1. Curriculum vitae Samiran kar, Ph.D.
SAMIRAN KAR, Ph.D.
Tel.: (091) -9432113678(mobile)
e-mail: samirankar2009@gmail.com
samiran24@hotmail.com
Present Address:
Sudama Apt., 2nd floor Permanent Address:
A-45/1/A, Nandan Kanan Vill: Basudevpur
Santoshpur P.O.:Ghatal-721212
Kolkata-700075 Dist. : Midnapur(W)
West Bengal West Bengal
OBJECTIVE:
Looking for an industrial position where my extensive knowledge in synthetic
organic chemistry will be effectively utilized.
HIGHLIGHTS
• About fourteen years Job Experience in Contract Research
Organization and Pharma in the field of Organic small molecules,
Peptide building blocks and API products (Paclitaxel, Docetaxel,
Gemcitabine, Bortezomib, Fludarabine, Dehydroepiandrosterone).
• Three years Post Doctoral Experience in France, Taiwan and India in
the field of Synthetic Organic Chemistry, Medicinal Organic Chemistry
and Material Organic Chemistry.
• More than twenty two (22) years Research Experience in the field of
Organic Synthesis.
• Developed synthetic methods of APIs, Carried out synthesis of
biologically active compounds and designed molecules.
• Scale up of new product from R & D to pilot and pilot plant to
commercial scale.
• Extensive experience in design, synthesis (micro & macro scale), lead
identification & optimization of small molecules as potential drug
candidates.
• Widely experienced and efficient in chromatography, isolation,
purification and structural determination of various kinds of organic
compounds.
• Well acquainted with NMR, IR, UV, HPLC, and LC-MS.
• An excellent Team Player having excellent communication, problem
solving and independently working skill.
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2. Curriculum vitae Samiran kar, Ph.D.
EDUCATION AND PERSONAL
Ph.D. in Organic Chemistry, November 1998, Jadavpur University, India
M.Sc. in Organic Chemistry, 1991 (held in 1992), Vidyasagar University, India.
B.Sc. 1989 (Honors in Chemistry), Vidyasagar University, India.
Date of Birth: May 06, 1966, Indian
PUBLICATIONS
1) "Novel Copper (II)-mediated photocyclization of methoxynaphthyl Analogues of Chalcone:
Unusual Electron Transfer from Excited Vinyl Arenes", Samiran Kar and Saswati Lahiri,
J.Chem.Soc. Chem. Commun., 1995, 957.
2) "Vibronic Interaction and Photo physics of Chalcone Derivatives", P. R. Bangal, S.Lahiri, S.
Kar and S. Chakravorti, J. of Luminescence, 1996, 69, 49.
3) "Intramolecular Charge Transfer as Probing Reaction: Fluorescence Monitoring of Protein-
Surfactant Interaction", R. Das, D. Guha, S. Mitra, S. Kar, S. Lahiri and S. Mukherjee, J. Phys.
Chem. A 1997, 101, 4042.
4) "Photochemical intramolecular cyclization routes to heterocycles", Samiran Kar and Saswati
Lahiri, J. Indian Chem. Soc., 1999, 76, 607.
5) "Intramolecular charge transfer in naphthalene analogues of chalcone" S. Kar, S. Aich, S.
Basu and S. Lahiri, Research on Chemical Intermediates, 1999, 25(9), 903.
6) "Photo induced electron transfer reaction: Photo cyclization of methoxynaphthyl analogues of
chalcone", Samiran Kar and Saswati Lahiri, Indian J. Chem., 2001, Vol. 40B, 1121.
7) “COCHO-modified oxides nanoparticles by using phosphonic acid as grafting agent”
Samiran Kar, Jean-Olivier Durand, Michel Granier, Pascal Joly and Oleg Melnyk, Tetrahedron
Letter , 44(2003), 5617-5619.
8) “Syntheses and chemical reactivity of α-oxo aldehyde supported silicas” Samiran Kar,
Pascal Joly, Michel Granier, Oleg Melnyk, Jean-Olivier Durand, Eur. J. Org. Chem. 2003, 4132.
