Peptic ulcer disease
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This document discusses peptic ulcer disease. It introduces peptic ulcers as areas of degeneration and necrosis in the gastrointestinal mucosa exposed to acid-peptic secretions. It notes that peptic ulcers commonly occur in the stomach or duodenum. The document explores the etiology of peptic ulcers, including how H. pylori and NSAIDs cause ulcers by disrupting the mucosal defenses. Grossly, peptic ulcers appear as small, round-to-oval shaped lesions. Microscopically, there is destruction of mucosal and submucosal tissues. The document references several medical textbooks and acknowledges Barry Marshall for his Nobel Prize-winning discovery of H. py
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![INTRODUCTION
Peptic ulcer are the area of degeneration and necrosis
of gastrointestinal mucosa exposed to acid-peptic
secretions.[Harsh Mohan]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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- 1. PEPTIC ULCER DISEASE AADARSH BHADEL 2ND YEAR, MBBS DMCRI
- 2. INTRODUCTION Peptic ulcer are the area of degeneration and necrosis of gastrointestinal mucosa exposed to acid-peptic secretions.[Harsh Mohan]
- 4. Etiology
- 5. PATHOGENESIS
- 6. How H.pylori causes PUD??
- 7. How NSAIDS and Corticosteroids causes PUD???
- 8. MORPHOLOGY
- 9. GROSS Solitary Small (1-2.5 cm in diameter) Round to Oval Sharply punched out lesion
- 10. MICROSCOPIC
- 11. REFERENCES Robbins Basic Pathology (9th Edition) Harsh Mohan - Textbook of Pathology, 6th Edition Guyton and Hall Textbook of Medical Physiology (12th Edition)
- 12. THANK YOU
- 13. Name: Barry Marshall Known for: H. pylori Award: Noble prize in physiology and medicine