Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
C. Scala, A. Familiari, A. Pinas, A.T. Papageorghiou, A. Bhide, B. Thilaganathan, A. Khalil
Volume 49, Issue 4, Date: April (pages 450–459)
Slides prepared by Dr Yael Raz (UOG Editor-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15943/full
Increased nuchal translucency thickness and risk of neurodevelopmental disorders
S. G. Hellmuth, L. H. Pedersen, C. B. Miltoft, O. B. Petersen, S. Kjærgaard, C. Ekelund, A. Tabor
Volume 49, Issue 5; Date: May (pages 592–598)
Slides prepared by Dr Maddalena Morlando (UOG Editors-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15961/full
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data
V. Berghella, M. Palacio, A. Ness, Z. Alfirevic, K. H. Nicolaides and G. Saccone
Volume 49, Issue 3, Date: March (pages 322–329)
Slides prepared by Dr Shireen Meher (UOG Editors-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.17388/full
Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations
N. O'Gorman, D. Wright, L. C. Poon, D. L. Rolnik, A. Syngelaki, M. de Alvarado, I. F. Carbone, V. Dutemeyer, M. Fiolna, A. Frick, N. Karagiotis, S. Mastrodima, C. de Paco Matallana, G. Papaioannou, A. Pazos, W. Plasencia, K. H. Nicolaides
Volume 49, Issue 6, Pages 756–760
Slides prepared by Dr Fiona Brownfoot (UOG Editor-for-Trainees)
Read the free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.17455/full
Longitudinal hemodynamics in acute phase of treatment with labetalol in hypertensive pregnant women to predict need for vasodilatory therapy
D. Stott, M. Bolten, D. Paraschiv, I. Papastefanou, J.B. Chambers and N.A. Kametas
Volume 49, Issue 1, Date: January (pages 85–94)
Read the free-access article here: http://onlinelibrary.wiley.com/doi/10.1002/uog.17335/full
Serial hemodynamic monitoring to guide treatment of maternal hypertension leads to reduction in severe hypertension
D. Stott, I. Papastefanou, D. Paraschiv, K. Clark and N.A. Kametas
Volume 49, Issue 1, Date: January (pages 95–103)
Read the free-access article here: http://onlinelibrary.wiley.com/doi/10.1002/uog.17341/full
Slides prepared by Dr Katherine Goetzinger (UOG Editor for Trainees)
Accuracy of saline contrast sonohysterography in detection of endometrial polyps and submucosal leimyomas in women of reproductive age with abnormal uterine bleeding: systematic review and meta-analysis
C. A. Bittencourt, R. dos Santos Simões, W.M. Bernardo, L. F. P. Fuchs,J. M. Soares Júnior, A.R. Pastore and E.C. Baracat
Volume 50, Issue 1, Date: July Pages: 32–39
Slides prepared by Dr Joel Naftalin (UOG Editor-for-Trainees)
Read the free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.17352/full
Genomic microarray in fetuses with increased nuchal translucency and normal karyotype: systematic review and meta-analysis
M. Grande, F. A. R. Jansen, Y. J. Blumenfeld, A. Fisher, A. O. Odibo, M. C. Haak and A. Borrell
Volume 46, Issue 6, Date: December, pages 650–658
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14880/abstract
Screening for trisomies 21, 18 and 13 by cell-free DNA analysis of maternal blood at 10–11 weeks’ gestation and the combined test at 11–13 weeks
M. S. Quezada, M. M. Gil, C. Francisco, G. Oròsz and K. H. Nicolaides
Volume 45, Issue 1, pages 36–41, January 2015
http://onlinelibrary.wiley.com/doi/10.1002/uog.14664/full
Increased nuchal translucency thickness and risk of neurodevelopmental disorders
S. G. Hellmuth, L. H. Pedersen, C. B. Miltoft, O. B. Petersen, S. Kjærgaard, C. Ekelund, A. Tabor
Volume 49, Issue 5; Date: May (pages 592–598)
Slides prepared by Dr Maddalena Morlando (UOG Editors-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15961/full
