The researchers analyzed genomic data from 367 tissue samples from 18 locations and 20 ethnic groups in India and found evidence of 5 distinct ancestral components among the Indian population. They compared the Indian genomic data to the HUMAN GENOME DIVERSITY PANEL. In a separate study, scientists used algorithms to digitally analyze and sort cells by their cell cycle phase, providing a less toxic alternative to traditional staining methods. This new computational approach opens up opportunities for further cell cycle research and other areas of science. Studying genomic differences in populations can provide insights into disease susceptibility and help tailor medical treatments based on a person's ancestral origins and genome.
The histomorphological study of prostate lesionsiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Use of Simulation- based Training for Cancer Education among Nigerian Cliniciansasclepiuspdfs
Background: Among the many limitations of cancer control in Nigeria are lower awareness/competence and poorer training of health-care professionals (HCP). These manifest as deficiencies in advocacy, screening/diagnostic practices, and patient management. Medical simulation (MS) using models is an effective approach for sustainably improving the competence of HCP, especially regarding clinical breast examination (CBE), pelvic examination (PE), and digital rectal examination (DRE). The study evaluates the effect of MS during a Nigerian training course focusing on CBE, PE, and DRE. It answers the question: What is the immediate outcome of MS-based training, as well as the perspectives of HCP on the use of MS for cancer education? Methods: Participants included a convenience sample of Nigerian physicians and nurses who attended the American Society of Clinical Oncology-sponsored Multidisciplinary Cancer Management Course. The intervention was MS using high-fidelity models. The models demonstrated normal anatomic and common pathologic features of the breast, cervical, and prostate. Participants cycled through MS stations (i.e., CBE, PE, and DRE). Pre- and post-training surveys with comments evaluating self-reported comfort levels were the basis for comparison. Data analysis included descriptive statistics, Wilcoxon signed-rank test, Chi-square, and thematic analysis. Results: A total of 51 participants completed course evaluation forms (physicians - 35 and nurses - 16), with an average number of years in practice as 8 (±5.2) years. Pre-training survey showed non-significant differences in practices patterns; 71% (22/35) of physicians rarely performed PE (P=0.92), and 93% (14/16) of nurses rarely performed DRE (P=0.07). According to some participants, “the use of simulation is quite commendable as it gives room for improvement before using a human; it is the best method of learning I have ever enjoyed.” Conclusion: MS-based training significantly improved the comfort levels of participants regarding CBE and PE, as well as their likelihood to perform CBE, PE, and DRE. Participants recommend widespread use of MS for continuing medical education and undergraduate training.
The histomorphological study of prostate lesionsiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Use of Simulation- based Training for Cancer Education among Nigerian Cliniciansasclepiuspdfs
Background: Among the many limitations of cancer control in Nigeria are lower awareness/competence and poorer training of health-care professionals (HCP). These manifest as deficiencies in advocacy, screening/diagnostic practices, and patient management. Medical simulation (MS) using models is an effective approach for sustainably improving the competence of HCP, especially regarding clinical breast examination (CBE), pelvic examination (PE), and digital rectal examination (DRE). The study evaluates the effect of MS during a Nigerian training course focusing on CBE, PE, and DRE. It answers the question: What is the immediate outcome of MS-based training, as well as the perspectives of HCP on the use of MS for cancer education? Methods: Participants included a convenience sample of Nigerian physicians and nurses who attended the American Society of Clinical Oncology-sponsored Multidisciplinary Cancer Management Course. The intervention was MS using high-fidelity models. The models demonstrated normal anatomic and common pathologic features of the breast, cervical, and prostate. Participants cycled through MS stations (i.e., CBE, PE, and DRE). Pre- and post-training surveys with comments evaluating self-reported comfort levels were the basis for comparison. Data analysis included descriptive statistics, Wilcoxon signed-rank test, Chi-square, and thematic analysis. Results: A total of 51 participants completed course evaluation forms (physicians - 35 and nurses - 16), with an average number of years in practice as 8 (±5.2) years. Pre-training survey showed non-significant differences in practices patterns; 71% (22/35) of physicians rarely performed PE (P=0.92), and 93% (14/16) of nurses rarely performed DRE (P=0.07). According to some participants, “the use of simulation is quite commendable as it gives room for improvement before using a human; it is the best method of learning I have ever enjoyed.” Conclusion: MS-based training significantly improved the comfort levels of participants regarding CBE and PE, as well as their likelihood to perform CBE, PE, and DRE. Participants recommend widespread use of MS for continuing medical education and undergraduate training.
