy, and risk of autism spectrum
disorders: population based case-control study
OPEN ACCESS
Dheeraj Rai clinical lecturer 1 2 3, Brian K Lee assistant professor 4, Christina Dalman associate
professor2, Jean Golding professor emeritus5, Glyn Lewis professor1, Cecilia Magnusson professor2
1Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK;
2Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; 3Avon and Wiltshire
Partnership Mental Health NHS Trust, Bristol, UK; 4Department of Epidemiology and Biostatistics, Drexel University School of Public Health,
Philadelphia, PA, USA; 5Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, UK
Abstract
Objective To study the association between parental depression and
maternal antidepressant use during pregnancy with autism spectrum
disorders in offspring.
Design Population based nested case-control study.
Setting Stockholm County, Sweden, 2001-07.
Participants 4429 cases of autism spectrum disorder (1828 with and
2601 without intellectual disability) and 43 277 age and sex matched
controls in the full sample (1679 cases of autism spectrum disorder and
16 845 controls with data on maternal antidepressant use nested within
a cohort (n=589 114) of young people aged 0-17 years.
Main outcome measure A diagnosis of autism spectrum disorder, with
or without intellectual disability.
Exposures Parental depression and other characteristics prospectively
recorded in administrative registers before the birth of the child. Maternal
antidepressant use, recorded at the first antenatal interview, was
available for children born from 1995 onwards.
Results A history of maternal (adjusted odds ratio 1.49, 95% confidence
interval 1.08 to 2.08) but not paternal depression was associated with
an increased risk of autism spectrum disorders in offspring. In the
subsample with available data on drugs, this association was confined
to women reporting antidepressant use during pregnancy (3.34, 1.50 to
7.47, P=0.003), irrespective of whether selective serotonin reuptake
inhibitors (SSRIs) or non-selective monoamine reuptake inhibitors were
reported. All associations were higher in cases of autism without
intellectual disability, there being no evidence of an increased risk of
autism with intellectual disability. Assuming an unconfounded, causal
association, antidepressant use during pregnancy explained 0.6% of
the cases of autism sp ...
The main purpose of the present study was to determine the effect of regular home visits on the developmental indices of low birth weight infants. The present study was an on-site clinical investigation. 90 infants ranging between 1500 to 2500g born in Razi Hospital of Marand town having the entrance criteria to the present study were taken into consideration through the available sampling method and then they were divided into two intervention and control groups. The intervention group has received the whole routine cares since the first to fourth week and then they were visited at home for 45 minutes a week. The control group received the routine cares. The evolutionary indices of both groups were also completed monthly for three months by referring homes. The related data gathering tool was also subjected to the demographic information through registration list and the Persian version of the Low Weight Infant Inventory (LWII) (2 months) that have been completed by the researcher on the birthday, first, second and third months of the birth through the interview. SPSS-15 software and the application of the inferential and descriptive statistical tests (K2 and T-tests) were also applied in order to analyze the related data in this study. The significance level was considered as p<0.05.
More than half of these related research units of both groups had experience (61.5%) and control (55.8%) regarding all women in this study; the mean score of the low weight infants on the first month had not shown any statistical significant difference; but on the second months (p=0.04) and the third months (p=0.001), they had shown statistical significant difference progressively. The healthcare based on home-visit had influence on the recovery indices of the low weight infants. Hence, nurses and other health monitors of the infants should apply for the healthcare programs based on home-visit particularly in caring infants.
Similar to Prenatal exposure to recreational drugs affects global motion perception in preschool children Arijit Chakraborty1, Nicola S. Anstice1, Robert J. Jacobs1, Linda L. LaGasse2, Barry M. Lester2, Trecia A. Wouldes3,* & Benjamin Thompson1, (20)
Conclusions reached from my involvement with the Canadian criminal justice system. 2011.
amd- 2021
References of papers published by Dr Mansfield Mela, and others regarding FASD, PAE, Mental Health, and the Justice System.
Dr Mela is one of the very few Forensic Psychiatrists who understands and advocates for those with FASD.
The Nomenclature of the Consequences of Prenatal Alcohol Exposure: PAE, and t...BARRY STANLEY 2 fasd
An historical account of the nomenclature relating to the effects of alcohol on the developing fetus.
The significance of facial features; the dose/threshold question; epigenetics, transgenerational consequences, and adult health issues, are raised.
The inadequacy of the present nomenclature is detailed
Effects of Hyperbaric Oxygen Therapy on Brain Perfusion, Cognition and Behavi...BARRY STANLEY 2 fasd
Abstract
A 15-year-old girl diagnosed with FASD underwent 100 courses of hyperbasic oxygen therapy (HBOT). Prior to HBOT, single motion emission compute tomographic begin imaging (SPECT)
revealed areas of hypo-perfusion bilaterally in the orbitofrontal region, temporal lobes and right dorsolateral—frontal, as well the medial aspect of the left cerebellum. Following two sets of HBOT treatments (60 plus 40), over 6 months, there was improvement in perfusion to the left cerebellum as well as the right frontal lobe. This was paralleled by improvement in immediate cognitive tests and an increase in functional brain volume. A follow-up 18 months after HBOT showed sustained
improvement in attention with no need for methylphenidate, as well as in math skills and writing.
This year as a priority of Proof Alliance’s legislative platform, major legislation that requires all children entering foster care be screened for prenatal exposure to alcohol in Minnesota was passed and signed into law. It is believed Minnesota is the first state in the nation to pass this legislation.
