PRP therapy involves concentrating platelets from whole blood through centrifugation to increase growth factor levels and promote healing. Platelets contain growth factors that attract stem cells, promote cell proliferation and healing. While research on platelet growth factors dates back to the 1980s, interest in clinical PRP applications grew due to studies on treating tennis elbow. PRP involves extracting a patient's blood, centrifuging it to separate platelets from plasma, then injecting the concentrated platelets into injured tissues like tendons. Studies support PRP for tennis elbow but not rotator cuff repair. Future research may refine PRP techniques and indications.
Aula sobre tratamento com terapia celular em ortopedia e trauma do esporte, apresentada no Simpósio de Medicina Regenerativa de Campinas - 26 e 27 de outubro de 2012
Aula sobre tratamento com terapia celular em ortopedia e trauma do esporte, apresentada no Simpósio de Medicina Regenerativa de Campinas - 26 e 27 de outubro de 2012
Platelet rich fibrin | Dental Implants with PRF | PRF In regenerative surgeri...Dr. Rajat Sachdeva
PRF is a by product of blood that is exceptionally rich in platelets.
PRF is a second generation PRP where autologous platelets and leucocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and used as a tissue engineering scaffold for endodontics .
PRF has been used to accelerate the body's own healing process.
Call us regarding Dental Treatment:-
Dr. Rajat Sachdeva
+919818894041,01142464041
drrajatsachdeva@gmail.com
Follow us here:-
• Google+ link: https://goo.gl/vqAmvr
• Facebook link: https://goo.gl/tui98A
• Youtube link: https://goo.gl/mk7jfm
• Linkedin link: https://goo.gl/PrPgpB
• Slideshare link : http://goo.gl/0HY6ep
• Twitter Page : https://goo.gl/tohkcI
• Instagram page : https://goo.gl/OOGVig
Learn more:-
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
Dr. David Greene R3 Stem Cell Injections Platelet-Rich Plasma.pptxR3 Stem Cell
Regenerative medicine therapies use the body's natural healing agents to promote tissue regeneration and repair, such as bones and joints. Dr David Greene uses this type of regenerative medicine with his r3 stem cell injection, PRP therapy, and platelet-rich plasma therapy. If you’re looking for a doctor who can help you promote healing through advanced regenerative medicine therapies, call today!
Platelet Rich Plasma ( PRP ) is very popular in the treatment of musculo skeletal pathologies. This ppt gives a brief introduction to platelets and in sights into developing a PRP kit.
A current review by Milano G et al. (http://dx.doi.org/10.1136/jisakos-2019-000274) has duly indicated the safe, cost-effective, and pain-relieving benefits of Platelet Rich Plasma (PRP) in orthopedic sports injuries and several other musculoskeletal conditions.
With several other publications supporting regenerative therapies, S.T.A.R 2020 workshop on the applications of regenerative medicine products in the field of orthopedics helps you understand the medical benefits of PRP and other regenerative therapies like BMAC and SYNOJEL, with advanced hands-on training under the guidance of professional experts.
Register now
www.advancells.com/star-2020/
Journal of Sustainable Regional health systems issue Ruby Med Plus
Background: Creating a culture of safety has received great attention to ensure that patients receive the safest possible care. A key
precept of patient safety programs is the removal of the “culture of blame.” Patient safety has been and still is a priority in Italian
Hospitals. The aim of this study was to measure the safety culture in teaching and non-teaching hospitals of Italy.
Methods: Data were collected from 261 staffs working in the teaching and non-teaching hospitals by means of the Italian version
of the Safety Attitudes Questionnaire-Short form 2006.
Results: Mean response rate from returned valid questionnaires was 60%. Both hospitals did not differ significantly in SAQ
dimensions except unit management. Clinical departments differ with each SAQ dimension as indicated by Kruskal Wallis test.
Regression analysis showed positive trend between safety climate and other SAQ dimensions except for stress recognition dimension.
