Presentation by Professor Sarah Cleaveland of the University of Glasgow at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
The Real World: One Health - zoonoses, ecosystems and wellbeingNaomi Marks
Opening keynote presentation by Professor Jeremy Farrar, Director, Wellcome Trust, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
A critical social analysis of poverty and zoonotic disease riskNaomi Marks
Presentation by Professor Jo Sharp of the University of Glasgow at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Understanding zoonotic impacts: the added value from One Health approachesNaomi Marks
Presentation by Professor Jakob Zinsstag of the Swiss Tropical and Public Health Institute at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Framing zoonoses: from single diseases to systemic challengesNaomi Marks
Presentation by Professor David Waltner-Toews of Veterinarians without Borders, Canada, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Agricultural intensification and Nipah virus emergenceNaomi Marks
Presentation by Dr Jonathan Epstein, EcoHealth Alliance, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Keynote presentation by Dr Delia Grace of the International Livestock Research Institute, Nairobi, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
The Real World: One Health - zoonoses, ecosystems and wellbeingNaomi Marks
Opening keynote presentation by Professor Jeremy Farrar, Director, Wellcome Trust, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
A critical social analysis of poverty and zoonotic disease riskNaomi Marks
Presentation by Professor Jo Sharp of the University of Glasgow at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Understanding zoonotic impacts: the added value from One Health approachesNaomi Marks
Presentation by Professor Jakob Zinsstag of the Swiss Tropical and Public Health Institute at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Framing zoonoses: from single diseases to systemic challengesNaomi Marks
Presentation by Professor David Waltner-Toews of Veterinarians without Borders, Canada, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Agricultural intensification and Nipah virus emergenceNaomi Marks
Presentation by Dr Jonathan Epstein, EcoHealth Alliance, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Keynote presentation by Dr Delia Grace of the International Livestock Research Institute, Nairobi, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Seroprevalence and risk factors for Coxiella burnetii (Q fever) infection in ...ILRI
Poster prepared by DK Mwololo, PM Kitala, SK Wanyoike and B Bett presented at the 3rd International One Health Congress, Amsterdam, the Netherlands, 15-18 March 2015.
One Health – an interdisciplinary approach in combating emerging diseasesILRI
Presentation by Hung Nguyen-Viet, Delia Grace and Jakob Zinsstag at the International Symposium of Health Sciences (iSIHAT 2013), Kuala Lumpur, Malaysia, 20-21 August 2013.
Averting future pandemics: Legal and illegal trade in animals, meat and wildmeatILRI
Presentation by Delia Grace at a webinar on Wildlife trafficking prevention: How can airports support the UN Sustainable Development Goals?, 2 September 2021.
Framework for assessing the economic costs and burdens of zoonotic diseaseILRI
Presented by Alexandra Shaw, Ian Scoones, Melissa Leach, Francis Wanyoike and Delia Grace at the EcoHealth 2014 conference, Montreal, Canada, 11-14 August 2014.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Human-bat interactions and diseases: transmission risks in GhanaNaomi Marks
Presentation by Professor Yaa Ntiamoa-Baidu of the University of Ghana at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Motivation, culture and health in a socio-ecological system in AfricaNaomi Marks
Keynote presentation by Professor Bassirou Bonfoh, Director-General, Swiss Centre for Scientific Research (CSRS), Côte d'Ivoire, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Seroprevalence and risk factors for Coxiella burnetii (Q fever) infection in ...ILRI
Poster prepared by DK Mwololo, PM Kitala, SK Wanyoike and B Bett presented at the 3rd International One Health Congress, Amsterdam, the Netherlands, 15-18 March 2015.
One Health – an interdisciplinary approach in combating emerging diseasesILRI
Presentation by Hung Nguyen-Viet, Delia Grace and Jakob Zinsstag at the International Symposium of Health Sciences (iSIHAT 2013), Kuala Lumpur, Malaysia, 20-21 August 2013.
Averting future pandemics: Legal and illegal trade in animals, meat and wildmeatILRI
Presentation by Delia Grace at a webinar on Wildlife trafficking prevention: How can airports support the UN Sustainable Development Goals?, 2 September 2021.
