Mendal (1866) proposed that inheritance is controlled by paired germinal units or factors , now called genes. Genes are present in all cells of the body and are transferred to the next generation through gametes .Factors or genes are thus physical basis of Heredity.
Inability of a plant with functional pollen to set seed when self-pollinated.
Hindrance to self-fertilization.
Prevents inbreeding and promotes outcrossing.
Reported in about 70 families of angiosperms including crop species.
Inability of a plant with functional pollen to set seed when self-pollinated.
Hindrance to self-fertilization.
Prevents inbreeding and promotes outcrossing.
Reported in about 70 families of angiosperms including crop species.
History of Genetics - Pre-Mendelian GeneticsAsad Afridi
this presentation is about history of genetics. all theory suggested and proposed after Mendel are discussed in this presentation. such as fluid theories, preformation theories and particulate theories
Some references are coming from the internet, i just copied it.. credits to the owner. some information are not mine as well as the slide i just download it from the internet. My report in my Masters.
History of Genetics - Pre-Mendelian GeneticsAsad Afridi
this presentation is about history of genetics. all theory suggested and proposed after Mendel are discussed in this presentation. such as fluid theories, preformation theories and particulate theories
Some references are coming from the internet, i just copied it.. credits to the owner. some information are not mine as well as the slide i just download it from the internet. My report in my Masters.
GENETICS - Dr. P. Saranraj, Assistant Professor, Department of Microbiology, Sacred Heart College (Autonomous), Tirupattur, Vellore District, Tamil Nadu, India
Mr. Rakesh Sharma. M, M.Sc., in Applied Microbiology, Research Assistant with seven years of experience in Central Inter- Disciplinary Research Facility (CIDRF), SBV - Puducherry has joined as Research Associate in Mahatma Gandhi Medical Preclinical Research Centre (MGMPRC). A talk by him on “Zebrafish as an animal model for biomedical research” is scheduled on 19th November, 2022 (Saturday) at 2.30 pm in A1 conference hall, 1st floor Hospital block, MGMCRI.”
Theory of preformation,
Epigenetic theory,
Theory of pengenesis,
Recapitulation theory,
Germplasm theory,
Mosaic theory,
Regulated theory,
Gradient theory
Theory of organizers.
Plant breeding - History, Objectives & ActivitiesShovan Das
Discussion is about the detailed history of plant breeding, various objectives of plant breeding and activities of plant breeding. All topics are discussed to the point.
A process where an embryo is derived from a single somatic cell or group of somatic cells. Somatic embryos (SEs) are formed from plant cells that are not normally involved in embryo formation.
Embryos formed by somatic embryogenesis are called Embryoids.
The process was discovered for the first time in Daucas carota L. (carrot) by Steward (1958), Reinert (1959).
A genetic disorder is a genetic problem caused by one or more abnormalities formed in the genome. Most genetic disorders are quite rare and affect one person in every several thousands or millions.
The process of production of RNA copy(exspecially mRNA) of a DNA sequence is called transcription.This reaction is catalysed by DNA-directed RNA polymerase enzyme or RNA polymerase .
RNA Polymerase enzyme plays a major role in synthesis of RNA from DNA.
In Prokaryote-ONLY ONE TYPE
This theory was proposed by a Drosophilist Calvin Blackman Bridges in 1921.
This theory fully explains
the sex determination in
Drosophila.
This theory shows that the
Maleness - Autosomes
Femaleness -X chromosomes.
Gene mapping means the mapping of genes to specific locations on chromosomes.
Such maps indicates the positions of genes in the genome and also distance between them.
It is the fundamental law of population genetics and provides the basis for studying Mendelian populations ( Mendelian population: A group of sexually inbreeding organisms living within a circumscribed area). It describes populations that are not evolving.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
1. Course Teacher
Dr. M. Kanimoli Mathivathana
Assistant Professor
Department of Plant Breeding & Genetics
PRESENTED BY
M. THARANI
ID No.: 2017021080
COLLEGE OF AGRICULTURAL TECHNOLOGY
(Affiliated to Tamil Nadu Agricultural University,Coimbatore-3)
((Accredited by Indian Council of Agricultural Research, New Delhi)
Kullapuram (Po), Via Vaigai Dam, Theni - 625 562.
3. Mendal (1866) proposed that inheritance is controlled by
paired germinal units or factors , now called genes.
Genes are present in all cells of the body and are
transferred to the next generation through gametes .
Factors or genes are thus physical basis of Heredity.
MENDAL THEORY
4. Everyone had a question how a offspring produced from
a parent which is similar to his / her parent or their grand
parents .
Before the correct definition given by Mendal how the
people or scientist have a idea about heredity [ ie before
1866 ]
Thus the concept or ideas or theories arise before the
Mendal discovery are said to be Pre – Mendalian
Theories .
HOW PEOPLE THINK EARLIER ???