Physicians scored high in team climate, safety climate and job satisfaction and non-physicians scored high in stress recognition
and job satisfaction. Comparing the gender scores, stress recognition and job satisfaction dimensions scored high with females and
Males scored high in team climate and job satisfaction. Both at professional and gender level hospital management scores were
low.
Conclusion: This cross sectional survey provides benchmark data for both hospital safety cultures. Results point out critical
attention to patient safety at teaching and nonteaching hospitals. Further research is needed to check safety culture impact on
patient outcomes in both the hospitals.
Keywords: patient safety, safety culture and safety attitudes
CHALLENGES IN THE DECENTRALISATION OF HEALTH CARE AND DISASTER PREPAREDNESS I...Ruby Med Plus
Lack of proper commitment by state government towards decentralization. Political Decentralization.( Control of Local Politicians on Non-Teaching Hospitals). Indian Medical Association Against Political Decentralization.
Platelet rich fibrin | Dental Implants with PRF | PRF In regenerative surgeri...Dr. Rajat Sachdeva
PRF is a by product of blood that is exceptionally rich in platelets.
PRF is a second generation PRP where autologous platelets and leucocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and used as a tissue engineering scaffold for endodontics .
PRF has been used to accelerate the body's own healing process.
Call us regarding Dental Treatment:-
Dr. Rajat Sachdeva
+919818894041,01142464041
drrajatsachdeva@gmail.com
Follow us here:-
• Google+ link: https://goo.gl/vqAmvr
• Facebook link: https://goo.gl/tui98A
• Youtube link: https://goo.gl/mk7jfm
• Linkedin link: https://goo.gl/PrPgpB
• Slideshare link : http://goo.gl/0HY6ep
• Twitter Page : https://goo.gl/tohkcI
• Instagram page : https://goo.gl/OOGVig
Learn more:-
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
Dr. David Greene R3 Stem Cell Injections Platelet-Rich Plasma.pptxR3 Stem Cell
Regenerative medicine therapies use the body's natural healing agents to promote tissue regeneration and repair, such as bones and joints. Dr David Greene uses this type of regenerative medicine with his r3 stem cell injection, PRP therapy, and platelet-rich plasma therapy. If you’re looking for a doctor who can help you promote healing through advanced regenerative medicine therapies, call today!
Platelet Rich Plasma ( PRP ) is very popular in the treatment of musculo skeletal pathologies. This ppt gives a brief introduction to platelets and in sights into developing a PRP kit.
A current review by Milano G et al. (http://dx.doi.org/10.1136/jisakos-2019-000274) has duly indicated the safe, cost-effective, and pain-relieving benefits of Platelet Rich Plasma (PRP) in orthopedic sports injuries and several other musculoskeletal conditions.
With several other publications supporting regenerative therapies, S.T.A.R 2020 workshop on the applications of regenerative medicine products in the field of orthopedics helps you understand the medical benefits of PRP and other regenerative therapies like BMAC and SYNOJEL, with advanced hands-on training under the guidance of professional experts.
Register now
www.advancells.com/star-2020/
Journal of Sustainable Regional health systems issue Ruby Med Plus
Background: Creating a culture of safety has received great attention to ensure that patients receive the safest possible care. A key
precept of patient safety programs is the removal of the “culture of blame.” Patient safety has been and still is a priority in Italian
Hospitals. The aim of this study was to measure the safety culture in teaching and non-teaching hospitals of Italy.
Methods: Data were collected from 261 staffs working in the teaching and non-teaching hospitals by means of the Italian version
of the Safety Attitudes Questionnaire-Short form 2006.
Results: Mean response rate from returned valid questionnaires was 60%. Both hospitals did not differ significantly in SAQ
dimensions except unit management. Clinical departments differ with each SAQ dimension as indicated by Kruskal Wallis test.
Regression analysis showed positive trend between safety climate and other SAQ dimensions except for stress recognition dimension.
Physicians scored high in team climate, safety climate and job satisfaction and non-physicians scored high in stress recognition
and job satisfaction. Comparing the gender scores, stress recognition and job satisfaction dimensions scored high with females and
Males scored high in team climate and job satisfaction. Both at professional and gender level hospital management scores were
low.
