Physical-Cyber-Social Computing involves the integration of observations from physical sensors, knowledge and experiences from cyber systems, and social interactions from people. This will allow machines to understand contexts, correlate multi-domain data, and provide personalized solutions by leveraging background knowledge spanning physical, cyber, and social domains. Semantic computing plays a key role in bridging differences between domains to derive insights. The vision is for systems that can proactively initiate information needs with minimal human involvement.