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Numbness in chin/lip region
JAMEEL KIFAYATULLAH
causes
• neoplastic
• traumatic
• Dental
• Toxic
• drug-induced
• inflammatory
• autoimmune
• infectious
causes
Neoplasm
• breast cancer(40%)
• lymphoma (21%)
• prostate (7%)
• leukaemia (5%)
Causes
Dental and traumatic injury
• Iatrogenic injury
• removal of impacted teeth or cysts
• local anaesthetic block
• bone grafting
• endodontic therapy
• orthognathic surgery
• dental implant placement,
Causes
Toxin or drug-induced
Bisphosphonate
mefloquine
allopurinol
interferon-alpha
trichloroethylene
Causes
Infection
• Syphilis
• Lyme disease
• herpes simplex virus
• human immunodeficiency virus
Causes
Inflammatory/Autoimmune
Multiple sclerosis
sensorimotor mononeuritis multiplex
giant cell arteritis
post-hepatitis B vaccination
systemic lupus erythematosus
Sjögren syndrome
scleroderma
rheumatoid arthritis
mixed connective tissue disease
dermatomyositis
Investigations
• detailed case history along with systematic systemic
and local examination.
• History of all the systems, general health of the patient,
recent illness and weight loss
• radiographic studies:Panoramic radiography
cone-beam computed tomography (CBCT)
Computerized tomography (CT) scan or magnetic
resonance imaging (MRI), with gadolinium
administration, of the head and neck should be done if
possible as these can yield an accurate anatomic image
of the inferior alveolar nerve and its surrounding
Investigations
• Nuclear bone scintigraphy (bone scanning)
may also benefit in identifying mandibular
bone disease such as metastasis or
osteomyelitis
Investigations
• FNAC and biopsy of the lesion are
indispensable for confirmation of the
diagnosis
• Lumbar puncture and cytologic analysis of
cerebrospinal fluid can be of assistance in
cases where radiography is negative
MANAGEMENT PLAN
• Identification of the underlying pathology and
its treatment formulate the basic principle for
management of these cases.
• Patients with NCS caused by dental diseases
may recover after the local conditions have
improved, while those caused by malignancy
are usually treated by analgesic and antitumor
therapy with little effect and poor prognosis.

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