Conclusion: This cross sectional survey provides benchmark data for both hospital safety cultures. Results point out critical
attention to patient safety at teaching and nonteaching hospitals. Further research is needed to check safety culture impact on
patient outcomes in both the hospitals.
Keywords: patient safety, safety culture and safety attitudes
CHALLENGES IN THE DECENTRALISATION OF HEALTH CARE AND DISASTER PREPAREDNESS I...Ruby Med Plus
Lack of proper commitment by state government towards decentralization. Political Decentralization.( Control of Local Politicians on Non-Teaching Hospitals). Indian Medical Association Against Political Decentralization.
Medical Records Management – Evolution, Regulation & DisruptorsRuby Med Plus
eed for Medical Records and Management Structure Three Primary Reasons • Ensures continuity of care • Can be retrieved at later date on re-admission, for F/U or medico legal requirements • For medical audit, research & training Challenges Gross inadequacies of health information Cumbersome retrieval process Hosp statistics collected by paramedics e.g. nurses Medical certification of cause of death not maintained Few hospitals report data to state health authorities No proper maintenance of health statistics at state & national level.
Record maintenance was emphasized by American College of Surgeons & American College of Physicians in first quarter of 20th century JCAHO (Joint Commission on Accreditation of Healthcare Organizations) Assumed responsibility of standardization, leading to improvement of medical care 1946 Bhore Committee – Stressed on it’s importance and recommended maintenance of MR 1962 Mudaliar Committee – Reiterated recommendation of Bhore CMC, Vellore first to organize MRD & hold training courses for technicians Computerized medical records in present era-GAME CHANGER
Infection Prevention and Control for COVID 19Ruby Med Plus
IPC strategies for COVID-19
• Standard precautions
• Triage, Early identification and source control
• Additional precautions
• Additional control measures
• Environmental cleaning and disinfection
• Biomedical waste management
To reduce transmission of healthcare associated
infections
2. To enhance the safety of staff, patients and visitors
3. To enhance the ability of the organization/health
facility to respond to an outbreak
4. To lower or reduce the risk of the hospital (health
care facility) itself amplifying the outbreak
Preparedness planning is essential in order to respond effectively to outbreaks and epidemics. Sharing and aligning activities in the area of public health emergency preparedness adds value to the efforts of single countries to strengthen their capacities and ensure coordinated and effective support when faced with cross-border health threats.
Standard Precautions are the minimum infection prevention practices that apply to all patient care, regardless of suspected or confirmed infection status of the patient, in any setting where health care is delivered. These practices are designed to both protect DHCP and prevent DHCP from spreading infections among patients.
COVID-19- Its Impact on Employment in IndiaRuby Med Plus
Kasireddy Venkata Reddy Government College for Women (A) conducted one day national webinar on COVID-19-its Impact on Employment in India. This webinar highlighted that Job loss is the most severe immediate impact of COVID-19 crisis while lower economic growth and rise in would be the long-term effects. job creation, cash transfers and social security while the long-term measures included need for building a stronger public health system, universalisation of social security and policies for welfare and rights of migrants.The Central Government as well as few State Governments such as Haryana, Uttar Pradesh, Maharashtra, Karnataka have issued advisories/ orders asking employers to refrain from terminating or reducing wages of their employees pursuant to Covid-19. CMIE report says India’s urban unemployment rate soars to 30.9% even as overall rate rises to 23.4%, indicating covid-19’s impact on the economy.CMIE’s estimates on unemployment shot up from 8.4% in mid-March to the current 23%. Based on a rough calculation, about 50 million people might have lost jobs in just two weeks of the lockdown.
R Programming Data Science was conducted by Mahaveer Institute of Science and Technology.
The Faculty development programme covered practical issues in statistical computing which includes programming in R, reading data into R, accessing R packages, writing R functions, debugging, profiling R code, and organizing and commenting R code. It was excellent programme.
