This document discusses immediate implant placement using platelet-rich fibrin (PRF) and provisionalization. It describes a case where a fenestration defect around an implant was treated using PRF, a bone graft, and guided tissue regeneration membrane. PRF is a simple, natural, and inexpensive concentrate that helps healing by stimulating osteoblastic activity, angiogenesis, and growth factor release. The document reviews literature supporting the use of PRF and immediate implant placement techniques.
Platelet-Rich Fibrin (PRF) is a new second-generation platelet concentrate, with simplified processing, and no biochemical blood handling. It has several advantages over traditionally prepared PRP, which has been widely used for accelerating soft tissue and hard tissue healing for years. Strictly autologous preparation, the amount of PRF obtained is limited, includes its disadvantages. Choukroun's PRF incorporates leucocytes, platelets and a wide range of healing proteins within a dense fibrin matrix. It is a natural bioactive membrane, which can enhance soft/hard tissue healing, at the same time, can also protect surgical sites, grafted materials from external aggressions. This article describes the evolution of this second-generation platelet concentrate and its multiple uses in various surgical procedures.
Platelet rich fibrin | Dental Implants with PRF | PRF In regenerative surgeri...Dr. Rajat Sachdeva
PRF is a by product of blood that is exceptionally rich in platelets.
PRF is a second generation PRP where autologous platelets and leucocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and used as a tissue engineering scaffold for endodontics .
PRF has been used to accelerate the body's own healing process.
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Dr. Rajat Sachdeva
+919818894041,01142464041
drrajatsachdeva@gmail.com
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• www.sachdevadentalcare.com
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• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
Platelet-Rich Fibrin (PRF) is a new second-generation platelet concentrate, with simplified processing, and no biochemical blood handling. It has several advantages over traditionally prepared PRP, which has been widely used for accelerating soft tissue and hard tissue healing for years. Strictly autologous preparation, the amount of PRF obtained is limited, includes its disadvantages. Choukroun's PRF incorporates leucocytes, platelets and a wide range of healing proteins within a dense fibrin matrix. It is a natural bioactive membrane, which can enhance soft/hard tissue healing, at the same time, can also protect surgical sites, grafted materials from external aggressions. This article describes the evolution of this second-generation platelet concentrate and its multiple uses in various surgical procedures.
Platelet rich fibrin | Dental Implants with PRF | PRF In regenerative surgeri...Dr. Rajat Sachdeva
PRF is a by product of blood that is exceptionally rich in platelets.
PRF is a second generation PRP where autologous platelets and leucocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and used as a tissue engineering scaffold for endodontics .
PRF has been used to accelerate the body's own healing process.
Call us regarding Dental Treatment:-
Dr. Rajat Sachdeva
+919818894041,01142464041
drrajatsachdeva@gmail.com
Follow us here:-
• Google+ link: https://goo.gl/vqAmvr
• Facebook link: https://goo.gl/tui98A
• Youtube link: https://goo.gl/mk7jfm
• Linkedin link: https://goo.gl/PrPgpB
• Slideshare link : http://goo.gl/0HY6ep
• Twitter Page : https://goo.gl/tohkcI
• Instagram page : https://goo.gl/OOGVig
Learn more:-
• www.sachdevadentalcare.com
• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
Platelet Rich Fibrin (PRF) in Dentistry, What is PRF ? , What are the difference between PRP,PRGF and PRF ?, Preparation of PRF , shapes of PRF, Role of PRF in wound healing, APPLICATIONS OF PRF, Applications of PRF In Oral and Maxillofacial Surgery, Applications of PRF In Periodontics, Applications of PRF In Endodontics, Applications of PRF In Tissue Engineering
Platelet rich fibrin: an autologous bioactive membraneApollo Hospitals
Platelet-Rich Fibrin (PRF) is a new second-generation platelet concentrate, with simplified processing, and no biochemical blood handling. It has several advantages over traditionally prepared PRP, which has been widely used for accelerating soft tissue and hard tissue healing for years. Strictly autologous preparation, the amount of PRF obtained is limited, includes its disadvantages. Choukroun’s PRF incorporates leucocytes, platelets and a wide range of healing proteins within a dense fibrin matrix. It is a natural bioactive membrane, which can enhance soft/hard tissue healing, at the same time, can also protect surgical sites, grafted materials from external aggressions. This article describes the evolution of this second-generation platelet concentrate and its multiple uses in various surgical procedures.
L-PRF for increasing the width of keratinized mucosa around implants: A split...MD Abdul Haleem
Journal Club Presentation: L-PRF for increasing the width of keratinized mucosa around implants: A split-mouth, randomized, controlled pilot clinical trial.
Introduction. The differences in the supporting structure of the implant make them more susceptible to inflammation and bone
loss when plaque accumulates as compared to the teeth. Therefore, a comprehensive maintenance protocol should be followed
to ensure the longevity of the implant. Material and Method. A research to provide scientific evidence supporting the feasibility
of various implant care methods was carried out using various online resources to retrieve relevant studies published since 1985.
Results.The electronic search yielded 708 titles, out of which a total of 42 articles were considered appropriate and finally included
for the preparation of this review article. Discussion. A typicalmaintenance visit for patients with dental implants should last 1 hour
and should be scheduled every 3 months to evaluate any changes in their oral and general history. It is essential to have a proper
instrument selection to prevent damage to the implant surface and trauma to the peri-implant tissues. Conclusion. As the number
of patients opting for dental implants is increasing, it becomes increasingly essential to know the differences between natural teeth
and implant care and accept the challenges of maintaining these restorations.
