A talk which aims to show the value of the use of computers in scientific research, particularly research involving the sequencing and analysis of the Aspergillus Genome (DNA)
Presentation offered at http://www.smartiotlondon.com/2016-seminar-programme/big-data-and-genomics-the-future-of-genetic-engineering
Bioinformatics: the marriage of biology and Big Data, and how this will change the way we perform genetic engineering.
This presentation explain our company (Alkol Biotech) compares DNA strands, focusing on its development of the “EunergyCane” sugarcane crop: Europe’s only sugarcane variety. It explain the tools the company uses such as Big Data, Machine Learning, and Fast Sequencing.
Learning Outcomes:
1 – Learn on the new field of “Bioinformatics”, which is the marriage of IT and biology
2 – Learn how Big Data is changing the game on genetic engineering
3 – Learn what are the tools used and expected results
This document summarizes an analysis of insect-host plant data derived from museum collections. It describes the development of an algorithm to assess the quality and confidence in insect-plant associations by evaluating factors like number of collecting events, host specificity, and presence of larvae. The algorithm was applied to data on aphids, plant bugs, and leafhoppers and their hosts. It identified high confidence associations and reasons for low scores, like mislabeling. The analysis concluded the data demonstrated a significant degree of host specificity and the algorithm provided a method to evaluate data quality on a large scale.
The structure of insect—plant host data as derived from museum collections: ...Katja C. Seltmann
The structure of insect—plant host data as derived from museum collections: An analysis based on data from the NSF-funded Tritrophic Database —Thematic Collections Network
(TTD-TCN)
Randall T. Schuh
Katja Seltmann
Christine A. Johnson
American Museum of Natural History
Entomological Collections Network Meeting, 2013
Bioinformatics is the application of statistics and computer science to biology. It is used for DNA sequencing and comparing genes and genomes between different or similar organisms. The document describes a bioinformatics workshop where students sequenced chicken and plant DNA using an NIH website to compare their genomes and answer questions. Bioinformatics is widely used in biology and genetics for sequencing DNA and comparing samples, as well as sequencing proteins and modeling protein structures.
Giant virus resurrected from 30,000 year-old iceMohan Doshi
Pithovirus sibericum is a giant virus that was revived from permafrost buried for 30,000 years in Siberia and is still infectious. It is the largest virus discovered at 1.5 micrometers long and comparable in size to small bacteria. The virus was found using amoebae as bait to fish for giant viruses in permafrost samples provided by Russian scientists. Pithovirus has unusual properties for a virus, including building replication factories in its host's cytoplasm rather than the nucleus, and having a smaller genome than similar giant viruses despite its larger size. While giant viruses primarily infect amoebae, there is evidence that another giant virus may have infected a human, indicating these viruses
This lab familiarized students with DNA sequence databases that allow comparison of sequences between different species and genes. The databases were used to identify an unknown monkey DNA sequence being studied in the lab, which revealed that one staff member was working with an illegal monkey species. After blasting the sequence in the database, it returned a 100% similarity match to the illegal species.
TB Mobile: Appifying data on antituberculosis molecule targetsSean Ekins
This document describes the development of an app called TB Mobile that provides a mobile interface for accessing data on antituberculosis molecule targets. The app was designed to make scientific data more accessible on mobile devices and features a database connecting molecules, genes, pathways and literature related to tuberculosis. It allows users to browse datasets, search for similar molecules, and filter data. Evaluation showed it could successfully retrieve and rank known tuberculosis drugs and hits from high-throughput screens. The goal is to update the app with more data and improve its predictive capabilities to help accelerate tuberculosis drug discovery.
This document provides guidance on effectively communicating scientific information to different audiences. It prompts the user to identify their scientific questions, which elements to highlight, why the information matters to the audience, potential benefits, and key takeaways. An example response is given for a scientific audience focused on bacteria roles in carbon cycling and climate change. Another example is given for a K-12 student audience highlighting that bacteria have different functions and populations in various environments. The takeaway emphasizes that more bacteria are helpful than harmful.
Presentation offered at http://www.smartiotlondon.com/2016-seminar-programme/big-data-and-genomics-the-future-of-genetic-engineering
Bioinformatics: the marriage of biology and Big Data, and how this will change the way we perform genetic engineering.
This presentation explain our company (Alkol Biotech) compares DNA strands, focusing on its development of the “EunergyCane” sugarcane crop: Europe’s only sugarcane variety. It explain the tools the company uses such as Big Data, Machine Learning, and Fast Sequencing.
Learning Outcomes:
1 – Learn on the new field of “Bioinformatics”, which is the marriage of IT and biology
2 – Learn how Big Data is changing the game on genetic engineering
3 – Learn what are the tools used and expected results
This document summarizes an analysis of insect-host plant data derived from museum collections. It describes the development of an algorithm to assess the quality and confidence in insect-plant associations by evaluating factors like number of collecting events, host specificity, and presence of larvae. The algorithm was applied to data on aphids, plant bugs, and leafhoppers and their hosts. It identified high confidence associations and reasons for low scores, like mislabeling. The analysis concluded the data demonstrated a significant degree of host specificity and the algorithm provided a method to evaluate data quality on a large scale.