Four year follow-up of a randomized controlled trial of choline for neurodeve...BARRY STANLEY 2 fasd
Abstract
Background
Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits. FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windows are emerging. We present a long-term follow-up study evaluating the neurodevelopmental effects of choline supplementation in children with FASD 4 years after an initial efficacy trial
Abstract
This presentation includes a brief review of research into boredom, normal brain resting state and corresponding default mode[s].
The possible equivalence to the brain activity of those with FASD in relation to “being bored” is explored, with reference to brain anatomy and function.
Actual FASD clinical cases are presented to illustrate what individuals with FASD mean by “boredom”: describing the role of perseveration as a relief process.
Finally, the manner in which these processes are misinterpreted is explored, with implications for Psychiatry and the Justice System.
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...BARRY STANLEY 2 fasd
IMPORTANCE Research to date has not determined a safe level of alcohol or tobacco use during pregnancy. Electroencephalography (EEG) is a noninvasive measure of cortical function that has previously been used to examine effects of in utero exposures and associations with
neurodevelopment.
OBJECTIVE To examine the association of prenatal exposure to alcohol (PAE) and tobacco smoking (PTE) with brain activity in newborns.
CONCLUSIONS AND RELEVANCE These findings suggest that even low levels of PAE or PTE are
associated with changes in offspring brain development.
Submitted to –
National Institute for Health and Care Excellence Fetal alcohol spectrum disorder
Consultation on draft quality standard – deadline for comments 5pm on 03/04/20
Clinical course and risk factors for mortality of adult inpatients with covid...BARRY STANLEY 2 fasd
Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help
clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale
for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Outcomes of Online Mindfulness-Based Cognitive Therapy for Patients With Residual Depressive SymptomsA Randomized Clinical Trial
Zindel V. Segal, PhD1; Sona Dimidjian, PhD2; Arne Beck, PhD3; et alJennifer M. Boggs, PhD3; Rachel Vanderkruik, MA2; Christina A. Metcalf, MA2; Robert Gallop, PhD4; Jennifer N. Felder, PhD5; Joseph Levy, BA2
Author Affiliations
JAMA Psychiatry. Published online January 29, 2020. doi:10.1001/jamapsychiatry.2019.4693
Significance for fasd
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
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Prenatal exposure to recreational drugs affects global motion perception in preschool children Arijit Chakraborty1, Nicola S. Anstice1, Robert J. Jacobs1, Linda L. LaGasse2, Barry M. Lester2, Trecia A. Wouldes3,* & Benjamin Thompson1,
1. 1Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
www.nature.com/scientificreports
Prenatal exposure to recreational
drugs affects global motion
perception in preschool children
Arijit Chakraborty1
, Nicola S. Anstice1
, Robert J. Jacobs1
, Linda L. LaGasse2
,
Barry M. Lester2
, Trecia A. Wouldes3,*
& Benjamin Thompson1,4,*
Prenatal exposure to recreational drugs impairs motor and cognitive development; however it is
currently unknown whether visual brain areas are affected. To address this question, we investigated
the effect of prenatal drug exposure on global motion perception, a behavioural measure of
processing within the dorsal extrastriate visual cortex that is thought to be particularly vulnerable
to abnormal neurodevelopment. Global motion perception was measured in one hundred and forty-
five 4.5-year-old children who had been exposed to different combinations of methamphetamine,
alcohol, nicotine and marijuana prior to birth and 25 unexposed children. Self-reported drug use
by the mothers was verified by meconium analysis. We found that global motion perception was
impaired by prenatal exposure to alcohol and improved significantly by exposure to marijuana.
Exposure to both drugs prenatally had no effect. Other visual functions such as habitual visual acuity
and stereoacuity were not affected by drug exposure. Prenatal exposure to methamphetamine did
not influence visual function. Our results demonstrate that prenatal drug exposure can influence a
behavioural measure of visual development, but that the effects are dependent on the specific drugs
used during pregnancy.
Prenatal exposure to recreational drugs is a growing problem1,2
. Research into the impact of prenatal drug
exposure has focused primarily on cognitive and motor development following maternal use of opioids
such as cocaine or methadone3–5
. More recently, the effects of prenatal exposure to amphetamine-type
stimulants such as methamphetamine have been investigated because of the high prevalence of users, par-
ticularly within Australasia6,7
. Such studies include the Infant Development, Environment and Lifestyle
(IDEAL) study which has reported impaired motor development in young children exposed prenatally
to methamphetamine6,8
.
The effect of prenatal drug exposure on visual development is less well understood; however current
evidence suggests that prenatal drug exposure does affect the visual system. A recent large-scale retro-
spective comparative case series found substantial increases in the rate of strabismus and nystagmus in
infants with prenatal drug exposure that persisted at 5 years of age9
. There is also recent evidence that
prenatal drug exposure can affect visual cortex function. McGlone et al. found that 6-month old infants
with prenatal exposure to methadone exhibited abnormal visual evoked potentials10
, suggesting disrup-
tion within the visual pathway. Abnormal visual cortex responses have also been reported in a small
group of children with prenatal exposure to amphetamine11
.