Atrophied Edentulous Mandible with Implant-Supported Overdenture; A 10-year f...Abu-Hussein Muhamad
Abstract: Severe atrophy of the inferior alveolar process and underlying basal bone often results in problems with a lower denture. These problems include insufficient retention of the lower denture, intolerance to loading by the mucosa, pain, difficulties with eating and speech, loss of soft-tissue support, and altered facial appearance. These problems are a challenge for the prosthodontist and surgeon. In this case report, patient with resorbed edentulous mandible was successfully rehabilitated using two dental implants placed in the interforaminal region with ball abutments opposing conventional maxillary complete denture. Key Words: dental implants; dental prosthesis, implant-supported; resorption,
Platelet Rich Fibrin (PRF) in Dentistry, What is PRF ? , What are the difference between PRP,PRGF and PRF ?, Preparation of PRF , shapes of PRF, Role of PRF in wound healing, APPLICATIONS OF PRF, Applications of PRF In Oral and Maxillofacial Surgery, Applications of PRF In Periodontics, Applications of PRF In Endodontics, Applications of PRF In Tissue Engineering
Platelet rich fibrin: an autologous bioactive membraneApollo Hospitals
Platelet-Rich Fibrin (PRF) is a new second-generation platelet concentrate, with simplified processing, and no biochemical blood handling. It has several advantages over traditionally prepared PRP, which has been widely used for accelerating soft tissue and hard tissue healing for years. Strictly autologous preparation, the amount of PRF obtained is limited, includes its disadvantages. Choukroun’s PRF incorporates leucocytes, platelets and a wide range of healing proteins within a dense fibrin matrix. It is a natural bioactive membrane, which can enhance soft/hard tissue healing, at the same time, can also protect surgical sites, grafted materials from external aggressions. This article describes the evolution of this second-generation platelet concentrate and its multiple uses in various surgical procedures.
L-PRF for increasing the width of keratinized mucosa around implants: A split...MD Abdul Haleem
Journal Club Presentation: L-PRF for increasing the width of keratinized mucosa around implants: A split-mouth, randomized, controlled pilot clinical trial.
Introduction. The differences in the supporting structure of the implant make them more susceptible to inflammation and bone
loss when plaque accumulates as compared to the teeth. Therefore, a comprehensive maintenance protocol should be followed
to ensure the longevity of the implant. Material and Method. A research to provide scientific evidence supporting the feasibility
of various implant care methods was carried out using various online resources to retrieve relevant studies published since 1985.
Results.The electronic search yielded 708 titles, out of which a total of 42 articles were considered appropriate and finally included
for the preparation of this review article. Discussion. A typicalmaintenance visit for patients with dental implants should last 1 hour
and should be scheduled every 3 months to evaluate any changes in their oral and general history. It is essential to have a proper
instrument selection to prevent damage to the implant surface and trauma to the peri-implant tissues. Conclusion. As the number
of patients opting for dental implants is increasing, it becomes increasingly essential to know the differences between natural teeth
and implant care and accept the challenges of maintaining these restorations.
Atrophied Edentulous Mandible with Implant-Supported Overdenture; A 10-year f...Abu-Hussein Muhamad
Abstract: Severe atrophy of the inferior alveolar process and underlying basal bone often results in problems with a lower denture. These problems include insufficient retention of the lower denture, intolerance to loading by the mucosa, pain, difficulties with eating and speech, loss of soft-tissue support, and altered facial appearance. These problems are a challenge for the prosthodontist and surgeon. In this case report, patient with resorbed edentulous mandible was successfully rehabilitated using two dental implants placed in the interforaminal region with ball abutments opposing conventional maxillary complete denture. Key Words: dental implants; dental prosthesis, implant-supported; resorption,
Healing of Periapical Bone Lesion After Periradicular Surgery And Graft Place...QUESTJOURNAL
Objectives: 1.To clinically evaluate the healing process following periapical surgery with Chitra granules 2.To radiographically evaluate healing, following periapical surgery with Chitra granules. 3.To compare the bone healing in the study group, clinically and radiographically following the modalities of treatment, with that of the control group (without graft). Materials: 1.Chitra hydroxyapatite granules. 2. Gutta-percha — for root canal obturation by lateral condensation. 3. High Copper amalgam used as retrofilling materials. To evaluate healing after periapical surgery using Chitra granules, 22 patients were selected from out patient section of Department of Conservative Dentistry and Endodontics, Govt. Dental College, Kozhikode,based on clinical and radiographical evaluation. The study group consisted of 13 males and 9 females. All were of the age group 15-35 years. After selection they were randomly divided into two groups A and B. In group A the Chitra granule were placed in the bony defect and in group B the defect were left as such after surgery. Results: Clinical parameters showed better early symptom free condition in group A compared to group B. But data found statistically insignificant (t-7.27,df-1.8, P >0.05). Radiographical evaluation data analysis showed statistically significant difference among group A and group B. Conclusion: Biocompatible Chitra granule not only obliterates the cavity but act as a scaffold for bone growth and prevent scar tissue formation.It is osteoconductive. In comparison to the conventional periapical surgery, the placement of Chitra granules facilitates bone regeneration more easily. The material is found to be very cost effective, easily available, easy to manipulate and involves least complication to both clinicians and patients.
Atrophied Edentulous Mandible with Implant-Supported Overdenture; A 10-year f...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Clinical Replacement Therapy and the Immediate Post-extraction Dental ImplantAbu-Hussein Muhamad
Immediate dental implants have greatly reduced the treatment time and the number of surgical intervene tions. Recently it has been noted that this treatment modality can be used in aesthetically demanding cases especially the anterior maxilla. The aim of this article is to describe a clinical case in which a fractured maxillary canine was replaced by an osseointegrated implant using a simplified technique in a patient who was a smoker and presented poor oral hygiene. The technique adopted permits a reduction of the number of implant components and consequently a lower cost of treatment, while at the same time maintaining acceptable aesthetic and functional outcomes.