5. The Vapour Theory
The Fluid Theory
The Theory of Spontaneous Generation
The Magnetic Power Theory
The Preformation Theory
The Theory of Epigenesis
PRE MENDALIAN THEORY :
6. The Particulate Theory
The Theory of Acquired characters
The Theory of Pangenes
The Germplasm Theory
Evolution Theory of Inheritance by natural
selection
Mutation Theory of Inheritance
7. 1. THE VAPOUR THEORY
Greek Philosopher Pythagorus
(600 BC )
Moist vapour
From body of male
Development of embryo
In uterus of female
8. 2. THE FLUID THEORY
Proposed by the
Greek Philosopher
Empeddes
Each parent produce
fliud ( Semen )
From various parts of the
body
Responsible for
production of an embryo
in the uterus of female .
9. 3. THE THEORY OF SPONTANEOUS
GENERATION
ORIGINATED FROM NON LIVING
ORGANIC ( DECAYING ) MATTER
PRIMITIVE
ORGANISMS
PLANTS
ANIMALS
The Greek Biologist
Aristotle
10. 4. MAGNETIC POWER THEORY
WILLIAM HARVEY ( 1578 – 1657 )
Experiment made on
deer
Iron by fiction
with a magnet
possess the
magnetic
property
Uterus by fiction
of coitus acquire
some magnetic
power to
concieve an
embryo
11. 5. THE PREFORMATION THEORY
SWAMMERDAN & BONNET
(1720-1793 )
Miniature
human called
Humuncules
present in egg
and sperm
A miniature
human was
preform in
the gametes
Developme
nt of zygote
resulted
only in the
growth of
miniature
human .
12. 6. THE THEORY OF EPIGENESIS
WOLFF ( 1738 – 1794 )
This concept was universally
accepted
That egg or sperm
cells do not
contain miniature
human
They are
undifferentiated
cells - undergo
differentation
after fertilization
– zygote –
development of
adult tissues and
organs
13. 7. THE PARTICULATE THEORY
MAUPERTIUS ( 1698 – 1758 )
semen
Produced by
both parents
During capulation
- form embryo
Each organ of
the embryo –
formed by fusion
Contain many
tiny particles
Two particles
produced by
both the parents
14. 8.THE THEORY OF ACQUIRED
CHARACTERS
Proposed by JEAN BAPTISTE DE
LAMARCK ( 1744 – 1829 )
This theory was disproved
by Weismann
New
character by
individual –
pass on to
progeny
EG : muscle of
man &
children
Weismann
cut tail – 22
generations –
got baby mice
with tail ..
15. 9. THE THEORY OF PANGENES
CHARLES DARWIN
(1809 – 1882 )
Very small , exact but
individual copies of each
body organ called
gemmules
Transported
by the blood
stream to the
sex organ
Gemmules
are
assembled
in gametes
After
fertilization
Gemmules move
to diff parts –
development of
respective organ
Defective
gemmule
produce
defective organ
In the individual
16. 10.THE GERMPLASM THEORY ( 1887 )
AUGUST WEISMANN
( 1834 – 1917 )
Genes ( ids ) situated in chromosome ( idants )
Reduction in chromosome no
during the formation of egg and
sperm
Restore when the egg and sperm
fused
Body tissue
Germplasm
Independent of the body
Somatoplasm
17. 11. EVOLUTIONARY THEORY OF
INHERITANCE BY NATURAL SELECTION
Proposed by CHARLES
DARWIN
BATESON – disagree - he
believed evolution due to large
discontinous variations
Evolution is due to
natural selection of small
heredity variations
according among
individuals of any species .
18. 12. MUTATION THEORY OF
INHERITANCE ( 1901 )
DE VERIES ( 1848 – 1935 )
Observed in some plants Oenothera lamarckiana
Introduced term
mutation for these large
discontinous variation in
the genotype
19. REFERENCES
Krishnan V . Senthil N . Kalaiselvi Senthil .2018 . Third edition ,
Thannanmbikkai Publications , Coimbatore . Pp 1 – 8
Karvita .b . Ahluwalia , 1996 . Genetics , second edition , New
age international Publishers , New Delhi . Pp 1 – 10
Roberts .H.F. 1929. Plant Hybridisation before Mendal .
Princeton University .Press .n.J
Whitehouse , H.L.K . 1973 . Mechanism of Heredity . Third
edition . S.t. Martin’s Press , New York . Pp 8 – 9
20. Mc Kusick .v. 1969 . Human Genetics . Second edition .
Prentice hall . N.J . Jaipur .
Dunn .L.C . 1965 . A Short History of Genetics – MC Graw
– hill , NewYork .
Carlson.E.A.1966. The Gene: A Critical History . Sauders,
Philadelphia .
Phudan Singh . 2005 . Genetics . First edition . Kalyani
Publishers , New Delhi . Pp 11 – 20 .
Acquaah george . 2006. Principles of Plant Genetics and
Breeding. Black well Publishers . Pp 4 -6 .