Framework for assessing the economic costs and burdens of zoonotic diseaseILRI
Presented by Alexandra Shaw, Ian Scoones, Melissa Leach, Francis Wanyoike and Delia Grace at the EcoHealth 2014 conference, Montreal, Canada, 11-14 August 2014.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Human-bat interactions and diseases: transmission risks in GhanaNaomi Marks
Presentation by Professor Yaa Ntiamoa-Baidu of the University of Ghana at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Motivation, culture and health in a socio-ecological system in AfricaNaomi Marks
Keynote presentation by Professor Bassirou Bonfoh, Director-General, Swiss Centre for Scientific Research (CSRS), Côte d'Ivoire, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
A unified framework for the infection dynamics of zoonotic spillover and spreadNaomi Marks
Presentation by Dr Gianni Lo Iacono of Public Health England at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Pre-empting the emergence of zoonoses by understanding their socio-ecologyNaomi Marks
Keynote presentation by Dr Peter Daqszak, President, EcoHealth Alliance, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Presentation by Dr Lina Moses of Tulane University at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
One Health networks - why should we bother?Naomi Marks
Presentation by Professor Victor Galaz of the Stockholm Resilience Institute at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, 17-18 March 2016.
Patches, Tsetse and Livelihoods in the Zambezi Valley, ZimbabweNaomi Marks
Presentation by Professor Vupenyu Dzingirai of the University of Zimbabwe at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Tsetse, trypanosomiasis and communities in transition: investigations into he...Naomi Marks
Presentation by Dr Neil Anderson of the University of Edinburgh at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Investigating the spatial epidemiology of zoonotic viral haemorrhagic feversNaomi Marks
Presentation by Dr David Pigott of the University of Oxford at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Presentation by Professor Neil Ferguson of Imperial College London at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Malaria parasitaemia and socioeconomic status of selected residents of Emohua...IOSRJPBS
In Nigeria, malaria consistently ranks among the five most common cause of death in children. This study investigated the prevalence of malaria and socioeconomic status of someresidents of Emohua Community, Rivers State, Nigeria.Following ethical clearance which was obtained from the University of Port Harcourt and the parents of the subjects who gave their written consents, blood samples were collected through vein puncture from 200 subjects within the age 0-17years, from July 2014-February 2015. Structured questionnaire were administered to the subjects and parents provided answers for younger children.Thick and Thin films were examined microscopically using oil immersion objective following the standardparasitological method. The thin films were fixed with methanol and all films were stained with 10% Giemsa stain diluted with 7.2 buffer water for 10 minutes. The demographic characteristics of 200 subjects examined in Emohua showed that 120(60%) were females and 60(40%) were males. Sex related prevalence showed that more females were infected with 66(62.3%) and had higher parasite density of 144720/ul than males with 40 (37.7%) and parasite density of 106160/ul though the difference was not significant (P>0.05). Out of the 200 subjects examined, 106(53.0%) were positive for Plasmodium falciparum. Age related prevalence showed that subjects within the age 0-3years and 4-6years had higher prevalence of 62 (31%) followed by those within the age 7-9years with 31(15.5%) and the least with zero prevalence was within the age 16-18 years. Those within the age of 4-6years had higher parasite density of 71680/ul followed by 0-3years of age with parasite density of 63360/ul while those within the age 16-18yrs had none (0). The difference in prevalence of malaria in relation to age was significant (P<0.05).>0.05). Subjects that used treated net were more with 117(58.5%), followed by those that do not use net at all with 54(27%) and those whose nets were untreated with 28(14%). Only 1(0.5%) person believed in the potency of prayer as a preventive measure against malaria while none trusted environmental sanitation. Subjects that are non- net users had higher prevalence of 46(85.2%) and more parasite density of 98080/ul followed by the untreated net users with 22(78.6%) and parasite density of 77280/ul while the least prevalence was recorded among the treated net users with 38(32.5%) and parasite density of 75520/ul. The differences in prevalence of infection in relation to preventive measures was significant (P<0.05).more><0.05).There is need to improve socio-economic status and awareness for total compliance to preventive measures among the subjects so as to reduce the malaria prevalence rate to the desired zero level
GRF One Health Summit 2012, Davos: Presentation by Dr. Berhe Tekola - Director - Animal Production and Health - Food and Agriculture Organization of the United Nations FAO
Schistosomiasis towards 2030: From Global Expectations to local realitiesCOUNTDOWN on NTDs
This presentation was given by Prof. Russell Stothard, in his capacity as COUNTDOWN Director to the Global Center for Infectious Diseases (GCID) Symposium in Korea and to the Korean Society for Parasitology in mid-Feb. 2017
A Retrospective Disease Surveillance Based Approach in the Investigation and ...Stephen Olubulyera
A Retrospective Disease Surveillance Based Approach in the Investigation and Linkage of Human Brucellosis to Animal Sources: One Health Approach Complementary Strategy Applicable in Nomadic Pastoralism, a Case Study of Turkana County, Kenya.
