This document discusses choline and its role in dairy cattle. It begins with background information on choline, noting that it is essential for cell membrane structure and lipid transport. Though not a vitamin, it acts as a methyl donor. The document then reviews studies showing that supplemental choline, protected from rumen degradation, can increase milk yield and fat percentage in dairy cows. It also may help prevent fatty liver in cows during the transition period due to its role in lipid transport. The final section discusses niacin and its anti-lipolytic effects when given in large pharmacological doses, though these effects are transient.
Insulin resistance in dairy animals...dr muneendraMuneendra Kumar
Insulin resistance in dairy animals can be corrected by reducing energy intake prepartum or supplementing chromium in the diet. Insulin resistance impairs glucose utilization and increases free fatty acids. Chromium supplementation alleviates insulin resistance by potentiating insulin action and enhancing cellular glucose uptake.
The document discusses amino acid metabolism and the amino acid pool. It makes the following key points:
1) The amino acid pool consists of around 100g of free amino acids in the adult body from different sources like dietary proteins and tissue breakdown.
2) Amino acids in the pool are in dynamic equilibrium, being used for protein synthesis, energy production, or excretion as urea.
3) The major contributors to maintaining the amino acid pool are turnover of body proteins, dietary protein intake, and non-essential amino acid synthesis.
EFFECTS IN LACK OF PROTEIN INTAKE IN HUMAN BODY KayeMangubat22
1. This study examines the effects of inadequate protein intake in humans, finding it can lead to lean body mass loss and increased health risks like muscle wasting.
2. Adequate protein intake is important for weight regulation through increased satiety and thermogenesis, preserving lean body mass during weight loss.
3. Short-term inadequate protein intake in older adults can increase health risks like muscle wasting and metabolic issues.
This document discusses the benefits of fat supplementation for horses. It states that essential fatty acids cannot be made by the body and are important for cell development and function. Fat provides more energy than starch in a smaller volume. Fat can serve as an alternative energy source for horses with conditions like Equine Metabolic Syndrome. Omega-3 fatty acids may reduce inflammation in joints and tissues by decreasing pro-inflammatory molecules and encouraging anti-inflammatory molecules. Inadequate fat intake can stress the metabolism and increase stress hormones.
Effects of Micronised Dispersible Ferric Pyrophosphate combined with Alpha-La...Antonio Simone Laganà
This study compared the effects of micronized dispersible ferric pyrophosphate combined with alpha-lactalbumin versus ferrous gluconate in treating iron deficiency anemia in pregnant women. Fifty pregnant women with anemia were randomly assigned to receive either 30 mg of ferric pyrophosphate plus 300 mg of alpha-lactalbumin or 80 mg of ferrous gluconate daily for 30 days. The combination treatment was more effective at increasing hemoglobin, ferritin, and serum iron levels with no reported side effects, while the ferrous gluconate group saw increases but also had a 24% side effect rate. The combination treatment was more effective at treating iron deficiency anemia in
Adipose tissue as an endocrine organ:
Adipose tissue has been recognized as the quantitatively most important energy store of the human body for many years, in addition to its functions as mechanical and thermal insulator. During the last 10 years, adipose tissue has come into focus as an endocrine organ important for development of many diseases related to obesity including insulin resistance, type 2 diabetes, dyslipidemia, hypertension and cardiovascular disease. Adipose tissue secretes a variety of bioactive peptides that play important roles in insulin action, energy homeostasis, inflammation, and cell growth. These secretory proteins from the adipose organ are named adipokines and have many physiological effects on different organs including the brain, bone, reproductive organs, liver, skeletal muscles, immune cells and blood vessels. Adipokines may locally regulate fat mass by modulating adipocyte size/number or angiogenesis and inversely increased fat mass leads to dysregulation of adipocyte functions.
Insulin resistance in dairy animals...dr muneendraMuneendra Kumar
Insulin resistance in dairy animals can be corrected by reducing energy intake prepartum or supplementing chromium in the diet. Insulin resistance impairs glucose utilization and increases free fatty acids. Chromium supplementation alleviates insulin resistance by potentiating insulin action and enhancing cellular glucose uptake.
The document discusses amino acid metabolism and the amino acid pool. It makes the following key points:
1) The amino acid pool consists of around 100g of free amino acids in the adult body from different sources like dietary proteins and tissue breakdown.
2) Amino acids in the pool are in dynamic equilibrium, being used for protein synthesis, energy production, or excretion as urea.
3) The major contributors to maintaining the amino acid pool are turnover of body proteins, dietary protein intake, and non-essential amino acid synthesis.
EFFECTS IN LACK OF PROTEIN INTAKE IN HUMAN BODY KayeMangubat22
1. This study examines the effects of inadequate protein intake in humans, finding it can lead to lean body mass loss and increased health risks like muscle wasting.
2. Adequate protein intake is important for weight regulation through increased satiety and thermogenesis, preserving lean body mass during weight loss.
3. Short-term inadequate protein intake in older adults can increase health risks like muscle wasting and metabolic issues.
This document discusses the benefits of fat supplementation for horses. It states that essential fatty acids cannot be made by the body and are important for cell development and function. Fat provides more energy than starch in a smaller volume. Fat can serve as an alternative energy source for horses with conditions like Equine Metabolic Syndrome. Omega-3 fatty acids may reduce inflammation in joints and tissues by decreasing pro-inflammatory molecules and encouraging anti-inflammatory molecules. Inadequate fat intake can stress the metabolism and increase stress hormones.