9) “Steric-controlled excimer formation in naphthalene analogues of chalcone” Suchandra
Chatterjee, Samiran Kar, Saswati Lahiri, and Samita Basu, Spectrochimica Acta Part A:
Molecular and Biomolecular spectroscopy, volume 60 issues 8-9, July 2004, pages 1713-1718.
10) “Hybrid bioorganic-inorganic materials prepared by site-specific ligation of peptides to
functionalized polydisperse silica particles”, Pascal Joly, Nicolas Ardes-Guisot, Samiran Kar,
Michel Granier, Jean-Olivier Durand, Oleg Melnyk, Eur. J. Org. Chem., 2005, 12, 2473-2480.
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3. Curriculum vitae Samiran kar, Ph.D.
11) “Photoinduced intramolecular charge-transfer reactions in 4-amino-3-methyl benzoic acid
methyl ester: A fluorescence study in condensed-phase jet-cooled molecular beams”, J. Chem.
Sci., vol 119, No.2, March 2007, pp 195-204, Amrita Chakraborty, D. N. Nath, Samiran Kar and
Nikhil Guchhait
12) Photo-physical properties of 1-hydroxy-2-naphthaldehyde: A combined fluorescence
spectroscopy and quantum chemical calculations, Chemical Physics,Volume 331, Issues 2-3, 8
January 2007, Pages 373-384, Rupashree Balia Singh, Subrata Mahanta, Samiran Kar and
Nikhil Guchhait
13) Secondary amino group as charge donor for the excited state intramolecular charge transfer
reaction in trans-3-(4-monomethylamino-phenyl)-acrylic acid: Spectroscopic measurement and
theoretical calculations, Journal of Photochemistry and Photobiology A: Chemistry, Volume181,
Issues 2-3, 31July 2006, Pages 246-256, Amrita Chakraborty, Samiran Kar and Nikhil Guchhait
14) Photophysical properties of trans-3-(4-monomethylamino-phenyl)-acrylonitrile: Evidence of
twisted intramolecular chargetransfer (TICT) process, Chemical Physics, Volume 324, Issues 2-
3, 31May 2006, Pages 733-741, Amrita Chakraborty, Samiran Kar and Nikhil Guchhait
15) Photoinduced intramolecular charge transfer (ICT) reaction in trans-methyl p-
(dimethylamino) cinnamate: A combined fluorescence measurement and quantum chemical
calculations, Chemical Physics, Volume 320, Issues 2-3, 5January 2006, Pages 75-83, Amrita
Chakraborty, Samiran Kar and Nikhil Guchhait
16) Photoinduced Intramolecular Charge Transfer Reaction in (E)-3-(4-Methylamino-phenyl)-
acrylic Acid Methyl Ester: A Fluorescence Study in Combination with TDDFT Calculation, J.
Phys. Chem. A, 110 (44), 12089 -12095, 2006. Amrita Chakraborty, D. N. Nath, Samiran Kar
and Nikhil Guchhait
17) Excited state intramolecular proton transfer in 3-hydroxy-2-naphthaldehyde: A combined
study by absorption and emission spectroscopy and quantum chemical calculation,
Chemical,Physics, Volume 324, Issues 2-3, 31May 2006, Pages 742-752, Subrata Mahanta,
Rupashree Balia Singh, Samiran Kar and Nikhil Guchhait
18) Spectroscopic study of excited state intramolecular charge transfer in ethyl ester of N,N′-
Dimethylaminonaphthyl-(acrylic)-acid, Chemical Physics, Volume 342, Issues 1-3, 6 December
2007, Pages 33-42, Rupashree Balia Singh, Subrata Mahanta, Samiran Kar and Nikhil Guchhait
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4. Curriculum vitae Samiran kar, Ph.D.