Dr. Shweta Bansal - Modeling Emerging Disease in the US Swine HerdJohn Blue
Modeling Emerging Disease in the US Swine Herd - Dr. Shweta Bansal, PhD, Assistant Professor, Department of Biology at Georgetown University, from the 2015 NIAA Annual Conference titled 'Water and the Future of Animal Agriculture', March 23 - March 26, 2015, Indianapolis, IN, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2015_niaa_water_future_animal_ag
The context surrounding the emergence of infectious diseases and the need to ...ILRI
Presentation by Hung Nguyen-Viet at a Preventing Zoonotic Disease Emergence (PREZODE) side event at the Food and Agriculture Organization of the United Nations (FAO) Forum on Science and Innovation, 13 October 2022.
Domestic extensions: the bushmeat ban and the social realities of hunting and...Naomi Marks
Presentation by Dr Ann Kelly of the University of Exeter/King's College London, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, at the Zoological Society of London, 17-18 March, 2016
Beyond risk factors: untangling power and politics in zoonisis controlNaomi Marks
Presentation by Dr Kevin Bardosh of the University of Edinburgh at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, 17-18 March 2016.
Social dimensions of zoonoses in interdisciplinary researchNaomi Marks
Presentation by Dr Hayley MacGregor of the Institute of Development Studies, UK, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, 17-18 March 2016.
The FAO/OIE/WHO Tripartite: an institutional void?Naomi Marks
Presentation by Dr Jan Slingenbergh, independent One Health policy adviser, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Agent-based modelling as an integrative framework for One Health: trypanosomi...Naomi Marks
Presentation by Professor Peter Atkinson of Lancaster University of Zimbabwe at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
A mathematical model for Rift Valley fever transmission dynamicsNaomi Marks
Presentation by Dr Bernard Bett of the International Livestock Research Institute, Nairobi, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Irrigation and the risk of Rift Valley fever transmission - a case study from...Naomi Marks
Presentation by Dr Bernard Bett of the International Livestock Research Institute, Nairobi, at the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, London 17-18 March 2016
Estimating the contribution of human-to-human transmission to Lassa fever'Naomi Marks
'Estimating the contribution of human-to-human transmission to Lassa fever', presented by Gianni Lo Iacono, of the Dynamic drivers of Disease in Africa Consortium, at EWDA 2014
Ecohealth 2014 gianni lo iacono presentation on integrative modellingNaomi Marks
'A mechanistic model at the interface between epidemiology, ecology and environmental drivers', presented by Gianni Lo Iacono as part of a panel presentation on integrative modelling from the Dynamic Drivers of Disease Consortium at Ecohealth 2014
Dynamic Drivers of Disease in Africa 'Ecohealth 2014' presentation on integra...Naomi Marks
Panel presentation on integrative disease modelling given at Ecohealth 2014 conference. Panel members included: Delia Grace, Pete Atkinson, Gianni Lo Iacono, Johanna Lindahl and Catherine Grant.
Bernard bett delia grace climate change impacts on animal health and vector ...Naomi Marks
'Climate change impacts on animal health and vector borne diseases. Presentation by Bernard Bett and Delia Grace of the International Livestock Research Institute to a USAID climate change technical officers meeting
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
One Health for the Real World: partnerships and pragmatism
1. One Health for the Real World:
partnerships and pragmatism
Sarah Cleaveland
Institute of Biodiversity, Animal Health and Comparative Medicine
University of Glasgow
sarah.cleaveland@glasgow.ac.uk
One Health for the Real World, ZSL, March 18th 2016
2. Hampson et al. (2015) PLoS NTD,9(4): e0003709 ; Lembo et al. 2010. PLoS NTD 4: e626; Costa et al.
(2015) PLoS Negl Trop Dis 9(9): e0003898; http://www.who.int/csr/disease/ebola/en/
Emerging zoonosesEndemic zoonoses
Connecting health priorities
0
10,000
20,000
30,000
40,000
50,000
60,000
70,000
Estimatedannualhumandeaths
affecting mainly
poor and neglected
communities
with potential to affect
high-income countries
3. “A global surveillance and
control system that is
established primarily for
emerging infectious
zoonotic diseases with
pandemic potential can be
readily improvised to
address the endemic
diseases that are a priority
in many developing
countries….”