Effects of Micronised Dispersible Ferric Pyrophosphate combined with Alpha-La...Antonio Simone Laganà
This study compared the effects of micronized dispersible ferric pyrophosphate combined with alpha-lactalbumin versus ferrous gluconate in treating iron deficiency anemia in pregnant women. Fifty pregnant women with anemia were randomly assigned to receive either 30 mg of ferric pyrophosphate plus 300 mg of alpha-lactalbumin or 80 mg of ferrous gluconate daily for 30 days. The combination treatment was more effective at increasing hemoglobin, ferritin, and serum iron levels with no reported side effects, while the ferrous gluconate group saw increases but also had a 24% side effect rate. The combination treatment was more effective at treating iron deficiency anemia in
Adipose tissue as an endocrine organ:
Adipose tissue has been recognized as the quantitatively most important energy store of the human body for many years, in addition to its functions as mechanical and thermal insulator. During the last 10 years, adipose tissue has come into focus as an endocrine organ important for development of many diseases related to obesity including insulin resistance, type 2 diabetes, dyslipidemia, hypertension and cardiovascular disease. Adipose tissue secretes a variety of bioactive peptides that play important roles in insulin action, energy homeostasis, inflammation, and cell growth. These secretory proteins from the adipose organ are named adipokines and have many physiological effects on different organs including the brain, bone, reproductive organs, liver, skeletal muscles, immune cells and blood vessels. Adipokines may locally regulate fat mass by modulating adipocyte size/number or angiogenesis and inversely increased fat mass leads to dysregulation of adipocyte functions.
Palestra henry benefícios do omega-3 - r03Sucos Jandaia
This document contains abstracts from multiple studies on the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on health. The studies cover topics like the impact of DHA supplementation during pregnancy and lactation on infant neurodevelopment, the role of DHA in brain health and cognitive functions, differences in omega-3 fatty acid metabolism between men and women, DHA status in Brazilian pregnant women, and the cellular mechanisms of DHA-derived neuroprotectin D1.
1) The document reviews the potential ergogenic benefits of arginine supplementation, including its roles in growth hormone secretion, creatine synthesis, and nitric oxide production.
2) While arginine infusion has been shown to stimulate growth hormone release, studies on oral arginine supplementation have found mixed results on growth hormone levels.
3) It is unlikely that arginine supplementation alone can increase creatine stores enough to improve exercise performance, as creatine synthesis is limited by other factors beyond arginine levels.
Adipokines are signaling molecules secreted by adipose tissue. The document defines adipokines and categorizes them into factors that directly affect metabolism, pro-inflammatory factors, extracellular matrix components, and pro-mitogenic and pro-angiogenic factors. Several individual adipokines are then described in more detail, including their effects on metabolism, inflammation, and cardiovascular health. Key adipokines discussed include leptin, adiponectin, TNF-α, IL-6, resistin, PAI-1, visfatin, chemerin, and apelin.
This document discusses insulin resistance (IR) and its relationship to various medical conditions. It begins by defining IR and explaining common methods to assess IR, such as HOMA-IR and QUICKI. It then discusses the epidemiology of IR and its role in conditions like type 1 diabetes, metabolic syndrome, non-alcoholic fatty liver disease, obesity, hypertension, polycystic ovarian syndrome, and others. Management strategies for IR are also reviewed. The document provides an overview of the importance of recognizing and addressing IR in clinical practice.
Final physiological changesof metabolicn skeletal (2)AshwineeGC
Physiological changes in pregnancy include increased metabolism and changes in protein, carbohydrate, fat, iron, and calcium metabolism. Protein metabolism results in positive nitrogen balance and 500g gains each in the fetus/placenta and mother. Carbohydrate metabolism involves increased insulin resistance to ensure constant glucose supply to the fetus. Fat storage increases by an average of 3-4kg. Iron requirement is approximately 1000mg, and calcium requirement averages 1-1.5g daily. Musculoskeletal changes include loosened joints and ligaments to accommodate birth, causing back pain and waddling gait.
Adams 2016 Insulinotropic Effects of WheyRachel Adams
This document summarizes recent research on the insulinotropic (insulin-increasing) effects of whey protein. It discusses the composition of whey protein and the potential mechanisms by which whey may increase insulin levels, including increasing the gastric emptying rate, stimulating the release of incretin hormones like GIP and GLP-1, and inhibiting the enzyme DPP-IV. The document reviews recent clinical trials that have evaluated the effects of whey protein concentrate, isolate, and hydrolysate on managing blood glucose levels in people with type 2 diabetes and acute hyperglycemia. Additional research is still needed to determine the optimal dose, form, and delivery method of whey supplementation to manage glycemia.
Skeletal muscle plays an important role in whole body metabolism and can influence obesity. In obesity, skeletal muscle mass initially increases to support excess weight but then decreases. Multiple factors contribute to changes in skeletal muscle metabolism with obesity including reduced lipid oxidation, mitochondrial dysfunction, insulin resistance, increased inflammation, and impaired protein synthesis and breakdown. Skeletal muscle also acts as an endocrine organ secreting myokines that can impact metabolism and obesity.
The document provides information about insulin resistance and related mechanisms. It discusses how insulin resistance is caused by factors like obesity, inflammation, oxidative stress, and microbial dysbiosis. It outlines key regulators of insulin sensitivity including PPARγ, mTOR, AMPK, sirtuins, and miRNAs. The document promotes QIAGEN products for analyzing gene expression and signaling pathways involved in insulin resistance and related conditions.
This study investigated the effects of various artificial sweeteners on chick embryo development. Chick embryos were exposed to different concentrations of aspartame, saccharin, sucralose, and sucrose through in ovo injection. After 7 days of incubation, the embryos were examined. Results showed significant differences in body weight, length, and cell size between treatment groups. Aspartame exposure resulted in irregular cell shapes. Sucralose exposure decreased body weight and length the most. Saccharin increased body weight. Sucrose increased cell size. Overall, the study found artificial sweeteners can have teratogenic effects on developing chick embryos.
The document discusses menopause management options, focusing on phytoestrogens as a natural alternative to hormone replacement therapy (HRT). It notes that phytoestrogens from soy and other plants can act as selective estrogen receptor modulators (SERMs) to provide estrogenic effects without the health risks of HRT. Isoflavones like genistein are the most studied phytoestrogens and may help reduce menopausal symptoms and long-term conditions like osteoporosis and heart disease. The document reviews the sources, types, and pharmacology of various phytoestrogens.