The risks arising from climate change are many, such as unforeseen and extreme weather events like heat waves, typhoons and cyclones, coastal and river flooding, and prolonged droughts. These can have adverse economic, social and environmental consequences and affect human well-being and the overall quality of life.The rising demand for food due to rising population and incomes coupled with declining production of staples such as wheat, rice and maize due to the adverse effects of climate change will undermine food security and affect the poor and vulnerable people.
Building resilience to address these climate risks poses a challenge to governments, societies and entities. Mainstreaming ‘resilience’ into development plans is therefore critical to tackling poverty, inequality, ill health and poor sanitation, as well as realizing the Sustainable Development Goals (SDGs), since poor and marginalized people and poor countries that have low adaptive capacity are most vulnerable to the adverse consequences of climate change. Improving climate and disaster risk management can also lead to larger gains in development and poverty reduction.Building resilience will also be helpful in coping with uncertainties arising from the complex and dynamic interactions between climate change and other parameters such as health.
What are the likely impacts of climate change on human and natural ecosystems? How will it affect different sectors and sections of the society? What are the alternatives and policy options to address the risks posed by climate change and extreme weather events?
8th International Patient Safety Conference 2019Ruby Med Plus
The 8th International Patient safety conference 2019 highlightED the theme “Imagine, Innovate, Inspire” and provided an excellent opportunity to share views, exchange knowledge and establish research collaborations & networking. This event was supported by various knowledge partners including National Accreditation Board for Hospitals (NABH), Joint Commission International (JCI), World Innovation Summit for Health (WISH), the APAC Forum, World Health Organization (WHO), and Imperial College London.
Risk management in Health Care IndustryRuby Med Plus
Risk management in healthcare comprises the clinical and administrative systems, processes, and reports employed to detect, monitor, assess, mitigate, and prevent risks. By employing risk management, healthcare organizations proactively and systematically safeguard patient safety as well as the organization’s assets, market share, accreditation, reimbursement levels, brand value, and community standing. Due to expanding role of healthcare technologies, increased cybersecurity concerns, the fast pace of medical science, and the industry’s ever-changing regulatory, legal, political, and reimbursement climate, healthcare risk management has become more complex over time.
American Society for Healthcare Risk Management (ASHRM), “Enterprise risk management in healthcare promotes a comprehensive framework for making risk management decisions which maximize value protection and creation by managing risk and uncertainty and their connections to total value.”The medical culture that silently taught the ABCs as Accuse, Blame, and Criticize is fading. Rising in its place is a safety culture emphasizing blameless reporting, successful systems, knowledge, respect, confidentiality, and trust.”By establishing an ongoing and systematic approach to minimizing the risks inherently associated with the field of healthcare, more and more healthcare organizations are successfully protecting quality of care and financial strength while navigating the tumultuous era of change.
EIGHT RISK DOMAINS:
Operational
Clinical & Patient Safety
Strategic
Financial
Human Capital
Legal & Regulatory
Technological
Environmental- and Infrastructure-Based Hazards.
24 CME / PD 11TH MAKKAH INTERNATIONAL DENTAL CONFERENCERuby Med Plus
Earned 24 continuing professional development credits accredited by SCHS Saudi Dental Society BY ATTENDING AND UPGRADING DENTAL EDUCATION AWARENESS AT 11 TH Makkah INTERNATIONAL DENTAL CONFERENCE.
IDA's Continuing Dental Education (CDE) programmes are designed to offer ongoing education which is intrinsic to deliver high quality dental and oral health care services. cde PROGRAMS ATTENDANCE PROVES HOW ACTIVE YOU ARE IN LEARNING other than regular course work.
Participation of Oral Health Awareness of the CommunityRuby Med Plus
Colgate Bright smiles and Bright future awareness program on Brushing twice daily for prevention of dental caries, plaque accumulation, and prevention of periodontal diseases.
Rural Health Fellow at Rural Health SocietyRuby Med Plus
Rural Health Fellows program is an intensive program that develops leaders who can articulate a clear and compelling vision for rural India. The goal of the Rural Health Society is to educate, develop and inspire a networked community of rural health leaders who will step forward to serve in key positions in the National Rural Health Mission.