Immediate Implant Placement And Restoration With Natural Tooth In The Maxilla...Abu-Hussein Muhamad
Anterior tooth loss and restoration in the esthetic zone is a common challenge in dentistry today. The prominent visibility of the area can be especially distressing to the patient and requires a timely and esthetically pleasing solution. Immediate single-tooth implantation followed by immediate provisionalization is becoming an increasingly desirable treatment that offers numerous benefits over conventional delayed loading. Provisionalization for immediately-placed implants using the patient’s existing tooth can enhance the final aesthetic outcome if certain steps are
followed. If the natural tooth is intact and can be used as a provisional, the emergence profile can be very similar to the preoperative condition. This article outlines a technique to use the patient’s natural tooth after extraction to provisionalize an implant.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
Extraction and Immediate Implant Placement, and Provisionalization with two Y...Abu-Hussein Muhamad
Extraction and Immediate Implant Placement, and Provisionalization with two Years Follow-up: A Case Report. PDF
Abu-Hussein Muhamad, Bajali Musa, Abdulgani Azzaldeen
Congenital absence of maxillary lateral incisors is a frequent clinical challenge which must be solved by a multidisciplinary approach in order to obtain an
esthetic and functional restorative treatment. . Fixed prosthodontic and removable prostheses, resin bonded retainers, orthodontic movement of maxillary
canine to the lateral incisor site and single tooth implants represent the available treatment modalities to replace congenitally missing teeth. This case report
demonstrates the team approach in prosthetic and surgical considerations and techniques for managing the lack of lateral incisors. The aims of this case
report of replacement of bilaterally congenitally missing maxillary lateral incisors with dental implants.
Aesthetic Management of Fractured Anteriors: A Case ReportAbu-Hussein Muhamad
Introduction: Coronal fracture of anterior teeth is an important topic for esthetic dentistry. Such fractures may jeopardize esthetics, function, tissue biology
and occlusal physiology, thus endangering tooth vitality and integrity. Coronal fractures resulting from dental trauma most frequently occur to the maxillary
anterior teeth of adolescents and less frequently to mandibular teeth. Adult teeth may also suffer traumatic fracture, although less frequently than for
adolescents.
Case Report: In our case, an economical and time-saving novel technique has been described for direct composite restoration in a young patient with
uncomplicated fractured maxillary anterior tooth.
Conclusion: As restoring a fractured tooth is a complex procedure, this technique can prove as a simple, effective and appropriate technique that will fulfill all
the requirements of dental personnel. This technique can also prove to be easy for inexperienced beginner clinicians without requiring special skills in
providing the patients with direct composite restorations.
Impacted Maxillary Central Incisors: Surgical Exposure and Orthodontic Treat...Abu-Hussein Muhamad
The maxillary permanent central incisor develops early in life and forms part of an aesthetic smile. Disruption of the formation or eruption of the permanent
central incisor has multiple etiological factors. Treatment options depend to some extent on the cause of failure of eruption of the central incisor. Generally,
the earlier treatment is provided, the higher the likelihood of success and the less the complexity. Our results suggest that close monitoring and interdisciplinary
cooperation during the treatment phases led to a successful esthetic result, with good periodontal health and functional occlusion.
Excess of space in the dental arch is diagnosed as a
generalised spacing or a local divergence, often
observed in the maxillary anterior region, as a median
diastema, traumatic loss of central incisors, or
congenital absence of lateral incisors. Furthermore,
spacing is observed in aging individuals, due to
pathological migration of teeth caused by
periodontitis. Finally, adult individuals with partial
edentulous jaws demand pre-prosthetic orthodontic
treatment from functional aspects. Thus, indication for
orthodontic treatment in subjects with spacing of teeth
exists for aesthetic reasons, but also for facilitating
prosthetic restorations with optimal occlusalstability.
Dental implants represent one of the most successful treatment modalities in dentistry.
However, failures do occur in the range from 5 to 8% for routine procedures and up to 20% in major grafting
cases after at least 5 years of function . The majority of implant losses may be explained as biomechanically
induced failures, since low primary implant stability, low bone density, short implants and overload have been
identified as risk factors . Hence, achievement and maintenance of implant stability are pre-conditions for a
successful clinical outcome with dental implants.
The review focuses on different methods used to assess implant stability and recent advances in this field.
Aesthetic Management of Fractured Anteriors: A Case ReportAbu-Hussein Muhamad
Introduction: Coronal fracture of anterior teeth is an important topic for esthetic dentistry. Such fractures may jeopardize esthetics, function, tissue biology
and occlusal physiology, thus endangering tooth vitality and integrity. Coronal fractures resulting from dental trauma most frequently occur to the maxillary
anterior teeth of adolescents and less frequently to mandibular teeth. Adult teeth may also suffer traumatic fracture, although less frequently than for
adolescents.
Case Report: In our case, an economical and time-saving novel technique has been described for direct composite restoration in a young patient with
uncomplicated fractured maxillary anterior tooth.
Conclusion: As restoring a fractured tooth is a complex procedure, this technique can prove as a simple, effective and appropriate technique that will fulfill all
the requirements of dental personnel. This technique can also prove to be easy for inexperienced beginner clinicians without requiring special skills in
providing the patients with direct composite restorations
Orthodontic tooth movement is basically a biologic response towards a mechanical force. Osteoclast and osteoblast cells mediate bone resorption and apposition, which eventually produces tooth movement. Researches showed that the rate of orthodontic tooth movement can be altered by certain drugs locally or systemically. The Objective of this article is to discuss the current data concerning the effect of drugs on orthodontic tooth movement.