The document summarizes the interplay between adipose tissue and immunity. It begins by describing the structure of adipose tissue and the two types of adipocytes. It then discusses how adipose tissue secretes signaling molecules called adipokines that regulate metabolism and immunity. The document outlines the various immune cells present in adipose tissue like macrophages, neutrophils, and T cells. It explains how obesity leads to changes in immune cell profiles that promote inflammation. Specifically, it discusses how increased macrophages polarized towards the pro-inflammatory M1 phenotype contribute to insulin resistance.
Protein quality determination in monogastric animals, we can determine which protein is better in case of monogastric animals, Sri Venkateswara veterinary university, Animal nutrition, Vishnu Vardhan Reddy
This study examined the effects of daily antenatal micronutrient supplementation on biochemical indicators of micronutrient status and infection in pregnant women in rural Nepal. Blood samples were taken from pregnant women before and during supplementation to analyze concentrations of various micronutrients and markers of infection. Supplementation with folic acid alone or with iron decreased folic acid deficiency and improved status of some other micronutrients, but adding additional micronutrients like zinc did not further improve status. Multiple micronutrient supplementation most improved micronutrient status but had little effect on infection markers. The study suggests antenatal micronutrient supplementation can help address deficiencies in this population.
Adipose tissue, once thought to function simply for energy storage, is now recognized as an endocrine organ that secretes proteins called adipokines or adipocytokines. These proteins include hormones that regulate processes like food intake and insulin sensitivity, enzymes involved in lipid metabolism, cytokines that mediate inflammation and immunity, and other proteins that impact cardiovascular health and metabolic functions. Ongoing research continues to elucidate the roles of various adipokines in important physiological pathways and diseases.
This study investigated whether supplementing vitamin E to a conventional soybean lipid emulsion used in parenteral nutrition would help prevent parenteral nutrition-associated liver disease (PNALD) in neonatal piglets. Sixteen piglets received parenteral nutrition with either a standard soybean lipid emulsion (SO) or the same emulsion supplemented with additional vitamin E (SO+E). After 17 days, bile flow, liver enzymes, markers of inflammation and oxidative stress, and gene expression related to bile acid metabolism were measured and compared between the two groups. The study found no significant differences between the SO and SO+E groups in any of the outcomes measured, suggesting that simply adding vitamin E to the soybean lipid emulsion did not provide benefits in preventing
- Alanine amino transferase (ALT) concentrations were higher in obese adolescent girls who were heterozygous or homozygous for the MTHFR 677 C>T mutation, which decreases MTHFR enzyme activity.
- ALT levels were negatively correlated with reported folate intake and positively correlated with homocysteine concentrations. Lower folate intake and higher homocysteine are associated with increased liver damage.
- Girls with the MTHFR mutation also had lower erythrocyte folate levels and higher insulin levels compared to those without the mutation, suggesting the mutation enhances liver damage possibly by reducing antioxidant status and increasing insulin resistance.
1. The document discusses how maternal obesity affects molecular signals at the maternal-fetal interface. It modifies placental function and fetal growth through increased inflammatory pathways, leptin and fatty acid levels.
2. Obese women have higher levels of insulin, leptin and inflammatory markers in early pregnancy. Leptin from the placenta of obese women stimulates fatty acid uptake and inflammatory pathways.
3. The placenta of obese women shows increased inflammation and apoptosis, leading to higher levels of circulating cell-free DNA from the placenta in maternal blood. This cell-free DNA is associated with maternal adiposity measures.
Maternal obesity is associated with increased risks during pregnancy such as gestational diabetes and fetal overgrowth. This document summarizes recent research investigating how maternal obesity impacts placental function and fetal growth. Studies presented show that in obese mothers, the placenta exhibits increased expression of nutrient transporters for glucose, amino acids, and fatty acids. This enhanced placental transport is believed to stimulate fetal growth through increased delivery of nutrients to the fetus. Factors involved in regulating these placental changes include maternal hormones, cytokines, and nutrients. Understanding these pathways may help address health issues linked to abnormal fetal growth.
Palestra henry benefícios do omega-3 - r03Sucos Jandaia
This document contains abstracts from multiple studies on the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on health. The studies cover topics like the impact of DHA supplementation during pregnancy and lactation on infant neurodevelopment, the role of DHA in brain health and cognitive functions, differences in omega-3 fatty acid metabolism between men and women, DHA status in Brazilian pregnant women, and the cellular mechanisms of DHA-derived neuroprotectin D1.
1) The document reviews the potential ergogenic benefits of arginine supplementation, including its roles in growth hormone secretion, creatine synthesis, and nitric oxide production.
2) While arginine infusion has been shown to stimulate growth hormone release, studies on oral arginine supplementation have found mixed results on growth hormone levels.
3) It is unlikely that arginine supplementation alone can increase creatine stores enough to improve exercise performance, as creatine synthesis is limited by other factors beyond arginine levels.
Adipokines are signaling molecules secreted by adipose tissue. The document defines adipokines and categorizes them into factors that directly affect metabolism, pro-inflammatory factors, extracellular matrix components, and pro-mitogenic and pro-angiogenic factors. Several individual adipokines are then described in more detail, including their effects on metabolism, inflammation, and cardiovascular health. Key adipokines discussed include leptin, adiponectin, TNF-α, IL-6, resistin, PAI-1, visfatin, chemerin, and apelin.
This document discusses insulin resistance (IR) and its relationship to various medical conditions. It begins by defining IR and explaining common methods to assess IR, such as HOMA-IR and QUICKI. It then discusses the epidemiology of IR and its role in conditions like type 1 diabetes, metabolic syndrome, non-alcoholic fatty liver disease, obesity, hypertension, polycystic ovarian syndrome, and others. Management strategies for IR are also reviewed. The document provides an overview of the importance of recognizing and addressing IR in clinical practice.
Final physiological changesof metabolicn skeletal (2)AshwineeGC
Physiological changes in pregnancy include increased metabolism and changes in protein, carbohydrate, fat, iron, and calcium metabolism. Protein metabolism results in positive nitrogen balance and 500g gains each in the fetus/placenta and mother. Carbohydrate metabolism involves increased insulin resistance to ensure constant glucose supply to the fetus. Fat storage increases by an average of 3-4kg. Iron requirement is approximately 1000mg, and calcium requirement averages 1-1.5g daily. Musculoskeletal changes include loosened joints and ligaments to accommodate birth, causing back pain and waddling gait.
