Organochlorines are organic molecules containing chlorine that are commonly non-volatile solids found in many environments. They were widely used as pesticides from the 1940s-1960s, including DDT, but many have since been banned for their neurotoxicity. Symptoms of organochlorine toxicity include CNS excitation, seizures, respiratory issues, and dermatological effects. While dermal exposure is most common, inhalation and ingestion can also occur. Organochlorines affect nerve impulses and cardiac function. There are no antidotes, but decontamination, supportive care, and anticonvulsants may be used to treat toxicity.
This lecture includes Introduction to Poisons, Different Types of Classification of Poisons, Analysis of Poisons (Volatile, Nonvolatile) (Acidic, Basic, Neutral).
This lecture includes Introduction to Poisons, Different Types of Classification of Poisons, Analysis of Poisons (Volatile, Nonvolatile) (Acidic, Basic, Neutral).
Chloromethanes namely methyl chloride (CH3Cl), methylene chloride (CH2Cl2), Chloroform (CHCl3) and Carbon Tetrachloride (CCl4) are produced by direct chlorination of Cl2 in a gas phase reaction without any catalyst.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Introduction
Organochlorines (OCs) are organic molecules with chlorine in their
structure ( chlorinated hydrocarbons)
In general they are non-volatile
solids at room temperature
Organochlorine compounds usually have a large molecular mass.
They are very stable and are moderate polarity. This makes OC easily
soluble in fats.
They were found in all environments: air, water, soil, sediments, and
biota samples.
3. Organochlorines pesticides (OCPs)
Most organochlorines have a negative temperature coefficient
meaning they are more toxic at lower temperatures. This property
makes organochlorine agents more toxic to cold-blooded
creatures like insects and mammals.
Organochlorine pesticides are used extensively from the 1940s
through the 1960s in agriculture and mosquito control.
The compounds in this group include:
DDT(dichlorodiphenyltrichloroethane), methoxychlor, toxaphene,
mirex, kepone, lindane, cyclodine, and benzene hexachloride.
As neurotoxicants, many organochlorine pesticides were banned
in the United States and other countries.
4. Signs and symptoms
CNS excitation and depression, are the primary clinical effects of acute
organochlorine toxicity; therefore, patients may present with any of the
following:
Initial euphoria with auditory or hallucinations.
Seizures
Agitation or unconsciousness
Facial paresthesia
Inability to close eyelide
Drooping the mouth Facial nerve
Facial paresthesia
5. Other signs and symptoms include the following:
Pulmonary - Cough, shortness of breath
Dermatologic - Skin rash
Gastrointestinal - Nausea, vomiting, diarrhea, and abdominal pain
Nervous system - Headache, dizziness .
.
6. Route of Exposure
There are three types of exposure: dermal, inhalation, and ingestion.
Dermal exposure is the most common type of exposure for the applicator.
the skin is easily exposed when handling pesticides.
Inhalation or breathing a pesticide into the lungs is less common, but is
still a danger to the applicator.
Ingestion exposures occur when users eat, smoke, or drink around
pesticides or forget to wash after use. other parts of the body (eyes,
abdomen, groin) absorb pesticides more quickly.
7. Ingestion produces the following manifestations:
Nausea and vomiting
Confusion, tremor, myoclonus, coma, and seizures
Respiratory depression or failure
Skin absorption or inhalation produces the following manifestations:
Ear, nose, and throat irritation
Blurred vision
Cough, Acute lung injury
Dermatitis
Eczema by pesticide
8. Organochlorines affect nerve impulse transmission by altering
membrane Na+ K+ flux, resulting in CNS hyperexcitability.
Organochlorines produces myocardial irritability and cardiac
arrhythmias.
Mechanism of Toxicity
DDT(dichlorodiphenyltrichloroethane) and related compounds
act on sodium channel and sodium conductance across the
neuronal membrane, especially of axones.
Cyclodine and Lindane appear to inhibit the GABA mediated
chloride channels in CNS.
9.
10. An oral median lethal dose (LD50) is higher than 50 mg/kg in animal studies. The
estimated approximate minimum lethal dose for humans is 2-7 g
LD50 and toxicity rating
LD50 in the rats
113-800 mg/kg
DDT
88-190 mg/kg
lindane
100-210 mg/kg
cyclodine
11. Toxicity tests
The normal range for blood chlorine in most laboratories is 96 to
106 milliliters per liter. Diagnostics may use a chlorine meter to
determine the level of chloride in the blood.
If chloride level in the blood is more than 106 it will cause
hyperchloremia.
12. No specific antidotes are available for organochlorine poisoning.
Decontamination may be indicated to prevent continued absorption, as
well as exposure of health care personnel. For dermal decontamination,
remove clothing and wash skin with soap and water. This is best
performed in the field.
the medications used in relieve symptomes include gastrointestinal
decontaminants, beta-blockers, vasopressors, and benzodiazepines and
other anticonvulsants.
Antidote and treatment