National Conference on Leadership in Health Care @ CMC VelloreRuby Med Plus
Effective leadership drive changes at all levels of the health system for optimum delivery of health care. Leadership is the most potent factor in shaping organizational culture and ensuring the necessary leadership behaviors, strategies, and
qualities. Direction ensures to achieve, consistent with vision, values and strategy.
Role of P53 TSG in Oral Cancers @ 58th IDC VijaywadaRuby Med Plus
p53 is the most commonly inactivated TSG in human oral cancers. p53 is a TSG which is located on chromosome 17p13. p53 plays a major role in cell-cycle progression, cellular differentiation, DNA repair and apoptosis, and it is regarded as a guardian of the genome. TSG p53 is known to be mutated in approximately 70% of all oral and other tumors.In squamous cell carcinoma of head and neck region (SCCHN) 40–50% of the tumors have mutation P53 gene
State Level Symposium on HIV disease@ GunturRuby Med Plus
Paper presented on "Application of CDC and Occupational Safety and Health Administration (OSHA) standards in dental settings". Dental patients and DHCP can be exposed to pathogenic microorganisms including cytomegalovirus (CMV), HBV, HCV, herpes simplex virus types 1 and 2, HIV, Mycobacterium tuberculosis, staphylococci, streptococci, and other viruses and bacteria that colonize or infect the oral cavity and respiratory tract. These organisms can be transmitted in dental settings through 1) direct contact with blood, oral fluids, or other patient materials; 2) indirect contact with contaminated objects (e.g., instruments, equipment, or environmental surfaces); 3) contact of conjunctival, nasal, or oral mucosa with droplets (e.g., spatter) containing microorganisms generated from an infected person and propelled a short distance (e.g., by coughing, sneezing, or talking); and 4) inhalation of airborne microorganisms that can remain suspended in the air for long periods. OSHA sets and enforces standards that address potential workplace hazards; provides training, outreach, and education; establishes partnerships; and encourages continual improvement in workplace safety and health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Flubrotizolam CAS: 57801-95-3
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
Plasma Rich Platelets use in Medicine
1. PRP Therapy in Cosmetology
By Dr. Shoeb Ahmed
BS, BDS, M.Sc., MPH, EMSRHS,
FHTA.
Ruby Dental Clinics
Mandi Bazar
Warangal-506002
Email: Shoebilyas@gmail.com
2. What is PRP?
PRP is simply whole
blood that is
centrifuged to create
an increased
concentration of
platelets with or
without WBC’s
03/05/17 2Dr.Shoeb AHMED Ruby Dental
Clinics, Warangal-506002
3. What’s so special about Platelets?
• Platelets contain granules that store
large numbers of “growth factors”
• Alpha granules released (activated)
when platelets aggregate and
adhere to a site of injury or
inflammation
• Listing of other growth factors:
interleukin-1, tumor necrosis
factor, transforming growth factor,
insulin growth factor and more
• It is the activation of platelets and
release of the various growth
factors that makes them special
and is the key to enhancing tissue
repair and healing!
03/05/17 3Dr.Shoeb AHMED Ruby Dental
Clinics, Warangal-506002
4. Platelet Rich Plasma Biology
What do these Growth Factors Do??
• Chemotaxis
– Directional movement in response to a chemical
stimulus
– Stems cells are attracted to the growth factors and
migrate into the area
• Cell proliferation
– Significant increase in cellular reproduction
activity
• Possibly even a systemc effect
– Performance enhancing?