Adams 2016 Insulinotropic Effects of WheyRachel Adams
This document summarizes recent research on the insulinotropic (insulin-increasing) effects of whey protein. It discusses the composition of whey protein and the potential mechanisms by which whey may increase insulin levels, including increasing the gastric emptying rate, stimulating the release of incretin hormones like GIP and GLP-1, and inhibiting the enzyme DPP-IV. The document reviews recent clinical trials that have evaluated the effects of whey protein concentrate, isolate, and hydrolysate on managing blood glucose levels in people with type 2 diabetes and acute hyperglycemia. Additional research is still needed to determine the optimal dose, form, and delivery method of whey supplementation to manage glycemia.
Skeletal muscle plays an important role in whole body metabolism and can influence obesity. In obesity, skeletal muscle mass initially increases to support excess weight but then decreases. Multiple factors contribute to changes in skeletal muscle metabolism with obesity including reduced lipid oxidation, mitochondrial dysfunction, insulin resistance, increased inflammation, and impaired protein synthesis and breakdown. Skeletal muscle also acts as an endocrine organ secreting myokines that can impact metabolism and obesity.
The document provides information about insulin resistance and related mechanisms. It discusses how insulin resistance is caused by factors like obesity, inflammation, oxidative stress, and microbial dysbiosis. It outlines key regulators of insulin sensitivity including PPARγ, mTOR, AMPK, sirtuins, and miRNAs. The document promotes QIAGEN products for analyzing gene expression and signaling pathways involved in insulin resistance and related conditions.
This study investigated the effects of various artificial sweeteners on chick embryo development. Chick embryos were exposed to different concentrations of aspartame, saccharin, sucralose, and sucrose through in ovo injection. After 7 days of incubation, the embryos were examined. Results showed significant differences in body weight, length, and cell size between treatment groups. Aspartame exposure resulted in irregular cell shapes. Sucralose exposure decreased body weight and length the most. Saccharin increased body weight. Sucrose increased cell size. Overall, the study found artificial sweeteners can have teratogenic effects on developing chick embryos.
The document discusses menopause management options, focusing on phytoestrogens as a natural alternative to hormone replacement therapy (HRT). It notes that phytoestrogens from soy and other plants can act as selective estrogen receptor modulators (SERMs) to provide estrogenic effects without the health risks of HRT. Isoflavones like genistein are the most studied phytoestrogens and may help reduce menopausal symptoms and long-term conditions like osteoporosis and heart disease. The document reviews the sources, types, and pharmacology of various phytoestrogens.
The document summarizes the interplay between adipose tissue and immunity. It begins by describing the structure of adipose tissue and the two types of adipocytes. It then discusses how adipose tissue secretes signaling molecules called adipokines that regulate metabolism and immunity. The document outlines the various immune cells present in adipose tissue like macrophages, neutrophils, and T cells. It explains how obesity leads to changes in immune cell profiles that promote inflammation. Specifically, it discusses how increased macrophages polarized towards the pro-inflammatory M1 phenotype contribute to insulin resistance.
Protein quality determination in monogastric animals, we can determine which protein is better in case of monogastric animals, Sri Venkateswara veterinary university, Animal nutrition, Vishnu Vardhan Reddy
This study examined the effects of daily antenatal micronutrient supplementation on biochemical indicators of micronutrient status and infection in pregnant women in rural Nepal. Blood samples were taken from pregnant women before and during supplementation to analyze concentrations of various micronutrients and markers of infection. Supplementation with folic acid alone or with iron decreased folic acid deficiency and improved status of some other micronutrients, but adding additional micronutrients like zinc did not further improve status. Multiple micronutrient supplementation most improved micronutrient status but had little effect on infection markers. The study suggests antenatal micronutrient supplementation can help address deficiencies in this population.
Adipose tissue, once thought to function simply for energy storage, is now recognized as an endocrine organ that secretes proteins called adipokines or adipocytokines. These proteins include hormones that regulate processes like food intake and insulin sensitivity, enzymes involved in lipid metabolism, cytokines that mediate inflammation and immunity, and other proteins that impact cardiovascular health and metabolic functions. Ongoing research continues to elucidate the roles of various adipokines in important physiological pathways and diseases.
This study investigated whether supplementing vitamin E to a conventional soybean lipid emulsion used in parenteral nutrition would help prevent parenteral nutrition-associated liver disease (PNALD) in neonatal piglets. Sixteen piglets received parenteral nutrition with either a standard soybean lipid emulsion (SO) or the same emulsion supplemented with additional vitamin E (SO+E). After 17 days, bile flow, liver enzymes, markers of inflammation and oxidative stress, and gene expression related to bile acid metabolism were measured and compared between the two groups. The study found no significant differences between the SO and SO+E groups in any of the outcomes measured, suggesting that simply adding vitamin E to the soybean lipid emulsion did not provide benefits in preventing
- Alanine amino transferase (ALT) concentrations were higher in obese adolescent girls who were heterozygous or homozygous for the MTHFR 677 C>T mutation, which decreases MTHFR enzyme activity.
- ALT levels were negatively correlated with reported folate intake and positively correlated with homocysteine concentrations. Lower folate intake and higher homocysteine are associated with increased liver damage.
- Girls with the MTHFR mutation also had lower erythrocyte folate levels and higher insulin levels compared to those without the mutation, suggesting the mutation enhances liver damage possibly by reducing antioxidant status and increasing insulin resistance.
1. The document discusses how maternal obesity affects molecular signals at the maternal-fetal interface. It modifies placental function and fetal growth through increased inflammatory pathways, leptin and fatty acid levels.
2. Obese women have higher levels of insulin, leptin and inflammatory markers in early pregnancy. Leptin from the placenta of obese women stimulates fatty acid uptake and inflammatory pathways.
