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Antigenic and genetic
characterization of FMDV serotype O
circulating in South East Asia
S. Upadhyaya, M. Mahapatra, S. Aviso, G. Hutchings and S. Parida
Vaccine Differentiation Group
FMD: South East Asia	
•  Economically	important	livestock	disease	-global	distribu7on	
•  Endemic	in	Asian	con7nent	including	South	East	Asia	
•  Three	of	the	seven	known	FMDV	serotypes	(A,	O,	and	Asia	1)	
are	circula7ng	in	South	East	Asia		
•  Most	of	the	outbreaks	are	caused	by	serotype	O	(>60%)		
•  Three	different		topotypes		circula7ng	in	SEA	countries	(SEA,	
Cathay	and	ME-SA)	
•  SEA:	Mya-98	lineage	viruses,	ME-SA:	PanAsia	viruses		
•  Recently	Ind2001d	lineage	-	Lao	PDR,	Myanmar,	Vietnam
FMD - South East Asia	
SEA	
ME-SA	
Cathay	
Virus	(n=97)	2007-2012	
Vaccine	(n=5)	
SEA:	2	
ME-SA:	2	
Cathay:	1	
	
Capsid	sequences	
Serology:	2D-VNT
VNT results	
Best	vaccine:	PanAsia-2	
r1-values	
No.	of	isolates
Acknowledgements	
www.pirbright.ac.ukThe Pirbright Institute receives strategic funding from BBSRC.
The	Pirbright	InsNtute	
Aravindh	Babu	
Nigel	Ferris	
WRL	FMD	
	
Nico	Visser	
Danny	Gooverts	
IIL,	India	
V	A	Srinivasan	
M	Madhan	Mohan	
	
PD-FMD,	India	
B	PaXnaik	
Murdoch	Univ,	Australia	
Ian	Robertson

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OS16 - 3.1.l Antigenic and Genetic Characterization of FMD Virus Serotype O Circulation in South-East Asia - S. Upadhyaya, M. Mahapatra

  • 1. www.pirbright.ac.ukThe Pirbright Institute receives strategic funding from BBSRC. Antigenic and genetic characterization of FMDV serotype O circulating in South East Asia S. Upadhyaya, M. Mahapatra, S. Aviso, G. Hutchings and S. Parida Vaccine Differentiation Group
  • 2. FMD: South East Asia •  Economically important livestock disease -global distribu7on •  Endemic in Asian con7nent including South East Asia •  Three of the seven known FMDV serotypes (A, O, and Asia 1) are circula7ng in South East Asia •  Most of the outbreaks are caused by serotype O (>60%) •  Three different topotypes circula7ng in SEA countries (SEA, Cathay and ME-SA) •  SEA: Mya-98 lineage viruses, ME-SA: PanAsia viruses •  Recently Ind2001d lineage - Lao PDR, Myanmar, Vietnam
  • 3. FMD - South East Asia SEA ME-SA Cathay Virus (n=97) 2007-2012 Vaccine (n=5) SEA: 2 ME-SA: 2 Cathay: 1 Capsid sequences Serology: 2D-VNT
  • 5. Acknowledgements www.pirbright.ac.ukThe Pirbright Institute receives strategic funding from BBSRC. The Pirbright InsNtute Aravindh Babu Nigel Ferris WRL FMD Nico Visser Danny Gooverts IIL, India V A Srinivasan M Madhan Mohan PD-FMD, India B PaXnaik Murdoch Univ, Australia Ian Robertson