The structure of insect—plant host data as derived from museum collections: ...Katja C. Seltmann
The structure of insect—plant host data as derived from museum collections: An analysis based on data from the NSF-funded Tritrophic Database —Thematic Collections Network
(TTD-TCN)
Randall T. Schuh
Katja Seltmann
Christine A. Johnson
American Museum of Natural History
Entomological Collections Network Meeting, 2013
Bioinformatics is the application of statistics and computer science to biology. It is used for DNA sequencing and comparing genes and genomes between different or similar organisms. The document describes a bioinformatics workshop where students sequenced chicken and plant DNA using an NIH website to compare their genomes and answer questions. Bioinformatics is widely used in biology and genetics for sequencing DNA and comparing samples, as well as sequencing proteins and modeling protein structures.
Giant virus resurrected from 30,000 year-old iceMohan Doshi
Pithovirus sibericum is a giant virus that was revived from permafrost buried for 30,000 years in Siberia and is still infectious. It is the largest virus discovered at 1.5 micrometers long and comparable in size to small bacteria. The virus was found using amoebae as bait to fish for giant viruses in permafrost samples provided by Russian scientists. Pithovirus has unusual properties for a virus, including building replication factories in its host's cytoplasm rather than the nucleus, and having a smaller genome than similar giant viruses despite its larger size. While giant viruses primarily infect amoebae, there is evidence that another giant virus may have infected a human, indicating these viruses
This lab familiarized students with DNA sequence databases that allow comparison of sequences between different species and genes. The databases were used to identify an unknown monkey DNA sequence being studied in the lab, which revealed that one staff member was working with an illegal monkey species. After blasting the sequence in the database, it returned a 100% similarity match to the illegal species.
TB Mobile: Appifying data on antituberculosis molecule targetsSean Ekins
This document describes the development of an app called TB Mobile that provides a mobile interface for accessing data on antituberculosis molecule targets. The app was designed to make scientific data more accessible on mobile devices and features a database connecting molecules, genes, pathways and literature related to tuberculosis. It allows users to browse datasets, search for similar molecules, and filter data. Evaluation showed it could successfully retrieve and rank known tuberculosis drugs and hits from high-throughput screens. The goal is to update the app with more data and improve its predictive capabilities to help accelerate tuberculosis drug discovery.
This document provides guidance on effectively communicating scientific information to different audiences. It prompts the user to identify their scientific questions, which elements to highlight, why the information matters to the audience, potential benefits, and key takeaways. An example response is given for a scientific audience focused on bacteria roles in carbon cycling and climate change. Another example is given for a K-12 student audience highlighting that bacteria have different functions and populations in various environments. The takeaway emphasizes that more bacteria are helpful than harmful.
Project Unity: The Way of the Future for Plant BreedingPhenome Networks
Project Unity is a platform that will host all phenotype-to-genotype public-domain data in a common and unified platform, offered as a free service for academia. Each researcher will be able to load their data and connect it to existing global knowledge, by linking traits to ontology, markers to genetic/physical maps and germplasms to pedigree and their sources. Initially, each dataset is stored privately, and can only be accessed by the researcher comparing his results to public ones. Data is made public once the researcher decides to do so typically after the publication of the corresponding scientific paper.
This document discusses using a rules-based data linking tool to connect disparate biodiversity data sources. It proposes applying the tool to link (1) plant names in floras to the International Plant Names Index, (2) cited type specimens in IPNI to actual specimen records, (3) flora accounts to herbarium specimens, and (4) duplicate specimen records between herbaria collections. The tool transforms and matches fields in tabular datasets using customizable rules to identify relationships between entities from different sources.
Amanuens.is HUmans and machines annotating scholarly literature TheContentMine
Published on May 19, 2016 by PMR
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
The document discusses Illumina's next-generation sequencing (NGS) workflow solutions for microbial genomics research. It describes how NGS can provide high-resolution genomic data to study microbial pathogenesis, gene transfer, pan-genomes, and host-parasite coevolution. Illumina's push-button bioinformatics tools allow researchers to easily analyze and share microbial genomic variant data. The document outlines several microbiology applications of Illumina's sequencing systems like human health, infectious disease, agriculture, biopharma, population studies, and reproductive health.
Pierre Lapaquette, an assistant professor at the University of Burgundy, wrote a letter of recommendation for Deirdra Flaherty. The letter details that Deirdra completed a 10-week internship in Lapaquette's lab, where she worked with PhD student Elissar Al Tarraf on exploring the role of nutrients in modulating the anti-inflammatory properties of probiotic bacteria. During her internship, Deirdra learned and practiced various lab skills and was able to independently perform experiments that generated useful data. She also wrote a literature review on the project and was an author on a poster presented at a young researchers meeting. Lapaquette recommends Deirdra without reservation.
This project aims to help poor families in their orchards by developing an organic biofungicide from local resources to treat fungi attacking vegetable roots. Researchers tested natural fungicides like garlic, vanilla, and neem, which were ineffective. Testing then focused on cinnamon, which showed positive anti-fungal results when mixed with concentrated neem against Aspergillus, providing an organic solution for the community's orchards.
