pentosephosphatepathway-200706121125.pdf

1. PENTOSE
PHOSPHATE
PATHWAY

2. Hexose monophosphate shunt
It is an alternate branch off glycolysis
Occurs in cytosol
No ATP is produced or used

3. Aims of the process
 Generation of NADPH
 Synthesis of sugar that makes up DNA or RNA

4. NADPH
Nicotinamide adenine dinucleotide phosphate

5. NADPH
 Electron donor
NADP+ NADPH
CATABOLISM
ANABOLISM

6. Role of NADPH
 Biosynthesis of some important compounds
 Role in photosynthesis
 Helps antioxidants to fight free radicals

7. SYNTHESIS OF SUGAR FOR
NUCLEOTIDESS
 Nucleotide: building block of nucleic acids
 Components of nucleotides:

8. Other processes

9. Phases of the pathway
 The oxidative phase
 The non-oxidative phase

10. The oxidative phase
 Oxidation
 Two irreversible steps

11. Step 1
Glucose-6-
phosphate
6-phosphogluconate

12. Step 2
Ribulose-5-phosphate
6-phosphogluconate

13. The non-oxidative phase
 Handy process
 Reversible steps