This document discusses improving health care practices in developing countries. It outlines objectives of identifying an effective pathway for change, core principles, and factors for building local capacity. The challenges of change efforts and scale-up are discussed. Research shows many health care practice changes are not sufficiently scaled up. The document emphasizes the importance of generating long-term commitment to change through understanding the full change process. It discusses roles of local, mid-level and supporting change agents in diffusing innovations to improve health.