Multidisciplinary Approach in the Rehabilitation of Congenitally Maxillary C...Abu-Hussein Muhamad
Objective: This case report describes the multidisciplinary
approach to treat a congenitally missed maxillary canine, how to
improve patient’s smile using orthodontic fixed appliance, endosseous
dental implant, and porcelain veneer to achieve the treatment results of
function and esthetic.
Materials and procedures: Unilateral agenesis of the permanent
maxillary canines in healthy individuals is extremely rare. This
paper presents the case of a female patient diagnosed with congenital
unilateral agenesis of the permanent maxillary canines as well as
occlusal abnormalities in the form of left-side crossbite. To restore the
proper aesthetics and function, interdisciplinary therapeutic treatment
was implemented. In the case presented in this paper, the aim of
oral rehabilitation was to restore a functional balance by obtaining
proper skeletal relationships, creating optimal occlusal conditions and
obtaining arch continuity.
Conclusion: Interdisciplinary treatment combined of orthodontics,
implant surgery, and prosthodontics was useful to treat a nonsyndromic
oligodontia patient. Especially, with the new strategy, implantanchored
orthodontics, which can facilitate the treatmentand make it
more simply with greater predictability.
The multifactorial factors influenc cleft Lip-literature review Abu-Hussein Muhamad
Congenital cleft-Lip and cleft palate have been the subject of many genetic
studies, but until recently there has been no consensus as to their modes of
inheritance. In fact, claims have been made for just about every genetic
mechanism one can think of. Recently, however, evidence has been
accumulating that favors a multifactorial basis for these malformations. The
purpose of the present paper is to present the etiology of cleft lip and cleft palate
both the genetic and the environmental factors. It is suggested that the genetic
basis for diverse kinds of common or uncommon congenital malformations may
very well be homogeneous, whilst, at the same, the environmental basis is
heterogeneous.
Dental implants represent one of the most successful treatment modalities in dentistry.
However, failures do occur in the range from 5 to 8% for routine procedures and up to 20% in major grafting cases after at least 5 years of function . The majority of implant losses may be explained as biomechanically induced failures, since low primary implant stability, low bone density, short implants and overload have been identified as risk factors . Hence, achievement and maintenance of implant stability are pre-conditions for a successful clinical outcome with dental implants.
The review focuses on different methods used to assess implant stability and recent advances in this field
Over time, progressively shorter implants have been placed such that short implants are now available that are less than 6 mm in length. The viability and high success rates seen with short implants can be explained by osseointegration, the macro geometric design of the implant, as well as physics and the distribution of forces. This paper was aimed to review the stability and survival rate of short implants under functional loads. Numerical and clinical studies were reviewed. Keywords: Short dental implants, sinus augmentation, factors affecting bone regeneration in dental implantology
Porcelain laminate veneers are among the most esthetic means of creating a more pleasing and beautiful smile. Porcelain veneers within reason allow for the alteration of tooth position, shape, size and color. They require a minimal amount of tooth preparation, approximately 0.5 mm to 0.7mm of surface enamel reduction. This study describes the use of ceramic veneers without tooth wear, reinforcing the concept that minimally invasive porcelain laminate veneers could become versatile and conservative allies in the fi eld of esthetic dentistry. Keywords: Ceramics, dentin-bonding agents, esthetics
Immediate Restoration of Single Implants Replacing Lateral Incisor Compromis...Abu-Hussein Muhamad
Today, the diagnosis of internal root resorption is significantly improved by the three-dimensional imaging. Furthermore, the CBCT’s superior diagnosis accuracy resulted in an improved management of the resorptive defects and a better outcome of Implant therapy of teeth with internal resorption.Implant has become a wide option to maintain periodontal architecture. Diagnosis and treatment planning is the key factors in achieving the successful outcomes after placing and restoring implants placed immediately after tooth extraction. The purpose of this clinical update is to report on the success and survival of Immediate restoration of single implants replacing right lateral incisor compromised by internal resorption.
Clinical Management of Bilateral Impacted Maxillary CaninesAbu-Hussein Muhamad
Introduction: Impaction of maxillary canines is a frequently encountered clinical problem in orthodontic therapy. When a preventive
approach fails, treatment involves surgical exposure of the impacted tooth, followed by orthodontic traction to guide and align it into the
dental arch. The aim of the present report was to demonstrate by case reports of an adult patient with bilateral impacted maxillary canines
treated with surgical exposure and orthodontic treatment.
Material and Methods: A 15year-old female with various degrees of bilateral palatal impaction of maxillary canines were managed
by the described technique.
Results and Discussion: Autonomous eruption of the impacted canines after surgical uncovering was witnessed in all patients
without the need for application of a vertical orthodontic force for their extrusion.
Conclusion: The described method of surgical uncovering and autonomous eruption created conditions for biological eruption of the
palatally impacted canines into the oral cavity and facilitated considerably the subsequent orthodontic treatment for their proper alignment
in the dental arch.
Keywords: Impacted canines; Surgical; Tooth exposure; Orthodontic treatment
“One-Piece” Immediate-Load Post-Extraction Implant In Maxillary Central IncisorAbu-Hussein Muhamad
Abstract: This case report describes extraction of a fractured left maxillary central incisor tooth, followed by immediate placement of an one-piece implant in the prepared socket and temporization by a bonded restoration.