3. The placenta of obese women shows increased inflammation and apoptosis, leading to higher levels of circulating cell-free DNA from the placenta in maternal blood. This cell-free DNA is associated with maternal adiposity measures.
Maternal obesity is associated with increased risks during pregnancy such as gestational diabetes and fetal overgrowth. This document summarizes recent research investigating how maternal obesity impacts placental function and fetal growth. Studies presented show that in obese mothers, the placenta exhibits increased expression of nutrient transporters for glucose, amino acids, and fatty acids. This enhanced placental transport is believed to stimulate fetal growth through increased delivery of nutrients to the fetus. Factors involved in regulating these placental changes include maternal hormones, cytokines, and nutrients. Understanding these pathways may help address health issues linked to abnormal fetal growth.
This document discusses hyperhomocysteinemia in pregnancy. It begins with an overview of hyperhomocysteinemia, its prevalence in pregnancy, and its association with adverse clinical outcomes. It then discusses diagnostic measures and treatment, with an emphasis on supplementation with vitamins B6, B9, and B12. Studies show these vitamins play an important role in homocysteine metabolism and that supplementation is effective and safe at reducing homocysteine levels and potentially improving pregnancy outcomes. The document provides evidence that hyperhomocysteinemia is linked to complications like preeclampsia, intrauterine growth restriction, and neural tube defects.
- 26 subjects participated in a 56-day study where they consumed 100g of Emmental cheese, 20g of butter, and 40g of almonds daily, providing an extra 760 kcal per day mainly from dairy fat.
- The concentrations of four fatty acids (C14:0, C15:0, tC16:1, C17:0) suggested to be biomarkers for dairy consumption were measured before and after the overfeeding period.
- Only the concentrations of C15:0 and tC16:1 significantly increased after the overfeeding, supporting their use as biomarkers for dairy fat intake. C14:0 and C17:0 levels did not change.
Diabetes mellitus is spreading around the world, penetrating populations not only in poor and developing countries, but also in developed ones. Propolis, a complex resinous material collected by honey bees from buds and exudates of certain plant sources, containing flavonoids pinocebrin, galangin, chrysin, and caffeic acid phenethyl ester.
The use of propolis as an alternative healing therapy for type-2 diabetes mellitus has been claimed to alleviate the disease. Previous studies state that propolis improves normal homeostasis by balancing the body’s condition through the enhancement of the immune system. The histological analysis of the liver shows that at a dose of 50–200 mg/kg BW propolis does not show a toxic effect so that the dose is categorized safe.
Therefore, the ethanolic soluble derivative of propolis (EEP) extract warrant further studies as an antidiabetic agent that is safe for humans.
Balancing Fat Nutrition to Optimise Transition Cow Performance
A cow’s transition period is a key time since most of the metabolic and infectious diseases occur then.
Higher demand of energy and nutrients for the synthesis of colostrum and milk coupled with decreased feed intake force the transition cows to undergo negative energy balance (NEB) and micronutrient deficiencies. When metabolism does not meet production demands, incidence of clinical or subclinical metabolic disorders increases. Because innate and acquired immunity are suboptimal during this period, animals are more prone to infection
Proper supplementation at this moment may prevent future diseases and production losses.
In early lactation, the challenge for the cow to shift gear to accelerate copious milk production against loss of appetite results in nutrient deficiencies and subsequent negative energy balance leading to mobilisation of body reserves and compromised immunity
(Fiore et al., 2017).
Endocrine, adipose tissue, liver, digestive system and mammary gland are key components of the adaptations that dairy cows experience to achieve the necessary balance to adjust to the onset of sustained increasing milk production.
If unchecked metabolic stress in the affected cows can burden dairy producers with increased poor cow health, infertility, culling rates, inefficient nutrient utilisation and economic loss
In early lactation, the challenge for the cow to shift gear to accelerate copious milk production against loss of appetite results in nutrient deficiencies and subsequent negative energy balance leading to mobilisation of body reserves and compromised immunity
(Fiore et al., 2017).
Endocrine, adipose tissue, liver, digestive system and mammary gland are key components of the adaptations that dairy cows experience to achieve the necessary balance to adjust to the onset of sustained increasing milk production.
If unchecked metabolic stress in the affected cows can burden dairy producers with increased poor cow health, infertility, culling rates, inefficient nutrient utilisation and economic loss
In early lactation, the challenge for the cow to shift gear to accelerate copious milk production against loss of appetite results in nutrient deficiencies and subsequent negative energy balance leading to mobilisation of body reserves and compromised immunity
(Fiore et al., 2017).
Endocrine, adipose tissue, liver, digestive system and mammary gland are key components of the adaptations that dairy cows experience to achieve the necessary balance to adjust to the onset of sustained increasing milk production.
If unchecked metabolic stress in the affected cows can burden dairy producers with in
Edible Bird’s Nest Attenuates Procoagulation Effects of High-Fat Diet in RatsElabscience
Edible bird’s nest (EBN) is used traditionally in many parts of Asia to improve wellbeing, but there are limited studies on its
efficacy. We explored the potential use of EBN for prevention of high fat diet- (HFD-) induced insulin resistance in rats.
1. The study investigated the effects of a high-fat diet, corn oil supplementation, and omega-3 fatty acid supplementation on nerve conduction velocity and markers of oxidative stress and inflammation in the sciatic nerves of rats.
2. Rats fed a high-fat diet for 12 weeks developed obesity and showed slowed nerve conduction velocity, increased oxidative stress and inflammation in the sciatic nerve, compared to controls.
3. Rats that were obese and continued on a high-fat diet, or were given corn oil or omega-3 supplements alongside the high-fat diet for 5 additional weeks, showed improvements in some markers like nerve conduction velocity, oxidative stress and inflammation compared to rats that remained on just the high-fat
Loss of the RNA polymerase III repressor Maf1 confers obesity resistanceAsh Byrnes
1) Mice with whole-body knockout of the RNA polymerase III repressor MAF1 are resistant to diet-induced obesity and nonalcoholic fatty liver disease. They have reduced food intake and increased metabolic inefficiency.