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data
V. Berghella, M. Palacio, A. Ness, Z. Alfirevic, K. H. Nicolaides and G. Saccone
Volume 49, Issue 3, Date: March (pages 322–329)
Slides prepared by Dr Shireen Meher (UOG Editors-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.17388/full
Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations
N. O'Gorman, D. Wright, L. C. Poon, D. L. Rolnik, A. Syngelaki, M. de Alvarado, I. F. Carbone, V. Dutemeyer, M. Fiolna, A. Frick, N. Karagiotis, S. Mastrodima, C. de Paco Matallana, G. Papaioannou, A. Pazos, W. Plasencia, K. H. Nicolaides
Volume 49, Issue 6, Pages 756–760
Slides prepared by Dr Fiona Brownfoot (UOG Editor-for-Trainees)
Read the free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.17455/full
Longitudinal hemodynamics in acute phase of treatment with labetalol in hypertensive pregnant women to predict need for vasodilatory therapy
D. Stott, M. Bolten, D. Paraschiv, I. Papastefanou, J.B. Chambers and N.A. Kametas
Volume 49, Issue 1, Date: January (pages 85–94)
Read the free-access article here: http://onlinelibrary.wiley.com/doi/10.1002/uog.17335/full
Serial hemodynamic monitoring to guide treatment of maternal hypertension leads to reduction in severe hypertension
D. Stott, I. Papastefanou, D. Paraschiv, K. Clark and N.A. Kametas
Volume 49, Issue 1, Date: January (pages 95–103)
Read the free-access article here: http://onlinelibrary.wiley.com/doi/10.1002/uog.17341/full
Slides prepared by Dr Katherine Goetzinger (UOG Editor for Trainees)
Accuracy of saline contrast sonohysterography in detection of endometrial polyps and submucosal leimyomas in women of reproductive age with abnormal uterine bleeding: systematic review and meta-analysis
C. A. Bittencourt, R. dos Santos Simões, W.M. Bernardo, L. F. P. Fuchs,J. M. Soares Júnior, A.R. Pastore and E.C. Baracat
Volume 50, Issue 1, Date: July Pages: 32–39
Slides prepared by Dr Joel Naftalin (UOG Editor-for-Trainees)
Read the free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.17352/full
Genomic microarray in fetuses with increased nuchal translucency and normal karyotype: systematic review and meta-analysis
M. Grande, F. A. R. Jansen, Y. J. Blumenfeld, A. Fisher, A. O. Odibo, M. C. Haak and A. Borrell
Volume 46, Issue 6, Date: December, pages 650–658
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14880/abstract
Screening for trisomies 21, 18 and 13 by cell-free DNA analysis of maternal blood at 10–11 weeks’ gestation and the combined test at 11–13 weeks
M. S. Quezada, M. M. Gil, C. Francisco, G. Oròsz and K. H. Nicolaides
Volume 45, Issue 1, pages 36–41, January 2015
http://onlinelibrary.wiley.com/doi/10.1002/uog.14664/full
UOG Journal Club: October 2013
Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)
C. Lees, N. Marlow, B. Arabin, C. M. Bilardo, C. Brezinka, J. B. Derks, J. Duvekot, T. Frusca, A. Diemert, E. Ferrazzi, W. Ganzevoort, K. Hecher, P. Martinelli, E. Ostermayer, A. T. Papageorghiou, D. Schlembach, K. T. M. Schneider, B. Thilaganathan, T. Todros, A. van Wassenaer-Leemhuis, A. Valcamonico, G. H. A. Visser and H. Wolf
Link to the free-access article:
http://onlinelibrary.wiley.com/doi/10.1002/uog.13190/abstract
Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis
G. Pagani, B. Thilaganathan and F. Prefumo
Volume 44, Issue 3, Date: September 2014, Pages 254-260
http://onlinelibrary.wiley.com/doi/10.1002/uog.13364/abstract
Systematic review of accuracy of ultrasound in the diagnosis of vasa previa
L. Ruiter, N. Kok, J. Limpens, J.B. Derks, I.M. de Graaf, B.W.J. Mol and E. Pajkrt
Volume 45, Issue 5, pages 516–522, May 2015
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14752/full
Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis–fundus height
M. Griffin, P. T. Seed, L. Webster, J. Myers, L. MacKillop, N. Simpson, D. Anumba, A. Khalil, M. Denbow, A. Sau, K. Hinshaw, P. von Dadelszen, S. Benton, J. Girling, C. W. G. Redman, L. C. Chappell and A. H. Shennan
Volume 46, Issue 2, pages 182–190, August 2015
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14860/full
Prevention of postpartum hemorrhage and hysterectomy in patients with morbidly adherent placenta: a cohort study comparing outcomes before and after introduction of the Triple-P procedure
M. Teixidor Vinas, A. M. Belli, S. Arulkumaran and E. Chandraharan
Volume 46, Issue 3, Date: September, pages 350–355
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14728/full
Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis
M. M. Gil, M. S. Quezada, R. Revello, R. Akolekar and K. H. Nicolaides
Volume 45, Issue 3, pages 249–266, March 2015
http://onlinelibrary.wiley.com/doi/10.1002/uog.14791/full
UOG Journal Club: Reassessing critical maternal antibody threshold in RhD alloimmunization: a 16-year retrospective cohort study
C. A. Walsh, B. Doyle, J. Quigley, F. M. McAuliffe, J. Fitzgerald, R. Mahony, S. Higgins, S. Carroll and P. McParland
Volume 44, Issue 6, pages 669–673, December 2014
http://onlinelibrary.wiley.com/doi/10.1002/uog.13383/abstract
Clinical implementation of routine screening for fetal trisomies in the UK NHS: cell-free DNA test contingent on results from first-trimester combined test
M. M. Gil, R. Revello, L. C. Poon, R. Akolekar and K. H. Nicolaides
Volume 47, Issue 1; pages 45–52
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15783/full
UOG Journal Club: December 2013
Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review with meta-analysis
B.J. Voskamp, H. Fleurke-Rozema, K.O. Rengerink, R.J.M. Snijders, C.M. Bilardo, B.W.J. Mol and E. Pajkrt
Link to free access article:
http://onlinelibrary.wiley.com/doi/10.1002/uog.12541/abstract
GENETIC TESTING: Introduction, definition, methods: molecular, chromosomal and biochemical, indications, types: preimplantation, forensic, newborn, carrier, prenatal, ethical, social and legal issues, interpretation of tests, risks and limitations, role of nurse
Neonatal and Obstetric Risk Assessment (NORA) Pregnancy Cohort Study in Singa...Premier Publishers
The Neonatal and Obstetric Risk Assessment (NORA) pregnancy cohort study was set up to assess clinical, biochemical and biophysical markers for risk assessment and prediction of the outcomes early in pregnancy. A total of 3271 patients who were in KK Women’s and Children’s Hospital between September 2010 and October 2014 were screened and 1013 patients consented to participate in the study. Women were followed at 18 to 22 weeks, 28 to 32 weeks and 34 weeks and above, till their postnatal discharge from the hospital. Finally, 926 patients remained for studying the outcome. In NORA study, we established locally derived and gestational age-specific reference intervals for the five thyroid hormone parameters. Higher serum progesterone levels at 28–32 weeks of pregnancy were observed in women who had preterm deliveries compared with women with term deliveries in the cohort. We also found that extracellular vesicle (EV) biomarkers enhanced the predictive robustness of an existing pre-eclampsia (PE) biomarker sufficiently to justify PE screening in a low-risk general obstetric population. We plan to further conduct a range of serial assessments from the biosamples which will provide a comprehensive and valuable information of the dynamics of maternal conditions and fetal development during pregnancy.