Materials And Methods: The tooth was extracted with minimal hard and soft tissue trauma and without flap reflection. The socket was prepared to the required depth and a Implant was inserted.
Results: The atraumatic operating technique and the immediate insertion of the one-piece Implant resulted in the preservation of the hard and soft tissues at the extraction site.
Conclusion: The “One-piece” dental implant and provisional restoration provided the patient with immediate esthetics, function, comfort and most importantly preservation of tissues. The one-piece implant design resulted in a high cumulative implant survival rate and beneficial marginal bone levels.
Single Visit Replacement of Central Maxillary Using Fiber-Reinforced Composi...Abu-Hussein Muhamad
Fiber reinforced composites are high strength filling materials composed of conventional composites and glass fibres. They exhibit extensive applications in different fields of dentistry. This clinical report present a case where FRC technology was successfully used to restore central maxillary incisor edentulous area in terms of esthetic-cosmetic values and functionality.
Zirconium Dental Implants And Crown for Congenitally Missing Maxillary Latera...Abu-Hussein Muhamad
Zirconia implants were familiarized into dental implantology. Zirconia appears
to be an appropriate implant material due to its low plaque affinity, tooth like color, biocompatibility and mechanical properties. The following a case presentations will show how the acid-etched zirconia Implant can be used to functionally and aesthetically replace congenitally missing left lateral incisor tooth germ in the maxilla, and achieve optimal soft tissues and health.
Surgery of Labially Impacted Canine & Orthodontic Management – A Case ReportAbu-Hussein Muhamad
Maxillary canines are one of the most common teeth that are impacted among patients seeking orthodontic treatment. Depending on the position of these impacted teeth, various surgical techniques have been employed for their exposure. His primary goal of surgical phase is to provide the means for correct position of orthodontic anchorage. Additionally, the technique used must ensure favorable tissue anatomy that will permit long-term maintenance of periodontal health. In the present case, a labially impacted maxillary left canine was surgically exposed using an apically positioned flap. Orthodontic extrusion was carried out further.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
EXTRACTION AND IMMEDIATE IMPLANT PLACEMENT USING A COMBINED PRF, AND PROVISIONALIZATION TECHNIQUE
1. International Journal of Dental and Health Sciences
Volume 01, Issue 05Case Report
EXTRACTION AND IMMEDIATE IMPLANT
PLACEMENT USING A COMBINED PRF,
AND PROVISIONALIZATION TECHNIQUE
Abu-Hussein Muhamad1
,Abdulgani Azzaldeen2
1.University of Naples Federic II, Naples, Italy, Department of Pediatric Dentistry, University
of Athens, Athens, Greece.
2. Department of Conservative Dentistry, Al-Quds University, Jerusalem, Palestine.
ABSTRACT:
The placement of dental implant into fresh extraction sockets was introduced in
1970 and is a well established treatment option for replacing missing teeth, allowing the
restoration of masticatory function, speech and esthetics. Immediate post extraction
implant placement is a well accepted protocol because of shorter total treatment time,
maintenance of socket wall, reduced operative time and better actual implant placemen1
. In
immediate implant placement there is gap present between implant surface and socket wall
and there are various materials used to fill this gap for better osseointegration but these
materials are either expensive or not so effective. Platelet- rich fibrin (PRF) is simple,
natural and inexpensive. Platelet-rich fibrin(PRF) concentrate helps in healing process,
osteoblastic activity, angiogenesis, release growth factors and able to stimulate defense
mechanism. PRF has been used as graft material in sinus lift procedure with simultaneous
implant with success. This article describes a case in which the fenestration defect around
an implant was treated by the application of platelet rich fibrin, a second generation platelet
concentrate along with bone graft, and guided tissue regeneration membrane.
Key words: Guided bone regeneration, growth factors, platelet rich fibrin
INTRODUCTION:
Teeth replacement using dental implants
has proven to be a successful and
predictable treatment procedure;
different placement and loading protocols
have evolved from the first protocols in
order to achieve quicker and easier
surgical treatment times [1]
. In situations
where a tooth requires extraction and
replacement, original protocol (gold
standard) suggested a 6-12 month waiting
period before implant placement [2]
. The
original protocol has been challenged
within the last decade and new protocols
have been developed in which implants
are placed at the time of extraction of the
tooth. This protocol where implants have
been placed at the time of tooth
*Corresponding Author Address: Abdulgani Azzaldeen,Department of Conservative Dentistry, Al-Quds University,
Jerusalem, Palestine. Email: abdulganiazzaldeen@gmail.com
2. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
extraction is known as immediate
implants[3]
.
When an implant is placed in a fresh or
recent extraction alveolus a gap between
the implant surface and the bone walls of
the socket may occur. The presence or
size of the gap is both influenced by the
configuration of the alveolus and by the
design and width of the implant [4]
. Wilson
et al.[8]
and Paolantonio et al.[9]
demonstrated that for implants with a
horizontal defect of 2 mm or less,
spontaneous bone healing and
osseointegration take place if the implant
has a rough surface [5,6]
. Horizontal defects
in excess of 2 mm have been shown to not
heal predictably with bone[5]
. So To
compensate for these problems, guided
bone regeneration (GBR) using autografts,
allografts, or alloplasts; barrier
membranes; or combination therapy has
been accomplished with what appear to
be successful clinical results [3,7]
.