1
School of Optometry and Vision Science, Faculty of Medical and Health Sciences, University of Auckland,
Private Bag 92019, Auckland, 1142, New Zealand. 2
Brown Center for the Study of Children at Risk, Warren Alpert
Medical School at Brown University, 101 Dudley Street, Providence, RI 02905, USA. 3
Department of Psychological
Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New
Zealand. 4
School of Optometry andVision Science, Faculty of Science, University ofWaterloo, 200 Columbia Street
West, Waterloo, Ontario, ON N2L, Canada. *
These authors contributed equally to this work. Correspondence and
requests for materials should be addressed to B.T. (email: ben.thompson@uwaterloo.ca)
received: 03 July 2015
accepted: 22 October 2015
Published: 19 November 2015
OPEN
2. www.nature.com/scientificreports/
2Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
Participants in the IDEAL study were recruited to two groups on the basis of prenatal methampheta-
mine exposure (methamphetamine exposed vs. controls). Many mothers of methamphetamine-exposed
children were poly-drug users. The control group included children who were also exposed to a range
of drug combinations with the exception of methamphetamine as well as non-drug exposed children.
Prenatal drug exposure was verified objectively by meconium analysis. Therefore, this group of children
provided a unique opportunity to study the effects on visual development of prenatal exposure to a range
of substances.
The aim of this study was to investigate higher-level processing within the extrastriate visual cortex
in 4.5-year-old children enrolled in the New Zealand arm of the IDEAL study. Specifically, we assessed
the effect of prenatal drug exposure on a psychophysical measure of global motion perception, which is
dependant on visual areas such as V5 in the dorsal visual stream. This particular stream connects the
magnocellular layers of the lateral geniculate nucleus, the primary visual cortex and extrastriate areas
such as V3a and V5 within the occipito-parietal cortex12,13
. Visual areas V3a and V5 process global
motion by integrating local motion signals from the primary visual cortex14
.
Global motion perception was chosen as a measure of extrastriate visual function because it has been
suggested that dorsal stream function is particularly vulnerable to the effects of abnormal neurodevel-
opment; the dorsal stream vulnerability hypothesis15,16
. For example, impaired global motion perception
has been found in children born with developmental risk factors such as William’s syndrome, dyslexia,
autistic spectrum disorder and foetal alcohol syndrome17–22
. Poor global motion perception has also been
associated with deficits in visuomotor tasks involving reaching, grasping, and locomotor action17,23–25
.
Performance of such tasks is mediated by regions of the posterior parietal lobe that receive input from the
dorsal visual stream26,27
. In this context, our choice of global motion perception was further motivated by
the delayed motor development at birth28
and between 1 and 3 years of age8
that has been found within
the IDEAL study cohort.
Methods
The Auckland District Health Board ethics committee, the Waitematā District Health Board ethics com-
mittee, and the New Zealand Ministry of Health Northern Regional Ethics Committee approved the
study. All caregivers provided full informed consent and the study conformed to the principles of the
Declaration of Helsinki.
The design of the New Zealand IDEAL study is described in detail by Wouldes et al.6,8
. Mothers were
referred to the study by independent or hospital based midwives and prenatal drug use was assessed using
the Substance Use Inventory29
. In addition, meconium was collected soon after birth and was sent to
the United States Drug Testing Laboratory, Des Plaines, Illinois, USA for drug metabolite analysis using
gas chromatography – mass spectrometry in order to objectively determine prenatal drug exposure6
.
All methamphetamine and non-methamphetamine exposed children were matched for socio-economic
status, maternal education level (fifth form certificate achieved or not achieved), birth weight (grouped
as < 1500 g, 1500–2500 g and > 2500 g) and gestational age.
The Wechsler Preschool and Primary Scale of Intelligence (WPPSI)-III30
was administered by expe-
rienced assessors as part of a comprehensive neurodevelopmental assessment conducted at 4.5 years of
age for the IDEAL study cohort. The verbal IQ score from the WPPSI-III was used within this study of
visual funtion to control for any effects of cognitive or verbal development on performance of the global
motion perception task. The Verbal IQ score was chosen as it does not include any measures that rely
directly on visual function.
The IDEAL study cohort were assessed at 4.5 years of age because children start school after 5 years of
age in New Zealand and therefore data collected at an older age may have been influenced by differential
educational experiences. Measures of visual function were included in the 4.5 year assessment protocol
because 4.5-year-old children are capable of completing behavioural measures of visual acuity and global
motion perception.
Measurement of global motion perception. Global motion perception was assessed using random
dot kinematograms (RDK) that consisted of 100 circular dots (dot diameter 0.24°, dot density 1.27 dot/
deg2
) presented within a circular aperture (10° diameter) at a viewing distance of 60 cm. Dot speed was
6°/second and the presentation time was 1 second. These parameters were chosen on the basis of previous
studies that have investigated global motion perception in children18,31,32
. Dots had a limited lifetime,
whereby each dot had a 5% chance of disappearing on each frame and being redrawn in a random loca-
tion. Dots were presented at maximum brightness (137 cd/m2
) on a grey background (45 cd/m2
) and dot
contrast was 0.51 as defined using the Michelson equation: (Ldots − Lbackground)/(Ldots + Lbackground). Signal
dots moved coherently upwards or downwards and noise dots moved in random directions. Dots that
reached the edge of the stimulus aperture were wrapped around to maintain an even dot density. Stimuli
were presented on a 15” Dell cathode ray tube (CRT) monitor (model: E771p) with a 120 Hz refresh rate
and 1024 × 768 resolution. Stimuli were generated using MATLAB 2013a and psychtoolbox-333
. Prior
to threshold measurement, children were familiarized with the stimuli and task. First, the children were
presented with 100% coherent (all signal dots), high contrast RDKs moving up or down. After 4 succes-
sive correct responses at the 100% coherence level, the experimenter varied manually the direction and
coherence of the RDK to demonstrate the appearance of RDKs with different coherence levels. Once the
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3Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
child was familiar with the stimulus and task, a 2-down-1-up adaptive staircase test was used to vary the
coherence of the RDK to measure a motion coherence threshold34
. Children were asked to judge whether
the dots were moving mostly up or mostly down and could respond verbally and/or by pointing to the
top or bottom of the screen. The staircase began at 100% coherence and had a proportional step size
of 50% until the first reversal and 25% thereafter. The staircase was terminated after 5 reversals and the
threshold was calculated by averaging the last 4 reversals.