This document provides contact information for Lyra McKee of The Muckraker and Farset Labs, including their email, Twitter handles, and websites. It lists Lyra McKee's email as Lyra@muckraker.me and their Twitter handles as @readmuck and @farsetlabs.
This document provides an overview of an Advanced Diploma of Information Technology course offered by Kent International College over 80 hours. The document outlines topics that will be covered in the course including the history and structure of the internet, how internet protocols and addressing work, markup languages like HTML and XML, connecting to the internet, and emerging technologies like internet2 and the semantic web.
The document describes Carl F, a Danish family-owned business established in 1881 that supplies products for the global building industry. Carl F has grown to become a global supplier with subsidiaries in Germany, Britain, and India, while maintaining strong traditions and quality. The document then provides details on Carl F's line of bathroom accessories and fittings made from stainless steel, with product photos, specifications, and reference numbers.
The document discusses cash management, receivables management, and inventory management. It outlines the objectives, strategies, and factors to consider for cash management including holding cash, cash budgeting, and cash flow. It also discusses credit policies, credit analysis, credit terms, and collection policies for receivables management. Finally, it mentions the objectives and costs/benefits considerations for inventory management.
Our initial idea was to film our extract in black and white, we were rather sceptical of this before our presentation as we weren't sure how our audience would recieve a film in black and white as there aren't many films in the modern age made in black and white but the feedback that we got from our teachers was very positive for our black and white idea and we have now decided to develope this idea and film it in black and white.
In our extract the majority of it is two characters sitting on a bench having a conversation when we presented this idea Mr. Alison pointed out that we have to be very careful on how we filmed it and we have to make sure that it is pleasing to the eye and that it looks like a real film and not just two people talking on a bench.
We were also advised that the extract would have to be written well in order for the story to make sense and for it to be interesting and last for two minutes.
The document discusses identifying and preventing problems with log homes through proper design, construction, and maintenance. It recommends designing homes to allow water to drain away from logs, using self-draining notches, gutters, and coatings to protect logs from moisture. It also discusses inspecting homes annually for issues like insect infestation, cracks and rot, and treating problems promptly to prevent further damage. Maintaining a quality finish on logs and sealing cracks and joints can help limit moisture, heat loss and pest entry.
Theertha Prasad V is a semi-qualified chartered accountant seeking a position that allows him to fully utilize his skills and expertise. He has cleared the CA Inter and CS Inter exams on his first and second attempts respectively. He is currently working as an Assistant Audit Manager and has over 3 years of work experience, including an articleship. He has exposure to statutory audits, internal audits, tax audits, and financial reporting. He is proficient in SAP, Tally, QuickBooks, Oracle, MS Office, and operating the internet.
The document discusses ant colony optimization (ACO), a metaheuristic optimization algorithm inspired by the behavior of ants. It provides examples of how ACO has been applied to solve shortest path problems, the traveling salesperson problem, and protein folding. It also notes that ACO is a robust method applicable to general non-static optimization problems and has achieved state-of-the-art results for some problems when combined with local search techniques and elitism in pheromone updates.
El documento anuncia el carnaval que se celebrará en la localidad de Sanzoles. Se trata de una fiesta popular que incluye desfiles, bailes y disfraces. Los vecinos de Sanzoles están invitados a participar en las diversas actividades programadas durante los días de carnaval.
This document summarizes real estate data for Magnolia, TX (zip code 77354) from January 2013. It includes charts showing the average and median home sale prices, average price per square foot, and average number of days on the market, each reported monthly over a two year period. It also lists the monthly number of home sales, average and median sale prices, and average days on market for individual months from December 2010 through December 2012.
Recorded webinar: http://slidesha.re/18pOceU
Subscribe: http://www.ksmartin.com/subscribe
Karen’s Books: http://ksmartin.com/books
Businesses routinely attempt to accomplish too much and quickly lose focus when the next fire erupts or a new "shiny ornament" appears.
Strategy Deployment (also known as hoshin kanri and policy deployment) is a highly effective means for prioritizing and maintaining focus on the projects and improvement activities that lead to outstanding business performance. But many organizations need to build fundamental skills before they're ready to fully utilize strategy deployment as it was intended.
In this webinar, you'll learn how to build fundamental skills by:
• Prioritizing the laundry list of what you COULD focus on as an organization and create a "must do, can't fail" list of what you WILL focus on.
• Gaining organization-wide alignment, the key to successful plan execution.
• Managing the plan to keep distractions at bay and generate the level of results all organizations are capable of.
In short, you'll learn how to accomplish meaningful improvement in a way that aligns rather than divides, and puts improvement in its rightful place as an integral part of achieving overarching business goals.
Project Unity: The Way of the Future for Plant BreedingPhenome Networks
Project Unity is a platform that will host all phenotype-to-genotype public-domain data in a common and unified platform, offered as a free service for academia. Each researcher will be able to load their data and connect it to existing global knowledge, by linking traits to ontology, markers to genetic/physical maps and germplasms to pedigree and their sources. Initially, each dataset is stored privately, and can only be accessed by the researcher comparing his results to public ones. Data is made public once the researcher decides to do so typically after the publication of the corresponding scientific paper.