19) Photoinduced intramolecular charge transfer in methyl ester of N,N′-
Dimethylaminonaphthyl-(acrylic)-acid: Spectroscopic measurement and quantum chemical
calculations, Journal of Photochemistry and Photobiology A: Chemistry, Volume 194, Issues 2-
3, 20 February 2008, pages 318-326, Subrata Mahanta, Rupashree Balia Singh, Samiran Kar and
Nikhil Guchhait
20) Spectroscopic and theoretical evidence for the photoinduced twisted intramolecular charge
transfer state formation in N,N-Dimethyl aminonaphthyl-(acrylo)-nitrile, Journal of
Luminescence, Volume 128, Issue 9, September 2008, pages 1421-1430, Rupashree Balia Singh,
Subrata Mahanta, Samiran Kar and Nikhil Guchhait
21) Dual emission from (E)-3-(4-methylamino-phenyl)-acrylic acid ethyl ester(MAPAEE) and
its application as fluorescence probe for studying micellar and protein microenvironment,
Journal of Molecular structure,Vol 917, Issues 2-3,, January 15, 2009, pages 148-157, Amrita
Chakraborty, Shalini Ghosh, Samiran Kar, D.N. Nath, Nikhil Guchhait
22) Evidence of coupled photoinduced photoinduced proton transfer and intramolecular charge
transfer reaction in para-N,N-dimethylamino-ortho hydroxy benzaldehyde: spectroscopic and
theoretical studies, Chemical physics, Volume 354, Issues 1-3, 10 December 2008, Pages 118-
129, Subrata Mahanta, Rupashree Balia Singh, Samiran Kar and Nikhil Guchhait.
23) A Combined Experimental and Theoretical Study on Photoinduced Intramolecular Charge
Transfer in trans-ethyl p-(dimethylamino) cinamate” T. Sanjoy Singh, S. Mitra, A. K. Chandra,
N. Tamai and S. Kar, J. Photochem. Photobiol. A: Chem. 2008, 197, 295
24) Photo-induced charge transfer emission in (E)-3-(4-Dimethylamino-naphthalen-1-yl)-acrylic
acid and its use as metal ion fluorosensor, Journal of Luminescence, Vol 129, Issue 5, May 2009,
Pages 482-491, Shalini Ghosh, Amrita Chakraborty, Samiran Kar, Nikhil Guchhait.
25) Photoinduced properties of methyl ester of 2,6-dimethyl-1-amino-4-benzoic acid: Evidence
of charge transfer emission from week primary amino donor, Spectrochimica Acta Part A:
Molecular and Biomolecular Spectroscopy, Vol 75, issue1, January 2010, Pages 320-324, Shalini
Ghosh, Amrita Chakraborty, Samiran Kar, Nikhil Guchhait.
26) Evidence for excited state intramolecular charge transfer reaction in donor-acceptor molecule
5-(4-dimethylamino-phenyl)-penta-2,4-dienoic acid methyl ester: Experimental and quantum
chemical approach, Journal of Luminescence, Vol 130, Issue 7, July 2010, Pages 1258-1267,
Bijan kumar Paul, Anuva Samanta, Samiran Kar , Nikhil Guchhait.
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5. Curriculum vitae Samiran kar, Ph.D.
27) Evidence of acid mediated enhancement of photoinduced charge transfer reaction in2-
methoxy -4(N,N-dimethylamino0benzaldehyde: Spectroscopic and quantum chemical study,
Journal of Photochemistry and Photobiology A: Chemistry, Volume 212, Issues 2-3, 20 May
2010, Pages 161-169, Anuva Samanta, Bijan kumar Paul, Subrata Mahanta, Rupashree Balia
Singh, Samiran Kar and Nikhil Guchhait.
28) Lactim-lactam tautomerisation is favoured over enol-keto tautomerisation in 2-hydroxy-5-
(4-fluorophenyl)nicotinic acid: Experimental and Quantum chemical approach, Journal of
Photochemistry and Photobiology A: Chemistry, Volume 214, Issues 2-3, 15 August 2010,
Pages 203-214, Bijan kumar Paul, Anuva Samanta, Samiran Kar , Nikhil Guchhait.
29) Photoinduced intramolecular charge transfer phenomena in 5-(4-dimethylamino-phenyl)-
penta-2, 4-dienoic acid, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,
Vol 78, issue 1, January 2011, Pages 463-468, Sankar Jana, Shalini Ghosh, Sasanka Dalapati,
Samiran Kar , Nikhil Guchhait.
30) Excited State Charge Transfer reaction with dual emission from 5-(4-dimethylamino-
phenyl)-penta-2,4-dienenitrile: Spectral measurement and theoretical density functionaltheory
calculation, Journal of molecular structure, Volume 998, Issues 1-3, 13 July 2011, Pages 136-
143, Sankar Jana, Sasanka Dalapati, Shalini Ghosh, Samiran Kar, Nikhil Guchhait.