A comprehensive vision screening was also conducted to rule out the influence of ocular disease,
significant refractive error or other visual deficits on global motion perception. This screening consisted
of measuring habitual visual acuity using the crowded Keeler logMAR chart, stereoacuity with the VAO
fly stereotest, ocular motility using a cover test, a broad H-test and a 20-prism-diopter base out test.
Ocular health was also assessed using the red reflex test, external inspection and pupillary evaluation.
Statistical analysis. To understand the effect of individual drugs on global motion perception, a
univariate general linear model was constructed with fixed factors of drug exposure, sex and ethnic-
ity and covariates of verbal IQ, stereoacuity and better eye habitual visual acuity. The fixed factor of
drug exposure coded exposure to each of the following drugs as yes or no; nicotine, alcohol, marijuana
and methamphetamine. Note that exposure to opiates was an exclusion criterion for the IDEAL study.
Significant main effects and interactions were investigated using post-hoc paired sample t-tests.
As a secondary analysis, we assessed the relationship between the estimated extent of drug exposure
and global motion perception using multiple linear regression. This analysis was conducted only for mar-
ijuana and alcohol use, because only these two drugs had significant effects on global motion perception
in the primary analysis. Furthermore, this analysis was conducted only for children who were exposed
to marijuana in the absence of alcohol, or vice versa, as the effects of marijuana and alcohol were found
to interact in the primary analysis.
Drug exposure was estimated from the Substance Use Inventory based on the subset of questions
that addressed the frequency (how many times marijuana or alcohol was used per week) and amount
(amount of marijuana or alcohol that was consumed on each occasion) of drug use. The frequency of
use was categorized as < 1 day per week, 1–4 days per week, or 5–7 days per week. For marijuana, the
amount of drug was categorized as light (< 1 joint per occasion), moderate (1–2 joints per occasion), or
heavy (> 2 joints per occasion). Because joints can be shared, these responses were modified to reflect
the consumption of whole joints based on additional questionnaire data relating to joint sharing. For
alcohol, the amount of drug was categorized as light (< 2 drink per occasion), moderate (2–5 drinks
per occasion), or heavy (> 5 drinks per occasion). Within the Substance Use Inventory, these questions
were completed separately for each trimester of pregnancy. A single estimate of frequency and a single
estimate of amount of drug use were calculated for each participant from the responses for each tri-
mester. To achieve this, we ranked the frequency of drug use in each of the trimesters (1 for < 1 day a
week, 2 for 1–4 days a week, and 3 for 5–7 days a week) and then took the median of the ranks across
all trimesters. Similarly, the amount of drug (marijuana or alcohol) use was also ranked for each of the
trimesters (1 for light users, 2 for moderate users and 3 for heavy users), and the median of the ranks
across all trimesters was used for the analysis. These categories were dummy coded (no = 0, yes = 1) for
multiple linear regression analyses. The multiple regression model controlled for other drug use (yes/no
for methamphetamine and nicotine), sex, ethnicity, stereoacuity, visual acuity, and verbal IQ.
Results
One hundred and seventy 4.5-year-old (54 ± 2 months) children were recruited from the New Zealand
arm of IDEAL study. One hundred and sixty-five children (93 male) successfully completed a psycho-
physical measure of global motion perception and a comprehensive vision screening including habitual
visual acuity, stereoacuity, ocular motility assessment and external eye examination. Demographically the
cohort was 52.5% European, 36.5% Māori and 11% other. The children had been exposed to a range of
different drugs: 75.2% to nicotine, 56.4% to alcohol, 44.2% to methamphetamine and 40% to marijuana.
The majority of children (81.3%) had been exposed to multiple drugs. Twenty-five children (15%) had
no drug exposure and provided a non-drug exposed comparison group.
Only alcohol and marijuana exposure had independent effects on global motion perception after con-
trolling for the effects of multiple drug exposure, verbal IQ, ethnicity, habitual visual acuity, stereoacuity,
and sex. Children who were exposed prenatally to alcohol had elevated (worse) motion coherence thresh-
olds (Fig. 1A) whereby global motion perception was significantly poorer (t163 = − 2.26, p = 0.002) than
that of children not exposed to alcohol (alcohol exposed, n = 95: 59 ± 21% motion coherence threshold
vs alcohol non-exposed, n = 70: 50 ± 23%). Unexpectedly, children exposed to marijuana had signifi-
cantly lower (better) motion coherence thresholds (Fig. 1B) (t163 = 3.52, p = 0.001) than those of chil-
dren not exposed to marijuana [marijuana exposed, n = 67: 46 ± 20% vs marijuana non-exposed, n = 98:
63 ± 25%]. A significant interaction between the effects of alcohol exposure and marijuana exposure on
motion coherence thresholds was also present (Fig. 1C, F1,114 = 7.7, p = 0.006), whereby exposure to mar-
ijuana in the absence of alcohol was associated with improved global motion perception (mean motion
coherence threshold = 34 ± 11%, n = 20), which was significantly lower (better) (t41 = 4.42, p < 0.001)
than that of children who had not experienced prenatal drug exposure (mean motion coherence thresh-
old = 58 ± 23%, n = 25). However global motion perception for children exposed to both marijuana and
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4Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
alcohol (mean motion coherence threshold = 53 ± 24%, n = 48) was no different (t70 = − 0.28, p = 0.39)
from that of children who had no drug exposure (mean motion coherence threshold = 58 ± 23%, n = 25).