This document discusses using a rules-based data linking tool to connect disparate biodiversity data sources. It proposes applying the tool to link (1) plant names in floras to the International Plant Names Index, (2) cited type specimens in IPNI to actual specimen records, (3) flora accounts to herbarium specimens, and (4) duplicate specimen records between herbaria collections. The tool transforms and matches fields in tabular datasets using customizable rules to identify relationships between entities from different sources.
Amanuens.is HUmans and machines annotating scholarly literature TheContentMine
Published on May 19, 2016 by PMR
about 10,000 scholarly articles ("papers") are published each day. Amanuens.is is a symbiont of ContentMine and Hypothes.is (both Shuttleworth projects/Fellows) which annotates theses using an array of controlled vocabularies ("dictionaries"). The results, in semantic form are used to annotate the original material. The talk had live demos and used plant chemistry as the examples
The document discusses Illumina's next-generation sequencing (NGS) workflow solutions for microbial genomics research. It describes how NGS can provide high-resolution genomic data to study microbial pathogenesis, gene transfer, pan-genomes, and host-parasite coevolution. Illumina's push-button bioinformatics tools allow researchers to easily analyze and share microbial genomic variant data. The document outlines several microbiology applications of Illumina's sequencing systems like human health, infectious disease, agriculture, biopharma, population studies, and reproductive health.
Pierre Lapaquette, an assistant professor at the University of Burgundy, wrote a letter of recommendation for Deirdra Flaherty. The letter details that Deirdra completed a 10-week internship in Lapaquette's lab, where she worked with PhD student Elissar Al Tarraf on exploring the role of nutrients in modulating the anti-inflammatory properties of probiotic bacteria. During her internship, Deirdra learned and practiced various lab skills and was able to independently perform experiments that generated useful data. She also wrote a literature review on the project and was an author on a poster presented at a young researchers meeting. Lapaquette recommends Deirdra without reservation.
This project aims to help poor families in their orchards by developing an organic biofungicide from local resources to treat fungi attacking vegetable roots. Researchers tested natural fungicides like garlic, vanilla, and neem, which were ineffective. Testing then focused on cinnamon, which showed positive anti-fungal results when mixed with concentrated neem against Aspergillus, providing an organic solution for the community's orchards.
This document provides contact information for Lyra McKee of The Muckraker and Farset Labs, including their email, Twitter handles, and websites. It lists Lyra McKee's email as Lyra@muckraker.me and their Twitter handles as @readmuck and @farsetlabs.
This document provides an overview of an Advanced Diploma of Information Technology course offered by Kent International College over 80 hours. The document outlines topics that will be covered in the course including the history and structure of the internet, how internet protocols and addressing work, markup languages like HTML and XML, connecting to the internet, and emerging technologies like internet2 and the semantic web.
The document describes Carl F, a Danish family-owned business established in 1881 that supplies products for the global building industry. Carl F has grown to become a global supplier with subsidiaries in Germany, Britain, and India, while maintaining strong traditions and quality. The document then provides details on Carl F's line of bathroom accessories and fittings made from stainless steel, with product photos, specifications, and reference numbers.
The document discusses cash management, receivables management, and inventory management. It outlines the objectives, strategies, and factors to consider for cash management including holding cash, cash budgeting, and cash flow. It also discusses credit policies, credit analysis, credit terms, and collection policies for receivables management. Finally, it mentions the objectives and costs/benefits considerations for inventory management.
Our initial idea was to film our extract in black and white, we were rather sceptical of this before our presentation as we weren't sure how our audience would recieve a film in black and white as there aren't many films in the modern age made in black and white but the feedback that we got from our teachers was very positive for our black and white idea and we have now decided to develope this idea and film it in black and white.
In our extract the majority of it is two characters sitting on a bench having a conversation when we presented this idea Mr. Alison pointed out that we have to be very careful on how we filmed it and we have to make sure that it is pleasing to the eye and that it looks like a real film and not just two people talking on a bench.
We were also advised that the extract would have to be written well in order for the story to make sense and for it to be interesting and last for two minutes.
The document discusses identifying and preventing problems with log homes through proper design, construction, and maintenance. It recommends designing homes to allow water to drain away from logs, using self-draining notches, gutters, and coatings to protect logs from moisture. It also discusses inspecting homes annually for issues like insect infestation, cracks and rot, and treating problems promptly to prevent further damage. Maintaining a quality finish on logs and sealing cracks and joints can help limit moisture, heat loss and pest entry.
Theertha Prasad V is a semi-qualified chartered accountant seeking a position that allows him to fully utilize his skills and expertise. He has cleared the CA Inter and CS Inter exams on his first and second attempts respectively. He is currently working as an Assistant Audit Manager and has over 3 years of work experience, including an articleship. He has exposure to statutory audits, internal audits, tax audits, and financial reporting. He is proficient in SAP, Tally, QuickBooks, Oracle, MS Office, and operating the internet.
The document discusses ant colony optimization (ACO), a metaheuristic optimization algorithm inspired by the behavior of ants. It provides examples of how ACO has been applied to solve shortest path problems, the traveling salesperson problem, and protein folding. It also notes that ACO is a robust method applicable to general non-static optimization problems and has achieved state-of-the-art results for some problems when combined with local search techniques and elitism in pheromone updates.