2) Energy expenditure is increased in MAF1 knockout mice through multiple mechanisms, including increased precursor tRNA synthesis and futile cycling of tRNAs and hepatic lipids.
3) Metabolite profiling reveals elevated levels of amino acids and spermidine in MAF1 knockout mice, linking induction of autophagy to their extended lifespan. Increased spermidine and reduced nicotinamide N-methyltransferase are associated with obesity resistance.
transition period is an important period for milch animals. during this period feeding is also utmost important. During this time feeding and management decide the future of dairy animals.
This document summarizes research on the effects of polyunsaturated fatty acids (PUFAs) on male and female reproduction. It discusses how PUFAs can influence the timing of labor through their role in prostaglandin synthesis. A high n-6 PUFA diet is associated with preterm delivery, while increased n-3 PUFA intake through fish or supplements may decrease preterm birth risk. PUFAs also impact male fertility, as spermatozoa require PUFAs for fluidity but are vulnerable to oxidative damage from too many PUFAs. Altering egg yolk PUFA content can decrease chick embryonic survival and hatchability.
Protective Gut And Nutritional StratigiesPerwin Waly
Early and aggressive nutrition is recommended for preterm infants to support growth and development. This includes starting total parenteral nutrition within the first hours and minimal enteral feeding beginning on the first day using human milk when possible. Human milk provides important immune and nutritional benefits and is preferred over formula when available due to its protection against infection and promotion of development.
Chapter 02 Boland Effects of Nutrition on Fertility in Dairy Cows .pdfGilson Antonio Pessoa
This document summarizes research on the effects of nutrition on fertility in dairy cows. Key findings include:
- Nutrition can influence fertility through effects on endocrine factors, follicular development, oocyte quality, and early embryo development.
- Both undernutrition and overnutrition can negatively impact fertility. Undernutrition can decrease LH and follicle growth, while overnutrition can decrease progesterone levels important for embryo survival.
- Nutrition influences oocyte quality and development - restricting feed intake before slaughter improved subsequent oocyte development, while overfeeding impaired embryo quality in some studies.
- High producing dairy cows with low body condition scores yielded lower quality oocytes in one study, indicating an interaction between genetics, nutrition, and reproduction
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
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Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
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Novichol 25
Background.
Choline is often referred to as a vitamin or micronutrient, but it does not fit the classical definition. It can be
synthesized endogenously, it is not an enzyme cofactor in metabolic pathways, and it is typically
supplemented in much larger quantities than vitamins. Choline is an essential nutrient for many animal
species including pre-ruminating sheep, and calves. Choline serves as a methyl donor in biochemical
reactions and as a constituent of phosphatidylcholine (PC). Methionine serves as a methyl donor for choline
synthesis; therefore, choline and methionine can spare the requirement of each other. Involvement of biotin,
folic acid, and vitamin B12 in one-carbon methyl metabolism yields potential interactions between these
vitamins and choline. Phosphatidylcholine can be synthesized from tri-methylation of
phophatidylethanolamine or directly from choline. As a component of phospholipids, choline is essential for
maintaining cell membrane structure and permeability, and for transport of lipid from the liver as a constituent
of very low-density lipoproteins (VLDL). Choline deficiency leads to fatty liver estimates of ruminal choline
degradation are 80-98% (Atkins et al., 1988, Sharma and Erdman, 1989b). Differential milk yields response
between ruminal and abomasal infusion of choline support invitro data and suggest ruminal degradation of
choline (Sharma and Erdman, 1989a). The main fate of dietary choline is ruminal conversion to
trimethylamine followed by conversion to methane. Ruminal production of choline is negligible (Erdman,
1992). Protected choline supplements have been developed to decrease microbial degradation in the
rumen and increase delivery of choline to the small intestine.
Increased Milk Production.
A summary of milk and milk component responses to postruminal infusion of choline or feeding protected
choline are shown in Figures 1-3. In each, the control treatment mean has been plotted against the choline
treatment mean. Amounts of choline chloride supplied for most of the studies was 15 g/day, although
amounts may have been as high as 50 g/day in some of the postruminal infusion trials. We plotted the data in
this fashion to try and examine if the response was related to level of production or milk components.
In the 16 treatment comparisons summarized in Figure 1, there was a significant increase (P < 0.05) in milk
yield in 6 comparisons and a trend (P < 0.15) toward an increase in one comparison. Response to choline
was not dependent on high milk yield because some of the biggest responses were obtained from moderate
(30-35 kg/d) producing cows.
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Figure 1. Milk yield response, plotted as control treatment vs. choline treatment, for cows fed rumen- protected choline or postruminally
infused with choline. References: Abeni et al., 2007; Davidson et al., 2006; Emanuele et al., 2007; Erdman and Sharma, 1991; Hartwell
et al., 2000; Janovick Guretzky et al., 2006; Lima et al., 2007; Ondarza et al., 2007; Piepenbrink and Overton, 2003; Sharma and
Erdman, 1988; Sharma and Erdman, 1989; Thering et al. 2007; Toghdory et al., 2007; Zahra et al., 2006.
Reasons for the increases in milk yield or variability in milk yield response are not known. For studies in
which protected choline was fed, it may be related to the level of protection and/or degree of release in the
intestine. It may be related to status of other methyl donors (i.e. methionine) or cofactors associated with
one-methyl carbon metabolism (folic acid, vitamin B12). Further studies are needed to establish the
relationship between supplemental choline and other nutrients involved in one-carbon methyl metabolism.
Increased Milk Fat
Some of the early studies by Erdman and co-workers (Erdman et al., 1984) hypothesized that choline
supplementation may increase milk fat percentage. They suggested “choline aided the transport of mobilized
free fatty acids from adipose tissue through the liver to the mammary gland”. Figure 2 shows a summary of
the responses of milk fat percentage to rumen-protected or postruminally infused choline. Of the 12 studies
summarized, fat percentage was increased statistically in 3 of the studies (P < 0.05) and tended to increase
in 1 of the studies (P < 0.15).