The Evolution of In Situ Genetic Technologyasclepiuspdfs
In situ genetic technology was historically developed and mainly focused on detection purpose, allowing specific nucleic acid sequences to be visualized in morphologically preserved tissue sections. With the synergy of genetics and immunohistochemistry, in situ detection can correlate microscopic topological information with gene activity at the transcriptional or post-transcriptional levels in specific tissues. Furthermore, its resolution allows spatial distribution of nucleic acid products to be revealed in a heterogeneous cell population. The newest member to the franchise of in situ genetic technology is a direct-on-specimen enrichment methodology specifically for cell-free DNA liquid biopsy. Contrary to in situ detection, this in-well in situ innovation tackles the very first sample preparation step to reduce material loss, thereby improving overall sensitivity. Genomic nucleic acids purified from specimens have been proven to be time consuming and suffered from damages and losses; the evolution of in situ genetic technology offers a powerful tool for precision functional genomics, enabling cross-check between in vitro and in vivo findings. It further opens the door to ultimate genetic engineering in situ.
A Systematic Review of the Cobalt Content of the Normal Human Prostate Glandasclepiuspdfs
Background: The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases remain not well understood. Moreover, despite technological advancements, the differential diagnosis of prostate disorders has become progressively more complex and controversial. It was suggested that the cobalt (Co) level in prostatic tissue plays an important role in prostatic carcinogenesis and its measurement may be useful as a cancer biomarker. These suggestions promoted more detailed studies of the Co content in the prostatic tissue of healthy subjects. Materials and Methods: The present study evaluated by systematic analysis the published data for Co content analyzed in prostatic tissue of “normal” glands. This evaluation reviewed 1949 studies, all of which were published in the years from 1921 to 2020 and were located by searching the databases Scopus, PubMed, MEDLINE, ELSEVIER-EMBASE, Cochrane Library, and the Web of Science. The articles were analyzed and “Median of Means” and “Range of Means” were used to examine heterogeneity of the measured Co content in prostates of apparently healthy men. The objective analysis was performed on data from the 23 studies, which included 1207 subjects. Results: It was found that the range of means of prostatic Co content reported in the literature for “normal” gland varies widely from 0.0035 mg/kg to 0.11 mg/kg with median of means 0.0077 mg/kg on a wet mass basis and the level of intraprostatic metal increases with age in adults. Conclusions: Because of small sample size and high data heterogeneity, we recommend other primary studies be performed.
First mitotic division: criterion for selection of potential IVF embryo – A ...theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
The role of traf3 and cyld mutationin the etiology of human papillomavirus dr...TÀI LIỆU NGÀNH MAY
Để xem full tài liệu Xin vui long liên hệ page để được hỗ trợ
: https://www.facebook.com/thuvienluanvan01
HOẶC
https://www.facebook.com/garmentspace/
https://www.facebook.com/thuvienluanvan01
https://www.facebook.com/thuvienluanvan01
tai lieu tong hop, thu vien luan van, luan van tong hop, do an chuyen nganh
Prof Richard Gibbs - Director, Baylor College of Medicine Human Genome Sequencing Centre
Wofford Cain Professor of Human & Molecular Genetics. http://www.garvan.org.au/news-events/leaders-in-science-and-society
The Evolution of In Situ Genetic Technologyasclepiuspdfs
In situ genetic technology was historically developed and mainly focused on detection purpose, allowing specific nucleic acid sequences to be visualized in morphologically preserved tissue sections. With the synergy of genetics and immunohistochemistry, in situ detection can correlate microscopic topological information with gene activity at the transcriptional or post-transcriptional levels in specific tissues. Furthermore, its resolution allows spatial distribution of nucleic acid products to be revealed in a heterogeneous cell population. The newest member to the franchise of in situ genetic technology is a direct-on-specimen enrichment methodology specifically for cell-free DNA liquid biopsy. Contrary to in situ detection, this in-well in situ innovation tackles the very first sample preparation step to reduce material loss, thereby improving overall sensitivity. Genomic nucleic acids purified from specimens have been proven to be time consuming and suffered from damages and losses; the evolution of in situ genetic technology offers a powerful tool for precision functional genomics, enabling cross-check between in vitro and in vivo findings. It further opens the door to ultimate genetic engineering in situ.