31) A Schiff base-derived new model compound for selectivefluorescence sensing of Cu(II) and
Zn(II) with ratiometric sensing potential: Synthesis, photophysics and mechanismof sensory
action, Journal of Photochemistry and Photobiology A: Chemistry, Volume 220, Issues 2-3, 20
May 2011, Pages 153-163, Bijan kumar Paul, Samiran Kar, Nikhil Guchhait.
Abstracts
32) “Electron Transfer Reactions in Vinylarenes: Metal Mediated Photocyclization of
Naphthalene Analogous of Chalcone", S. Lahiri, S. Maitra, S. Kar, Workshop on Recent Trends
in Photochemical Sciences, At the RRL, Trivandrum, India, 1998, Page - 67.
33) "Synthesis of peptides-based bioorganic-inorganic materials." KAR Samiran, DURAND
Jean-Olivier, BLANCHET Carl, GRANIER Michel, LANNEAU Gérard, MELNYK Oleg,
JOLY Pascal, GRAS-MASSE Hélène, 27th European Peptide symposium, Sorrento, Italy,
September 2002.
34) “Syntheses of silica-based hybrid materials and biomaterials” DURANd Jean-Olivier,
KAR Samiran, LANNEAU Gerard, GRANIER Michel, FRANTZ Richard, CARBONNEAU
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6. Curriculum vitae Samiran kar, Ph.D.
Celine, JOLY Pascal, GRAS-MASSE Helene, MELNYK Oleg, ALONSO Bruno, MASSIOT
Dominique, European Congress on Advanced Materials and Processes, 1-5 September 2003,
Lausanne, Switzerland.
35) Posters
Photo induced Electron Transfer (PET) Reactions of Vinyl naphthalene, S. Kar and S. Lahiri, I.
A. C. S., Jadavpur, Kolkata, India, 1998.
PROFESSIONAL EXPERIENCE
July 1993 – March 1999 Junior and Senior Research Fellow, Department of Organic
Chemistry, IACS, Jadavpur, Calcutta, India.
Research: A) Syntheses and characterization of vinyl naphthalene analogues of chalcones.
B) Photoreactions of naphthaleneanalogues of chalcone in presence of transition metals.
Copper(II)-mediated photocyclization of methoxynaphthyl analogues of chalcone to
naphthofurans via an electron transfer process is reported. Examples of photoinduced electron
transfer (PET) mediated cyclization of methoxynaphthyl analogues of chalcone using electron
acceptors has been reported.
C) Photochemical intramolecular cyclization routes to indole derivatives. The 2-aroylindole
derivatives are easily prepared from these derivatives in a tandem reaction sequence in moderate
yields. Photolytic process is found to be much more facile than the thermal process in this
transformation.
Title of the Thesis: "Chalcone Analogs: Syntheses And Their Photo reactivity''.
Post-doctoral Studies with:
(1) Professor Jim-Min Fang,
Department of Chemistry
National Taiwan University, Taipei, Taiwan-106, ROC.
1999 to 2000
(2) Professor Jean-Olivier Durand, Professor G. F. Lanneau and Prof. R.J.P. Corriu
Laboratoire de Chimie Moléculaire et Organisation du Solide, UMR 5637,cc 007,
Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5, FRANCE
2000 to 2001
Post Doctoral Research Work in Taiwan:
Rational Design and Development of Chemosensors: Applications in Medicinal Chemistry.
Post Doctoral Research Work in France:
"Covalently grafting Fab' fragment on metal oxide or model surfaces and application to the
recognition of D-antigen":
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7. Curriculum vitae Samiran kar, Ph.D.