No other significant main effects or interactions between drugs were found for global motion percep-
tion. Also, visual acuity (measured with habitual refractive correction if worn), stereoacuity, and verbal
IQ (measured with Wechsler Preschool and Primary Scale of Intelligence-III) were unaffected by drug
exposure in this group of children.
Multiple linear regression conducted on the subset of children (n = 20) who were exposed to mar-
ijuana, but not to alcohol, revealed that both the frequency of maternal marijuana use (β = − 0.90;
F3,16 = 28.19, p < 0.001; adjusted R2
= 0.75) and amount of joints consumed per occasion (β = − 0.89;
F3,16 = 33.26, p < 0.001; adjusted R2
= 0.78) had a negative linear association with motion coherence
threshold. More frequent maternal use of marijuana (Fig. 2a) during pregnancy and more joints smoked
per occasion (Fig. 2b) were associated with lower motion coherence thresholds, indicating better global
motion perception. The opposite of this was true for children (n = 46) exposed to alcohol, but not to
marijuana, whereby both frequency of maternal alcohol use (β = 0.62; F3,42 = 10.81, p < 0.001; adjusted
R2
= 0.39) and amount of alcohol consumed per occasion (β = 0.67; F3,42 = 12.06, p < 0.001; adjusted
R2
= 0.42) had a positive linear association with motion coherence threshold. More frequent maternal
use of alcohol (Fig. 2a) during pregnancy and a greater number of alcoholic drinks per occasion (Fig. 2b)
were associated with higher motion coherence thresholds, indicating poorer global motion perception.
Discussion
Our results indicate that 1) global motion perception, a behavioural measure of extrastriate visual
function, is susceptible to the effects of prenatal drug exposure, and 2) interaction effects occur when
children are exposed to multiple drugs. Specifically, we found that alcohol exposure impaired, and mar-
ijuana exposure improved, global motion perception. These effects were dependant on the frequency
and amount of prenatal marijuana or alcohol exposure. Furthermore, these effects appeared to cancel
one another whereby prenatal exposure to both drugs resulted in no effect on global motion perception.
Our finding that prenatal alcohol exposure was associated with impaired global motion perception
is consistent with previous reports documenting detrimental effects of alcohol exposure on neurodevel-
opment35
and ocular development36,37
. However, the majority of prior studies have focused on children
Figure 1. The effect of prenatal exposure to alcohol, marijuana and their combination on motion
coherence thresholds, a measure of global motion perception. (a) Prenatal alcohol exposure (n = 95)
impaired global motion perception (b) Prenatal marijuana exposure (n = 67) improved global motion
perception (c) Exposure to marijuana in the absence of alcohol (n = 20) was associated with a substantial
improvement in global motion perception that was significantly better (p < 0.001) than children with no
history of drug exposure (dotted line, n = 25). Error bars and the shaded area show standard error of the
mean.
5. www.nature.com/scientificreports/
5Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
with foetal alcohol syndrome. In contrast, none of the children in this study had been diagnosed with
foetal alcohol syndrome. This suggests that prenatal exposure to levels of alcohol that are not sufficient to
induce foetal alcohol syndrome can still impair the cortical processing of visual information as assessed
using a behavioural measure of global motion perception. Furthermore, this deficit would not be evident
from the results of a vision screening, as clinical measures of visual perception such as habitual visual
acuity and stereoacuity were unaffected in our group of children. However, clinical tests of stereopsis
such as the VAO Fly Stereotest used in this study are unlikely to be sensitive enough to detect small
differences in stereoacuity.
The finding that prenatal marijuana exposure influenced global motion perception was consistent
with the idea that extrastriate visual cortex development is effected by maternal drug use. However
the direction and size of the effect was unexpected; the children exposed to marijuana in the absence
of alcohol were almost 50% better at the global motion task than children with no drug exposure. It is
important to note that although prenatal marijuana exposure has not been studied widely, detrimen-
tal effects have been reported for motor and cognitive development38
. Therefore our results cannot be
extrapolated beyond global motion perception or interpreted as marijuana having beneficial effects on
foetal development. Furthermore, superior performance on a single behavioural task does not necessarily
indicate supernormal neurodevelopment. For example, children with autism have superior performance
on a mirror symmetric global pattern task compared to controls39
; however their motor control is poorer
than non-autistic individuals40–42
.
One possible explanation for the improved global motion perception we observed in marijuana-exposed
children relates to the potential neurochemical effects of this drug on the developing visual system.
Endocannabinoid receptors are present throughout the visual pathway of non-human primates and have
particularly high expression within dorsal stream brain areas such as the middle temporal area (MT;
the primate equivalent of human V5) and the middle superior temporal area (MST)43
. Both MT/V5
and MST are motion sensitive areas within the extrastriate visual cortex of humans and non-human
primates44,45
. Although the role of endocannabinoid receptors in dorsal stream function is unknown,
there is evidence that cannabinoids can enhance the function of specific neural pathways. For example,
cannabinoids improve movement and locomotion of rats in a dose-dependent manner46
. Therefore, it is
possible that prenatal marijuana exposure acts upon endocannabinoid receptors in MT/MST in a way
that improves global motion perception in human infants. It has also been found that cannabinoids facil-
itate neurogenesis by acting as anti-oxidants and regulating mitochondrial activity in preclinical models
of neurodegenerative disorders47
. These effects may also occur within the extrastriate visual cortex.