El documento anuncia el carnaval que se celebrará en la localidad de Sanzoles. Se trata de una fiesta popular que incluye desfiles, bailes y disfraces. Los vecinos de Sanzoles están invitados a participar en las diversas actividades programadas durante los días de carnaval.
This document summarizes real estate data for Magnolia, TX (zip code 77354) from January 2013. It includes charts showing the average and median home sale prices, average price per square foot, and average number of days on the market, each reported monthly over a two year period. It also lists the monthly number of home sales, average and median sale prices, and average days on market for individual months from December 2010 through December 2012.
Recorded webinar: http://slidesha.re/18pOceU
Subscribe: http://www.ksmartin.com/subscribe
Karen’s Books: http://ksmartin.com/books
Businesses routinely attempt to accomplish too much and quickly lose focus when the next fire erupts or a new "shiny ornament" appears.
Strategy Deployment (also known as hoshin kanri and policy deployment) is a highly effective means for prioritizing and maintaining focus on the projects and improvement activities that lead to outstanding business performance. But many organizations need to build fundamental skills before they're ready to fully utilize strategy deployment as it was intended.
In this webinar, you'll learn how to build fundamental skills by:
• Prioritizing the laundry list of what you COULD focus on as an organization and create a "must do, can't fail" list of what you WILL focus on.
• Gaining organization-wide alignment, the key to successful plan execution.
• Managing the plan to keep distractions at bay and generate the level of results all organizations are capable of.
In short, you'll learn how to accomplish meaningful improvement in a way that aligns rather than divides, and puts improvement in its rightful place as an integral part of achieving overarching business goals.
The document provides information about an upcoming exam, including the date, time, location, and topics to be covered. Exam 7 will take place on Saturday, January 4th from 9:00 to 11:30 AM in rooms Men BG 088 and Women B3 059. The exam will cover material from lectures 22 on asymmetric information and behavioral economics, as well as previous exams and key terms related to agency theory, information asymmetry, moral hazard, adverse selection, and behavioral economics concepts.
In a previous Point of View, I argued that big data is not replacing research—it is liberating it. Researchers are liberated from generating a new survey for each new learning occasion; instead, ongoing big-data assets can be leveraged for many topics, allowing subsequent primary research to go deeper and fill in the gaps. Researchers are liberated from needing to rely upon bloated surveys and
instead can keep surveys short and focused on those variables that they are ideally suited for, resulting in better data quality.
The interstellar medium is the matter that exists between stars in galaxies, consisting of gas and microscopic dust particles. About 1% of a galaxy's mass is made up of interstellar medium. In the Milky Way, the density of the interstellar medium is about 1 atom per cubic centimeter, much less dense than Earth's atmosphere. Molecular clouds within the interstellar medium can be enormous, many light years across and containing thousands of times the mass of the Sun. The interstellar medium plays an important role in the formation of stars, planets and other astronomical objects.
This document discusses concepts of elasticity in microeconomics including:
- Price elasticity of demand which measures the responsiveness of quantity demanded to changes in price. It uses the midpoint formula and compares values to benchmarks to determine if demand is elastic or inelastic.
- Cross-price elasticity of demand which measures the responsiveness of quantity demanded of one good to price changes in another good, identifying if goods are substitutes or complements.
- Income elasticity of demand which measures the responsiveness of quantity demanded to changes in income, identifying if goods are inferior, normal, or luxury goods.
- Price elasticity of supply which measures the responsiveness of quantity supplied to changes in price, identifying if
Some of the latest progress for the prevention, diagnosis and treatment of as...Graham Atherton
This document summarizes a support meeting for patients with aspergillosis led by Graham Atherton and supported by Marie Kirwan, Georgina Powell, and Debbie Kennedy. The meeting covered advances in prevention, detection, and treatment of aspergillosis, including identifying vulnerable individuals, preventing exposure to resistant strains, improving diagnosis, developing new drugs and treatments like nanotechnology, and exploring stem cell research and the possibility of growing new lungs. The meeting also discussed changes to the Fungal Research Trust becoming the Fungal Infection Trust and improvements to future patient support meetings.
This document discusses the polymerase chain reaction (PCR) amplification of the Alu sequence, a repetitive element in the human genome, from DNA samples. The author describes extracting DNA from cheek cells using a buccal swab and saline rinse, then using PCR to amplify the Alu sequence region. After PCR, the amplified DNA fragments will be run on an agarose gel electrophoresis to check for the presence of the Alu sequence band. The results will then be compared between samples from the author's biology lab class and published data from the United States.
Food researchers are joining forces with hardware and ICT
developers and mobile phone app writers to build a new type of
scanner. Integrating three sensor devices with advanced software,
the PhasmaFOOD will provide miniaturized and on-the-spot
analysis for the detection of food spoilage and food fraud.
Introduction to Gene Mining Part A: BLASTn-off!adcobb
In this lesson, students will learn to use bioinformatics portals and tools to mine plant versions of human genes. Student handout and teacher resource materials are available at www.Araport.org, Teaching Resources (Community tab). Suitable for grades 9-12 or first year undergraduate students.
