Role of P53 TSG in Oral Cancers @ 58th IDC Vijaywada
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p53 is the most commonly inactivated TSG in human oral cancers. p53 is a TSG which is located on chromosome 17p13. p53 plays a major role in cell-cycle progression, cellular differentiation, DNA repair and apoptosis, and it is regarded as a guardian of the genome. TSG p53 is known to be mutated in approximately 70% of all oral and other tumors.In squamous cell carcinoma of head and neck region (SCCHN) 40–50% of the tumors have mutation P53 gene