A Systematic Review of the Cobalt Content of the Normal Human Prostate Glandasclepiuspdfs
Background: The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases remain not well understood. Moreover, despite technological advancements, the differential diagnosis of prostate disorders has become progressively more complex and controversial. It was suggested that the cobalt (Co) level in prostatic tissue plays an important role in prostatic carcinogenesis and its measurement may be useful as a cancer biomarker. These suggestions promoted more detailed studies of the Co content in the prostatic tissue of healthy subjects. Materials and Methods: The present study evaluated by systematic analysis the published data for Co content analyzed in prostatic tissue of “normal” glands. This evaluation reviewed 1949 studies, all of which were published in the years from 1921 to 2020 and were located by searching the databases Scopus, PubMed, MEDLINE, ELSEVIER-EMBASE, Cochrane Library, and the Web of Science. The articles were analyzed and “Median of Means” and “Range of Means” were used to examine heterogeneity of the measured Co content in prostates of apparently healthy men. The objective analysis was performed on data from the 23 studies, which included 1207 subjects. Results: It was found that the range of means of prostatic Co content reported in the literature for “normal” gland varies widely from 0.0035 mg/kg to 0.11 mg/kg with median of means 0.0077 mg/kg on a wet mass basis and the level of intraprostatic metal increases with age in adults. Conclusions: Because of small sample size and high data heterogeneity, we recommend other primary studies be performed.
First mitotic division: criterion for selection of potential IVF embryo – A ...theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
The role of traf3 and cyld mutationin the etiology of human papillomavirus dr...TÀI LIỆU NGÀNH MAY
Để xem full tài liệu Xin vui long liên hệ page để được hỗ trợ
: https://www.facebook.com/thuvienluanvan01
HOẶC
https://www.facebook.com/garmentspace/
https://www.facebook.com/thuvienluanvan01
https://www.facebook.com/thuvienluanvan01
tai lieu tong hop, thu vien luan van, luan van tong hop, do an chuyen nganh
Prof Richard Gibbs - Director, Baylor College of Medicine Human Genome Sequencing Centre
Wofford Cain Professor of Human & Molecular Genetics. http://www.garvan.org.au/news-events/leaders-in-science-and-society
Manuela Echavarría Noreña
Medicine student
UPB
Molecular Biology
"Viruses in genome important for our brain." and "Study finds new target for controlling cell division."
This pdf file tries to answer the question as to why model organisms are used is research. By definition, Model organisms are a group of species of organisms that have been studied extensively, largely because they are easy to maintain under controlled laboratory conditions. The reason for them being studied is usually because they possess a number of experimental advantages.
Applied Research Essay example
Ethics in Research Essay
Research Critique Essay example
Essay on Types Of Research
Methodology of Research Essay examples
Qualitative Research Evaluation Essay
Essay about Sampling
Sample Methodology Essay
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Fundamentals of Research Essay
Experimental Research Designs Essay
Sampling Methods Essay
Human organoid are miniature sized, self-organized structures, that are derived from stem cells or tissues in culture. The progress, potential, limitations and challenges are discussed.