The document discusses the development of Phytophthora and Pythium databases to support the identification and monitoring of these major plant pathogen groups. It describes the objectives of building a cyberinfrastructure to archive genotype, phenotype and distribution data on Phytophthora species/isolates. The Phytophthora Database provides tools for sequence analysis, phylogenetic analysis and molecular identification. Future directions include expanding to other plant pathogen databases and integrating genomic and geospatial data.
The Allen Institute for Brain Science uses an "open science" model, making all of its data freely available online without fees in order to accelerate research breakthroughs on brain diseases. This includes a comprehensive molecular map of the mouse brain and a human whole-brain atlas. While charging fees could generate revenue, the Institute's mission is to spark breakthroughs and not exclude any neuroscientists. The Institute conducts large-scale collaborative research and rapidly shares its raw data online as soon as it passes quality control in order to speed other scientists' discoveries. Open science demands ongoing maintenance and updates of databases, which the Institute provides free of charge through online and in-person resources. This open access model is proving successful, with the databases
Biovision2017 Accessing the scientific literaturepetermurrayrust
This document summarizes discussions from the ContentMine fellowship on using text mining to extract information from scientific literature. Several fellows describe their projects involving text mining papers to build databases on topics like depressive behaviors in animals, cancer research facts, cell migration patterns, genomic software tools, and weevil-plant associations. One fellow discusses being prevented from downloading papers in bulk by Elsevier to text mine for his research on detecting problematic studies.
This document provides an overview of bioinformatics and genomics. It begins with an acknowledgement and abstract section. The introduction defines bioinformatics and its role in analyzing genetic sequences and biological data through computational methods. Major research areas of bioinformatics discussed include sequence analysis, genome annotation, evolutionary biology, measuring biodiversity, gene expression analysis, protein analysis, cancer mutation analysis, and protein structure prediction. Comparative genomics and modeling biological systems are also summarized. The document concludes with a definition of genomics as the study of genomes through sequencing efforts and mapping genetic interactions.
This document discusses ways to help advance research for rare and orphan diseases through open collaboration and data sharing. It provides examples of how collaborative platforms and tools can help organizations with limited resources pool data and expertise. Specifically, it describes a secure web-based platform that allows private and public data to be simultaneously searched to facilitate partnerships across various sectors.
The document discusses how genomic sequencing is changing scientific research by providing three examples of how genome sequencing was used: to diagnose genetic conditions in fetuses non-invasively, to track the transmission of hospital-acquired infections, and to investigate global nutrient cycling in oceans by identifying previously unknown microbes. The author is an assistant professor who discusses his background and how cheap genome sequencing allows more genomes to be analyzed to generate data that provides unexpected results and interpretations.
This document summarizes two scientific articles. The first article describes a new method called PIP-seq that establishes a complete footprint of RNA-protein interactions by comparing protein-bound RNA segments protected from degradation to a control sample. The second article describes a novel approach using the single-celled fungus saccharomyces cerevisiae to understand how individual genetic variants affect gene expression over a two-and-a-half year study period. The observation notes that choosing a simple organism provides insights into RNA expression, genetic variations, and protein regulation applicable to human genetics, with implications for precision medicine through understanding disease vulnerability and tailoring treatments.
K Bobyk - %22A Primer on Personalized Medicine - The Imminent Systemic Shift%...Kostyantyn Bobyk
This newsletter discusses various topics related to science and healthcare. It provides information on free smartphone apps that can help with work, personalized medicine and the shift towards more tailored healthcare, the science and policy around marijuana, potential for an NIH equipment library, and a conference for NIDDK fellows. The conference will feature keynote speakers and discuss various research topics, with the goal of networking and career development for fellows.
This document provides an overview of bioinformatics and related topics across 7 parts:
Part I introduces bioinformatics and its areas including genomics, proteomics, computational biology, and databases.
Part II discusses the history of bioinformatics from Darwin's theory of evolution to the human genome project.
Part III focuses on the human genome project, its goals of identifying genes and sequencing DNA, and its benefits like improved medicine.
Part IV explains how the internet plays an important role in bioinformatics for retrieving biological information and resources like databases, tools, and software.
Part V describes different types of biological databases including primary, secondary, and composite databases that combine different sources.
Part VI discusses knowledge discovery
ContentMining for France and Europe; Lessons from 2 years in UKpetermurrayrust
This document summarizes Peter Murray-Rust's presentation on two years of content mining in the UK and lessons for France and Europe. Some key points discussed include:
- Content mining can save lives by enabling researchers to search literature and find past warnings, as in the case of Ebola.
- However, publishers like Elsevier and Wiley have stopped researchers' content mining efforts, hampering their work.
- France, Europe and the UK must actively support content mining through funding, tools, training and protecting researchers from restrictive publishers.
- Examples are given of ContentMine fellows' projects mining literature on topics like weevil-plant associations, cell migration and depression in animals.
Break through in biochemistry biotechnology[616]Dr.K Madhuri
The document discusses recent breakthroughs in biotechnology, biochemistry, and biology. Some key points include:
- Researchers have developed a device called the Moosy 32 eNose that can detect colon diseases by analyzing volatile compounds.
- Scientists have created human-pig embryos and developed an artificial womb to help extremely premature lambs survive.