5. The Primary Growth Factors Role in
Soft Tissue Healing and Repair
• PDGF
– 2 polypeptide chains
– AB, BB and AA types (AB in human platelets)
– Stored in alpha granules in platelets
– Receptors are found in tendon, cartilage, synovium and
elsewhere
• TGF beta
– Also polypeptide, multiple chains, TGF beta-1 most
studied form
– Found in platelets and bone, cartilage
– Also found in macrophages
– Receptors are universal in cells throughout the body
03/05/17 5Dr.Shoeb AHMED Ruby Dental
Clinics, Warangal-506002
6. Effect of PDGF on Tissues
• Immediate (within 5 minutes)
– Second messenger stimulation
– Inflammatory response
• Early (30min to 4 hours)
– M-RNA stimulation, protein synthesis
– Chemotaxis (draws cells to the area)
• Late (4-24 hours)
– Fibroblast mitosis
03/05/17 6Dr.Shoeb AHMED Ruby Dental
Clinics, Warangal-506002
7. Effect of TGF-Beta on Tissues
• Actually inhibits cell growth
• More of a modulator of cell growth,
differentiation
– Very important in wound repair
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Clinics, Warangal-506002
8. Summary of Effect of Platelet
Growth Factors on Tissues
It appears that through a complex series of
biochemical and cellular events, these
growth factors cause a rapid and sustained
increase in the number of fibroblasts in an
area and then through a poorly understood
interaction among factors modulates
cellular activity to cause stem cell
maturation.
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Clinics, Warangal-506002
9. Breaking News?
So when did all this
information about
platelets get
discovered?
Is this Twitter
Worthy News????
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Clinics, Warangal-506002
10. AOSSM sponsored Sports Induced
Inflammation Workshop.
Bethesda, Maryland. May 1989.
“Although the cellular events involved in the healing
and repair of musculoskeletal connective tissue
injuries are reasonably well described, the
molecular mechanisms regulating these responses
are incompletely understood. New information,
particularly on the roles of various cytokines and
growth factors in inflammation and wound healing,
however, is continually being published. This
information may ultimately have far reaching
therapeutic implications.”
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Clinics, Warangal-506002
11. Round Table Discussion on
Clinical uses of PRP
Dr. Steven Arnoczky - moderator.
Orthopedics Today March 2009
“Platelet rich plasma (PRP) is generically defined as an
increase (above baseline) in the concentration of platelets
and their associated growth factors. While the clinical
benefits of PRP in enhancing the healing of
musculoskeletal tissues are only beginning to be
explored, the substantial amount of basic science data
supporting the role of growth factors in enhancing cell
migration, proliferation and matrix synthesis has provided
a compelling rationale for use of PRP in the treatment
and repair of various connective tissue structures.”
03/05/17 11Dr.Shoeb AHMED Ruby Dental
Clinics, Warangal-506002
12. PRP IS NOT!
• Stem cells
• MSC’s
• Lipocytes
• Bone Marrow
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Clinics, Warangal-506002
13. Current Clinical Uses of PRP
• Everything and
anything!
• Internet marketing for
host of ailments
• Snake oil of today
“Cures rheumatism,
grows hair, gets rid of
wrinkles, etc., etc.”
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14. Current Clinical Uses of PRP
Compelling Rationale!
• Meniscus repair
• Tendonitis (office based
injection)
• Arthritis?
• Ligament surgery?
• Tendon repairs?
• Acute injury?
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Clinics, Warangal-506002
15. Past Clinical Use in Improving Healing
of Meniscus Repairs Using - Fibrin Clot
• Dr. Warren and Dr. Arnoczky at HSS
• Whole blood, clotted and injected
• Difficult to handle, difficult to inject
• No commercial backing
• Fell out of favor
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Clinics, Warangal-506002
16. Why the interest in PRP?
Historically there has been interest for a long
time at the research level.
Clinical interest started with an hypothesis by
Mishra et al.
Could the treatment of a common clinical
disorder - lateral epicondylitis be improved
by injecting PRP into the tendon?
