1. The document discusses several emergency drugs used in obstetrics including tranexamic acid, lidocaine, misoprostol, anti-D immunoglobulin, and dexamethasone.
2. Tranexamic acid and misoprostol are used to prevent and treat postpartum hemorrhage. Lidocaine is used for local anesthesia during procedures like episiotomies. Anti-D immunoglobulin prevents Rh isoimmunization. Dexamethasone is given to improve outcomes for premature babies by promoting lung maturation.
3. The document provides information on the indications, dosages, administration methods, and nursing responsibilities for each drug. Side effects are also outlined.
Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy and is defined as glucose intolerance that first emerges or is first recognized during pregnancy. Gestational diabetes mellitus (GDM) affects between 2% and 5% of pregnant women. Data show that increasing levels of plasma glucose are associated with birth weight above the 90th percentile, cord blood serum C-peptide level above the 90th percentile, and, to a lesser degree, primary cesarean deliveries and neonatal hypoglycemia
Pruritus affects upto 20% of pregnant women.
There are conditions unique to pregnancy that involve pruritus as a leading symptom.
This is called dermotoses of pregnancy.
May produce risk to mother and foetus.
Approach to skin lesions in pregnancy: Pruritus related to pregnancy, Pruritus not related to pregnancy
Endometrial hyperplasia - irregular proliferation of the endometrial glands with an increase in the gland to stroma ratio when compared with proliferative endometrium
Endometrial Ca - most common gynaecological maglinancy in the western country, endometrial hyperplasia as the precursor
Incidence of endometrial hyperplasia 3 folds higher than endometrial Ca
Fourth most common cancer in women in Peninsular Malaysia
Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy and is defined as glucose intolerance that first emerges or is first recognized during pregnancy. Gestational diabetes mellitus (GDM) affects between 2% and 5% of pregnant women. Data show that increasing levels of plasma glucose are associated with birth weight above the 90th percentile, cord blood serum C-peptide level above the 90th percentile, and, to a lesser degree, primary cesarean deliveries and neonatal hypoglycemia
Pruritus affects upto 20% of pregnant women.
There are conditions unique to pregnancy that involve pruritus as a leading symptom.
This is called dermotoses of pregnancy.
May produce risk to mother and foetus.
Approach to skin lesions in pregnancy: Pruritus related to pregnancy, Pruritus not related to pregnancy
Endometrial hyperplasia - irregular proliferation of the endometrial glands with an increase in the gland to stroma ratio when compared with proliferative endometrium
Endometrial Ca - most common gynaecological maglinancy in the western country, endometrial hyperplasia as the precursor
Incidence of endometrial hyperplasia 3 folds higher than endometrial Ca
Fourth most common cancer in women in Peninsular Malaysia
Depo-Provera CI (Medroxyprogesterone Acetate Injectable Suspension) The Swiss Pharmacy
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Early pregnancy loss by dr alka mukherjee dr apurva mukherjee nagpur ms indiaalka mukherjee
Early pregnancy loss, or loss of an intrauterine pregnancy within the first trimester, is encountered commonly in clinical practice. Obstetricians and gynecologists should understand the use of various diagnostic tools to differentiate between viable and nonviable pregnancies and offer the full range of therapeutic options to patients, including expectant, medical, and surgical management.
Early pregnancy loss is defined as a nonviable, intrauterine pregnancy with either an empty gestational sac or a gestational sac containing an embryo or fetus without fetal heart activity within the first 12 6/7 weeks of gestation 1. In the first trimester, the terms miscarriage, spontaneous abortion, and early pregnancy loss are used interchangeably, and there is no consensus on terminology in the literature.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
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Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
4. Cont..
• Tranexamic Acid (TXA) is a lysine analogue and works by binding to
plasminogen, thereby inhibiting fibrinolysis.
• TXA has been used for years in the management and prevention of
hemorrhage ,in the surgical setting including cardiac, orthopedic
and trauma surgery.
• TXA has also been used to prevent PPH in vaginal delivery
Brand Name:
• Hemostan, Cyclokapron, Fibrinon, Lysteda, Transamin
5. Cont..
Goals:
1. To reduce the incidence of postpartum hemorrhage in
patients at high risk for hemorrhage due to known risk
factors.