- A new method called "cellular leapfrogging" allows mature cells like liver cells to be transformed into other cell types like neurons.
- CAR T-cell immunotherapy was approved for cancer treatment, engineering immune cells to target tumors.
- Advances could help address problems like malnutrition, crop failure, and extend human lifespans.
Similar to Aspergillosis Patient Support Meeting March 2011 - Jane Mabey Gilsenan (16)
Danielle Yuill: Giving patients a VOICE project (Patients helping in research at NAC) http://www.uhsm.nhs.uk/racrf/Pages/involved.aspx.
NB this meeting was confidential so audio is not broadcast in the second part of this support meeting.
A discussion to collect ideas and discuss the forthcoming new handout for the purpose of communicating our support with patients who do not use computers
Pseudomonas infections and a new type of antifungal drugGraham Atherton
This document provides an agenda and information for a support meeting for aspergillosis patients and carers. The meeting will be led by Graham Atherton and supported by Chris Harris from the NAC Centre. The agenda includes presentations on new antifungal medications, itraconazole as a potential anticancer drug, and Pseudomonas bacteria by Pippa Newton from the National Aspergillosis Centre. There will also be a question and answer session.
Aspergillosis Support Group Christmas Quiz 2013Graham Atherton
The December meeting of the Aspergillosis Support Group for Patients & Carers is a quiz played for the David MacIntyre Trophy. Questions are based around the information presented in the previous years meeting and other information about aspergillosis. See how you do!
Poet in Residence Caroline Hawkridge talks about our achievements in holding events to raise awareness of fungal infections using poetry written with patients & carers at earlier meetings.
Graham Atherton talked about GAFFI and about how antifungal drugs work to kill fungal infections
Involving Patients (and carers) in research at NWLC & NACGraham Atherton
Danielle Yuill tells us about her project to discover how best to involve patients and carers in research at the North West Lung Centre & National Aspergillosis Centre - amd not just reviewing grant requests and providing tissue samples.
Graham Atherton takes us through some of the many features & structures we can see in a lung x-ray - what does aspergillosis look like??.
Comparing parts of UK & US Healthcare systems, IgG explainedGraham Atherton
NAC consultant Eavan Muldoon introduces herself as our new medic and talks a little about her background, part of which was spent at Tufts Medical Centre, Boston, USA. Then Graham Atherton talks about IgG, what they are and how they work.
Management of Chronic Pulmonary Aspergillosis and IgE for the LaypersonGraham Atherton
Professor Denning summarises how we manage CPA at the National Aspergillosis Centre, what we have learned, what we are still learning.
Graham Atherton describes IgE and how it affects Aspergillosis
- The document discusses a support meeting for aspergillosis patients and carers. It includes an agenda with presentations on new NHS structures, changes in commissioning of specialized services like the National Aspergillosis Centre, and a Q&A session.
- Graham Atherton will present on funding streams for treatment which may change between clinical commissioning groups and specialized commissioning.
- Any changes from the patient perspective will be minor, with the main difference being funding approval processes for expensive antifungal drugs.
Steve Webster of the Manchester Carers Centre, UK talks about the support and services offered by the centre in Manchester and the other centres throughout the UK. Graham Atherton talks about our progress in the understanding of the health effects caused by damp homes, and how to avoid them!
Chronic illness health psychologist Alison Wearden talks about how stress effects our health and our recovery from illness, and specialist physiotherapist Phil Langridge talks about breathlessness and what we can do to control it.
Graham Atherton discusses gardening for those with allergies, the signs of heart disorder to be aware of if you are taking itraconazole and advice on travel.
Dr Mike Bromley talks about the role of Manchester University in the research and development of new antifungal drugs, followed by Dr Iain Page talking about our research projects in Africa that have the potential to reveal much larger numbers of people suffering from Chronic Pulmonary Aspergillosis (CPA) than is currently thought.
Creative Writing Projects at the National Aspergillosis CentreGraham Atherton
This document discusses using creative projects to raise public awareness of Aspergillosis and the North American Coccidioidomycosis (NAC) clinic. It provides examples of poems written by patients that could be used in newsletters, leaflets, and the clinic waiting room. It also announces an upcoming poetry event and suggests helping patients write and collect their own stories and poems.
Maintaining or Improving your health status in CPA (Khaled Al-shair)Graham Atherton
This document summarizes a presentation on factors affecting health status in chronic pulmonary aspergillosis. The presentation discusses that approximately 70% of patients responded positively to antifungal treatment, while 30% deteriorated. Important factors influencing response and health include underlying diseases, smoking, physical activity, age, nutrition status, and acute chest infections. Previous tuberculosis, asthma, COPD, and pneumonia are common underlying conditions. Smoking negatively impacts lung function, and physical activity is important for health. Nutrition and avoiding chest infections also impact health status in patients with chronic pulmonary aspergillosis.
Dr Libby Radcliffe talks about the aches & pains suffered by aspergillosis patients, the different causes and what can be done to reduce them. Professor Malcolm Richardson talks about the types of moulds we all come across every day and the damage they can cause in the wrong places. Dr Graham Atherton talks about the correct specification for facemasks used to reduce the inhalation of mould spores when carrying out routine daily tasks & hobbies.