Juergen Voegele, Director,
Agriculture and Rural Development,
The World Bank
4. “A global surveillance and
control system that is
established primarily for
emerging infectious
zoonotic diseases with
pandemic potential can be
readily improvised to
address the endemic
diseases that are a priority
in many developing
countries….”
Juergen Voegele, Director,
Agriculture and Rural Development,
The World Bank
A global surveillance and
control system that is
established primarily for
endemic diseases that are
a priority in many
developing countries can
be readily improvised to
address the emerging
infectious zoonotic
diseases with pandemic
potential ….
Halliday et al. (2012) Phil. Trans. R.
Soc. B 367: 2872-3880
5. Rabies surveillance: lessons learned
• Engaging frontline health
workers
– Incentivisation and
empowerment
– Effective response that provides
an immediate benefit
– Building trust and motivation…..
“which comes from a sense of
common good”
Mtema et al. (in press) Mobile phones as
surveillance tools: implementing and evaluating a
large-scale intersectoral surveillance system in
Tanzania. PLoS Medicine
6. Novel Lyssaviruses
• Surveillance of endemic rabies allowed detection of a novel lyssavirus
???
Marston et al. (2012) Emerg Infect Dis 18(4):664-7.
Horton et al. (2014) Gen Virol. 95: 1025–1032.
To date, no serological evidence of
infection in bats in Kenya or Tanzania
(n= 483 sera from 11 bat species)
?
7. Zoonotic Disease Unit, Kenya
Vision
A country with reduced burden of zoonotic diseases and better able to respond
to epidemics of emerging and re-emerging infectious diseases
Priority zoonoses: Anthrax,
trypanosomiasis, rabies,
brucellosis, Rift Valley Fever
8. Brucellosis (5.3%)
Leptospirosis (10.1%)
Q fever (7.9%)
Spotted fever group
rickettsiosis (8.7%)
Typhus group
rickettsiosis (1.0%)
Malaria – Overall
1.9%
ALL INFECTIONS
Causes of febrile illness in
adults and adolescents
Moshi, Tanzania
Biggs et al., 2011; Prabhu et al., 2011;
Crump et al., 2013
Malaria
(61.6%)
Other
(38.4%)
Clinical diagnosis No diagnosis (33.2%)
Fungal (18.8%)
Mycobacterial (12.5%)
Bacterial (61.6%)
Bloodstream
infections (27.8%)
Chikungunya (5.7 %)
12. Changing livestock systems
– Shifts from traditional pastoralism with greater reliance on crops
– Increasing pressure on grazing lands
– Changing patterns of demand for meat and milk
– Increasing complexity of milk and meat value changes
14. How do perceptions of livestock status
influence policy and practice?
How do
understandings of
‘milk’ affect public
health messages?
“The poor man’s cow…”
Georgia Ladbury Jo Sharp
16. Investments in dog vaccination can provide a cost-effective and
equitable approach to human rabies prevention
$0.15
PEP
$0.34
PEP
$0.24
PEP
Data from Hampson et al. (2015) PLoS NTD,9(4): e0003709
17.
18. Pragmatic Interventions
• Many tools already exist for effective control of
endemic and neglected zoonoses
– Design of interventions to mitigate on-going burden of
disease
– Strengthening institutions, leadership, building trust
through common good
– Interventions that prevent infection at source likely to
provide a broader ‘safety net’ than reliance on clinical
management of human cases alone
19. Acknowledgements
Supported by the Zoonoses and Emerging Livestock Systems Initiative:
-Social, Economic and Environmental Drivers of Zoonoses in Tanzania (SEEDZ)
-Molecular Epidemiology of Brucellosis in northern Tanzania
-Hazards Associated with Zoonotic enteric pathogens in Emerging Livestock meat
pathways (HAZEL)
http://livestocklivelihoodsandhealth.org
@Zoonoses_TZ