Previous studies have reported that prenatal exposure to heavy marijuana use impairs performance
on a range of standardized neuropsychological tests of attention, memory, and executive function that
involve a visual component48–53
. These tests typically require the encoding, memorization, and recog-
nition of visual patterns and objects. Therefore, they may involve processing within the ventral visual
stream that includes regions of extrastriate visual cortex specialized for object recognition26,27
. In com-
bination with our results, this raises the interesting possibility that prenatal marijuana exposure may
Figure 2. The relationship between motion coherence thresholds and the (a) frequency and (b) amount
of maternal marijuana or alcohol use. The red and blue lines indicate maternal marijuana and alcohol use,
respectively. Data points in panel (a) indicate mean motion coherence thresholds for children who were
prenatally exposed to marijuana or alcohol < 1 day/week (marijuana n = 6, alcohol n = 10), 1–4 days/week
(marijuana n = 5, alcohol n = 14), or 5–7 days/week (marijuana n = 9, alcohol n = 22). Data points in panel
(b) indicate mean motion coherence thresholds for children whose marijuana or alcohol exposure on each
occasion was light (marijuana, < 1 joint, n = 6; alcohol, < 2 drinks, n = 19), moderate (marijuana, 1–2 joints,
n = 7; alcohol, 2–5 drinks, n = 9), or heavy (marijuana, > 2 joints, n = 7; alcohol, > 5 drinks, n = 18). Drug
use data are maternal self-report; see methods for further details. The error bars indicate standard error of
the mean. Other drug use (yes/no for methamphetamine and nicotine), sex, ethnicity, stereoacuity, visual
acuity, and verbal IQ were controlled for in the multiple regression model.
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6Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
improve dorsal stream function but impair ventral stream function. Alternatively, the detrimental effects
of marijuana on visual processing reported in previous studies may reflect impairments at the level of
visual attention, visual memory, or response inhibition rather than visual perception53
.
The antagonistic effects we report for marijuana and alcohol exposure on motion processing highlight
the importance of considering poly-drug interactions when investigating the consequences of prenatal
drug exposure. Marijuana neutralizes the effect of nicotine in an animal model of addiction54
; however
interactions between drugs administered prenatally have not been explored comprehensively in animal
models. If antagonistic drug effects on foetal and infant neurodevelopment can be confirmed, a pathway
for the development of interventions that minimize the harmful effects of prenatal drug exposure may
be opened.
The absence of any effect of prenatal nicotine exposure on global motion perception is consistent with
previous neuropsychological studies suggesting that nicotine impairs global cognitive function and audi-
tory processing rather than tasks that involve visual processing49,48
. However, deficits in visual attention
have been reported in children with prenatal nicotine exposure55
. Our data indicate that any deficits in
visual attention do not impact on habitual visual acuity, stereopsis, or global motion perception in chil-
dren with prenatal nicotine exposure. Similarly, prenatal exposure to methamphetamine did not affect
habitual visual acuity, stereopsis, or global motion perception in our study cohort. No previous prospec-
tive studies have investigated the effect of methamphetamine on visual development in humans, although
there is evidence for ocular and optic nerve abnormalities in rats parentally exposed to methampheta-
mine56,57
. No children in our study exhibited visual deficits that would suggest serious ocular or optic
nerve pathology; however retinal structure was not specifically investigated as part of our study protocol.
The average motion coherence thresholds we report for non-drug exposed children are slightly
elevated (worse) compared to a number of previous studies of global motion perception in preschool
children58,59
. This was likely because of differing stimulus parameters and psychophysical techniques.
However, because children within the IDEAL study were matched for factors such as socioeconomic
status and maternal education, it is possible that low socioeconomic status and its related risk factors had
a negative impact on global motion development for the whole group. We also note that other studies
have reported higher (worse) global motion thresholds than ours for normally developing children of a
similar age60
.
Overall, our results demonstrate that the development of global motion perception is affected by pre-
natal exposure to alcohol or marijuana but not nicotine or methamphetamine. Our finding that global
motion perception was improved by marijuana exposure and that marijuana reduced the negative effect
of alcohol exposure may provide a foundation for further studies investigating new ways to prevent or
ameliorate the negative developmental effects of prenatal drug exposure.
References
1. Wouldes, T., Lagasse, L., Sheridan, J. & Lester, B. Maternal methamphetamine use during pregnancy and child outcome : what
do we know? Prenatal methamphetamine exposure and child development. N. Z. Med. J. 117, 1–9 (2004).
2. Kuczkowski, K. M. The effects of drug abuse on pregnancy. Curr. Opin. Obstet. Gynecol. 19, 578–585 (2007).
3. Miller-Loncar, C. et al. Predictors of motor development in children prenatally exposed to cocaine. Neurotoxicol. Teratol. 27,
213–220 (2005).
4. Minnes, S. et al. The effects of prenatal cocaine exposure on problem behavior in children 4–10 years. Neurotoxicol. Teratol. 32,
443–51 (2010).
5. Nulman, I. et al. Neurodevelopment of adopted children exposed in utero to cocaine: the Toronto Adoption Study. Clin. Invest.
Med. 24, 129–137 (2001).
6. Wouldes, T. A. et al. Co-morbidity of substance use disorder and psychopathology in women who use methamphetamine during
pregnancy in the US and New Zealand. Drug Alcohol Depend. 127, 101–107 (2013).
7. Abar, B. et al. Cross-national Comparison of Prenatal Methamphetamine Exposure on Infant and Early Child Physical Growth:
A Natural Experiment. Prev. Sci. 1–10 doi: 10.1007/s11121-013-0431-5 (2013).