Support meeting for aspergillosis patients with Paul Bowyer, Senior Scientist on recent advances in research on susceptibility to Chronic Pulmonary Aspergillosis
Chronic Cough: What it is and how to try to reduce its impact on your lifeGraham Atherton
This document summarizes a support meeting for patients with aspergillosis. The meeting will be led by Graham Atherton and supported by Marie Kirwan, Georgina Powell, and Debbie Kennedy. It will include an introduction, a presentation on cough by Dr. Jaclyn Smith, a break for tea and coffee, an announcement of changes to the meeting, and will conclude at 3pm. The meeting aims to provide support for patients and help improve their quality of life.
Cheryl Pearse, Specialist Nurse in Smoking Cessation at UHSM, Manchester gives the Aspergillosis Patients Meeting a presentation on giving up smoking. July 2012
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Nano-gold for Cancer Therapy chemistry investigatory project
Aspergillosis Patient Support Meeting March 2011 - Jane Mabey Gilsenan
1. LED BY GRAHAM ATHERTON SUPPORTED BY GEORGINA POWELL, MARIE KIRWAN & DEBBIE KENNEDY NAC CENTRE MANAGER CHRIS HARRIS TALKS GIVEN JANE MABEY GILSENAN RESEARCHER, NAC NATIONAL ASPERGILLOSIS CENTRE UHSM MANCHESTER Support Meeting for Aspergillosis Patients Fungal Research Trust
4. A talk of two parts: An introduction to Aspergilli and a little genetics An introduction to the use of computers in research, in particular Aspergillus research
6. What are Aspergilli? They are a sub-group of the kingdom fungi - but what’s that?
7. What’s so special about fungi and Aspergilli? Many fungi are model organisms – they have been well studied and have increased our knowledge of more complex animals Although they are simple organisms, their cell structure is similar to mammals. This means we can investigate them easily in the lab and learn more about us! The Aspergilli are a very interesting group of fungi – they are found everywhere and they can be both harmful and helpful to other organisms A human, for example, can be helped or hindered by Aspergillus fumigatus.
10. Why do these organisms display such characteristics? We need to look at the cellular level: DNA encodes all the information a living organism needs to survive. Genes are units of information within DNA. Proteins are the products of genes and are the molecules in the organism that are both building blocks and work horses.
11. Bringing computers into biology can be likened to the tools used by a project manager to build a skyscraper!
13. Computers help researchers organise and analyse genomic information 1970 1980 1990 2000 Everything written in lab notebooks passed down the research group. Disorganised and work usually made available through publication. First attempts to organise information. A protein database developed (SWISSPROT) – a basic on-line catalogue for scientists. By this time, researchers were using computers more to keep notes. There were also many different databases developed for proteins and genes. Also more accessible on the internet, so links made between databases. This made it easier for scientists to gather information to help their research. Life was brought to the 1D information. On-line resources and databases began to use still and moving graphics to illustrate biological data. With the surge of data, this made information much easier to take in.
14. What does all this mean? 1970 1980 1990 2000 A random list of items in a shop, that each shop assistant passes around when its needed. An organised list of each item, description and price available to the shop assistants and shoppers, just like an Argos catalogue but without pictures! Different shops now offering catalogues WITH pictures – Argos, Boots, Mothercare, B&Q etc. Internet shopping using individual stores (e.g., Argos and Boots) or one big super on-line store like Amazon.
15. What was happening around 2000 with Aspergillus information? We only had fragments of information about the genes and proteins Data was scattered across many different databases around the world For patients, anti-fungal medication was limited A resource had developed to provide medical information to a variety of people – The Aspergillus Website
16. What was happening around 2000 with Aspergillus information? We needed to gather all the genetic information, to understand Aspergillus better and to link this with the medical information….. Better drug development
17. C A DRE: Central Aspergillus Data Repository This project began as part of a pilot study for investigating the DNA sequence of Aspergillus fumigatus The intention was to enable the management and visualisation of information arising from this genome project – DNA sequence, genes and proteins This has expanded to house several other Aspergillus genomes and we can do a lot more with the data….. A web site primarily aimed at researchers but it is accessible to everyone with internet access www.cadre-genomes.org.uk This project began in 2001 – its our 10 th Anniversary this year!
22. Why are we interested in several genomes? The Aspergillus group share similarities in their genome and some have been studied more than others…..
23.
24. Wherever possible, all our information is made public In doing this, researchers in Manchester, the UK and abroad can use C A DRE to aid Aspergillus research New information is added to the website thereby improving the data
25. In summary, computers can… Aid in organisation and visualisation of biological data Aid in sharing and collaborating with other research groups Better understanding of Aspergillus Improved drug development Improved use in other industries
26. Thank you! www.aspergillus-genomes.org.uk - a combined website for presenting medically relevant genomic data. It is maintained by the C A DRE and The Aspergillus Website groups. www.aspercyc.org.uk - a website presenting the network of interactions between proteins in Aspergillus . Maintained by the C A DRE group. www.cadre-genomes.org.uk - a website that presents genomic information for Aspergillus genomes. Maintained by the C A DRE group.