Designed and synthesized :
o α-oxo aldehyde-supported silicas by sol-gel procedure, semicarbazide- or
glyoxylyl functionalized polydisperse silica particles and their use for the
preparation of hybrid polypeptide-silica materials.
o phosphonic acid possessing a protected COCHO group by using the Heck
reaction
The peptides were attached to the surface of functionalized silicas by site-specific α-oxo
hydrazone or semicarbazone ligation. The reaction of semicarbazide silicas with a model
glyoxylyl peptide was found to be very efficient under stoichiometric conditions and led to
ligation yields of about 90%. The use of glyoxylyl silicas and of hydrazinoacetyl peptides led to
lower yields. After grafting of the phosphonic acid on metal oxides, the cleavage of the dithiane
group was successful. The reactivity of the supported-COCHO group was examined by using
model reaction with hydroxylamine and hydrazine derivatives.
Industry:
1. Senior Research Scientist, "CHEMBIOTEK Research International Pvt Ltd"., Kolkata ,
India. November 2001 to April 2004.
Organic synthesis in R & D, leading a group of 10 chemists. Synthesis of organic compounds as
per Client specification and delivery on time.
2. Group Leader, “CHEMGEN PHARMA International Pvt. Ltd., Kolkata, India
May 2004 to Dec 2008.
Organic synthesis in R & D, leading a group of 10 chemists.
Managing groups with good productivity, planning and execution of projects, delivery in time
using chemistry knowledge, library synthesis, cost cutting using innovativeness and timely
communication.
3. Manager, Neuland Laboratories LTD, Hyderabad, India, January 2009 to Feb 2010.
Organic synthesis in R & D, leading a group of 10 chemists.
Research & development, developing new process, scale up, identification of impurities.
4. Manager II, Fresenius Kabi Oncology Ltd., Kalyani, India, Feb 2010 to March 2012.
Research & development, developing new process of Onco/Non Onco APIs at Lab scale,
optimization of process, validation at lab scale, identification of impurities, preparation of TTD.
Transfer the technology to commercial scale under cGMP condition in pilot plant/plant.
The development of non-infringing processes and /or patent free process of Oncology APIs.
To lead and guide scientist engaged in developing processes and scale up activities in lab / plant
for chemicals, intermediates and pharmaceuticals.
5. Senior Research Scientist, Navin Fluorine International Limited, Dewas, MP, Oct 2012
to 31st October 2015.
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8. Curriculum vitae Samiran kar, Ph.D.
Research & development, developing new process, scale up, identification of impurities.
To lead and guide scientist engaged in developing processes and scale up activities in lab / plant
for chemicals, intermediates and pharmaceuticals. Scale up of new product from R & D to pilot
and pilot plant to commercial scale.
6. Sr. Manager, Helios Life sciences, Malanpur Industrial Area, Bhind, MP, March 2016 to
Nov 2016. Research & development, developing new process, scale up, identification of
impurities.
7. Sr. Manager, Sai Phytoceuticals Pvt. Ltd., C-118, Malanpur Industrial Area, Bhind, MP,
Dec 2016 to Till.
Technical Experience
Recording and interpretation of spectroscopic data for organic
structure and organic inorganic hybrids materials structure determination (UV,
IR, NMR, BET, EDX, Fluorescence spectroscopy).
Chromatographic analysis and separation.
Ion-exchange chromatography.
AWARDS
(1) GATE (Graduate Aptitude Test for Engineering), 1993.
(2) NET (National Eligibility Test), 1997.
(3) C.N.R.S Fellowship, 2000.
REFERENCES
(1) Prof. Saswati Lahiri (Thesis Advisor) (Retd.) (2) Prof. B.C.Ranu, F.A.Sc
Department of Organic Chemistry Department of Organic Chemistry
Indian Association for the Cultivation of Science Indian Association for the
Jadavpur, Calcutta-700032, INDIA Cultivation of Science
(m).: 09433343317 Jadavpur, Calcutta - 700032, India
Fax: Tel.: (091)(33)-2473-4971
E-mail:saswatil@hotmail.com Fax: (091)(33)-2473-2805
E-mail:ocbcr@mahendra.iacs.res.in
(3) Prof. Jean-Olivier Durand
Chimie Moléculaire et Organisation du Solide,
UMR 5253 cc 1701,
Institut Charles Gerhardt
Université Montpellier 2,
Place Eugène Bataillon,
34095 Montpellier cedex 05 France
Tel 00 33 (0) 4 67 14 45 01 or 00 33 (0) 4 67 14 30 38
Fax 00 33(0) 4 67 14 38 52
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