Figure 2. Milk fat response, plotted as control treatment vs. choline treatment, for cows fed rumen- protected choline or postruminally
infused with choline. References: Abeni et al., 2007; Davidson et al., 2006; Emanuele et al., 2007; Erdman and Sharma, 1991; Hartwell
et al., 2000; Janovick Guretzky et al., 2006; Ondarza et al., 2007; Piepenbrink and Overton, 2003; Sharma and Erdman, 1988; Sharma
and Erdman, 1989; Toghdory et al., 2007; Zahra et al., 2006.
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Milk protein
Response to supplemental choline is summarized in Figure 3. The response is neutral with only one study
indicating a trend for a change; a decrease (P < 0.15). Given the potential ability of choline to spare
methionine, it is surprising that positive treatment effects were never observed. In the great majority of
studies, diet methionine status was not described.
Figure 3. Milk protein response, plotted as control treatment vs. choline treatment, for cows fed rumen- protected choline or
postruminally infused with choline. References: Abeni et al., 2007; Davidson et al., 2006; Emanuele et al., 2007; Erdman and Sharma,
1991; Hartwell et al., 2000; Janovick Guretzky et al., 2006; Ondarza et al., 2007; Piepenbrink and Overton, 2003; Sharma and Erdman,
1988; Sharma and Erdman, 1989; Thering et al. 2007; Toghdory et al., 2007; Zahra et al., 2006.
Animal Health Benefits.
1)Choline deficiency causes an increase in accumulation of triglyceride (TAG) in liver. Triglyceride is
transported out of the liver as a constituent of VLDL.
2) Choline Sparing effect of methionine (also a methyl donor) which is an amino acid that is required for
synthesis of protein (a constituent of VLDL).
3) Choline also serves as a substrate for synthesis of PC, another constituent of VLDL.
4)Fatty liver is a metabolic disorder that can affect up to 50% of high producing cows during the transition
period, potentially compromising health, production and reproduction. Fatty liver develops when
plasma nonesterified fatty acid (NEFA) concentrations are high due to depressed feed intake and
altered endocrine status associated with initiation of parturition and lactation. The NEFA
concentration at which TAG begins to accumulate in liver is not well established, but is known that
the hepatic uptake of NEFA is directly associated with its concentration in blood. Research involving
frequent blood and liver sampling in periparturient Holstein cows has shown liver TAG accumulation
within 1 day after calving, which was preceded by an acute increase in plasma NEFA concentration
and depressed feed intake immediately prior to and at calving (Vazquez-Añon et al., 1994).
Therefore, if the flow of choline to the intestine of dairy cattle is insufficient during the periparturient
period when feed intake is low and fat mobilization is high, synthesis of VLDL could be limited and
fatty liver could result.
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Novicin 50
Background.
The vitamin niacin is a precursor of the coenzyme nicotinamide adenine dinucleotide (NAD) which
participates in a large number of oxidation- reduction reactions, both in anabolic (NADPH/NADP) and
catabolic (NADH/NAD) pathways. Niacin can be found in two common forms: nicotinic acid (NA) and
nicotinamide (NAM). Both compounds have similar nutritional properties, and both can be used in the
synthesis of NAD but have distinct biological properties (Dipalma and Thayer, 1991; Carlson, 2005).
Early studies from the 1960’s showed that NA has anti-lipolytic effects in humans. Both oral or
intravenous administrations of NA boluses lead to dramatic and acute reductions of plasma NEFA
concentrations, followed by a rebound above baseline levels and a subsequent return to baseline (Carlson,
2005). In dairy cows, large oral boluses of NA cause transient decreases in NEFA concentration followed by
a rebound (160 g, Waterman and Schultz, 1972; Waterman et al., 1972; 12 or 120 g, Jaster et al., 1983).
Pharmacological doses of NA inhibit lipolysis in adipose tissue (Dipalma and Thayer, 1991; Carlson, 2005),
but have minimal direct effects on subsequent fatty acid metabolism in the bovine (Waterman and Schultz,
1973). The rebound is thought to occur when NA action in adipose tissue ceases, possibly due to clearance
of NA from blood (Waterman and Schultz, 1972). In contrast to NA, NAM does not have anti-lipolytic
properties in humans (Dipalma and Thayer, 1991; Carlson, 2005). Accordingly, oral administration of 12 g/d
of NAM to feed-restricted cows failed to reduce plasma NEFA or BHBA concentrations (Jaster and Ward,
1990), even though rumen microbes are able to convert NAM to NA(Harmeyer and Kollenkirchen, 1989;
Campbell et al., 1994).
Productive performance and health.
A meta-analysis of 27 feeding studies involving free NA supplementation to dairy rations showed no
improvement in lactation performance when NA was given at a rate of 6 g/d (Schwab et al., 2005).
Supplementation of 12g NA/d did not change in milk production (0.4 kg; P = 0.12) and resulted in modest
increases in fat (25.8 g/d; P = 0.01) and protein (17.4 g/d; P = 0.08) yields compared to controls (Schwab et
al., 2005). The authors questioned the economic return from supplementing free NA in dairy rations due to
high variability of results and small production responses.
Plasma NEFA concentrations were reduced in only one out of 11 studies in which periparturient cows were
supplemented with niacin (6 to 12 g/d of free NA or NAM; NRC, 2001). Accordingly, meta-analysis of multiple
studies involving NA feeding showed no statistical effects of NA in plasma NEFA and BHBA concentrations
(Schwab et al., 2005). The absence of positive results of niacin supplementation in most feeding trials
contrasts with the positive effects of NA in reducing NEFA levels in humans, and with the acute reduction in
plasma NEFA when supraphysiological doses of NA were given to cows. There are several factors that may
explain the lack of success with using niacin to reduce NEFA. The active form of niacin modulating adipose
tissue metabolism in humans is NA, therefore, effects may not be expected in the bovine if NAM is fed.