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17. Clinical Model
Lateral Tendinosis
(aka lateral epicondylitis/tennis elbow)
• Common Disorder
– 5 per 1000 pts per year seen in general
practice
• Natural history—
– Highly variable - lack of uniform
response to treatment
• Typically seen over age 35
• Repetitive activities
– Most common cause
– May occur from injury (acutely)
18. Tendinopathy or Tendinosis
Definitions - Histologically
Speaking
–Loss of longitudinal alignment of
collagen fibers
–Hypercellularity with
neovascularization
–-No acute inflammatory cells
–Angiofibroblastic Hyperplasia
(Nirschl)
–Grossly--no longer white but
rather gray
19. Disappointing Effects of Current
Clinical Rx of Inflammation
Oral NSAID’S or
Corticosteroid injection
• interrupts the inflammatory
cycle
• GI intolerance of many oral
meds
• decreases proteoglycan
synthesis
• weakens tendon tissue
• atrophy of subQ fat
• skin discoloration
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20. Clinical Application
for Use of PRP
In the Treatment of Tendinopathy - Mishra
•Current clinical investigations being performed in
the treatment of lateral epicondylitis
•Difficult patient mix with some having failed
surgery or multiple cortisone injections
•Part of approval process for FDA certification for
this use
•First step towards insurance co recognition of this
as treatment modality worthy of reimbursement
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21. Office Injection of PRP
- The Protocol
• PRP Application TechniquePRP Application Technique
– Withdraw 30 cc of peripheral bloodWithdraw 30 cc of peripheral blood
– Place blood in GPS canisterPlace blood in GPS canister
– Centrifuge for 15 minutes at 3200Centrifuge for 15 minutes at 3200
RPMsRPMs
22. Office Injection of PRP
- The Protocol
• PRP Application TechniquePRP Application Technique
– Remove PPPRemove PPP
– Shake vigorously for 30 secondsShake vigorously for 30 seconds
Platelet Poor Plasma
(PPP)(PPP)
Platelet Rich PlasmaPlatelet Rich Plasma
(PRP)(PRP)
Packed Red Blood Cells
23. Office Injection of PRP
- The Protocol
• PRP Application TechniquePRP Application Technique
– Inject 2-3 cc of PRP into theInject 2-3 cc of PRP into the
ECRB--Peppering techniqueECRB--Peppering technique
– Average Dose 3.3 million platelets
per patient
24. Post injection Management
• Rest (sling/crutches) for a few days to a week
• NO NSAID’S
• PT (HEP or Rx)
• Slow stretching program
• Low weight/hi rep pain free isotonic PRE’s
• No high loading activities until criteria met
– No rest pain
– Minimal tenderness
– Full motion
– Normal strength
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Clinics, Warangal-506002
25. Platelet Rich Plasma
Conclusions
Platelet Rich Plasma has emerged as a valuable
biologic treatment for chronic tendonitis of the elbow
Level I support for use only in the Elbow
Since giving in office injections I have
Only rarely needed to do surgery.Only rarely needed to do surgery.
A recent study found that office injectionA recent study found that office injection
For tennis elbow was more cost effectiveFor tennis elbow was more cost effective
And just as successful as an outpatientAnd just as successful as an outpatient
surgery.!surgery.!
26. PRP use in RCR
Despite a Compelling Rationale
There have been a handful of good Level I
studies that have shown no benefit in terms of
clinical scores or healing rate when PRP is
used to augment the surgical repair of a
rotator cuff tear.
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27. Future of PRP
Expanding role in the treatment of many conditions and
an adjunct to healing in the care of connective and
musculoskeletal tissues.
We have only scratched the surface.
Future use will likely involve staged biochemical
manipulation of the healing and inflammatory
process.
The future is bright but uncertain until more clinical
series are completed.
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28. Limitations in the use of PRP
• Efficacy
– Lack of clinical data
• Number of studies being
done
• Indications are being
developed
• Uniformity of prep
– PRP classification
• Insurance recognition
– CMS tracking code
• $$$$$$$ - Evidence based?
– Shady clinics
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Clinics, Warangal-506002
29. My Experience with PRP
Early but good for Office Injection
– Achilles tendonitis
– Lateral/Medial epicondylitis
– Patella tendonitis
– Chronic Hamstring
– Labral tear shoulder
– Rotator Cuff Tendonitis
– Knee/Shoulder Arthritis
• Also used in OR for tendon repair
Augment
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Clinics, Warangal-506002