Implant therapy based on the principle of
osseointegration has seen a remarkable
expansion of its application in dentistry, in
recent years. In the last decade, dental
implants have become a reliable
procedure for the treatment of partially or
completely edentulous jaws. The lack of
bone adjacent to an implant can be
considered a true "bony defect" and
several techniques have been proposed to
promote defect fill with newly formed
bone. One of the most popular
procedures is guided bone regeneration
(GBR), which involves placing a membrane
over the defect to create a secluded space
into which osteogenic cells can migrate
and remain undisturbed over the exposed
part of the implant[7,8]
.
Short-term animal and human studies
have shown these immediate implants to
be comparable to implants placed into
healed bone. The advantage of the
procedure include fewer surgical sessions,
elimination of the waiting period for
socket healing, shortened edentulous
time period, reduced overall cost, as well
as preservation of bone height and width
[2,9]
. Although immediate implantation is
more demanding both surgically and
prosthetically compared to the
conventional placement technique, the
advantages make it very appealing to
patients who are in need of both
extractions and implant therapy.[1,3,7,10]
Platelet-rich plasma (PRP) is an
autologous product that concentrates a
large number of platelets in a small
volume of plasma. PRP functions as a
fibrin tissue adhesive with hemostatic and
tissue sealing properties, but it differs
from fibrin glue and other platelet-poor
tissue adhesives because its platelets
provide a unique ability to promote
wound healing and enhance
osteogenesis[1,2]
.
PRP provides an immediate surgical
hemostatic agent that is biocompatible,
safe, and effective. PRP accelerates
endothelial, epithelial, and epidermal
regeneration, stimulates angiogenesis,
enhances collagen synthesis, promotes
soft tissue healing, decreases dermal
scarring, enhances the hemostatic
response to injury, and reverses the
inhibition of wound healing caused by
175
3. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
glucocorticoids. The high leukocyte
concentration of PRP has an added
antimicrobial effect. Since PRP is an
autologous blood product, it carries no
risk of transmitting infectious disease.[4,5,6]
PRP has an extremely broad range of
clinical healing applications in head and
neck surgery, otolaryngology,
cardiovascular surgery, burns and wound
healing, oral and maxillofacial surgery,
cosmetic surgery, and periodontics In
addition to its effectiveness for patients
with chronic non-healing wounds, it has
also been used as an antiangiogenic agent
and as a carrier for growth factors.[1,3,4]
In surgical settings, PRP decreases the
frequency of intraoperative and
postoperative bleeding at donor and
recipient sites, accelerates soft-tissue
healing, supports the initial stability of
grafted tissue at recipient sites as a result
of its cohesive and adhesive nature,
promotes rapid vascularization of healing
tissue by delivering growth factors and,
when used in combination with bone
replacement materials, induces
regeneration.[3]
The term tissue engineering was originally
coined to denote the construction in the
laboratory of a device containing viable
cells and biologic mediators (e.g., growth
factors and adhesins) in a synthetic or
biologic matrix, which could be implanted
in patients to facilitate regeneration of
particular tissues. The role of tissue
oxygenation in wound healing became the
focal point in the 1980s. Tissue
oxygenation enhances phagocytic and
bactericidal ability of host immune cells
and supports collagen as well as other
protein synthetic events. The importance
of growth factors in enhancing wound
healing has become the focus of research
in the present day. In addition, a link has
been established between tissue
oxygenation and growth factors.
Macrophage stimulation causes the
release of angiogenic and other growth
factors that support wound healing and
resist infection. In general, tissue
engineering combines three key elements,
namely scaffolds (collagen, bone mineral),
signaling molecules (growth factors), and
cells (osteoblasts, fibroblasts). Tissue
engineering has been redefined presently
as the relatively new, highly promising
field of reconstructive biology, which
draws on the recent advances in medicine
and surgery, molecular and cellular
biology, polymer chemistry, and
physiology.[4,5,6]
Platelets isolated from peripheral blood
are an autologous source of growth
factors. When platelets in a concentrated
form are added to graft materials, a more
predictable outcome is derived. Platelet-
rich plasma (PRP) is an easily accessible
source of growth factors to support bone-
and soft-tissue healing. It is derived by
methods that concentrate autologous
platelets and is added to surgical wounds
or grafts and to other injuries in need of
supported or accelerated healing. A blood
clot is the center focus of initiating any
soft-tissue healing and bone regeneration.
In all natural wounds, a blood clot forms
and starts the healing process. PRP is a
simple strategy to concentrate platelets or
enrich natural blood clot, which forms in
176
4. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
normal surgical wounds, to initiate a more
rapid and complete healing process. A
natural blood clot contains 95% red blood
cells, 5% platelets, less than 1% white
blood cells, and numerous amounts of
fibrin strands. A PRP blood clot contains
4% red blood cells, 95% platelets, and 1%
white blood cells[2,7,9]
.
The use of PRP in place of recombinant
growth factors has several advantages, in
that growth factors obtained from
platelets not only have their own specific
action on tissues but also interact with
other growth factors, resulting in the
activation of gene expression and protein
production. Therefore, the properties of
PRP are based on the production and
release of multiple growth and
differentiation factors upon platelet
activation. These factors are critical in the
regulation and stimulation of the wound
healing process, and they play an
important role in regulating cellular
processes such as mitogenesis,
chemotaxis, differentiation, and
metabolism.
Platelet rich fibrin, which is a second
generation platelet concentrate, offers
the surgeon an access to growth factors
with a simple and available technology.
These growth factors which are
autologous, nontoxic and non
immunogenic, enhance and accelerate the
normal bone regeneration pathways.
[10,11,12]
This article presents a case report in which
a fenestration defect around an implant
was treated by GBR with platelet rich
fibrin (PRF)-enhanced bone graft and the
PRF smeared barrier membrane for
guided bone regeneration.