Supplemental niacin is extensively degraded or transformed in the rumen. Only 6.7% to 17% of supplemental
NA was estimated to reach the duodenum in the bovine (Zinn et al., 1987; Campbell et al., 1994). Absorption
of NA through the rumen is probably insignificant (Harmeyer and Kollenkirchen, 1989; Erickson et al., 1991;
Campbell et al., 1994). The dosage of niacin fed to periparturient dairy cows (either as NA or NAM) usually
ranges from 6 to 12 g/d (NRC, 2001; Schwab et al., 2005). This supplementation level is probably insufficient
to elicit a significant and sustained decrease in NEFA, especially when taking into consideration the limited
flow of supplemental NA to the lower gut (Zinn et al., 1987; Campbell et al., 1994). Recent experiments
involving the supplementation of periparturient dairy cows with high doses of rumen available NA have
produced inconsistent results. Jersey cows supplemented with 48 g/d of free NA from 30 d prepartum until
calving had lower levels of plasma NEFA at calving and less DMI decline during the last week of gestation
(French, 2004). However, these results were not replicated when both Holstein and Jersey cows were
supplemented with up to 98 mg NA/d per kg BW, from 30 d prepartum to 21 d postpartum (Chamberlain and
French, 2006). We suspect that only a small fraction of the NA was absorbed because a free form of NA was
used. Furthermore, the antilipolytic effects could have been transient, and the inconsistent results on plasma
NEFA may have reflected the time of blood sampling relative to NA feeding.
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Current research.
We hypothesized that, if delivered in sufficient quantities to the intestine, NA would limit lipolysis in adipose
tissue and induce sustained reductions in plasma NEFA concentration during periods of negative energy
balance. In experiment 1, we studied the effect of single NA abomasal bolus on plasma NEFA of feed-
restricted cows (Pires and Grummer, 2007). Treatments were a bolus of 0, 6, 30 or 60 mg NA/kg BW,
corresponding to 0, 5, 24 and 49 g of NA, given as a single abomasal infusion each period. Cows were feed-
restricted for 48 h prior to abomasal infusion to stimulate mobilization of fatty acids and elevate plasma NEFA
concentration. All NA doses caused dramatic reductions of plasma NEFA, followed by a rebound during
which NEFA increased transiently above baseline levels (Figure 4).
ntrol
ed rumen-
d with
avidson et
nd Sharma,
zky et al.,
d Overton,
and
a et al.,
s control
ed rumen-
d with
avidson et
nd Sharma,
zky et al.,
d Overton,
and
ry et al.,
Figure 4. Effects of abomasal infusion of single doses
of nicotinic acid on plasma NEFA. Fixed effects in
the statistical model: treatment (P = 0.001), time and
treatment x time interaction (P < 0.001). Treatment
differences within a time point are indicated by * (P <
0.001; Pires and Grummer, 2007).
Figure 5. Effects of abomasal infusions of nicotinic
acid at a rate of 0, 6, or 10 mg/h per kg of BW on
plasma NEFA. Infusion of treatments started at 48 h
of feed restriction (time 0) and was repeated at 1, 2, 3,
4, 5, 6, 7, and 8 h thereafter. Fixed effects in the
statistical model: treatment (P = 0.06), time (P < 0.001)
and treatment x time (P < 0.001). Treatment
differences within a time point are indicated by *
(P < 0.001) and ‡ (P = 0.05; Pires and Grummer, 2007).
Figure 4. Effects of abomasal infusion of single doses of nicotinic acid on plasma NEFA. Fixed effects in the statistical model: treatment
(P = 0.001), time and treatment x time interaction (P < 0.001). Treatment differences within a time point are indicated by * (P < 0.001;
Pires and Grummer, 2007).
The initial pattern of plasma NEFA decrease suggests that blood NA concentrations initially reached a
threshold that induced maximum inhibition of adipose lipolysis. The rebound of plasma NEFA followed a
pattern observed in other animal models. A second experiment was conducted to assess whether successive
abomasal infusions of NA could induce sustained reductions of plasma NEFA concentration (Pires and
Grummer, 2007). Six non- pregnant, non-lactating Holstein cows were feed- restricted for 48 h to increase
plasma NEFA. At 48 h of feed restriction, cows received 9 hourly abomasal infusions of 0, 6 or 10 mg NA/kg
BW per h, which corresponded to 0, 4.9 and 8.3 g NA/h. Both NA treatments reduced plasma NEFA in a
similar pattern, from 550 to approximately 100 uEq/L. Again, a dramatic rebound was observed after NA
infusions were discontinued at 8 h (Figure 5).
trol
ed rumen-
with
vidson et
d Sharma,
ky et al.,
d Overton,
nd
et al.,
control
ed rumen-
with
vidson et
d Sharma,
ky et al.,
Figure 4. Effects of abomasal infusion of single doses
of nicotinic acid on plasma NEFA. Fixed effects in
the statistical model: treatment (P = 0.001), time and
treatment x time interaction (P < 0.001). Treatment
differences within a time point are indicated by * (P <
0.001; Pires and Grummer, 2007).
Figure 5. Effects of abomasal infusions of nicotinic
acid at a rate of 0, 6, or 10 mg/h per kg of BW on
plasma NEFA. Infusion of treatments started at 48 h
of feed restriction (time 0) and was repeated at 1, 2, 3,
4, 5, 6, 7, and 8 h thereafter. Fixed effects in the
statistical model: treatment (P = 0.06), time (P < 0.001)
and treatment x time (P < 0.001). Treatment
differences within a time point are indicated by *
(P < 0.001) and ‡ (P = 0.05; Pires and Grummer, 2007).
Figure 5. Effects of abomasal infusions of nicotinic acid at a rate of 0, 6, or 10 mg/h per kg of BW on plasma NEFA. Infusion of
treatments started at 48 h of feed restriction (time 0) and was repeated at 1, 2, 3, 4, 5, 6, 7, and 8 h thereafter. Fixed effects in the
statistical model: treatment (P = 0.06), time (P < 0.001) and treatment x time (P < 0.001). Treatment differences within a time point are
indicated by * (P < 0.001) and ‡ (P = 0.05; Pires and Grummer, 2007).