UOG Journal Club: October 2013
Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)
C. Lees, N. Marlow, B. Arabin, C. M. Bilardo, C. Brezinka, J. B. Derks, J. Duvekot, T. Frusca, A. Diemert, E. Ferrazzi, W. Ganzevoort, K. Hecher, P. Martinelli, E. Ostermayer, A. T. Papageorghiou, D. Schlembach, K. T. M. Schneider, B. Thilaganathan, T. Todros, A. van Wassenaer-Leemhuis, A. Valcamonico, G. H. A. Visser and H. Wolf
Link to the free-access article:
http://onlinelibrary.wiley.com/doi/10.1002/uog.13190/abstract
Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis
G. Pagani, B. Thilaganathan and F. Prefumo
Volume 44, Issue 3, Date: September 2014, Pages 254-260
http://onlinelibrary.wiley.com/doi/10.1002/uog.13364/abstract
Systematic review of accuracy of ultrasound in the diagnosis of vasa previa
L. Ruiter, N. Kok, J. Limpens, J.B. Derks, I.M. de Graaf, B.W.J. Mol and E. Pajkrt
Volume 45, Issue 5, pages 516–522, May 2015
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14752/full
Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis–fundus height
M. Griffin, P. T. Seed, L. Webster, J. Myers, L. MacKillop, N. Simpson, D. Anumba, A. Khalil, M. Denbow, A. Sau, K. Hinshaw, P. von Dadelszen, S. Benton, J. Girling, C. W. G. Redman, L. C. Chappell and A. H. Shennan
Volume 46, Issue 2, pages 182–190, August 2015
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14860/full
Prevention of postpartum hemorrhage and hysterectomy in patients with morbidly adherent placenta: a cohort study comparing outcomes before and after introduction of the Triple-P procedure
M. Teixidor Vinas, A. M. Belli, S. Arulkumaran and E. Chandraharan
Volume 46, Issue 3, Date: September, pages 350–355
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.14728/full
Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis
M. M. Gil, M. S. Quezada, R. Revello, R. Akolekar and K. H. Nicolaides
Volume 45, Issue 3, pages 249–266, March 2015
http://onlinelibrary.wiley.com/doi/10.1002/uog.14791/full
UOG Journal Club: Reassessing critical maternal antibody threshold in RhD alloimmunization: a 16-year retrospective cohort study
C. A. Walsh, B. Doyle, J. Quigley, F. M. McAuliffe, J. Fitzgerald, R. Mahony, S. Higgins, S. Carroll and P. McParland
Volume 44, Issue 6, pages 669–673, December 2014
http://onlinelibrary.wiley.com/doi/10.1002/uog.13383/abstract
Clinical implementation of routine screening for fetal trisomies in the UK NHS: cell-free DNA test contingent on results from first-trimester combined test
M. M. Gil, R. Revello, L. C. Poon, R. Akolekar and K. H. Nicolaides
Volume 47, Issue 1; pages 45–52
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15783/full
UOG Journal Club: December 2013
Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review with meta-analysis
B.J. Voskamp, H. Fleurke-Rozema, K.O. Rengerink, R.J.M. Snijders, C.M. Bilardo, B.W.J. Mol and E. Pajkrt
Link to free access article:
http://onlinelibrary.wiley.com/doi/10.1002/uog.12541/abstract
GENETIC TESTING: Introduction, definition, methods: molecular, chromosomal and biochemical, indications, types: preimplantation, forensic, newborn, carrier, prenatal, ethical, social and legal issues, interpretation of tests, risks and limitations, role of nurse
Neonatal and Obstetric Risk Assessment (NORA) Pregnancy Cohort Study in Singa...Premier Publishers
The Neonatal and Obstetric Risk Assessment (NORA) pregnancy cohort study was set up to assess clinical, biochemical and biophysical markers for risk assessment and prediction of the outcomes early in pregnancy. A total of 3271 patients who were in KK Women’s and Children’s Hospital between September 2010 and October 2014 were screened and 1013 patients consented to participate in the study. Women were followed at 18 to 22 weeks, 28 to 32 weeks and 34 weeks and above, till their postnatal discharge from the hospital. Finally, 926 patients remained for studying the outcome. In NORA study, we established locally derived and gestational age-specific reference intervals for the five thyroid hormone parameters. Higher serum progesterone levels at 28–32 weeks of pregnancy were observed in women who had preterm deliveries compared with women with term deliveries in the cohort. We also found that extracellular vesicle (EV) biomarkers enhanced the predictive robustness of an existing pre-eclampsia (PE) biomarker sufficiently to justify PE screening in a low-risk general obstetric population. We plan to further conduct a range of serial assessments from the biosamples which will provide a comprehensive and valuable information of the dynamics of maternal conditions and fetal development during pregnancy.
Similar to UOG Journal Club: Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
Practice Bulletin #226, Screening for Chromosomal AbnormalitiesVõ Tá Sơn
Practice Bulletin #226, Screening for Chromosomal Abnormalities,
Hướng dẫn sàng lọc các bất thường nhiễm sắc thể
ACOG & SMFM 2020
Bs Võ Tá Sơn
0978846100 zalo
Prenatal Genetic Screening with VarSeqGolden Helix
Our past webcast explored the current approaches for screening and diagnosis of genetic disorders in prenatal testing. While the methods available at the time were robust, they were severely limited, creating a need for a higher diagnostic yield and more efficient analysis for a wider range of genetic tests. The solution proposed was to improve and simplify prenatal screening and diagnosis with whole exome sequencing (WES).