CASE DETAIL:
A healthy 27-year-old male oral surgery
resident was referred to the author’s
private office for a apical lesions in the
maxillary anterior teeth need to be
removed and implant restoration . He
gave the history of trauma four months
back and simultaneous avulsion of the left
central incisor tooth. On clinical
examination , height of the alveolar ridge
was adequate but the width of the ridge
was inadequate for an implant placement.
The ridge was found to be a class I defect
according to Siebert’s classification.
Intraoral radiographs also revealed a
deficient ridge. Ridge augmentation using
bone graft with platelet rich fibrin (PRF)
was planned. The patient was clinically
healthy with no history of systemic
diseases. Informed consent was taken
from the patient.Fig.1-2
PREPARATION OF PRF:
PRF belongs to a new generation of
platelet concentrate but with a simplified
processing as compared to platelet rich
plasma (PRP). Blood was drawn into 10ml
test tubes without an anticoagulant and
centrifuged immediately for 12 minutes at
2,700 rpm .
Indication for using PRF
I. BONE REGENERATION :
1. Sinus lift grafting
2. Ridge augmentation
3. Repair of bone defects created by
removal of teeth or small cyst
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5. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
4. Ridge preservation techniques
5. Periodontal defects
6. Closure of cleft lip and palate defects
7. Repair of oro-antral fistulas
8. Craniofacial reconstruction
II. SOFT TISSUE REGENERATION
1. Periosteal and connective tissue flaps
2. Free connective tissue and gingival
grafts
3. Root coverage procedures
4. Controlling soft tissue healing and
tissue maturity
CONTRAINDICATIONS
1. Unexplained anaemia where Hg is <12.5
g%
2. Thrombocytopenia < 100,000 / cu. mm
3. Diagnosed and treated anaemia Hg <
10.0 g%
4. Patients who have metastatic disease
5. Presence of tumour in the wound bed
6. History of platelet dysfunction
7. Active wound infection and sepsis
requiring systemic antibiotics
8. Patients with poor prognosis associated
with other disease process
9. Patient with bovine sensitivity
10. Patients with religious beliefs that
prevent the use of blood.
The resultant product consists of the
following three layers.
1. Topmost layer consists of acellular
platelet poor plasma (PPP).
2. PRF clot in the middle.
3. RBCs at the bottom.
Successful preparation of PRF requires
speedy blood collection and immediate
centrifugation, before the clotting cascade
is initiated. PRF can be obtained in the
form of a membrane by squeezing out the
fluids in the fibrin clot.
SURGICAL TECHNIQUE
The fractured root was carefully removed
and a thorough curettage of the
remaining alveolus was performed to
eliminate any residual infective tissue in
the avulsion socket that could
compromise the osseointegration of an
immediately placed implant. After
completely remove infected lesions found
that the buccal bone defect. A two - piece
implant (zimmer) of diameter 4.25 mm
and length 13 mm was placed in the
region, 21 , reaching 35 Ncm primary
stability. Then use the A-PRF to filling the
bone defect area(fig 5),and ues the APRF
membrane to cover the bone graft and
area(fig6);then suture.Fig.3-10
POST-OPERATIVE CARE
Patient was recalled after two weeks and
sutures were removed. Healing
wassatisfactory. Patient was reviewed
every two months and oral hygiene was
reinforced. Six month following the
surgery, the patient was again reviewed,
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6. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
clinically the width of the ridge showed an
increase. Radiographs showed an
adequate defect fill.
The sutures were removed 10 days after
the procedure. The surgical site was
examined for uneventful healing. There
was no post - operative complications and
healing was satisfactory. The patient did
not have any post-operative morbidity.
Six months after the GBR treatment, intra-
oral examination with the bone meter
revealed adequate buccolingual width of
the ridge of 7 mm. In order not to disturb
the minimal amount of bone that would
have formed over the fenestration defect,
reentry was not performed. The implant
was uncovered and a healing abutment
was connected to allow emergence of the
implant through the soft tissues, thus
facilitating access to the implant from the
oral cavity and final restoration was
placed.Fig.11-17
DISCUSSION:
GBR is based on the principle of guided
tissue regeneration, and was first
performed in an experimental dog study.
This technique was clinically tested in the
treatment of ridge deformities.
Improvements in this technique have led
to its wide-scale clinical applications to
augment deficient alveolar ridges, treat
implant fenestration or dehiscence, and
permit immediate implant placement in
large alveolar sockets.[11,12,13]
One of the most recent developments is
the use of the autologous Platelet Rich
Fibrin [PRF] for the enhancement of the
soft and hard tissue. It was first developed
in France by Choukroun et al. It eliminates
the risk associated with the use of bovine
thrombin. PRF is an immune and platelet
concentrate which is obtained on a single
fibrin membrane, containing all the
constituents of a blood sample which are
favourable for healing and immunity.PRF
releases a number of growth factors
namely, transforming growth factor
(TGF-beta- 1), vascular endothelial growth
factor (VEGF),platelet-derived growth
factor (PDGF-AB) and thrombospondin-1
(TSP-1) during 7 days. It also secretes
fibroblast growth factor (FGF), epidermal
growth factor (EGF) and proinflammatory
cytokines like IL-1 , IL-6, and TNF- . Due to
its mechanical function and a rapid
angiogenesis promoting ability,PRF
membranes are viable material for all
types of superficial cutaneous and
mucosal healing.[3,4,7,14]
PRF in the form of a membrane can be
used in conjunction with bone grafts,
which has several advantages, such as
promoting wound healing, bone growth,
maturation and density, wound sealing
and haemostasis, and imparting better
handling properties to graft material. PRF
as an adjunct to bone graft makes it
possible to enhance the graft volume
without injuring the maturation quality in
new bone.[5,15,16]
Ιn this case-report, there was class I
fenestration defect around the implant
and to group II of the classification given
by Daniel Buser, 1994, in which the
prosthetically guided placement of an
implant results in exposure of the buccal
implant surface.[4,5,17,18]
179
7. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
At present, it can be stated that
biodegradable membranes have the
potential to support bone formation if
they are supported by bone graft material
to resist collapse and if they are long-
lasting enough to maintain their barrier
function for extended periods in small to
moderate bone defects.