2. To reduce the severity of postpartum hemorrhage once a
patient has been identified as having a hemorrhage (EBL >
500 ml in vaginal delivery or > 1000 ml in Cesarean delivery)
delivery.
6. Cont..
Clinical Practice:
1. Prophylactic use: Consider prophylactic use in cesarean or
vaginal delivery with patients at increased risk for hemorrhage ,
especially in circumstances where uterotonics may be
contraindicated. Discuss possible use at briefing or at team
meeting.
2. Therapeutic use: Consider use when patient has been
identified as having a hemorrhage. Team agreement prior to
administration.
7. Cont..
Method of administration:
Dosage: 1 gram given intravenously over 10 minutes.
Possible methods of administration include 1g diluted into 10 ml of normal
saline or 1g diluted into 100 ml of normal saline.
Timing: Administer immediately after delivery of baby in either vaginal or
cesarean delivery, or when hemorrhage has been identified.
Consider redosing 1g after 30 minutes in continuing hemorrhage. Consider
infusion (5mg/kg/hr) if prolonged bleeding period is expected.
8. Cont..
Side effects:
• Minor: nausea, vomiting, GI upset, headaches, dizziness, hypotension, color
blindness
• Major: thromboembolic complications (PE, DVT, MI), seizure, anaphylaxis
contraindication
• History of thromboembolic disease (DVT, PE or CVA)
• History of ischemic heart disease
• Known disorder of hypercoagulability (ex. Factor V Leiden)
• Prior reactipn to txa
9. Cont..
Nursing Responsibilities:
• Unusual change in bleeding pattern should be immediately
reported to the physician.
• For women who are taking Tranexamic acid to control
heavy bleeding, the medication should only be taken during the
menstrual period.
• The medication can be taken with or without food.
• Inform the patient that she inform if severe side effects occurs:
allergic reaction, chest pain, shortness of breath etc.
11. lignocaine
• Lignocaine (Cadila) 2 % Injection is an effective agent that is
used to numb a specific area of the body to reduce pain and
discomfort caused by surgical or other invasive medical
procedures
• Lidocaine injection is also given in an epidural (spinal
block) to reduce the discomfort of contractions during
labor.
• Episiotomy is the most common obstetric surgical
procedure and discomfort and pain is a common
experience for all women exposed to episiotomy.
12. Cont..
Usual dose: 7 mg/kg
Onset: Rapid 60–90 min
Use:
• Local or pudendal block for episiotomy
• epidural or spinal for cesarean delivery
Nursing responsibility:
Carry out baseline and regular observations
14. Mesoprostol
• Misoprostol is a prostaglandin analogue
• It binds to myometrial cells to cause strong myometrial
contractions leading to expulsion of tissue.
• This agent also causes cervical ripening with softening and
dilation of the cervix.
• Given by PO/PV route
15. Cont..
Clinical use:
• Cervical ripening and Induction of labor.
• Medical termination of pregnancy.
• Medical management of miscarriage/ IUD ( For 1st trimester single
dose of 400mcg; From 12- 34 weeks 400mcg 3hrly ,max 5 doses)
• Postpartum hemorrhage- 800m
• For cervical ripening in advance of endometrial biopsy to reduce the
need for use of a tenaculum or cervical dilator.cg PR/PV
Side effects:
• nausea, vomiting, diarrhoea, abdominal pain
16. Cont..
Nursing responsibility
• Uterine activity and fetal status should be monitored
• Observe for any complication
• Assess the safety of mother and fetus during misoprostol
administration.
18. Anti D immunoglobulin
• Rho(D) immune globulin (RhIG) is a medication used to
prevent RhD isoimmunization in mothers who are RhD
negative and to treat idiopathic thrombocytopenic purpura (ITP)
in people who are Rh positive.
• It is often given both during and following pregnancy.
• It may also be used when RhD negative people are given RhD
positive blood.
• It is given by injection into muscle or a vein.
• Rho(D) immune globulin is made up of antibodies to
the antigen Rho(D) present on some red blood cells.
• It work by blocking a person's immune system from
recognizing this antigen.