I will show some news that are important to the understanding of the importance of the genetic transcription and how it provides important tools to the actual medicine
It´s a workshop about medical genetics where you would find two news that are related to medicine, biology and genetics, there are some opinions from a medicine student about them to explain how important was each research
NATIONAL INSTITUTE OF TECHNOLOGY, HAMIRPUR
CHEMICAL ENGINEERING DEPARTMENT
DISCOVERY THAT MATURE CELLS CAN BE
REPROGRAMMED TO BECOME PLURIPOTENT
SEMINAR REPORT
CH-327
NAME: MAYANK BHARDWAJ
ROLL NUMBER: 20BCH051
DISCOVERY THAT MATURE CELLS CAN BE
REPROGRAMMED TO BECOME PLURIPOTENT
ABSTRACT
The discovery of iPSCs has paved the way for numerous applications in the medical field,
including the use of patient-specific iPSCs to model diseases, the development of new drugs, and
the creation of personalized cell-based therapies. Additionally, the ability to reprogram cells
without the use of embryos has removed many ethical considerations associated with traditional
stem cell research.
Overall, the discovery of reprogramming mature cells has opened up new avenues of research
and holds immense promise for future medical treatments.
1. INTRODUCTION
Pluripotency refers to the ability of a cell to differentiate into any type of cell in the body.
Pluripotent cells are considered the building blocks of the body and have the potential to form
any tissue or organ. This unique property makes them of great importance in the field of biology
and medicine.
In biology, pluripotent cells provide a valuable tool for understanding cellular differentiation and
the development of tissues and organs. In medicine, pluripotent cells hold immense promise for
regenerative therapies and disease treatment. For example, scientists can use pluripotent cells to
generate replacement tissues and organs, thereby providing new treatments for conditions such as
heart disease, diabetes, and spinal cord injury. Additionally, the ability to generate
patient-specific pluripotent cells has allowed scientists to study the underlying causes of diseases
and develop new drugs.
Overall, pluripotency and the study of pluripotent cells are crucial for advancing our
understanding of biology and for developing new medical treatments.
The study of stem cells has a long and rich history that dates back to the early 20th century. In
the early days of stem cell research, scientists were primarily interested in the role of stem cells
in embryonic development. In the 1950s and 1960s, the discovery of stem cells in adult tissues
opened up new avenues of research and sparked interest in the potential therapeutic applications
of these cells.
In the late 20th and early 21st centuries, advances in cell culture techniques and genetic
engineering paved the way for the discovery of induced pluripotent stem cells (iPSCs). In 2006,
scientists showed that mature cells could be reprogrammed to become pluripotent, setting the
stage for a new era of stem cell research.
Since the discovery of iPSCs, the field of stem cell research has expanded rapidly, leading to
numerous scientific and medical breakthroughs. Today, stem cell research is a highly active and
interdisciplinary field that brings together scientists from diverse backgrounds, including
biology, medicine, and engineering.
Overall, the historical context of st
An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems, a type of artificial organ
In conclusion, both cell strains and primary cells have played vital roles in advancing our understanding of cellular processes, disease mechanisms, and drug discovery. While cell strains provide a continuous and convenient supply of cells, primary cells offer a more authentic representation of human biology, enabling researchers to study specific tissues and diseases in a physiologically relevant context. The growth of cell strains and the significance of primary cells have propelled biomedical research forward, leading to breakthroughs in various fields and fostering the development of innovative therapeutic strategies. As technologies continue to evolve, primary cells will remain indispensable in further unraveling the complexities of human health and disease.
This is my short presentation in one of my university classes. It's obvious that the future of the stem cell biology is tightly engaged with organoids and they will absolutely change the way science is going to.
Kind regards
Shahin Ahmadian
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. BIBLIOGRAPHY
• Basu, A., Sarkar-Roy, N. and
Majumder, P.
(2016). Genomic study of
Indian populations finds five
distinct ancestral components.
[online] Phys.org. Available at:
http://phys.org/news/2016-
01-genomic-indian-
populations-distinct-
ancestral.html?utm_source=m
enu&utm_medium=link&utm
_campaign=item-menu
[Accessed 29 Jan. 2016].
• Blasi, T. (2016). Optimizing
cell cycle analysis with the
right algorithms. [online]
Phys.org. Available at:
http://phys.org/news/2016-
01-optimizing-cell-analysis-
algorithms.html [Accessed 29
Jan. 2016].