The degradation and resorption kinetics of
a membrane for use in GBR should be set
such that it remains intact for at least 6-9
months in large volume defects and then
should be completely metabolized after
12-15months.[19,20]
In a recent systematic
review, a reasonable comparison between
bioresorbable and non-resorbable
membranes could not be drawn due to
lack of well designed studies. In this case
report, we used GTR membrane
(Healiguide), which is made of collagen
and PRF to treat the defect. This is a
significant benefit to the patient and
represents an important step in the
development of GBR procedures. For
successful outcomes with GBR, the factors
as outlined by Mellonig et al. were
followed.
Recent clinical and histologic findings
suggest that the use of platelet
concentrates have technical benefits and
may enhance bone regeneration when
used in conjunction with bone grafts.
The amplification of platelet derived
growth factor (PDGF) and transforming
growth factor (TGF) beta is seen as an
available and practical tool for enhancing
the rate of bone formation and the final
quality of bone formed.[9,11,18]
PRF has many advantages over platelet
rich plasma (PRP). It eliminates the
redundant process of adding
anticoagulant as well as the need to
neutralize it. It has been shown from the
literature that it increases the rate of
clinical graft consolidation, and PRF-
enhanced grafts produce more mature
and dense bone than do grafts without
PRF. PRF is in the form of a platelet gel
and can be used in conjunction with bone
grafts, which offers several advantages
including promoting wound healing, bone
growth and maturation, graft stabilization,
wound sealing and hemostasis and
improving the handling properties of graft
materials. In an experimental study
which used osteoblast cell cultures to
investigate the influence of PRP and PRF
on proliferation and differentiation of
osteoblasts, it was found that PRF had a
superior influence over PRP. Also, bone
augmentation grafts may act as space-
maintaining devices to allow coronal
migration of periodontal progenitor cells.
[17,18,20]
The development of biomaterials, ideally
coupled with the incorporation of bone
growth factors and bioactive peptides,
represents an important line of research
in this direction. Recent systematic
reviews regarding the survival rate of
implants into sites with
regenerated/augmented bone using
barrier membranes varied between 79%
and 100% with the majority of studies
indicating more than 90% after at least
one year of function.[4,7,8,11]
Immediate implants in the maxillary
esthetic area are currently used
frequently and are subtle, exacting
treatments. However immediate implant
180
8. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
placement and bone grafts are always
sensitive to the gingival quality, as the
gingival tissue has to cover and protect
the site. If the gingival tissue is weak or
damaged, dehiscence can appear in the
covering tissue leading to the
contamination of the grafted site. For this
reason, some authors recommend the use
of connective tissue grafts to reinforce the
peri-implant tissues. The L-PRF is
therefore especially indicated in this
application. The fibrin membrane of L-PRF
acts as a bio-barrier, protecting the
implant and the graft from the oral
environment. Moreover, by providing
growth factors, leukocytes, and a
permeable fibrin matrix for the growth of
endothelial and epithelial cells, this
healing material stimulates
neoangiogenesis and accelerates gingival
healing and maturation. The use of
healing materials such as L-PRF are well
suited to these applications because this
material has a robust stimulating effect on
the healing of soft and osseous tissues.
[13,17,19,20]
Thus, in this case report, a fenestration
defect was effectively treated by the
application of growth factors both to the
bone graft and GTR membrane.
CONCLUSION:
Platelet-rich fibrin (PRF) in patients with
chronic apical lesions after tooth
extraction performed immediately
implantation show high success rate of
bone graft, anti-infective ability. This
technique offers advantages for patient
comfort and the healing process. It also
facilitates a natural healing and
maturation of the periimplant bone and
soft tissues around the implant.
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FIGURES:
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Figure 1: Pre op photo Figure 2: Incisal matrix made with Triad Gel to
help realign the patient's natural tooth
Figure 3. After removal of the tooth
(coronal portion)
11. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
Figure 4. Pilot drill in place engaging palatal
bone
Figure 5: Blue Sky Bio Bond spreader in
place
Figure 6: 3.8mm drill at 75 r.p.m.'s to
harvest some autogenous bone to fill in on
the bucca
Figure 7: autogenous bone to fill in on the
buccal
Figure 8: Zimmer Peek Provisional
abutment before preparation
Figure 9: Platelet Rich Fibrin (centrifuged
whole blood for 12 min.)
Figure 10: Patient's existing tooth (after
removal of the lingual portion) secured to
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12. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
the Peek Provisional abutment in the
mouth with flowable resin
Figure 11: Closeup of the Peek abutment
cured to the patient's existing tooth
Figure 12: Closeup of the Peek abutment
cured to the patient's existing tooth
Figure 13: Bone fill on buccal with with
autogenous bone
Figure 14: Peek abutment cured to the
patient's existing tooth--screwed into
place
Figure 15: PRF membrane
Figure 16: Suture with 7/0 Prolene
sutures
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13. Muhamad A. et al., Int J Dent Health Sci 2014; 1(5): 847-858
Figure 17: Closeup
186