8. Wouldes, T. A. et al. Prenatal methamphetamine exposure and neurodevelopmental outcomes in children from 1 to 3 years.
Neurotoxicol. Teratol. 42, 77–84 (2014).
9. Cornish, S. K., Hrabovsky, M., Scott, N. W., Myerscough, E. & Reddy, A. R. The short- and long-term effects on the visual system
of children following exposure to maternal substance misuse in pregnancy. Am. J. Ophthalmol. 156, 190–4 (2013).
10. McGlone, L. et al. Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy. Br. J.
Ophthalmol. 98, 238–245 (2014).
11. Hansen, R. L., Struthers, J. M. & Gospe, S. M. Visual evoked potentials and visual processing in stimulant drug-exposed infants.
Dev. Med. Child Neurol. 35, 798–805 (1993).
12. De Haan, E. H. F. & Cowey, A. On the usefulness of ‘what’ and ‘where’ pathways in vision. Trends Cogn. Sci. 15, 460–466 (2011).
13. Grinter, E. J., Maybery, M. T. & Badcock, D. R. Vision in developmental disorders: is there a dorsal stream deficit? Brain Res.
Bull. 82, 147–160 (2010).
14. Andersen, R. A. Neural mechanisms of visual motion perception in primates. Neuron 18, 865–872 (1997).
15. Braddick, O., Atkinson, J. & Wattam-Bell, J. Normal and anomalous development of visual motion processing: motion coherence
and ‘dorsal-stream vulnerability’. Neuropsychologia 41, 1769–1784 (2003).
16. Spencer, J. et al. Motion processing in autism: evidence for a dorsal stream deficiency. Neuroreport 11, 2765–2767 (2000).
17. Atkinson, J. et al. A specific deficit of dorsal stream function in Williams’ syndrome. Neuroreport 8, 1919–1922 (1997).
18. Gunn, A. et al. Dorsal and ventral stream sensitivity in normal development and hemiplegia. Neuroreport 13, 843–847 (2002).
19. Manning, C., Charman, T. & Pellicano, E. Processing Slow and Fast Motion in Children With Autism Spectrum Conditions.
Autism Res. 6, 531–541 (2013).
20. Raymond, J. E. & Sorensen, R. E. Visual Motion Perception in Children with Dyslexia : Normal Detection but Abnormal
Integration. Vis. cogn. 5, 389–404 (1998).
21. Manning, C., Charman, T. & Pellicano, E. Processing Slow and Fast Motion in Children With Autism Spectrum Conditions.
Autism Res. 531–541 doi: 10.1002/aur.1309 (2013).
7. www.nature.com/scientificreports/
7Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
22. Gummel, K., Ygge, J., Benassi, M. & Bolzani, R. Motion perception in children with foetal alcohol syndrome. Acta Paediatr. 101,
e324–332 (2012).
23. Almeida, J., Mahon Z., B. & Alfonso, C. The role of the dorsal visual processing stream in tool identification. Pyschol Sci 21,
772–778 (2010).
24. Atkinson, J. & Braddick, O. Visual and visuocognitive development in children born very prematurely. Prog. Brain Res. 164,
123–149 (2007).
25. Shirai, N. & Imura, T. Looking Away Before Moving Forward: Changes in Optic-Flow Perception Precede Locomotor
Development. Psychol. Sci. 25, 485–493 (2014).
26. Goodale, M. A. Separate visual systems for perception and action: a framework for understanding cortical visual impairment.
Dev. Med. Child Neurol. 55, 9–12 (2013).
27. Goodale, M. A. & Milner, A. D. Separate visual pathways for perception and action. Trends Neurosci. 15, 20–25 (1992).
28. LaGasse, L. L. et al. Prenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New Zealand.
Neurotoxicol. Teratol. 33, 166–75 (2011).
29. Della Grotta, S. et al. Patterns of methamphetamine use during pregnancy: Results from the infant development, environment,
and lifestyle (IDEAL) study. Matern. Child Health J. 14, 519–527 (2010).
30. Welscher, D. Wechsler preschool and primary scale of intelligence. (Pearson, 2002).
31. Narasimhan, S. & Giaschi, D. The effect of dot speed and density on the development of global motion perception. Vision Res.
62, 102–107 (2012).
32. Lewis, T. L. & Maurer, D. Multiple sensitive periods in human visual development: Evidence from visually deprived children.
Dev. Psychobiol. 46, 163–183 (2005).
33. Pelli, D. G. The VideoToolbox software for visual psychophysics: transforming numbers into movies. Spat. Vis. 10, 437–442
(1997).
34. Newsome, T. & Pare, E. B. A Selective Impairment of Motion Perception the Middle Temporal Visual Area (MT) Following
Lesions of. J. Neurosci. 8, 2201–2211 (1988).
35. Landgren, M., Svensson, L., Strömland, K. & Andersson Grönlund, M. Prenatal alcohol exposure and neurodevelopmental
disorders in children adopted from eastern Europe. Pediatrics 125, e1178–e1185 (2010).
36. Strömland, K. Visual impairment and ocular abnormalities in children with fetal alcohol syndrome. Addict. Biol. 9, 153–157
(2004).
37. Strömland, K. & Pinazo-Durán, M. D. Ophthalmic involvement in the fetal alcohol syndrome: clinical and animal model studies.
Alcohol Alcohol 37, 2–8 (2002).
38. Huizink, A. C. & Mulder, E. J. H. Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and
cognitive functioning in human offspring. Neurosci. Biobehav. Rev. 30, 24–41 (2006).