MEDICAL UTILITY
• Studying the genome of a
population located in a
geographic area as India
and found those
diferences, is in some way
another clue about how
we humans have evolved,
and how desease can be
relationed with oringin
and genome of an specific
population giving answers
in treatment.
• This new method to
identify the phases of cell
cycle is an usefull tool for
medicine and science,
permiting a more complet
result with out causing
any damage to the cell.
CELL CYLE
Santiago Blandón C.
Molecular Biology
3. Genomic study of Indian
populations finds five
distinct ancestral
components
• Analabha Basu, Neeta
Sarkar-Roy and Partha
Majumder found evidence
that suggests indian
population from different
places have aproximately 5
ancestors from a diversity of
lines.
How
• 367 tissue samples- 18
locations- 20 ethnic groups
represented.
• Genomic analysis.
• Comparison with people in
the HUMAN GENOME
DIVERSITY PANEL.
Observation
This study is usefull because it
compares the genetic of diverse
population that does not have
any relation along history.
INTRODUCTION
• The cellular cycle is the
process how cells reproduct
themselves by copying their
genetic material and replaing
it. Principally one mother cell
gaves “birth” to two daughter
cells.
• Cellular cicle runs growing
and development in the
organism, including the
constant renovation of the
cells.
Optimizing cell cycle
analysis with the right
algorithms
• Scientists of the the Helmholtz
Zentrum München in
collaboration with the Broad
Institute of MIT and Harvard,
Swansea University,
Newcastle University and The
Francis Crick Institute
used algorithms to identify
the cell cycle phases. This
algorithms can sort the cell
digitally.
How
Observation
• This study opens the area for
new studies of cell cycle and
in other hand can help in
other aspects of science.
4. • Copy and replication of DNA is
an order process that takes place
in different stages.
• At the end of every stage the cell
verify for possible damages on the
genetic material that could lead to
mutations.
• There are two process: Mitosis
and Meiosis.
INTRODUCTION
• The cellular cycle is the
process how cells reproduct
themselves by copying their
genetic material and
replaying it. Principally one
mother cell gaves “birth” to
two daughter cells.
• Cellular cicle runs growing
and development in the
organism, including the
constant renovation of the
cells.
5. Genomic study of Indian
populations finds five
distinct ancestral
components
• Analabha Basu, Neeta Sarkar-
Roy and Partha Majumder
found evidence that suggests
indian population from
different places have
aproximately 5 ancestors from
a diversity of lines.
How
• 367 tissue samples- 18
locations- 20 ethnic groups
represented.
• Genomic analysis.
• Comparison with people in the
HUMAN GENOME DIVERSITY
PANEL.
Observation This study is
usefull because it compares the
genetic of diverse population
that does not have any relation
along history.
• The researchers in
the study identify
different types of
genoma in India
population.
6. Using a population of
367 in different
locations of the
ocntinental area and
the other islands that
gave to the researchers
more variability in
their studies. Making
more exactly the
research.
Genomic study of
Indian populations finds
five distinct ancestral
components
• Analabha Basu, Neeta
Sarkar-Roy and Partha
Majumder found evidence
that suggests indian
population from different
places have aproximately 5
ancestors from a diversity of
lines.
How
• 367 tissue samples- 18
locations- 20 ethnic groups
represented.
• Genomic analysis.
• Comparison with people in
the HUMAN GENOME
DIVERSITY PANEL.
Observation
This study is usefull because
it compares the genetic of
diverse population that does
not have any relation along
history.
7. Genomic study of Indian populations finds five distinct ancestral components
• Finding in their
study different
( haplotypes)
exactly a quantity
of five knowing
an amplitude of
descendence on
indian people.
8. Genomic study of Indian populations finds five distinct ancestral components
The researchers not only
found a bis variety on the
genome of indian peolpe also
they found that in all this
years the genome can change
for different process like
society and culture.
