Patient support programs have the potential to improve medication adherence and patient outcomes while also providing a return on investment. A personalized text message program for asthma patients improved adherence from 43% in the control group to 58% in the intervention group. The program continued to show benefits in adherence even after the intervention ended. A support program for age-related macular degeneration patients led to an 8-fold decrease in treatment discontinuation and a 941% return on investment. Personalized interventions that address patients' beliefs and perceptions have the most potential to positively impact adherence long-term.