During that webcast, we highlighted the advantages of WES over traditional methods such as karyotyping and chromosomal microarray, including improved accuracy, granularity, and cost-effectiveness. We also emphasized the potential of WES to expand diagnosis for many other adverse maternal-fetal complications beyond the large aneuploidy events previously covered. However, there was still an intimidation factor when it came to the massive data output from the exome. Fortunately, Golden Helix provided the necessary tools to build and standardize these genetic assays, simplifying the analytical process while leveraging increased diagnostic output. We explored our VarSeq software to demonstrate some example workflows of cases positive for Trisomy 21, an exon loss in DMD related to Duchenne Muscular Dystrophy, and detection of a single base change resulting in a LOF variant in RUNX1 relevant to hereditary leukemia.
Our goal was to expose our viewers to the methods of conquering this vast NGS-based data and play a role in dissolving any feeling of intimidation. Overall, exome sequencing has the potential to vastly improve diagnostic outcomes and widen discoveries in the research related to prenatal testing, and Golden Helix products are designed to facilitate this process.
When a lady visits her Obstetrician, she may be advised Ultrasonography Scan at some stage in pregnancy. It is a frequently asked question as to how many scans should she undergo during pregnancy? When? Why? (for what purpose?). I have explained this in simplified manner. Ultrasonography is an ideal and safe screening tool in pregnancy.
Similar to UOG Journal Club: Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis (20)
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
UOG Journal Club: Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
1. Perinatal and long-term outcomes in fetuses
diagnosed with isolated unilateral ventriculomegaly:
systemic review and meta-analysis
C. Scala, A. Familiari, A. Pinas, A.T. Papageorghiou,
A. Bhide, B. Thilaganathan, A. Khalil
Volume 49, Issue 4, Date: April (pages 450–459)
UOG Journal Club: April 2017
Journal club slides prepared by Dr Yael Raz
(UOG Editor for Trainees)
2. • Definition: atrial width >10 mm, measured at the level of the glomus of
the choroid plexus, perpendicular to the ventricular cavity and positioning
the calipers inside the echoes generated by the lateral walls.
• Can be symmetrical, affecting both lateral ventricles (bilateral), or
unilateral.
• Prevalence: 0.3 and 1.5 per 1000 births, depending on the gestational
age at examination, the technique of measurement and whether one or
both ventricles is/are evaluated.
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
Introduction - Fetal ventriculomegaly
3. • Etiology: normal variation, aneuploidy, genetic syndromes, primary brain
abnormalities, congenital infections, cerebrovascular accidents and
intracranial hemorrhage.
• Fetal ventriculomegaly is a common sonographic feature and has been
associated with a poor outcome.
• Even when fetal ventriculomegaly is isolated, there may be an associated
risk of abnormal neurodevelopmental outcome.
• Most relevant studies have assessed the outcomes of bilateral fetal
ventriculomegaly.
Introduction - Fetal ventriculomegaly
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
4. To quantify, via systematic review and meta-analysis, the
perinatal and long-term outcomes in fetuses diagnosed with
isolated unilateral ventriculomegaly during the second- or third-
trimester ultrasound examination
Aim of the study
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
5. Methods – study selection, data collection
• Studies reporting data on the perinatal outcome of fetuses with isolated
unilateral ventriculomegaly (atrial width >10 mm) detected during the
second or third trimester of pregnancy were included.
• ‘Apparently isolated ventriculomegaly’ – no additional brain or
extracerebral ultrasound abnormalities detected at the time of diagnosis.
• ‘Truly isolated ventriculomegaly’ - no additional brain or extracerebral
abnormalities, chromosomal abnormality or congenital infection were
detected pre- or postnatally.
• Ventriculomegaly was further classified into mild/moderate (atrial width
10–15 mm) and severe (atrial width ≥ 15 mm).
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
6. Results –
Included studies
CDSR, The Cochrane Database of Systematic Reviews;
CENTRAL, The Cochrane Central Register of Controlled Trials;
DARE, Database of Abstracts of Reviews of Effects.
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
7. Results – Apparently isolated unilateral
ventriculomegaly (108 cases)
• No case of abnormal karyotype
• Prevalence of congenital infection
(n=7: 5 CMV, 2 parvovirus): 8.2%
• Prevalence in fetuses with apparently isolated unilateral ventriculomegaly with
atrial width <15mm (101/108, 93.5%) were similar.