9. I think that the genomic studies are
very important not only in an specific
group of people although in all the
general population because they can
give to us to many answers about a
variety of diseases that could have
relation with determinate cultures and
society, and can help us to create
solutions for this deseases and for
different kinds of populations around
the world.
10. Optimizing cell cycle
analysis with the right
algorithms
• Scientists of the the Helmholtz
Zentrum München in
collaboration with the Broad
Institute of MIT and Harvard,
Swansea University,
Newcastle University and The
Francis Crick Institute
used algorithms to identify
the cell cycle phases. This
algorithms can sort the cell
digitally.
How
Observation
This study opens the area for
new studies of cell cycle and in
other hand can help in other
aspects of science.
• The scientists
on this study
changed the
way on how
the cell cycle
was studied,
using math
and computer
tools.
11. Optimizing cell cycle
analysis with the right
algorithms
• Scientists of the the Helmholtz
Zentrum München in
collaboration with the Broad
Institute of MIT and Harvard,
Swansea University,
Newcastle University and The
Francis Crick Institute
used algorithms to identify
the cell cycle phases. This
algorithms can sort the cell
digitally.
How
Observation
• This study opens the area for
new studies of cell cycle and
in other hand can help in
other aspects of science.
The use of stains is
toxic and in too
many cases can
alterate the results
of the researchesof
the cell cycle, by
using this new
maner of
algorythms in a
computer data base
the results are more
exactly and reliable.
12. Optimizing cell cycle analysis with the right algorithms
This research opens a
big door on the use of
computer based for
the study of the
images of cell cycle
and not only for this
moreover for too
many aspects of
cientific world.
13. Optimizing cell cycle analysis with the right algorithms
The chemicals uses
in all these studies
about the cell cycle
specific on the steps
have too many
problems including
the distort and the
damage on the
celular structure.
14. • I think that this research on the
cell cycle can help in too many
aspects, like more reliable results
on the steps of cell cycle and all
the studies that have relation
with the stain use, making more
easy to study the cell in general
and accessible for the population
in general.
15. The research about Indian genome have
a lot medical utility because it can help
founding the specific location of a
disease in the genome of an specific
region, society, ethnicity giving response
in the treatment and how can change
the different diseaes on time, and also
haplotypes and racial characteristics
that play an important role in the
comprehension of people.
MEDICAL UTILITY
• Studying the genome of a
population located in a
geographic area as India
and found those
diferences, is in some way
another clue about how
we humans have evolved,
and how desease can be
relationed with oringin
and genome of an specific
population giving answers
in treatment.
• This new method to
identify the phases of cell
cycle is an usefull tool for
medicine and science,
permiting a more complet
result with out causing
any damage to the cell.
16. The treatment in many ocassions
depends on the genetic reponse of
the person and this is bound in the
genome of the different populations
around the world, using this new
studies we can open the door for
more efective treatments and find
more usefull drugs for each one
depending of its specific genome.
17. The understandig of cell
cycle is very important
for clinical use because it
opens the door for the
comprehension of deseaes
like cancer and this new
study gives more facilities
for learning more about
deseases that affect the
cell cycle and the
structure of it.
18. The complicity of the
use of stains can be toxic
and dangerous for the
people that use it and is
not too practical to
amplify the studies of
the cell, but with the use
of algorithms is more
secure and easy for the
research in the medical
shield for different
diagnostics.
19. Basu, A., Sarkar-Roy, N. and Majumder, P. (2016). Genomic study of Indian populations finds five
distinct ancestral components. [online] Phys.org. Available at: http://phys.org/news/2016-01-
genomic-indian-populations-distinct-
ancestral.html?utm_source=menu&utm_medium=link&utm_campaign=item-menu [Accessed 29 Jan.
2016].
Blasi, T. (2016). Optimizing cell cycle analysis with the right algorithms. [online] Phys.org. Available
at: http://phys.org/news/2016-01-optimizing-cell-analysis-algorithms.html [Accessed 29 Jan. 2016].
Medmol.es, (2016). Ciclo celular - Medicina molecular. [online] Available at:
http://medmol.es/glosario/55/ [Accessed 29 Jan. 2016].