39. Perreault, A., Gurnsey, R., Dawson, M., Mottron, L. & Bertone, A. Increased sensitivity to mirror symmetry in autism. PLoS One
6, 4–8 (2011).
40. Mostofsky, S. H. et al. Decreased connectivity and cerebellar activity in autism during motor task performance. Brain 132,
2413–2425 (2009).
41. Nayate, A., Bradshaw, J. L. & Rinehart, N. J. Autism and Asperger’s disorder: Are they movement disorders involving the
cerebellum and/or basal ganglia? Brain Res. Bull. 67, 327–334 (2005).
42. Jansiewicz, E. M. et al. Motor signs distinguish children with high functioning autism and Asperger’s syndrome from controls.
J. Autism Dev. Disord. 36, 613–621 (2006).
43. Javadi, P., Bouskila, J., Bouchard, J.-F. & Ptito, M. The endocannabinoid system within the dorsal lateral geniculate nucleus of the
vervet monkey. Neuroscience doi: 10.1016/j.neuroscience.2014.12.029 (2015).
44. Rudolph, K. & Pasternak, T. Transient and permanent deficits in motion perception after lesions of cortical areas MT and MST
in the macaque monkey. Cereb. Cortex 9, 90–100 (1999).
45. Braddick, O. J. et al. Brain areas sensitive to coherent visual motion. Perception 30, 61–72 (2001).
46. Sañudo-Peña, M. C., Tsou, K. & Walker, J. M. Motor actions of cannabinoids in the basal ganglia output nuclei. Life Sci. 65,
703–713 (1999).
47. Bilkei-Gorzo, A. The endocannabinoid system in normal and pathological brain ageing. Philos. Trans. R. Soc. Lond. B. Biol. Sci.
367, 3326–3341 (2012).
48. Fried, P. A. & Watkinson, B. Visuoperceptual functioning differs in 9- to 12-year olds prenatally exposed to cigarettes and
marihuana. Neurotoxicol. Teratol. 22, 11–20 (2000).
49. Fried, P. A., Watkinson, B. & Gray, R. Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to
cigarettes and marihuana. Neurotoxicol. Teratol. 25, 427–436 (2003).
50. Day, N. L. et al. Effect of prenatal marijuana exposure on the cognitive development of offspring at age three. Neurotoxicol.
Teratol. 16, 169–175 (1994).
51. English, D. R., Hulse, G. K., Milne, E., Holman, C. D. & Bower, C. I. Maternal cannabis use and birth weight: a meta-analysis.
Addiction 92, 1553–1560 (1997).
52. Fried, P. A., Watkinson, B. & Gray, R. Differential effects on cognitive functioning 9-to 12-year olds prenatally exposed to
cigarettes and marihuana. Neurotoxicol. Teratol. 20, 293–306 (1998).
53. Smith, A. M., Fried, P. A., Hogan, M. J. & Cameron, I. Effects of prenatal marijuana on visuospatial working memory: an fMRI
study in young adults. Neurotoxicol. Teratol. 28, 286–295 (2006).
54. Han, J., Liu, Z., Ren, W. & Zhang, X. Counteractive effects of cannabinoid and nicotine-addictive behavior. Neuroreport 22,
181–184 (2011).
55. Jacobsen, L. K., Slotkin, T. A., Mencl, W. E., Frost, S. J. & Pugh, K. R. Gender-specific effects of prenatal and adolescent exposure
to tobacco smoke on auditory and visual attention. Neuropsychopharmacology 32, 2453–2464 (2007).
56. Melo, P., Rodrigues, L. G., Silva, M. C. & Tavares, M. A. Effects of prenatal exposure to methamphetamine on the development
of the rat retina. Ann. N. Y. Acad. Sci. 1074, 590–603 (2006).
57. Melo, P., Moreno, V. Z., Vázquez, S. P., Pinazo-Durán, M. D. & Tavares, M. A. Myelination changes in the rat optic nerve after
prenatal exposure to methamphetamine. Brain Res. 1106, 21–29 (2006).
58. Parrish, E. E., Giaschi, D. E., Boden, C. & Dougherty, R. The maturation of form and motion perception in school age children.
Vision Res. 45, 827–837 (2005).
59. MacKay, T. L. et al. Deficits in the processing of local and global motion in very low birthweight children. Neuropsychologia 43,
1738–1748 (2005).
60. Hadad, B. S., Maurer, D. & Lewis, T. L. Long trajectory for the development of sensitivity to global and biological motion. Dev.
Sci. 14, 1330–1339 (2011).
8. www.nature.com/scientificreports/
8Scientific Reports | 5:16921 | DOI: 10.1038/srep16921
Acknowledgements
This research was supported by the National Institutes on Drug Abuse grants 2RO1DA014948 and
RO1DA021757 and the Auckland Medical Research Foundation. We acknowledge the NZ IDEAL study
team: Jenny Rogers, Josephine Cliffe, Suzanne Cumming, and Heather Stewart.
Author Contributions
A.C. and B.T. wrote the manuscript. A.C., B.T., N.S.A., R.J.J. and T.A.W. designed the study. A.C., B.T.,
N.S.A., R.J.J., T.A.W., L.L.L. and B.M.L. reviewed the manuscript.
Additional Information
Competing financial interests: The authors declare no competing financial interests.
How to cite this article: Chakraborty, A. et al. Prenatal exposure to recreational drugs affects global
motion perception in preschool children. Sci. Rep. 5, 16921; doi: 10.1038/srep16921 (2015).
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