19. Cont..
• It is recommends that all RhD negative mothers, regardless of
fetal blood type, receive RhIG at about 28 weeks gestation,
and again shortly after delivery in the case of an RhD positive
or RhD unknown baby.
• It should be given within 3 days of a potential exposure to Rh
positive blood from the baby such as may occur during second
or third trimester miscarriage, amniocentesis, cordocentesis,
chorionic villus sampling, external cephalic version, trauma, or
delivery
20. Cont..
Dose of anti D immunoglobulin
• Rh-incompatible pregnancy:
RhoGAM(R): 1500 international units (300 mcg), IM, at gestational
week 26 to 28, or within 72 hours of birth of an RHo (D) positive
baby.
Rhophylac(R): 1500 international units (300 mcg), IV or IM, at
gestational week 29 to 30; repeat dose within 72 hours of birth of an
RHo (D) positive baby.
WinRho(R): 1500 international units (300 mcg), IV or IM, at
gestational week 28; give an additional 600 international units (120
mcg) dose within 72 hours of birth of an RHo (D) positive baby.
21. Cont.…
• Amniocentesis and chorionic villus sampling before 34 weeks
gestation:
RhoGAM(R): 1500 international units (300 mcg), IM
WinRho(R): 1500 international units (300 mcg), IV or IM,
immediately after the procedure
• Abortion or miscarriage of up to 12 weeks gestation:
BayRho-D Mini-Dose(R): 1 syringe, IM, within 3 hours, or as soon
as possible (within 72 hours of pregnancy termination).
• Abortion or miscarriage after 12 weeks gestation:
RhoGAM(R): 1500 international units (300 mcg), IM
22. Cont.…
• Abortion, amniocentesis, or any other manipulation after
34 weeks gestation:
WinRho(R): 600 international units (120 mcg), IV or IM, within
72 hours
• Ectopic pregnancy:
RhoGAM(R): 1500 international units (300 mcg), IM
23. Cont..
contraindication
• D-negative females whose fetus is known to be D-negative
D-negative females who have been previously alloimmunized to D
(they have already formed an anti-D alloantibody)
Any D-positive females
Women who test positive for one of the weak D mutations by
molecular testing should be considered RhD positive and not
receive RhIG
Women who test positive for one of the partial D mutations (by
molecular testing) should be treated as RhD negative and receive
RhIG as clinically indicated
24. Cont..
Nursing responsibility
• Consent
All pregnant women should receive appropriate written and verbal
information about anti-D immunoglobulin to inform their choice and be
given time to consider their options. As a human derived blood product
the administration of anti-D Immunoglobulin needs to be consented.
• Prescribing responsibilities
Anti-D Ig has been added to the exempt list of drugs for midwives,
therefore midwives can administer it to their patients without a
prescription or PGD.
25. Cont.…
• Individual responsibilities
Anti-D prophylaxis should be discussed with the patient in advance
and consent must be documented in the woman’s hand held
records and /or in the medical notes.
• Documentation responsibilities
All request forms need to be fully completed.
Full details of any anti-D immunoglobulin administered should be
fully recorded on the ward blood transfusion pathway. This must
include Woman’s identity including surname, forename, date of
birth and a unique ID number.
27. Dexamethasone
• Dexamethasone is a corticosteroid medication
• In preterm labor, it is used to improve outcomes in the baby
• Dexamethasone may be given to women at risk of delivering
prematurely to promote maturation of the fetus' lungs. This
administration, given from day to one week before delivery
28. Cont.…
• A single course of corticosteroids is recommended for pregnant
women between 24 0/7 weeks and 33 6/7 weeks of gestation who
are at risk of preterm delivery within 7 days, including for those with
ruptured membranes and multiple gestations.
• Dose:
Dexamethasone is available in:
• in tablet form (0.5 mg each);
• in the form of a solution in ampoules for intramuscular and
intravenous injections (4 mg / ml)
29. Cont.…
side effects:
• Fluid retention
• Increase blood pressure
• Increase blood glucose level in patient with diabetes mellitus
• Decrease patient’s resistance to infection
Nursing responsibility:
• Monitor for maternal vital sign and fetal heart rate
• Monitor blood glucose level of the patient and increase insulin as
prescribed