•Prevalence of associated extracerebral
abnormalities detected on US: 6.8%
*size of the boxes is proportional to study sample size
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
8. Results – Apparently isolated unilateral
ventriculomegaly (108 cases)
•Prevalence of associated brain abnormalities
detected by prenatal MRI: 5.1%
•Prevalence in fetuses with apparently isolated unilateral ventriculomegaly with atrial
width <15mm (101/108, 93.5%) were similar.
*size of the boxes is proportional to study sample size
•Prevalence of progression of
ventriculomegaly during pregnancy: 5.4%
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
9. • Median age at neurological assessment: 30.3 (range, 24.2–36.5) months.
Results – Neurodevelopmental delay –
apparently isolated unilateral ventriculomegaly (108 cases)
• Incidence of associated
neurodevelopmental delay: 8.0%
(atrial width <15mm: 5.9%)
*size of the boxes is proportional to study sample size
• Incidence of associated mild
neurodevelopmental delay (a): 2.1% and
severe neurodevelopmental delay (b): 4.1%
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
10. • 198/213 (93.0%) cases had postnatal neurodevelopmental assessment.
• Median age at neurological assessment: 38.0 (range, 27.0–49.8) months.
• Incidence of associated neurodevelopmental delay: 7% (in all cases, atrial width was <15mm)
Results – Neurodevelopmental delay –
truly isolated unilateral ventriculomegaly (213 cases)
*size of the boxes is proportional to study sample size
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
11. • In cases with apparently isolated unilateral ventriculomegaly detected on
prenatal ultrasound, additional brain abnormalities can be detected on
fetal MRI (pre- or postnatally)
• MRI should remain an important diagnostic tool in such cases.
• The same applies to screening for congenital infections and follow-up
scans to look for progression of the ventriculomegaly.
Discussion - apparently isolated unilateral ventriculomegaly
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
12. • Fetuses with truly isolated unilateral ventriculomegaly suffered from a low
incidence of neurodevelopmental impairment postnatally.
• The incidence of neurodevelopmental impairment is similar to that
reported in the general population.
Discussion - truly isolated unilateral ventriculomegaly
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
13. • In cases of mild apparently isolated unilateral ventriculomegaly the
prevalence of congenital infection is similar to that in fetuses with bilateral
ventriculomegaly.
• The observed prevalence of chromosomal abnormality (0%), risk of
ventriculomegaly progression (5%) and associated brain abnormalities
detected on fetal brain MRI (5%) seem to be lower than those for fetuses
with bilateral ventriculomegaly.
Discussion - Unilateral vs bilateral ventriculomegaly
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
14. Discussion - strengths and weaknesses
Strengths
•Comprehensive search strategy
•Inclusion of a number of key outcomes
identified in only isolated unilateral
ventriculomegaly cases.
•Previous data is limited, findings of
this meta-analysis could be valuable in
parental counseling.
Weaknesses
•Publication bias (small number of
cases in current literature)
•Study heterogeneity:
– Gestational age at time of diagnosis
– Diagnostic interpretation of US and MRI
images is difficult to standardize
– Method and period of follow-up used in
assessing neurodevelopmental outcome.
•Age at neurodevelopmental
assessment may be too early for
some neurodevelopmental delays to
be apparent (but less confounding
factors)
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
15. • The prevalence of aneuploidy, congenital infection and progression of
ventriculomegaly in fetuses with a prenatal diagnosis of apparently
isolated unilateral ventriculomegaly is low.
• The incidence of neurodevelopmental delay in cases of both apparently
and truly isolated unilateral ventriculomegaly with an atrial width
<15mm is likely to be similar to that reported in cases of isolated bilateral
ventriculomegaly and to that reported in the general population.
Conclusions
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017
16. • Should karyotype assessment be offered to women with apparently
isolated unilateral ventriculomegaly?
• Does gestational age at diagnosis correlate with the chance for
neurodevelopmental delay?
Points for discussion
Future perspectives
• Large multicenter prospective studies are needed to ascertain the risk of
neurodevelopmental delay and the possible risk factors that might
influence postnatal prognosis.
Outcomes in fetuses with isolated unilateral ventriculomegaly
Scala et al, 2017