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CSO201
O i Ch i t F d t l d A li tiOrganic Chemistry: Fundamentals and Applications
J. N. Moorthy (moorthy@) and R. Gurunath (gurunath@)
Organic Chemistry: Fundamentals and Applications
Basic Organic Chemistry Concepts: introduction to organic molecules and functional
groups, understanding organic reactions, stereochemistry and carbon-carbon bond forming
reactions in organic synthesis. (8 Lectures)
Drugssome examples including love drugs and molecules of death. (2 Lectures)
C f f ( )Chemistry of odours, dyes and flavors (3 Lectures)
Photochemistry: simple concepts and applications (semiconductor photochemistry, solar-
energy conversion by photovoltaic cells, photocatalysis, etc.); supramolecular
h h i (4 L )photochemistry. (4 Lectures)
Organic Materials: polymers (biodegradable polymers, conducting polymers, etc.), smart
materials, OLEDs, intelligent gels, dyes, etc. (4 Lectures)
Green Chemistry - introduction, principles, sustainability, atom economy, some green
initiatives, management of resources and its effect on health and environment. (6 Lectures)
C t l i d bi t l t i i h i t ti l ti it d hi l th iCatalysis and biocatalysts in organic chemistry. enantioselectivity and chiral synthesis,
organocatalysis. (6 Lectures)
Enzymes as drug targets and their inhibitors as model inhibitors (4 Lectures)
Solid phase synthesis and strategies for futuristic designs in organic chemistry. (4 Lectures)
Molecular Structures: Sterochemistry
A Recapp
Stereochemistry
Conformational Analysis
The case of n-butane
Conformational Analysis
Summary of Steric Strain
Cycloalkanes
1964
1980’sUnsuccessful so far!
Cyclohexane Ring Inversion
Stereoisomerism: Chirality
Molecules that lack ‘’ plane and ‘i’ center exhibit optical activity!
Chiral Center or Stereocenter!
Configurational IsomerismConformational Isomerism
Atrop isomers: restricted bond rotation!
Enantiomers: mirror images that are
nonsuperimposable.
Some important drugs are chiral!
Use of D/L, d/l and +/-
L
Enantiomeric Excess, ee
Diastereomers: stereoisomers that are not related by mirror symmetry.
Molecules with 2 Chiral Centers:
All substituents different or only one common to both stereocenters
2‐Amino‐3‐Hydroxybutanoic acid
Diastereomers
Properties depend on ‘Shapes’ and ‘Functional Groups’
Molecules display a variety of interactions
depending on the functional groups:
Soaps: Mechanism of Dirt Removal Material Transport across Lipid Bilayer
 van der Waals
 Hydrogen bonding
 Dipole-dipole interactions
 Electrostatic (ion…ion)
Protein Structures are controlled by these intermolecular interactions, and are
responsible for the structures that they assume and functions they carry out!
Substitutions Eliminations Additions
Reaction Types
Rearrangements Oxidations Reductions
Most reactions occur by two major reaction types: Homolysis and Heterolysis
(Pericylic reactions with no intermediates)
Typical SN1 Reaction
Can we worry about Carbocation
Reactivity???
Typical SN2 Reaction
A Contrast between SN1 and SN2 Reactions
S S 2 R ti ith M B (RX) th S b t tSome SN2 Reactions with MeBr (RX) as the Substrate
Nucleophilic Substitution Reactions in Biological Systems
Nucleophilic Substitution Reactions in the Synthesis of Drugs
TuberculosisTuberculosis
Antidepressant
Halogenation of Alcohols:
Examples of Mitsunobu Reactionp
organic chemistry
organic chemistry

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organic chemistry

  • 1. CSO201 O i Ch i t F d t l d A li tiOrganic Chemistry: Fundamentals and Applications J. N. Moorthy (moorthy@) and R. Gurunath (gurunath@)
  • 2. Organic Chemistry: Fundamentals and Applications Basic Organic Chemistry Concepts: introduction to organic molecules and functional groups, understanding organic reactions, stereochemistry and carbon-carbon bond forming reactions in organic synthesis. (8 Lectures) Drugssome examples including love drugs and molecules of death. (2 Lectures) C f f ( )Chemistry of odours, dyes and flavors (3 Lectures) Photochemistry: simple concepts and applications (semiconductor photochemistry, solar- energy conversion by photovoltaic cells, photocatalysis, etc.); supramolecular h h i (4 L )photochemistry. (4 Lectures) Organic Materials: polymers (biodegradable polymers, conducting polymers, etc.), smart materials, OLEDs, intelligent gels, dyes, etc. (4 Lectures) Green Chemistry - introduction, principles, sustainability, atom economy, some green initiatives, management of resources and its effect on health and environment. (6 Lectures) C t l i d bi t l t i i h i t ti l ti it d hi l th iCatalysis and biocatalysts in organic chemistry. enantioselectivity and chiral synthesis, organocatalysis. (6 Lectures) Enzymes as drug targets and their inhibitors as model inhibitors (4 Lectures) Solid phase synthesis and strategies for futuristic designs in organic chemistry. (4 Lectures)
  • 5. The case of n-butane Conformational Analysis Summary of Steric Strain
  • 7.
  • 8. Stereoisomerism: Chirality Molecules that lack ‘’ plane and ‘i’ center exhibit optical activity! Chiral Center or Stereocenter! Configurational IsomerismConformational Isomerism Atrop isomers: restricted bond rotation! Enantiomers: mirror images that are nonsuperimposable.
  • 9. Some important drugs are chiral! Use of D/L, d/l and +/- L Enantiomeric Excess, ee Diastereomers: stereoisomers that are not related by mirror symmetry.
  • 10. Molecules with 2 Chiral Centers: All substituents different or only one common to both stereocenters 2‐Amino‐3‐Hydroxybutanoic acid Diastereomers
  • 11. Properties depend on ‘Shapes’ and ‘Functional Groups’ Molecules display a variety of interactions depending on the functional groups: Soaps: Mechanism of Dirt Removal Material Transport across Lipid Bilayer  van der Waals  Hydrogen bonding  Dipole-dipole interactions  Electrostatic (ion…ion)
  • 12. Protein Structures are controlled by these intermolecular interactions, and are responsible for the structures that they assume and functions they carry out!
  • 13. Substitutions Eliminations Additions Reaction Types Rearrangements Oxidations Reductions Most reactions occur by two major reaction types: Homolysis and Heterolysis (Pericylic reactions with no intermediates)
  • 14.
  • 15. Typical SN1 Reaction Can we worry about Carbocation Reactivity???
  • 16.
  • 19. S S 2 R ti ith M B (RX) th S b t tSome SN2 Reactions with MeBr (RX) as the Substrate
  • 20. Nucleophilic Substitution Reactions in Biological Systems
  • 21. Nucleophilic Substitution Reactions in the Synthesis of Drugs TuberculosisTuberculosis Antidepressant
  • 22. Halogenation of Alcohols: Examples of Mitsunobu Reactionp